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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-2020-3-12-25</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-947</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>COVID-19</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COVID-19</subject></subj-group></article-categories><title-group><article-title>Динамика легочного повреждения и экстракорпоральные методы гемокоррекции у пациентов с Sars-Cov-2</article-title><trans-title-group xml:lang="en"><trans-title>Dynamics of pulmonary injury and extracorporeal methods of hemocorrection in patients with Sars-CoV-2</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1791-9163</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ревишвили</surname><given-names>А. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Revishvili</surname><given-names>A. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ревишвили Амиран Шотаевич – академик РАН, доктор мед. наук, профессор, директор</p><p>117997 Москва, ул. Большая Серпуховская, д. 27, Российская Федерация</p></bio><bio xml:lang="en"><p> </p><p>27, Bol'shaya Serpukhovskaia str, Moscow, 117997, Russian Federation</p></bio><email xlink:type="simple">amirevi@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9357-0998</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кармазановский</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kаrmаzаnovsky</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кармазановский Григорий Григорьевич – член-корр. РАН, доктор мед. наук, профессор, заведующий отделением рентгенологии и магнитно-резонансных исследований с кабинетом ультразвуковой диагностики; профессор кафедры лучевой диагностики и терапии медико-биологического факультета</p><p>117997 Москва, ул. Большая Серпуховская, д. 27, Российская Федерация;</p><p>Минздрава России; 117997 Москва, ул. Островитянова, д. 1, Российская Федерация</p></bio><bio xml:lang="en"><p> </p><p>27, Bol'shaya Serpukhovskaia str, Moscow, 117997, Russian Federation</p><p>1, Ostrivityanova str., Moscow, 117997, Russian Federation</p></bio><email xlink:type="simple">karmazanovsky@ixv.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4291-3380</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плотников</surname><given-names>Г. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Plotnikov</surname><given-names>G. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плотников Георгий Павлович – доктор мед. наук, заведующий отделением анестезиологии и реаниматологии</p><p>117997 Москва, ул. Большая Серпуховская, д. 27, Российская Федерация</p></bio><bio xml:lang="en"><p> </p><p>27, Bol'shaya Serpukhovskaia str, Moscow, 117997, Russian Federation</p></bio><email xlink:type="simple">geo-plotnikov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1643-6613</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Замятина</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zamyatina</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Замятина Ксения Андреевна – ординатор</p><p>117997 Москва, ул. Большая Серпуховская, д. 27, Российская Федерация</p></bio><bio xml:lang="en"><p> </p><p>27, Bol'shaya Serpukhovskaia str, Moscow, 117997, Russian Federation</p></bio><email xlink:type="simple">catos-zama@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7145-8516</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гейзе</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Geise</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гейзе Антон Викторович – канд. мед. наук, врач отделения анестезиологии, реанимации и интенсивной терапии</p><p>117997 Москва, ул. Большая Серпуховская, д. 27, Российская Федерация</p></bio><bio xml:lang="en"><p> </p><p>27, Bol'shaya Serpukhovskaia str, Moscow, 117997, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6542-8257</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галстян</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Galstyan</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Галстян Андраник Варужанович – врач отделения анестезиологии, реанимации и интенсивной терапии</p><p>117997 Москва, ул. Большая Серпуховская, д. 27, Российская Федерация</p></bio><bio xml:lang="en"><p> </p><p>27, Bol'shaya Serpukhovskaia str, Moscow, 117997, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5527-7494</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рубцов</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Rubtsov</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рубцов Михаил Сергеевич – врач отделения анестезиологии, реанимации и интенсивной терапии</p><p>117997 Москва, ул. Большая Серпуховская, д. 27, Российская Федерация</p></bio><bio xml:lang="en"><p> </p><p>27, Bol'shaya Serpukhovskaia str, Moscow, 117997, Russian Federation</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky National Medical Research Center of Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ “Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского” Минздрава России; ФГАОУ ВО “Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky National Medical Research Center of Surgery; Pirogov Russian National Research Medical University of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>08</day><month>10</month><year>2020</year></pub-date><volume>24</volume><issue>3</issue><fpage>12</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ревишвили А.Ш., Кармазановский Г.Г., Плотников Г.П., Замятина К.А., Гейзе А.В., Галстян А.В., Рубцов М.С., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ревишвили А.Ш., Кармазановский Г.Г., Плотников Г.П., Замятина К.А., Гейзе А.В., Галстян А.В., Рубцов М.С.</copyright-holder><copyright-holder xml:lang="en">Revishvili A.S., Kаrmаzаnovsky G.G., Plotnikov G.P., Zamyatina K.A., Geise A.V., Galstyan A.V., Rubtsov M.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/947">https://medvis.rdsmedia.ru/jour/article/view/947</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: оценить изменения степени легочного повреждения у пациентов с Sars-CoV-2 после проведения экстракорпоральных методов гемокоррекции (ЭКМГК).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. 27 пациентам с Sars-CoV-2 проведено 48 процедур ЭКМГК – плазмосепарации, неселективные цитосорбционные гемоперфузии, диализно-фильтрационные методики. При поступлении выполнялась МСКТ органов грудной клетки с использованием стандартного протокола и реконструкции soft и high-resolution на томографе Philips Ingenuity CT 64. Параметры сканирования: коллимация 64 × 0,625, реконструкция 1 мм, инкремент 0,5 мм. Оценка полученных изображений в модуле просмотра Diсom-изображений “АрхиМед” (Med-Ray, Россия, 2004). Процент поражения легочной паренхимы, а также степень тяжести (КТ1–4) были оценены с использованием рекомендаций “Лучевая диагностика коронавирусной болезни (COVID-19): организация, методология, интерпретация результатов”. Сравнивались КТ-исследования не ранее чем за 4 дня до ЭКМГК и не позднее 5 дней после.</p></sec><sec><title>Результат</title><p>Результат. При изолированной плазмосепарации зоны “матового стекла” перешли в зоны консолидаций, общий объем поражения уменьшился, пневматизация повысилась. При изолированной гемоперфузии динамика разнонаправленная: зон консолидаций больше, зон “матового стекла” меньше, в целом стабилизация процесса и уменьшение зон поражения легочной ткани. При изолированной гемодиафильтрации зоны консолидации уменьшились, пневматизация легочной ткани повысилась, в дальнейшем объем поражения и зоны консолидаций значительно увеличились. При комбинированных процедурах разнонаправленная динамика.</p></sec><sec><title>Заключение</title><p>Заключение. Влияния применения ЭКМГК на степень и объем повреждения легочной ткани у пациентов с Sars-CoV-2 не выявлено.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose. To assess changes in the degree of pulmonary injury in patients with Sars-CoV-2 after extracorporeal hemocorrection methods (ECHCM).</p></sec><sec><title>Material and methods</title><p>Material and methods. 27 patients with Sars-CoV-2 underwent 48 ECHCM procedures - plasma separation, nonselective cytosorption hemoperfusion, dialysis-filtration techniques. After arriving in the hospital all patients underwent MSCT of the chest organs. The examination was conducted according to the standard protocol of MSCT of the chest organs and reconstruction of soft and high-resolution on a Philips Ingenuity CT 64 multi- detector computed tomograph. The following scanning parameters were used for the standard protocol: 64 × 0.625 collimation, 1 mm reconstruction, 0.5 mm increment. The patient was lying on his back with his arms thrown back behind his head during the procedure. A scan area including the chest was planned by the plan scan. Assessment of the scans was carried out in the Diсom-images viewing module of medical hardware- software complex “ArchiMed” (Med-Ray. Russia, 2004). The percentage of lung parenchyma lesions as well as the severity (CT-1–4) were evaluated according to the recommendations “Radiation diagnosis of coronavirus disease (COVID-19): organization, methodology, interpretation of the results”. CT examinations were compared not earlier than 4 days before ECHCM and not later than 5 days after.</p></sec><sec><title>Result</title><p>Result. With isolated plasmaseparation, the “ground glass” zones passed into the consolidation zones, the total volume of the lesion decreased and the pneumatization increased. In isolated hemoperfusion the dynamics is multidirectional: there are more consolidation zones, less ground glass zones in general, the process is stabilized and the zones of lung tissue damage are reduced. With isolated hemodiafiltration, the consolidation zones decreased, the pneumatization of the lung tissue increased, and subsequently the volume of the lesion and the consolidation zones increased significantly. By combined procedures there are multidirectional dynamics.</p></sec><sec><title>Conclusion</title><p>Conclusion. The effect of ECMGC use on the degree and volume of lung tissue damage in patients with Sars- CoV-2 was not revealed.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>экстракорпоральные методы лечения</kwd><kwd>Covid-19</kwd><kwd>МСКТ органов грудной клетки</kwd><kwd>консолидация</kwd><kwd>“матовое стекло”</kwd></kwd-group><kwd-group xml:lang="en"><kwd>extracorporeal treatments</kwd><kwd>COVID-19</kwd><kwd>CT</kwd><kwd>ground-glass opacity</kwd><kwd>consolidation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ma J., Xia P., Zhou Y., Liu Z., Zhou X., Wang J., Li T., Yan X., Chen L., Zhang S., Qin Y., Li X. Potential effect of blood purification therapy in reducing cytokine storm as a late complication of critically ill COVID-19. Clin. Immunol. 2020; 214: 108408. http://doi.org/10.1016/j.clim.2020.108408. 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