medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-2019-3-8-18medvis-790Research ArticleГОЛОВА И ШЕЯHEAD AND NECKПротонная 3D-МР-спектроскопия в диагностике глиальных опухолей головного мозгаProton 3D MR spectroscopy in the diagnosis of glial brain tumorsТюринаА. Н.TyurinaA. N.

младший научный сотрудник

125047 Москва, ул. 4-я Тверская-Ямская, 16, Российская Федерация

8-916-634-25-22

Junior Researcher

4-ya Tverskaya-Yamskaya str., 16, Moscow, Russia 125047

Phone: +7-916-634-25-22

aturina@nsi.ruПронинИ. Н.ProninI. N.

академик РАН, доктор мед. наук, профессор

125047 Москва, ул. 4-я Тверская-Ямская, 16, Российская Федерация

Academician of the Russian Academy of Sciences, doct. of med. sci., Professor

4-ya Tverskaya-Yamskaya str., 16, Moscow, Russia 125047

ФадееваЛ. М.FadeevaL. M.

медицинский физик

125047 Москва, ул. 4-я Тверская-Ямская, 16, Российская Федерация

Medical Physicist

4-ya Tverskaya-Yamskaya str., 16, Moscow, Russia 125047

БаталовА. И.BatalovA. I.

младший научный сотрудник

125047 Москва, ул. 4-я Тверская-Ямская, 16, Российская Федерация

Junior Researcher

4-ya Tverskaya-Yamskaya str., 16, Moscow, Russia 125047

ЗахароваН. Е.ZakharovaN. E.

доктор мед. наук, профессор РАН

125047 Москва, ул. 4-я Тверская-Ямская, 16, Российская Федерация

doct. of med. sci., Professor of Russian Academy of Sciences

4-ya Tverskaya-Yamskaya str., 16, Moscow, Russia 125047

ПодопроигораА. Е.PodoprigoraA. E.

канд. мед. наук

125047 Москва, ул. 4-я Тверская-Ямская, 16, Российская Федерация

cand. of med. sci.

4-ya Tverskaya-Yamskaya str., 16, Moscow, Russia 125047

ШульцЕ. И.ShultsE. I.

канд. мед. наук

125047 Москва, ул. 4-я Тверская-Ямская, 16, Российская Федерация

cand. of med. sci

4-ya Tverskaya-Yamskaya str., 16, Moscow, Russia 125047

КорниенкоВ. Н.KornienkoV. N.

академик РАН, доктор мед. наук, профессор

125047 Москва, ул. 4-я Тверская-Ямская, 16, Российская Федерация

Academician of the Russian Academy of Sciences, doct. of med. sci., Professor

4-ya Tverskaya-Yamskaya str., 16, Moscow, Russia 125047

ФГАУ “Национальный медицинский исследовательский центр нейрохирургии имени академика Н.Н. Бурденко” Минздрава РоссииРоссияFederal State Autonomous Institution “N.N. Burdenko National Medical Research Center of Neurosurgery” of the Ministry of Health of the Russian FederationRussian Federation20190209201903818Copyright © Тюрина А.Н., Пронин И.Н., Фадеева Л.М., Баталов А.И., Захарова Н.Е., Подопроигора А.Е., Шульц Е.И., Корниенко В.Н., 20192019Тюрина А.Н., Пронин И.Н., Фадеева Л.М., Баталов А.И., Захарова Н.Е., Подопроигора А.Е., Шульц Е.И., Корниенко В.Н.Tyurina A.N., Pronin I.N., Fadeeva L.M., Batalov A.I., Zakharova N.E., Podoprigora A.E., Shults E.I., Kornienko V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/790

Цель исследования: изучение возможностей протонной 3D-МР-спектроскопии в диагностике первичных глиальных опухолей головного мозга.Материал и методы. Всего было обследовано 63 пациента в возрасте от 20 до 60 лет с глиальными опухолями головного мозга различной степени злокачественности. Были оценены индексы соотношений основных метаболитов в опухолевой ткани и их сравнение с метаболитами, полученными в сером и белом веществе противоположного полушария мозга. Индексы соотношений основных метаболитов: Cho/Cr, NAA/Cr, Cho/NAA имели достоверные (p < 0,005) различия при сравнении глиом низкой и высокой степени злокачественности.Результаты. Полученные данные доказывают эффективность метода протонной 3D-МР-спектроскопии в определении степени анаплазии глиальных опухолей головного мозга.

The purpose of this study was an assessment of the proton 3D MR spectroscopy efficacy in diagnosis of primary glial brain tumors.Material and methods. Sixty three patients aged from 20 to 60 years with primary glial brain tumors of varying degrees of malignancy were examined. The ratios of main metabolites indices were evaluated with following comparison with the metabolites obtained in gray and white matter of the opposite hemisphere.The ratios of main metabolites: Cho/Cr, NAA/Cr, Cho/NAA showed significant (p <0.005) differences in the groups of patients with low and high grade gliomas.Results. The obtained data proved the efficacy of the proton 3D MR-spectroscopy in predicting of the glial brain tumors malignancy.

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The authors declare that there are no conflicts of interest present.