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Effect of ultrasound machine settings on twinkling artifact visualization

https://doi.org/10.24835/1607-0763-1610

Abstract

Study objective: Determination of optimal parameters of ultrasound scanning of urinary stones for effective visualization of Doppler twinkling artifact.

Materials and Methods: A search of modern literature (from 2015 to 2025) devoted to the influence of ultrasound scanner settings on twinkling artifact visualization in Russian and English was conducted in the scientific databases Pubmed, Scopus and Elibrary.

The influence of scanning parameters on the intensity of Doppler twinkling artifact visualization studied using a specially designed phantom, in which a calcium oxalate urinary stone with a diameter of 5 mm placed.

The study performed on the following ultrasound machines: Philips Affinity 70, ALOKA ProSound F75, Canon Aplio i700, Siemens ACUSON NX3 Elite, GE Healthcare LOGIQ E9, Mindray DC-60 Pro X-Insight using a convex abdominal probe in Doppler mapping mode.

The following ultrasound parameters were determined: Transmitter power, Color Doppler reference frequency, B-mode probe frequency, Focal length, Color window width, Harmonic, Pulse repetition frequency, Multibeam scanning, Color-write priority, Doppler signal gain (C-gain), B-mode gain (B-gain), Tissue harmonic mode, Interframe averaging, Color mapping averaging, Flash suppression, and Vessel wall oscillation filter.

Results. The paper analyzes settings such as ultrasound frequency, signal gain level, and time setting parameters, clearly demonstrating how these factors affect image clarity and diagnostic accuracy. The following ultrasound scanner settings have been determined to increase twinkling artifact visualization efficiency: increasing the transmitter power to maximum; decreasing the color Doppler reference frequency; setting the focal zone below the object location depth; decreasing the color window width and increasing the pulse repetition rate. The influence of software solutions aimed at artifact suppression can be reduced by setting the priority to the color value; disabling flash suppression; increasing the wall filter values; disabling flash suppression and tissue harmonics.

Conclusions. Optimization of ultrasound scanning parameters can significantly increase the efficiency of twinkling artifact detection in urinary stones.

About the Authors

A. I. Gromov
N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center of the Ministry of Healthcare of Russian Federation; The Russian University of Medicine of the Ministry of Healthcare of the Russian Federation
Russian Federation

Alexander I. Gromov – Doct. of Sci., (Med.), Professor, Head of the Radiation Diagnostics and Treatment Group, N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center of the Ministry of Healthcare of Russian Federation;
Professor of the Department of Radiation Diagnostics of the Moscow State Medical University named after A.I. Evdokimov, Ministry of Health of the Russian Federation, Moscow
https://orcid.org/0000-0002-9014-9022



D. V. Leonov
Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department; Federal Research Center “Computer Science and Control” of the Russian Academy of Sciences; National Research University “Moscow Power Engineering Institute” (MPEI)
Russian Federation

Denis V. Leonov – Cand. of Sci. (Techn.), Leading researcher, Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department;
scientist, Federal Research Center “Computer Science and Control” of the Russian Academy of Sciences;
Associate professor, National Research University “Moscow Power Engineering Institute” (MPEI), Moscow
https://orcid.org/0000-0003-0916-6552



A. V. Sivkov
N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center of the Ministry of Healthcare of Russian Federation
Russian Federation

Andrey V. Sivkov – Cand. of Sci. (Med.), Deputy Director, N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center of the Ministry of Healthcare of Russian Federation, Moscow
https://orcid.org/0000-0001-8852-6485



D. A. Voitko
N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center of the Ministry of Healthcare of Russian Federation

Dmitry A. Voitko – Cand. of Sci. (Med.), Researcher at the Department of Urolithiasis,
N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiologiсal Center of the Ministry of Healthcare of Russian Federation
https://orcid.org/0000-0003-1292-1651



A. D. Kaprin
National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; P. Hertsen Moscow oncology research institute – Branch of National Medical Research Radiological Centre of the Ministry of Healthcare of the Russian Federation; Peoples' Friendship University of Russia named after Patrice Lumumba
Russian Federation

Andrey D. Kaprin – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Honored Physician of the Russian Federation,
Director General, National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation;
Director, P. Hertsen Moscow oncology research institute – Branch of National Medical Research Radiological Centre of the Ministry of Healthcare of the Russian Federation;
Head of the Department of Oncology and Roentgenology named after V.P. Kharchenko, Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University), Moscow
https://orcid.org/0000-0001-8784-8415



References

1. Rahmouni A., Bargoin R., Herment A. et al. Color Doppler Twinkling artifact in Hyperechoic regions. Radiology. 1996; 199: 269–271.

2. Jamallivani A., Behnam H., Tavakkoli J. Monitoring high-intensity focused ultrasound thermal therapy by ultrasound doppler imaging using twinkling artifact. PLOS ONE. 2025; 20 (7): e0324801. https://doi.org/10.1371/journal.pone.0324801

3. Abid A., Butt R.W., Abbas H.B. et al. Diagnostic accuracy of colour doppler ultrasound using twinkling artefact for the diagnosis of renal and ureteric calculi keeping non enhanced CT KUB as gold standard. Pak. Armed Forces Med. J. 2021; 71 (2): 522–525.

4. Adel H., Sattar A., Rahim A. et al.Diagnostic Accuracy of Doppler Twinkling Artifact for Identifying Urinary Tract Calculi. Cureus. 2019; 11 (9): e5647. https://doi.org/10.7759/cureus.5647

5. Bacha R., Manzoor I., Gilani S.A. Clinical Significance of Twinkling Artifact in the Diagnosis of Urinary Stones. Ultrasound Med. Biol. 2019; 45 (12): 3199–3206; https://doi.org/10.1016/j.ultrasmedbio

6. Nabheerong P., Kengkla K., Saokaew S. Diagnostic accuracy of Doppler twinkling artifact for identifying urolithiasis: a systematic review and meta-analysis. J. Ultrasound. 2023; 26 (2): 321–331. https://doi.org/10.1007/s40477-022-00759-z

7. Rokni E., Zinck S., Simon J.C. Evaluation of stone features that cause the color Doppler ultrasound twinkling artifact. Ultrasound Med. Biol. 2021; 47 (5): 1310–1318. https://doi.org/10.1016/j.ultrasmedbio.2021.01.016

8. Leonov D.V., Reshetnikov R.V., Kulberg N.S. et al. Doppler twinkling artifact observations: an open-access database of raw ultrasonic signals. Dig. Diagn. 2021; 2 (3): 261–276; https://doi.org/10.17816/DD76511

9. Vasiliev A.Yu., Gromov A.I. Color Doppler mapping using power Doppler in assessing prostate pathology. Military Medical Journal. 1997; 318 (4): 33–37. (In Russian)

10. Sorensen M.D., Harper J.D., Hsi R.S. et al. B-mode ultrasound versus color Doppler twinkling artifact in detecting kidney stones. J. Endourol. 2013; 27 (2): 149–153. https://doi.org/10.1089/end.2012.0430

11. Ortiz S.H.C., Chiu T., Fox M.D. Ultrasound image enhancement: A review. Biomed. Signal Proc. Control. 2012: 7 (5): 419–428. https://doi.org/10.1016/j.bspc.2012.02.002

12. Gromov A.I., Prosyannikov M.Yu., Voitko D.A. et al. Development of a method for assessing the twinkling artifact for diagnosing urinary stones on various ultrasound scanners. Experimental and Clinical Urology. 2024; 17 (3): 23–29; https://doi.org/10.29188/2222-8543-2024-17-3-23-29 (In Russian)

13. Gromov A.I., Sapozhnikov O.A., Kaprin A.D. Doppler twinkling artifact: physical mechanisms and place in diagnostic practice. State of the art. Medical Visualization. 2023; 27 (1): 120–134. http://doi.org/10.24835/1607-0763-1206 (In Russian)

14. Rokni E., Kitur E.C., Simon J.C. Dynamics of crevice microbubbles that cause the twinkling artifact. Ultrasonics Sonochemistry. 2024; 108: 106971; http://doi.org/10.1016/j.ultsonch.2024.106971

15. Lu W., Sapozhnikov O.A., Bailey M.R. et al. Evidence for trapped surface bubbles as the cause for the twinkling artifact in ultrasound imaging. Ultrasound Med. Biol. 2013; 39: 1026–1038. https://doi.org/10.1016/j.ultrasmedbio.2013.01.011

16. Poggi C., Palavecino M. Ultrasound principles and instrumentation. Surgery Open Science. 2024; 18: 123–128. http://doi.org/10.1016/j.sopen.2024.02.005

17. Yang J.H., Kang G., Choi M.J. The role of the acoustic radiation force in color Doppler twinkling artifacts. Ultrasonography. 2015; 34 (2): 109–114. http://doi.org/10.14366/usg.14065

18. Bacha R., Gilani S. A., Manzoor I. Relation of color Doppler twinkling artifact and scale or pulse repetition frequency. J. Med. Ultrasound. 2019; 27 (1): 13–18. http://doi.org/10.4103/JMU.JMU_129_18

19. Raheem A. Effects of Artifacts on the Diagnosis of Ultrasound Image. Medico-Legal Update. 2021; 21 (4): 327–336. http://doi.org/10.37506/mlu.v21i4.3152

20. Сhoi M.J., Cho C.H., Kang G., Yang J. Color Doppler Twinkling Artifact: Possible Mechanisms and Clinical Potential. Biomed. Eng. Lett. 2014; 4: 41–54. https://doi.org/10.1007/s13534-014-0124-4

21. Shabana W., Bude R.O., Rubin J.M. Comparison between color Doppler twinkling artifact and acoustic shadowing for renal calculus detection: an in vitro study. Ultrasound Med. Biol. 2009; 35 (2): 339–350. http://doi.org/10.1016/j.ultrasmedbio.2008.09.023

22. Gao J., Hentel K., Rubin J.M. Correlation between Twinkling artifact and color Doppler carrier frequency: Preliminary observations in renal calculi. Ultrasound Med. Biol. 2012; 38: 1534–1539. http://doi.org/10.1016/j.ultrasmedbio.2012.04.011


Review

For citations:


Gromov A.I., Leonov D.V., Sivkov A.V., Voitko D.A., Kaprin A.D. Effect of ultrasound machine settings on twinkling artifact visualization. Medical Visualization. 2026;30(2):56-67. (In Russ.) https://doi.org/10.24835/1607-0763-1610

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ISSN 1607-0763 (Print)
ISSN 2408-9516 (Online)