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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-2020-2-37-49</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-912</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>COVID-19</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COVID-19</subject></subj-group></article-categories><title-group><article-title>COVID-19. Вопросы диагностики и лечения поражения легких</article-title><trans-title-group xml:lang="en"><trans-title>COVID-19. Diagnosis and treatment of lung damage</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0310-0889</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдин</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Yudin</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юдин Андрей Леонидович – доктор мед. наук, профессор, заведующий кафедрой лучевой диагностики и терапии </p><p>117997 Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Andrey L. Yudin – Doсt. of Sсi. (Med.), professor, professor, head of radiology department</p><p>house 1, Ostrivityanova str., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9446-2163</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абович</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abovich</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абович Юлия Александровна – канд. мед. наук, доцент кафедры лучевой диагностики и терапии ; врач-рентгенолог отделения рентгенологии </p><p>117997 Москва, ул. Островитянова, д. 1;105203 Москва, ул. Нижняя Первомайская, д. 70</p></bio><bio xml:lang="en"><p>Yulia A. Abovich – Cand. of Sci. (Med.), associate professor of radiology department; radiologist of radiology department</p><p>house 1, Ostrivityanova str., Moscow, 117997;Nizhnyaya Pervomayskaya str., 70, Moscow, 105203</p></bio><email xlink:type="simple">abovich@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6020-9434</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юматова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yumatova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юматова Елена Анатольевна – канд. мед. наук, доцент кафедры лучевой диагностики и терапии</p><p>117997 Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Elena A. Yumatova – Cand. of Sci. (Med.), associate professor, radiology department</p><p>house 1, Ostrivityanova str., Moscow, 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2784-302X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бронов</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bronov</surname><given-names>O. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бронов Олег Юрьевич – канд. мед. наук, заведующий отделением рентгенологии </p><p>105203 Москва, ул. Нижняя Первомайская, д. 70</p></bio><bio xml:lang="en"><p>Oleg Yu. Bronov – Cand. of Sci. (Med.), head of radiology department</p><p>Nizhnyaya Pervomayskaya str., 70, Moscow, 105203</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО “Российский национальный исследовательский медицинский университет имени Н.И. Пирогова” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО “Российский национальный исследовательский медицинский университет имени Н.И. Пирогова” Минздрава России;&#13;
ФГБУ “Национальный медико-хирургический центр имени Н.И. Пирогова” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University of the Ministry of Health of Russia;&#13;
Pirogov National Medical Surgical Center of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ “Национальный медико-хирургический центр имени Н.И. Пирогова” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov National Medical Surgical Center of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>17</day><month>06</month><year>2020</year></pub-date><volume>24</volume><issue>2</issue><issue-title>Медицинская визуализация 2020№2</issue-title><fpage>37</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Юдин А.Л., Абович Ю.А., Юматова Е.А., Бронов О.Ю., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Юдин А.Л., Абович Ю.А., Юматова Е.А., Бронов О.Ю.</copyright-holder><copyright-holder xml:lang="en">Yudin A.L., Abovich Y.A., Yumatova E.A., Bronov O.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/912">https://medvis.rdsmedia.ru/jour/article/view/912</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: краткий обзор нерешенных вопросов лучевой диагностики и лечения COVID-19.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведен анализ публикаций за I квартал 2020 г. по лучевой диагностике и лечению COVID-19 с акцентом на морфорентгенологические сопоставления.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что КТ может быть использована для первичной “сортировки” пациентов при определении необходимости и условий госпитализации, но в дальнейшем зачастую приводит к разногласию пульмонологов и рентгенологов в оценке динамики развития заболевания. У большинства пациентов с COVID-19 патоморфологическая и рентгенологическая картина свидетельствует о формировании острой фазы диффузного альвеолярного повреждения, трансформирующегося в организующую пневмонию с типичными КТ-проявлениями. Однако до настоящего времени нет устоявшихся мнений по тактике ведения пациентов с подобным поражением легких.</p></sec><sec><title>Выводы</title><p>Выводы. Приведенные данные литературы об особенностях патоморфологической и рентгенологической картины COVID-19 обосновывают целесообразность применения кортикостероидов в лечении данного заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. This publication is devoted to a brief review of the unresolved questions of medical imaging and treatment of COVID-19.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The analysis of publications for the first quarter of 2020 on radiation diagnosis and treatment of COVID-19 with an emphasis on morpho-radiological comparisons was performed.</p></sec><sec><title>Results</title><p>Results. It was established that CT can be used for the initial “sorting” of patients in determining the need and conditions of hospitalization, but in the future, often leads to disagreement among pulmonologists and radiologists in assessing the dynamics of the development of the disease. In most patients with COVID-19, the pathomorphological and radiological patterns indicate the formation of the acute phase of diffuse alveolar damage, transforming into organizing pneumonia with typical CT manifestations. However, to date there are no established opinions on the management of patients with corresponding lung lesions.</p></sec><sec><title>Conclusion</title><p>Conclusion. The literature data on the peculiarities of the pathomorphological and radiological patterns of COVID-19 COVID-19 justify the advisability of using corticosteroids in the treatment of this disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>Covid-19</kwd><kwd>коронавирус SARS-CoV-2</kwd><kwd>лучевая диагностика</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Covid-19</kwd><kwd>SARS-CoV-2 coronavirus</kwd><kwd>medical imaging</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao W., Zhong Zh., Xie Х., Yu Q., Liu J. Relation Between Chest CT Findings and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study. Am. J. Roentgenol. 2020; 214: 1072–1077. http://doi.org/10.2214/AJR.20.22976</mixed-citation><mixed-citation xml:lang="en">Zhao W., Zhong Zh., Xie Х., Yu Q., Liu J. Relation Between Chest CT Findings and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study. Am. J. Roentgenol. 2020; 214: 1072–1077. http://doi.org/10.2214/AJR.20.22976</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hosseiny M., Kooraki S., Gholamrezanehad A., Reddy S., Myers L. Radiology perspective of coronavirus disease 2019 (COVID-19): lessons from severe acute respiratory syndrome and Middle East respiratory syndrome. Am. J. Roentgenol. 2020;214:1078–1082.</mixed-citation><mixed-citation xml:lang="en">Hosseiny M., Kooraki S., Gholamrezanehad A., Reddy S., Myers L. Radiology perspective of coronavirus disease 2019 (COVID-19): lessons from severe acute respiratory syndrome and Middle East respiratory syndrome. Am. J. Roentgenol. 2020;214:1078–1082.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hosseiny M., Kooraki S., Gholamrezanezhad A., Reddy S., Lee M. Radiology Perspective of Coronavirus Disease 2019 (COVID-19): Lessons From Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome. Am. J. Roentgenol. 2020;214:1078–1082. http://doi.org/10.2214/AJR.20.22969</mixed-citation><mixed-citation xml:lang="en">Hosseiny M., Kooraki S., Gholamrezanezhad A., Reddy S., Lee M. Radiology Perspective of Coronavirus Disease 2019 (COVID-19): Lessons From Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome. Am. J. Roentgenol. 2020;214:1078–1082. http://doi.org/10.2214/AJR.20.22969</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Guan W., Liu J., Yu Ch. CT Findings of Coronavirus Disease (COVID-19) Severe Pneumonia. Am. J. Roentgenol. 2020; 214:W85–W86. http://doi.org/10.2214/AJR.20.23035</mixed-citation><mixed-citation xml:lang="en">Guan W., Liu J., Yu Ch. CT Findings of Coronavirus Disease (COVID-19) Severe Pneumonia. Am. J. Roentgenol. 2020; 214:W85–W86. http://doi.org/10.2214/AJR.20.23035</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Huang G., Gong T., Wang G., Wang J., Guo X., Cai E., Li S., Li X., Yu Y., Lin L. Timely Diagnosis and Treatment Shortens the Time to Resolution of Coronavirus Disease (COVID-19) Pneumonia and Lowers the Highest and Last CT Scores From Sequential Chest CT. Am. J. Roentgenol. 2020; 215: 1–7. http://doi.org/10.2214/AJR.20.23078</mixed-citation><mixed-citation xml:lang="en">Huang G., Gong T., Wang G., Wang J., Guo X., Cai E., Li S., Li X., Yu Y., Lin L. Timely Diagnosis and Treatment Shortens the Time to Resolution of Coronavirus Disease (COVID-19) Pneumonia and Lowers the Highest and Last CT Scores From Sequential Chest CT. Am. J. Roentgenol. 2020; 215: 1–7. http://doi.org/10.2214/AJR.20.23078</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao W., Zheng Z., Xie X., Qizhi Y., Liu J. CT scans of patients with 2019 novel coronavirus (COVID-19) pneumonia. Theranostics. 2020; 10: 4606–4613. https://doi.org/10.7150/thno.45016</mixed-citation><mixed-citation xml:lang="en">Zhao W., Zheng Z., Xie X., Qizhi Y., Liu J. CT scans of patients with 2019 novel coronavirus (COVID-19) pneumonia. Theranostics. 2020; 10: 4606–4613. https://doi.org/10.7150/thno.45016</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hope M.D., Raptis C.A., Shah A. A role for CT in COVID-19? What data really tell us so far. Lancet. 2020; 395:1189– 1190. https://doi.org/10.1016/s0140-6736(20)30728-5</mixed-citation><mixed-citation xml:lang="en">Hope M.D., Raptis C.A., Shah A. A role for CT in COVID-19? What data really tell us so far. Lancet. 2020; 395:1189– 1190. https://doi.org/10.1016/s0140-6736(20)30728-5</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Сперанская А.А., Новикова Л.Н., Баранова О.П., Василь ева М.А. Лучевая диагностика вирусной пневмонии. Вестник рентгенологии и радиологии. 2016; 97 (3): 149–156. http://doi.org/10.20862/0042-4676-2016-97-3-149-156</mixed-citation><mixed-citation xml:lang="en">Speranskaia A.A., Novikova L.N., Baranova O.P., Vasilieva M.A. Radiology of viral pneumonia. Vestnik Rentgenologii i Radiologii = Russian Journal of Radiology. 2016; 97 (3): 149–156. http://doi.org/10.20862/0042-4676-2016-97-3-149-156. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Росстальная А.Л., Сабиров Д.М., Акалаев Р.Н., Шарипова В.Х., Росстальная М.Л., Мамиров А.О. Острое повреждение легких: спорные вопросы и нерешенные проблемы (обзор литературы). Журнал им. Н.В. Склифосовского “Неотложная медицинская помощь”. 2016; 3: 66–72.</mixed-citation><mixed-citation xml:lang="en">Rosstalnaya A.L., Sabirov D.M., Akalayev R.N., Sharipova V.K., Rosstalnaya M.L., Mamirov A.O. Acute lung injury: issues and remaining challenges (a literature review). Russian Sklifosovsky Journal “Emergency Medical Care”. 2016; 3: 66–72. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cardinal-Fernández P., Lorente J. A., Ballén-Barragán A., Matute-Bello G. Acute Respiratory Distress Syndrome and Diffuse Alveolar Damage. New Insights on a Complex Relationship. Ann. Am. Thorac. Soc. 2017; 14 (6): 844– 850. http://doi.org/10.1513/annalsats.201609-728ps</mixed-citation><mixed-citation xml:lang="en">Cardinal-Fernández P., Lorente J. A., Ballén-Barragán A., Matute-Bello G. Acute Respiratory Distress Syndrome and Diffuse Alveolar Damage. New Insights on a Complex Relationship. Ann. Am. Thorac. Soc. 2017; 14 (6): 844– 850. http://doi.org/10.1513/annalsats.201609-728ps</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Khilnani GC, Hadda V. Corticosteroids and ARDS: A review of treatment and prevention evidence. Lung India. 2011; 28 (2): 114–119. http://doi.org/10.4103/0970-2113.80324</mixed-citation><mixed-citation xml:lang="en">Khilnani GC, Hadda V. Corticosteroids and ARDS: A review of treatment and prevention evidence. Lung India. 2011; 28 (2): 114–119. http://doi.org/10.4103/0970-2113.80324</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mitchell O.J.L., Sternschein R., Kunzler N., Zhao Y., Uppal A. Acute Interstitial Pneumonia Versus Acute Respiratory Distress Syndrome: Is There a Difference? American Journal of Respiratory and Critical Care Medicine 2020;201:A5884</mixed-citation><mixed-citation xml:lang="en">Mitchell O.J.L., Sternschein R., Kunzler N., Zhao Y., Uppal A. Acute Interstitial Pneumonia Versus Acute Respiratory Distress Syndrome: Is There a Difference? American Journal of Respiratory and Critical Care Medicine 2020;201:A5884</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cordier J.F. Organising pneumonia. Thorax. 2000; 55 (4): 318–328 http://doi.org/10.1136/thorax.55.4.318</mixed-citation><mixed-citation xml:lang="en">Cordier J.F. Organising pneumonia. Thorax. 2000; 55 (4): 318–328 http://doi.org/10.1136/thorax.55.4.318</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Авдеев С.Н., Черняев А.Л. Организующаяся пневмония. Атмосфера. Пульмонология и аллергология. 2011; 1: 6–13.</mixed-citation><mixed-citation xml:lang="en">Avdeev S.N., Chernyaev A.L. Organized pneumonia. Atmosphere. Pulmonology and Allergology. 2011; 1: 6–13. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Beasley M. The pathologist’s approach to acute lung injury. Arch. Pathol. Lab. Med. 2010; 134 (5): 719–727. http://doi.org/10.1043/1543-2165-134.5.719</mixed-citation><mixed-citation xml:lang="en">Beasley M. The pathologist’s approach to acute lung injury. Arch. Pathol. Lab. Med. 2010; 134 (5): 719–727. http://doi.org/10.1043/1543-2165-134.5.719</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang D.M., Chamberlain D.W., Poutanen S.M., Low D.E., Asa S.L., Butany J. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod. Pathol. 2005; 18 (1): 1–10. https://doi.org/10.1038/modpathol.3800247</mixed-citation><mixed-citation xml:lang="en">Hwang D.M., Chamberlain D.W., Poutanen S.M., Low D.E., Asa S.L., Butany J. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod. Pathol. 2005; 18 (1): 1–10. https://doi.org/10.1038/modpathol.3800247</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Copin M., Parmentier E., Duburcq T. et al. Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med. Published online: 23 April 2020. https://doi.org/10.1007/s00134-020-06057-8</mixed-citation><mixed-citation xml:lang="en">Copin M., Parmentier E., Duburcq T. et al. Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med. Published online: 23 April 2020. https://doi.org/10.1007/s00134-020-06057-8</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kim J., Doo K., Jang H. Acute fibrinous and organizing pneumonia: Imaging features, pathologic correlation, and brief literature review. Radiol Case Rep. 2018; 13 (4): 867–870. http://doi.org/10.1016/j.radcr.2018.04.028</mixed-citation><mixed-citation xml:lang="en">Kim J., Doo K., Jang H. Acute fibrinous and organizing pneumonia: Imaging features, pathologic correlation, and brief literature review. Radiol Case Rep. 2018; 13 (4): 867–870. http://doi.org/10.1016/j.radcr.2018.04.028</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Самсонова М.В., Черняев А.Л., Михалева Л.М., Зайратьянц О.В., Мишнев О.Д. Патологическая анатомия легких при COVID-19. http://www.patolog.ru/sites/default/files/mv_samsonova_covid-19_.pdf</mixed-citation><mixed-citation xml:lang="en">Samsonova M.V. Chernyaev A.L. Mikhaleva L.M. Zairatyants O.V. Mishnev O.D. Pathological lung anatomy with COVID-19. http://www.patolog.ru/sites/default/files/mv_ samsonova_covid-19_.pdf (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lee N., Allen C., Hui D. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. J. Clin. Virol. 2004; 31 (4): 304–309. http://doi.org/10.1016/j.jcv.2004.07.006</mixed-citation><mixed-citation xml:lang="en">Lee N., Allen C., Hui D. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. J. Clin. Virol. 2004; 31 (4): 304–309. http://doi.org/10.1016/j.jcv.2004.07.006</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y, Jiang W, He Q, Wang C, Wang B, Zhou P et al. A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia. Signal Transduct. Target Ther. 2020; 5 (1): 57. http://doi.org/10.1038/s41392-020-0158-2</mixed-citation><mixed-citation xml:lang="en">Wang Y, Jiang W, He Q, Wang C, Wang B, Zhou P et al. A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia. Signal Transduct. Target Ther. 2020; 5 (1): 57. http://doi.org/10.1038/s41392-020-0158-2</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou Y., Qin Y., Lu Y. Effectiveness of glucocorticoid therapy in patients with severe novel coronavirus pneumonia: protocol of a randomized controlled trial. Chin. Med. J. (Engl). 2020; 133 (9): 1080–1086. http://doi.org/10.1097/CM9.0000000000000791</mixed-citation><mixed-citation xml:lang="en">Zhou Y., Qin Y., Lu Y. Effectiveness of glucocorticoid therapy in patients with severe novel coronavirus pneumonia: protocol of a randomized controlled trial. Chin. Med. J. (Engl). 2020; 133 (9): 1080–1086. http://doi.org/10.1097/CM9.0000000000000791</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA. Intern Med. 2020 Mar 13: e200994. http://doi.org/10.1001/jamainternmed.2020.0994.</mixed-citation><mixed-citation xml:lang="en">Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA. Intern Med. 2020 Mar 13: e200994. http://doi.org/10.1001/jamainternmed.2020.0994.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Fadel R., Morrison A., Vahia A., Smith Z., Chaudhry Z., Bhargava P. Early Short Course Corticosteroids in Hospitalized Patients with COVID-19. COVID-19 Management Task Force. medRxiv 2020.05.04.20074609. https://doi.org/10.1101/2020.05.04.20074609</mixed-citation><mixed-citation xml:lang="en">Fadel R., Morrison A., Vahia A., Smith Z., Chaudhry Z., Bhargava P. Early Short Course Corticosteroids in Hospitalized Patients with COVID-19. COVID-19 Management Task Force. medRxiv 2020.05.04.20074609. https://doi.org/10.1101/2020.05.04.20074609</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">EVMS Critical Care COVID-19 Management Protocol 05-14-2020 | evms.edu/covidcare (EVMS COVID website: https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf</mixed-citation><mixed-citation xml:lang="en">EVMS Critical Care COVID-19 Management Protocol 05-14-2020 | evms.edu/covidcare (EVMS COVID website: https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_ COVID-19_Protocol.pdf</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
