<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/10.24835/1607-0763-983</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-983</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОТ ПРИГЛАШЕННОГО РЕДАКТОРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FROM THE INVITED EDITOR</subject></subj-group></article-categories><title-group><article-title>Новые области применения компьютерной томографии сердца в диагностике ишемии миокарда</article-title><trans-title-group xml:lang="en"><trans-title>New applications of cardiac computed tomography for evaluation of myocardial ischemia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8402-7643</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лисицкая</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lisitskaya</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лисицкая Мария Валерьевна – канд. мед. наук, врач-рентгенолог отделения рентгенодиагностики с кабинетами КТ и МРТ</p><p>Scopus ID 57210604921</p><p>119192 Москва, Ломоносовский проспект, 27, к. 10</p><p>Тел.: +7-196-550-88-11</p></bio><bio xml:lang="en"><p>Maria V. Lisitskaya – Cand. of Sci. (Med.), Radiologist at Radiology department with CT and MRI </p><p>27-10, Lomonosovsky prospekt, 119192 Moscow</p><p>Phone: +7-196-550-88-11 </p></bio><email xlink:type="simple">lissenok@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1266-4926</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мершина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mershina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мершина Елена Александровна – канд. мед. наук, заведующая отделением рентгенодиагностики с кабинетами КТ и МРТ; доцент кафедры лучевой диагностики факультета фундаментальной медицины </p><p>Scopus ID 12787891900 </p><p>119192 Москва, Ломоносовский проспект, 27, к. 10</p></bio><bio xml:lang="en"><p>Elena A. Mershina – Cand. of Sci. (Med.), Head of Radiology department with CT and MRI </p><p>27-10, Lomonosovsky prospekt, 119192 Moscow</p></bio><email xlink:type="simple">elena_mershina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2484-5249</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ларина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Larina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ларина Ольга Михайловна – канд. мед. наук, врач-рентгенолог, отделения рентгенодиагностики с кабинетами КТ и МРТ</p><p>119192 Москва, Ломоносовский проспект, 27, к. 10</p></bio><bio xml:lang="en"><p>Olga M. Larina – Cand. of Sci. (Med.), Radiologist at Radiology department with CT and MRI </p><p>27-10, Lomonosovsky prospekt, 119192 Moscow</p></bio><email xlink:type="simple">larina-olga@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7533-9867</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плотникова</surname><given-names>М. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Plotnikova</surname><given-names>M. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плотникова Мария Леонидовна – врач-рентгенолог отделения рентгенодиагностики с кабинетами КТ и МРТ </p><p>119192 Москва, Ломоносовский проспект, 27, к. 10</p></bio><bio xml:lang="en"><p>Maria L. Plotnikova – Radiologist at Radiology department with CT and MRI </p><p>27-10, Lomonosovsky prospekt, 119192 Moscow</p></bio><email xlink:type="simple">mashamotyleva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1435-4729</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шляпкина</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shlyapkina</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шляпкина Ольга Сергеевна – врач-рентгенолог отделения рентгенодиагностики с кабинетами КТ и МРТ</p><p>119192 Москва, Ломоносовский проспект, 27, к. 10</p></bio><bio xml:lang="en"><p>Olga S. Shlyapkina – Radiologist at Radiology department with CT and MRI </p><p>27-10, Lomonosovsky prospekt, 119192 Moscow</p></bio><email xlink:type="simple">shlyapkinaolga571@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Медицинский научно-образовательный центр ФГБОУ ВО “Московский государственный университет имени М.В. Ломоносова”</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Research and Education Center of Lomonosov Moscow State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>03</month><year>2022</year></pub-date><volume>26</volume><issue>1</issue><fpage>70</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лисицкая М.В., Мершина Е.А., Ларина О.М., Плотникова М.Л., Шляпкина О.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Лисицкая М.В., Мершина Е.А., Ларина О.М., Плотникова М.Л., Шляпкина О.С.</copyright-holder><copyright-holder xml:lang="en">Lisitskaya M.V., Mershina E.A., Larina O.M., Plotnikova M.L., Shlyapkina O.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/983">https://medvis.rdsmedia.ru/jour/article/view/983</self-uri><abstract><p>КТ-коронарография показала высокую диагностическую точность в диагностике ишемической болезни сердца (ИБС) и стенозов венечных артерий. Тем не менее остаются вопросы функциональной оценки ишемии миокарда, так как степень стеноза артерий и клинические исходы не всегда коррелируют, а оценка гемодинамической значимости стенозов коронарных артерий остается сложной. Отмечено, что исключительное проведение функциональных неинвазивных тестов для оценки возможных стенозов может приводить к ложноотрицательным результатам и, как следствие, ухудшать долгосрочный прогноз вероятности кардиоваскулярных событий. Таким образом, сочетанное применение анатомической и функциональной оценки венечных артерий может улучшить прогноз пациентов с ИБС. В качестве единого (“всё-в-одном”) метода обследования может выступать КТ-коронарография н, дополненная стресс-перфузией и/или измерением фракционного резерва кровотока.Данный обзор представляет собой описание новых методов диагностики ишемии миокарда при проведении КТ коронарных сосудов при стабильной ИБС и перспективы их применения.</p></abstract><trans-abstract xml:lang="en"><p>MSCT is known for its extremely high diagnostic accuracy in coronary artery stenosis detection and quantification. However, there are still questions about physiological assessment of myocardial ischemia, since the degree of arterial stenosis and clinical outcomes do not always correlate. It is also noted that the exclusive use of functional non-invasive tests to assess the grade of stenosis can lead to false-negative results and worsen the long-term prognosis of cardiovascular events. Thus, the combined use of anatomical and functional tests can improve the prognosis in coronary heart disease patient. MSCT coronary angiography, combined with stress perfusion and/or CT derived fractional flow reserve, could be used as an all-in-one approach. This review describes new applications of cardiac MSCT.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>компьютерная томография сердца</kwd><kwd>КТ-коронарная ангиография</kwd><kwd>ишемия миокарда</kwd><kwd>перфузия миокарда</kwd><kwd>стресс-перфузия миокарда</kwd><kwd>двухэнергетическая компьютерная томография сердца</kwd><kwd>фракционный резерв кровотока</kwd><kwd>коронарокальциноз</kwd><kwd>атеросклероз коронарных артерий</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiac computed tomography</kwd><kwd>myocardial ischemia</kwd><kwd>myocardial perfusion</kwd><kwd>stress-myocardial perfusion</kwd><kwd>dual energy computed tomography</kwd><kwd>fractional flow reserve</kwd><kwd>atherosclerosis</kwd><kwd>coronary artery disease</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках государственного задания МГУ (номер ЦИТИС 121061800148-2)</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Masuda Y., Naito S., Aoyagi Y. et al. Coronary artery calcification detected by CT: clinical significance and angiographic correlates. Angiology. 1990; 41 (12): 1037– 1047. http://doi.org/10.1177/000331979004101203</mixed-citation><mixed-citation xml:lang="en">Masuda Y., Naito S., Aoyagi Y. et al. Coronary artery calcification detected by CT: clinical significance and angiographic correlates. Angiology. 1990; 41 (12): 1037– 1047. http://doi.org/10.1177/000331979004101203</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Budoff M.J., Dowe D., Jollis J.G. et al. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J. Am. Coll. Cardiol. 2008; 52 (21):1724–1732. http://doi.org/10.1016/j.jacc.2008.07.031.</mixed-citation><mixed-citation xml:lang="en">Budoff M.J., Dowe D., Jollis J.G. et al. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J. Am. Coll. Cardiol. 2008; 52 (21):1724–1732. http://doi.org/10.1016/j.jacc.2008.07.031.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ашихмин Я.И., Синицын В.Е., Плиева Н.В., Щекочихин Д.Ю., Копылов Д.Ю. Возможности компьютерной томографии сердца в стратификации риска и определении оптимальной стратегии первичной профилактики сердечнососудистых осложнений атеросклероза. Кардиология. 2019; 59 (6): 70–80. http://doi.org/10.18087/cardio.2019.6.n685. Ashikhmin Ya.I., Sinitsyn V.E., Plieva N.V., Shchekochikhin D.Yu., Kopylov F.Yu. Possibilities of Computed Tomography of the Heart in Risk Stratification and Determination of Optimal Strategy of Primary Prevention of Cardiovascular Complications of Atherosclerosis. Kardiologiia. 2019; 59 (6):70–80. (In Russian)</mixed-citation><mixed-citation xml:lang="en">Ашихмин Я.И., Синицын В.Е., Плиева Н.В., Щекочихин Д.Ю., Копылов Д.Ю. Возможности компьютерной томографии сердца в стратификации риска и определении оптимальной стратегии первичной профилактики сердечнососудистых осложнений атеросклероза. Кардиология. 2019; 59 (6): 70–80. http://doi.org/10.18087/cardio.2019.6.n685. Ashikhmin Ya.I., Sinitsyn V.E., Plieva N.V., Shchekochikhin D.Yu., Kopylov F.Yu. Possibilities of Computed Tomography of the Heart in Risk Stratification and Determination of Optimal Strategy of Primary Prevention of Cardiovascular Complications of Atherosclerosis. Kardiologiia. 2019; 59 (6):70–80. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Knuuti J., Wijns W., Saraste A. et al.; ESC Scientific Document Group. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur. Heart J. 2020; 41 (3): 407–477. http://doi.org/10.1093/eurheartj/ehz425</mixed-citation><mixed-citation xml:lang="en">Knuuti J., Wijns W., Saraste A. et al.; ESC Scientific Document Group. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur. Heart J. 2020; 41 (3): 407–477. http://doi.org/10.1093/eurheartj/ehz425</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Российское кардиологическое общество. Стабильная ишемическая болезнь сердца: Методические рекомендации. 2020, 114 с. https://scardio.ru/content/ Guidelines/2020/Clinic_rekom_IBS.pdf Russian Society of Cardiology. Russian Society of Cardiology. Stable ischemic heart disease. Methodological recommendations. 2020, 114 p. https://scardio.ru/content/Guidelines/2020/Clinic_rekom_IBS.pdf</mixed-citation><mixed-citation xml:lang="en">Российское кардиологическое общество. Стабильная ишемическая болезнь сердца: Методические рекомендации. 2020, 114 с. https://scardio.ru/content/ Guidelines/2020/Clinic_rekom_IBS.pdf Russian Society of Cardiology. Russian Society of Cardiology. Stable ischemic heart disease. Methodological recommendations. 2020, 114 p. https://scardio.ru/content/Guidelines/2020/Clinic_rekom_IBS.pdf</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Knuuti J., Ballo H., Juarez-Orozco L.E. et al. The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability. Eur. Heart J. 2018; 39 (35): 3322–3330. http://doi.org/10.1093/eurheartj/ehy267</mixed-citation><mixed-citation xml:lang="en">Knuuti J., Ballo H., Juarez-Orozco L.E. et al. The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability. Eur. Heart J. 2018; 39 (35): 3322–3330. http://doi.org/10.1093/eurheartj/ehy267</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mushtaq S., Conte E., Pontone G. et al. State-of-the-artmyocardial perfusion stress testing: Static CT perfusion. J. Cardiovasc. Comput. Tomogr. 2020; 14 (4): 294–302. http://doi.org/10.1016/j.jcct.2019.09.002</mixed-citation><mixed-citation xml:lang="en">Mushtaq S., Conte E., Pontone G. et al. State-of-the-artmyocardial perfusion stress testing: Static CT perfusion. J. Cardiovasc. Comput. Tomogr. 2020; 14 (4): 294–302. http://doi.org/10.1016/j.jcct.2019.09.002</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pelgrim G.J., Dorrius M., Xie X. et al. The dream of a onestop-shop: Meta-analysis on myocardial perfusion CT. Eur. J. Radiol. 2015; 84 (12): 2411–2420. http://doi.org/10.1016/j.ejrad.2014.12.032.</mixed-citation><mixed-citation xml:lang="en">Pelgrim G.J., Dorrius M., Xie X. et al. The dream of a onestop-shop: Meta-analysis on myocardial perfusion CT. Eur. J. Radiol. 2015; 84 (12): 2411–2420. http://doi.org/10.1016/j.ejrad.2014.12.032.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tonino P.A., Fearon W.F., De Bruyne B. et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J. Am. Coll. Cardiol. 2010; 55 (25): 2816–2821. http://doi.org/10.1016/j.jacc.2009.11.096</mixed-citation><mixed-citation xml:lang="en">Tonino P.A., Fearon W.F., De Bruyne B. et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J. Am. Coll. Cardiol. 2010; 55 (25): 2816–2821. http://doi.org/10.1016/j.jacc.2009.11.096</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann U., Ferencik M., Udelson J.E. et al.; PROMISE Investigators. Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain). Circulation. 2017; 135 (24): 2320–2332. http://doi.org/10.1161/CIRCULATIONAHA.116.024360</mixed-citation><mixed-citation xml:lang="en">Hoffmann U., Ferencik M., Udelson J.E. et al.; PROMISE Investigators. Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain). Circulation. 2017; 135 (24): 2320–2332. http://doi.org/10.1161/CIRCULATIONAHA.116.024360</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Rochitte C.E., George R.T., Chen M.Y. et al. Computed tomography angiography and perfusion to assess coronary artery stenosis causing perfusion defects by single photon emission computed tomography: the CORE320 study. Eur. Heart J. 2014; 35 (17): 1120–1130. http://doi.org/10.1093/eurheartj/eht488</mixed-citation><mixed-citation xml:lang="en">Rochitte C.E., George R.T., Chen M.Y. et al. Computed tomography angiography and perfusion to assess coronary artery stenosis causing perfusion defects by single photon emission computed tomography: the CORE320 study. Eur. Heart J. 2014; 35 (17): 1120–1130. http://doi.org/10.1093/eurheartj/eht488</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Douglas P.S., Hoffmann U., Patel M.R. et al. Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease. N. Engl. J. Med. 2015; 372: 1291–1300. http://doi.org/10.1056/nejmoa1415516</mixed-citation><mixed-citation xml:lang="en">Douglas P.S., Hoffmann U., Patel M.R. et al. Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease. N. Engl. J. Med. 2015; 372: 1291–1300. http://doi.org/10.1056/nejmoa1415516</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Assen M.V., Vonder M., Pelgrim G.J. et al. Computed tomo graphy for myocardial characterization in ischemic heart disease: a state-of-the-art review. Eur. Radiol. Exp. 2020; 4 (1): 36. http://doi.org/10.1186/s41747-020-00158-1</mixed-citation><mixed-citation xml:lang="en">Assen M.V., Vonder M., Pelgrim G.J. et al. Computed tomo graphy for myocardial characterization in ischemic heart disease: a state-of-the-art review. Eur. Radiol. Exp. 2020; 4 (1): 36. http://doi.org/10.1186/s41747-020-00158-1</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bucher A.M., De Cecco C.N., Schoepf U.J. et al. Cardiac CT for myocardial ischaemia detection and characterization--comparative analysis. Br. J. Radiol. 2014; 87 (1043): 20140159. http://doi.org/10.1259/bjr.20140159</mixed-citation><mixed-citation xml:lang="en">Bucher A.M., De Cecco C.N., Schoepf U.J. et al. Cardiac CT for myocardial ischaemia detection and characterization--comparative analysis. Br. J. Radiol. 2014; 87 (1043): 20140159. http://doi.org/10.1259/bjr.20140159</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sørgaard M.H., Kofoed K.F., Linde J.J. et al. Diagnostic accuracy of static CT perfusion for the detection of myocardial ischemia. A systematic review and metaanalysis. J. Cardiovasc. Comput. Tomogr. 2016; 10 (6): 450–457. http://doi.org/10.1016/j.jcct.2016.09.003</mixed-citation><mixed-citation xml:lang="en">Sørgaard M.H., Kofoed K.F., Linde J.J. et al. Diagnostic accuracy of static CT perfusion for the detection of myocardial ischemia. A systematic review and metaanalysis. J. Cardiovasc. Comput. Tomogr. 2016; 10 (6): 450–457. http://doi.org/10.1016/j.jcct.2016.09.003</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Davies J.E., Cook C.M. Is FFRCT Ready to Assume the Crown Jewels of Invasive FFR? J. Am. Coll. Cardiol. Img. 2017; 10 (4): 434–436. http://doi.org/10.1016/j.jcmg.2016.06.016</mixed-citation><mixed-citation xml:lang="en">Davies J.E., Cook C.M. Is FFRCT Ready to Assume the Crown Jewels of Invasive FFR? J. Am. Coll. Cardiol. Img. 2017; 10 (4): 434–436. http://doi.org/10.1016/j.jcmg.2016.06.016</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Pontone G., Baggiano A., Andreini D. et al. Stress Computed Tomography Perfusion Versus Fractional Flow Reserve CT Derived in Suspected Coronary Artery Disease: The PERFECTION Study. JACC Cardiovasc. Imaging. 2019; 12 (8, Pt 1): 1487–1497. http://doi.org/10.1016/j.jcmg.2018.08.023</mixed-citation><mixed-citation xml:lang="en">Pontone G., Baggiano A., Andreini D. et al. Stress Computed Tomography Perfusion Versus Fractional Flow Reserve CT Derived in Suspected Coronary Artery Disease: The PERFECTION Study. JACC Cardiovasc. Imaging. 2019; 12 (8, Pt 1): 1487–1497. http://doi.org/10.1016/j.jcmg.2018.08.023</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kurata A., Mochizuki T., Koyama Y. et al. Myocardial perfusion imaging using adenosine triphosphate stress multi-slice spiral computed tomography: alternative to stress myocardial perfusion scintigraphy. Circ. J. 2005; 69 (5): 550–557. http://doi.org/10.1253/circj.69.550</mixed-citation><mixed-citation xml:lang="en">Kurata A., Mochizuki T., Koyama Y. et al. Myocardial perfusion imaging using adenosine triphosphate stress multi-slice spiral computed tomography: alternative to stress myocardial perfusion scintigraphy. Circ. J. 2005; 69 (5): 550–557. http://doi.org/10.1253/circj.69.550</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Maffei E., Martini C., Rossi A. et al. Diagnostic accuracy of second-generation dual-source computed tomography coronary angiography with iterative reconstructions: a real-world experience. Radiol. Med. 2012; 117 (5): 725–738. http://doi.org/10.1007/s11547-011-0754-x</mixed-citation><mixed-citation xml:lang="en">Maffei E., Martini C., Rossi A. et al. Diagnostic accuracy of second-generation dual-source computed tomography coronary angiography with iterative reconstructions: a real-world experience. Radiol. Med. 2012; 117 (5): 725–738. http://doi.org/10.1007/s11547-011-0754-x</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Cademartiri F., Seitun S., Clemente A. et al. Myocardial blood flow quantification for evaluation of coronary artery disease by computed tomography. Cardiovasc. Diagn. Ther. 2017; 7 (2): 129–150. http://doi.org/10.21037/cdt.2017.03.22</mixed-citation><mixed-citation xml:lang="en">Cademartiri F., Seitun S., Clemente A. et al. Myocardial blood flow quantification for evaluation of coronary artery disease by computed tomography. Cardiovasc. Diagn. Ther. 2017; 7 (2): 129–150. http://doi.org/10.21037/cdt.2017.03.22</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Lu M., Wang S., Sirajuddin A. et al. Dynamic stress computed tomography myocardial perfusion for detecting myocardial ischemia: A systematic review and metaanalysis. Int. J. Cardiol. 2018; 258: 325–331. http://doi.org/10.1016/j.ijcard.2018.01.095.</mixed-citation><mixed-citation xml:lang="en">Lu M., Wang S., Sirajuddin A. et al. Dynamic stress computed tomography myocardial perfusion for detecting myocardial ischemia: A systematic review and metaanalysis. Int. J. Cardiol. 2018; 258: 325–331. http://doi.org/10.1016/j.ijcard.2018.01.095.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Hounsfield G.N. Computerized transverse axial scanning (tomography). 1. Description of system. Br. J. Radiol. 1973; 46 (552):1016–1022. http://doi.org/10.1259/0007-1285-46-552-1016</mixed-citation><mixed-citation xml:lang="en">Hounsfield G.N. Computerized transverse axial scanning (tomography). 1. Description of system. Br. J. Radiol. 1973; 46 (552):1016–1022. http://doi.org/10.1259/0007-1285-46-552-1016</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Danad I., Fayad Z.A., Willemink M.J., Min J.K. New Applications of Cardiac Computed Tomography: DualEnergy, Spectral, and Molecular CT Imaging. JACC Cardiovasc. Imaging. 2015; 8 (6): 710–723. http://doi.org/10.1016/j.jcmg.2015.03.005</mixed-citation><mixed-citation xml:lang="en">Danad I., Fayad Z.A., Willemink M.J., Min J.K. New Applications of Cardiac Computed Tomography: DualEnergy, Spectral, and Molecular CT Imaging. JACC Cardiovasc. Imaging. 2015; 8 (6): 710–723. http://doi.org/10.1016/j.jcmg.2015.03.005</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Jin K.N., De Cecco C.N., Caruso D. et al. Myocardial perfusion imaging with dual energy CT. Eur. J. Radiol. 2016; 85 (10): 1914–1921. http://doi.org/10.1016/j.ejrad.2016.06.023</mixed-citation><mixed-citation xml:lang="en">Jin K.N., De Cecco C.N., Caruso D. et al. Myocardial perfusion imaging with dual energy CT. Eur. J. Radiol. 2016; 85 (10): 1914–1921. http://doi.org/10.1016/j.ejrad.2016.06.023</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wang R., Yu W., Wang Y. et al. Incremental value of dualenergy CT to coronary CT angiography for the detection of significant coronary stenosis: comparison with quantitative coronary angiography and single photon emission computed tomography. Int. J. Cardiovasc. Imaging. 2011; 27 (5): 647–656. http://doi.org/10.1007/s10554-011-9881-7</mixed-citation><mixed-citation xml:lang="en">Wang R., Yu W., Wang Y. et al. Incremental value of dualenergy CT to coronary CT angiography for the detection of significant coronary stenosis: comparison with quantitative coronary angiography and single photon emission computed tomography. Int. J. Cardiovasc. Imaging. 2011; 27 (5): 647–656. http://doi.org/10.1007/s10554-011-9881-7</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Ko S.M., Choi J.W., Hwang H.K. et al. Diagnostic performance of combined noninvasive anatomic and functional assessment with dual-source CT and adenosineinduced stress dual-energy CT for detection of significant coronary stenosis. Am. J. Roentgenol. 2012; 198 (3): 512–520. http://doi.org/10.2214/AJR.11.7029</mixed-citation><mixed-citation xml:lang="en">Ko S.M., Choi J.W., Hwang H.K. et al. Diagnostic performance of combined noninvasive anatomic and functional assessment with dual-source CT and adenosineinduced stress dual-energy CT for detection of significant coronary stenosis. Am. J. Roentgenol. 2012; 198 (3): 512–520. http://doi.org/10.2214/AJR.11.7029</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada M., Jinzaki M., Kuribayashi S. et al. Beamhardening correction for virtual monochromatic imaging of myocardial perfusion via fast-switching dual-kVp 64-slice computed tomography: a pilot study using a human heart specimen. Circ. J. 2012; 76 (7): 1799– 1801. http://doi.org/10.1253/circj.CJ-12-0463</mixed-citation><mixed-citation xml:lang="en">Yamada M., Jinzaki M., Kuribayashi S. et al. Beamhardening correction for virtual monochromatic imaging of myocardial perfusion via fast-switching dual-kVp 64-slice computed tomography: a pilot study using a human heart specimen. Circ. J. 2012; 76 (7): 1799– 1801. http://doi.org/10.1253/circj.CJ-12-0463</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Bundhun P.K., Yanamala C.M., Huang F. Comparing the adverse clinical outcomes associated with fraction flow reserve-guided versus angiography-guided percutaneous coronary intervention: a systematic review and meta-analysis of randomized controlled trials. BMC Cardiovasc. Disord. 2016; 16 (1): 249. http://doi.org/10.1186/s12872-016-0427-8</mixed-citation><mixed-citation xml:lang="en">Bundhun P.K., Yanamala C.M., Huang F. Comparing the adverse clinical outcomes associated with fraction flow reserve-guided versus angiography-guided percutaneous coronary intervention: a systematic review and meta-analysis of randomized controlled trials. BMC Cardiovasc. Disord. 2016; 16 (1): 249. http://doi.org/10.1186/s12872-016-0427-8</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Ko B.S., Cameron J.D., Munnur R.K. et al. Noninvasive CT-Derived FFR Based on Structural and Fluid Analysis: A Comparison With Invasive FFR for Detection of Functionally Significant Stenosis. JACC Cardiovasc. Imaging. 2017; 10 (6): 663–673. http://doi.org/10.1016/j.jcmg.2016.07.005</mixed-citation><mixed-citation xml:lang="en">Ko B.S., Cameron J.D., Munnur R.K. et al. Noninvasive CT-Derived FFR Based on Structural and Fluid Analysis: A Comparison With Invasive FFR for Detection of Functionally Significant Stenosis. JACC Cardiovasc. Imaging. 2017; 10 (6): 663–673. http://doi.org/10.1016/j.jcmg.2016.07.005</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor C.A., Fonte T.A., Min J.K. Computational fluid dynamics applied to cardiac computed tomography for noninvasive quantification of fractional flow reserve: scientific basis. J. Am. Coll. Cardiol. 2013; 61 (22): 2233– 2241. http://doi.org/10.1016/j.jacc.2012.11.083</mixed-citation><mixed-citation xml:lang="en">Taylor C.A., Fonte T.A., Min J.K. Computational fluid dynamics applied to cardiac computed tomography for noninvasive quantification of fractional flow reserve: scientific basis. J. Am. Coll. Cardiol. 2013; 61 (22): 2233– 2241. http://doi.org/10.1016/j.jacc.2012.11.083</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Tonino P.A., De Bruyne B., Pijls N.H. et al.; FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N. Engl. J. Med. 2009; 360 (3): 213–224. http://doi.org/10.1016/s0145-4145(09)79763-1</mixed-citation><mixed-citation xml:lang="en">Tonino P.A., De Bruyne B., Pijls N.H. et al.; FAME Study Investigators. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N. Engl. J. Med. 2009; 360 (3): 213–224. http://doi.org/10.1016/s0145-4145(09)79763-1</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Ko B.S., Linde J.J., Ihdayhid A.R. et al. Non-invasive CTderived fractional flow reserve and static rest and stress CT myocardial perfusion imaging for detection of haemodynamically significant coronary stenosis. Int. J. Cardiovasc. Imaging. 2019; 35 (11): 2103–2112. http://doi.org/10.1007/s10554-019-01658-x</mixed-citation><mixed-citation xml:lang="en">Ko B.S., Linde J.J., Ihdayhid A.R. et al. Non-invasive CTderived fractional flow reserve and static rest and stress CT myocardial perfusion imaging for detection of haemodynamically significant coronary stenosis. Int. J. Cardiovasc. Imaging. 2019; 35 (11): 2103–2112. http://doi.org/10.1007/s10554-019-01658-x</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Zhuang B., Wang S., Zhao S. et al. GW29-e1123 Computed Tomography Angiography-Derived Fractional Flow Reserve (CT-FFR) for the Detection of Myocardial Ischemia-with Invasive Fractional Flow Reserve as Reference: Systematic Review and Meta-Analysis. J. Am. Coll. Cardiol. 2018; 72 (16_Suppl.) C200–C201. http://doi.org/10.1016/j.jacc.2018.08.874</mixed-citation><mixed-citation xml:lang="en">Zhuang B., Wang S., Zhao S. et al. GW29-e1123 Computed Tomography Angiography-Derived Fractional Flow Reserve (CT-FFR) for the Detection of Myocardial Ischemia-with Invasive Fractional Flow Reserve as Reference: Systematic Review and Meta-Analysis. J. Am. Coll. Cardiol. 2018; 72 (16_Suppl.) C200–C201. http://doi.org/10.1016/j.jacc.2018.08.874</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Zhuang B., Wang S., Zhao S., Lu M. Computed tomography angiography-derived fractional flow reserve (CT-FFR) for the detection of myocardial ischemia with invasive fractional flow reserve as reference: systematic review and meta-analysis. Eur. Radiol. 2020; 30 (2): 712–725. http://doi.org/10.1007/s00330-019-06470-8.</mixed-citation><mixed-citation xml:lang="en">Zhuang B., Wang S., Zhao S., Lu M. Computed tomography angiography-derived fractional flow reserve (CT-FFR) for the detection of myocardial ischemia with invasive fractional flow reserve as reference: systematic review and meta-analysis. Eur. Radiol. 2020; 30 (2): 712–725. http://doi.org/10.1007/s00330-019-06470-8.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Abbara S., Blanke P., Maroules C.D. et al. SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: A report of the society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI). J. Cardiovasc. Comput. Tomogr. 2016; 10 (6): 435–449. http://doi.org/10.1016/j.jcct.2009.03.004</mixed-citation><mixed-citation xml:lang="en">Abbara S., Blanke P., Maroules C.D. et al. SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: A report of the society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI). J. Cardiovasc. Comput. Tomogr. 2016; 10 (6): 435–449. http://doi.org/10.1016/j.jcct.2009.03.004</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma R.K., Arbab-Zadeh A., Kishi S. et al. Incremental diagnostic accuracy of computed tomography myocardial perfusion imaging over coronary angiography stratified by pre-test probability of coronary artery disease and severity of coronary artery calcification: The CORE320 study. Int. J. Cardiol. 2015; 201: 570–577. http://doi.org/10.1016/j.ijcard.2015.05.110</mixed-citation><mixed-citation xml:lang="en">Sharma R.K., Arbab-Zadeh A., Kishi S. et al. Incremental diagnostic accuracy of computed tomography myocardial perfusion imaging over coronary angiography stratified by pre-test probability of coronary artery disease and severity of coronary artery calcification: The CORE320 study. Int. J. Cardiol. 2015; 201: 570–577. http://doi.org/10.1016/j.ijcard.2015.05.110</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Koo B.K., Erglis A., Doh J.H. et al. Diagnosis of ischemiacausing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J. Am. Coll. Cardiol. 2011 Nov 1;58(19): 1989–1997. http://doi.org/10.1016/j.jacc.2011.06.066.</mixed-citation><mixed-citation xml:lang="en">Koo B.K., Erglis A., Doh J.H. et al. Diagnosis of ischemiacausing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study. J. Am. Coll. Cardiol. 2011 Nov 1;58(19): 1989–1997. http://doi.org/10.1016/j.jacc.2011.06.066.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Синицын В.Е., Глазкова М.А., Мершина Е.А., Архипова И.М. Возможности снижения лучевой нагрузки при проведении мСкТ коронарографии: использование адаптивной статистической итеративной реконструкции. Ангиология и сосудистая хирургия. 2012; 18 (3): 44–49. Sinitsyn V.E., Glazkova M.A., Mershina E.A., Arhipova I.M.. Possibilities of decreasing radiation load during MSRT coronarography: using adaptive statistic iterative reconstruction. Angiology and Vascular Surgery. 2012; 18 (3): 44–49. (In Russian)</mixed-citation><mixed-citation xml:lang="en">Синицын В.Е., Глазкова М.А., Мершина Е.А., Архипова И.М. Возможности снижения лучевой нагрузки при проведении мСкТ коронарографии: использование адаптивной статистической итеративной реконструкции. Ангиология и сосудистая хирургия. 2012; 18 (3): 44–49. Sinitsyn V.E., Glazkova M.A., Mershina E.A., Arhipova I.M.. Possibilities of decreasing radiation load during MSRT coronarography: using adaptive statistic iterative reconstruction. Angiology and Vascular Surgery. 2012; 18 (3): 44–49. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Маткевич Е.И., Синицын В.Е., Зеликман М.И., Кручинин С.А., Иванов И.В. Основные направления снижения дозы облучения пациентов при компьютерной томографии. REJR. 2018; 8 (3), 60–73. http://doi. org/10.21569/2222-7415-2018-8-3-60-73 Matkevich E.I., Sinitsyn V.E., Zelikman M.I., Kruchinin S.A., Ivanov I.V. Main directions of reducing patient irradiation doses in computed tomography. REJR. 2018; 8 (3), 60–73. http://doi.org/10.21569/2222-7415-2018-8-3-60-73 (In Russian)</mixed-citation><mixed-citation xml:lang="en">Маткевич Е.И., Синицын В.Е., Зеликман М.И., Кручинин С.А., Иванов И.В. Основные направления снижения дозы облучения пациентов при компьютерной томографии. REJR. 2018; 8 (3), 60–73. http://doi. org/10.21569/2222-7415-2018-8-3-60-73 Matkevich E.I., Sinitsyn V.E., Zelikman M.I., Kruchinin S.A., Ivanov I.V. Main directions of reducing patient irradiation doses in computed tomography. REJR. 2018; 8 (3), 60–73. http://doi.org/10.21569/2222-7415-2018-8-3-60-73 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Kerl J.M., Bauer R.W., Maurer T.B. et al. Dose levels at coronary CT angiography - a comparison of Dual Energy-, Dual Source- and 16-slice CT. Eur. Radiol. 2011; 21 (3): 530–537. http://doi.org/10.1007/s00330-010-1954-9</mixed-citation><mixed-citation xml:lang="en">Kerl J.M., Bauer R.W., Maurer T.B. et al. Dose levels at coronary CT angiography - a comparison of Dual Energy-, Dual Source- and 16-slice CT. Eur. Radiol. 2011; 21 (3): 530–537. http://doi.org/10.1007/s00330-010-1954-9</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS); European Association for Percutaneous Cardiovascular Interventions (EAPCI), Wijns W., Kolh P., Danchin N. et al. Guidelines on myocardial revascularization. Eur. Heart J. 2010; 31 (20): 2501–2555. http://doi.org/10.1093/eurheartj/ehq277</mixed-citation><mixed-citation xml:lang="en">Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS); European Association for Percutaneous Cardiovascular Interventions (EAPCI), Wijns W., Kolh P., Danchin N. et al. Guidelines on myocardial revascularization. Eur. Heart J. 2010; 31 (20): 2501–2555. http://doi.org/10.1093/eurheartj/ehq277</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
