medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-2020-2-131-137medvis-919Research ArticleГОЛОВАHEADИсследование нарушений функциональных связей между сетью пассивного режима работы мозга и структурами мозжечка у пациентов с легкой черепно-мозговой травмой в острой стадии по данным фМРТ состояния покояDysfunction of cerebellum functional connectivity between default mode network and cerebellar structures in patients with mild traumatic brain injury in acute stage. rsfMRI studyhttps://orcid.org/0000-0002-4627-9874УблинскийМ. В.UblinskiyM. V.

Ублинский Максим Вадимович – канд. биол. наук, научный сотрудник НИИ НДХиТ

119334 Москва, ул. Косыгина, 4;119180 Москва, ул. Большая Полянка, д. 22

Maxim V. Ublinskiy – Cand. of Sсi. (Biol.), researcher

4, Kosygina str., 119334 Moscow22, Bol’shaya Polyanka str., 119180 Moscow

maxublinsk@mail.ruhttps://orcid.org/0000-0002-6539-4616СеменоваН. А.SemenovaN. A.

Семенова Наталия Александровна – доктор биол. наук, главный научный сотрудник НИИ НДХиТ; ведущий научный сотрудник ИБХФ РАН

119334 Москва, ул. Косыгина, 4;119180 Москва, ул. Большая Полянка, д. 22

Nataliya A. Semenova – Doct. of Sci. (Biol.), chief researcher; leading researcher Institute of biochemical physics RAS

4, Kosygina str., 119334 Moscow22, Bol’shaya Polyanka str., 119180 Moscow

nmr-semen@mail.ruhttps://orcid.org/0000-0001-5022-9952МанжурцевА. В.ManzhurtsevA. V.

Манжурцев Андрей Валерьевич – канд. физ.-мат. наук, научный сотрудник НИИ НДХиТ; научный сотрудник ИБХФ РАН

119334 Москва, ул. Косыгина, 4; 119180 Москва, ул. Большая Полянка, д. 22

 

Andrei V. Manzhurtsev – Cand. of Sсi. (Phys.-Math.), researcher; researcher, Institute of biochemical physics RAS

4, Kosygina str., 119334 Moscow22, Bol’shaya Polyanka str., 119180 Moscow

andrey.man.93@gmail.comhttps://orcid.org/0000-0001-8193-6991МеньщиковП. Е.MenshchikovP. E.

Меньщиков Петр Евгеньевич – канд. физ.-мат. наук, научный сотрудник ИБХФ РАН

119180 Москва, ул. Большая Полянка, д. 22

Petr E. Menshchikov – Cand. of Sсi. (Phys.-Math.), researcher, Institute of biochemical physics RAS

22, Bol’shaya Polyanka str., 119180 Moscow

peeterem@gmail.comhttps://orcid.org/0000-0003-1736-6503ЯковлевА. Н.YakovlevA. N.

Яковлев Алексей Николаевич – научный сотрудник ИБХФ РАН

119180 Москва, ул. Большая Полянка, д. 22

Alexey N. Yakovlev – researcher, Institute of biochemical physics RAS

22, Bol’shaya Polyanka str., 119180 Moscow

yakovlevalekcej@bk.ruhttps://orcid.org/0000-0002-3235-8854АхадовТ. А.AkhadovT. A.

Ахадов Толибджон Абдуллаевич – доктор мед. наук, профессор, руководитель отдела лучевых методов диагностики НИИ НДХиТ

119334 Москва, ул. Косыгина, 4

Tolibdzhon A. Akhadov – Professor, Doct. of Sci. (Med.), head of radiology department

4, Kosygina str., 119334 Moscow

akhadov@mail.ruИнститут биохимической физики РАН имени Н.М. Эмануэля; НИИ неотложной детской хирургии и травматологии ДЗ г. Москвы;РоссияInstitute of biochemical physics (IBCP) RAS; Clinical and research institute of emergency pediatric surgery and trauma;Russian FederationНИИ неотложной детской хирургии и травматологии ДЗ г. Москвы;РоссияClinical and research institute of emergency pediatric surgery and trauma;Russian FederationИнститут биохимической физики РАН имени Н.М. Эмануэля;РоссияInstitute of biochemical physics (IBCP) RAS;Russian Federation202018062020242Медицинская визуализация 2020№2131137Copyright © Ублинский М.В., Семенова Н.А., Манжурцев А.В., Меньщиков П.Е., Яковлев А.Н., Ахадов Т.А., 20202020Ублинский М.В., Семенова Н.А., Манжурцев А.В., Меньщиков П.Е., Яковлев А.Н., Ахадов Т.А.Ublinskiy M.V., Semenova N.A., Manzhurtsev A.V., Menshchikov P.E., Yakovlev A.N., Akhadov T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/919

Легкая черепно-мозговая травма (лЧМТ) является наиболее распространенным неврологическим повреждением у детей, поэтому чрезвычайно важно идентифицировать и проанализировать биомаркеры, которые могут помочь в процессах лечения и выздоровления пациента с лЧМТ.

Цель исследования

Цель исследования: подтвердить гипотезу о том, что нарушения функциональных связей между неповрежденным мозжечком и узлами сети DMN включены в симптоматическое проявление лЧМТ.

Методы

Методы. Обследованы 28 МР-негативных пациентов с лЧМТв возрасте от 12 до 17 лет (средний возраст 14,7 года). Контрольная группа состояла из 23 здоровых детей. Все МРТ-исследования проводились на сканере Philips Achieva dStream 3,0 Tл, оборудованном 32-канальной головной катушкой Philips dStream. Проведена фМРТ состояния покоя (EPI последовательность, TR = 3000 мс, время эха (TE) = 30 мс, 80 динамиков с динамическим временем сканирования 3 с). Данные фМРТ обработаны с использованием программного пакета CONN.

Результаты

Результаты. Не обнаружено статистически значимого различия в значениях коэффициентов функциональных связей между областями сети DMN в группах пациентов и контроля. Межгрупповой анализ выявил статистически значимое (р < 0,05) различие в нейронных связях между частями DMN и червем мозжечка (vermis, структурная часть мозжечка): положительная связь в контрольной группе и отрицательная связь в группе пациентов.

Заключение

Заключение. Выявленные изменения в нейрональных связях между областями DMN и мозжечка у пациентов с лЧМТ в остром периоде могут быть начальным этапом повреждений, приводящих к когнитивному дефициту, который может развиться в будущем.

Mild traumatic brain injury (mTBI) is the most common neurological damage in children that's why it is extremely important to identify and analyze biomarkers that can help in predicting patient's treatment and recovery in period of mTBI. Aim of this study is to verify a hypothesis that functional connectivity disturbances between intact cerebellum and DMN nodes are included in symptomatic manifestation of mTBI.

Methods

Methods. 28 MR negative patients with mTBI were studied in age from 12 to 17 years (mean age – 14.7 years). The control group consisted of 23 healthy children. All MRI studies wereperformed on a Philips AchievadStream 3.0 T scanner equipped with a 32-channelPhilips dStream head coil. A 4 min rsfMRI gradient-echo echo planar imaging (EPI)sequence was acquired (TR = 3000 ms, echo time (TE) = 30 ms, 80 dynamics withdynamic scan time = 3 s). fMRI data were processed using functional connectivitytoolbox CONN.

Results

Results. No statistically significant differences in correlation strengths between control group and group of patients were detected as a result of DMN analysis. Intergroup seed-basedcorrelation ROI analysis revealed statistically significant (p < 0.05) differencein links between DMN regions and vermis (cerebellum): positive link in control group and negative link in groupof patients.

Conclusions

Conclusions. The revealed changes in DMN neuronal connection and cerebellar regions in acute stage of mTBI patients can be an initial step of damages leading to cognitive deficit which can be developed in future.

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The authors declare that there are no conflicts of interest present.