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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-2019-2-7-26</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-766</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОТ ПРИГЛАШЕННОГО РЕДАКТОРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FROM THE INVITED EDITOR</subject></subj-group></article-categories><title-group><article-title>Современный взгляд на принципы диагностики и лечения рака прямой кишки по данным МРТ (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Contemporary view to the principles of rectal cancer diagnostics and treatment according to MRI (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришко</surname><given-names>П. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Grishko</surname><given-names>P. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гришко Павел Юрьевич – врач-рентгенолог отделения лучевой диагностики</p><p>197758, п. Песочный, Ленинградская область, Ленинградская ул., д. 68</p><p>Тел.: +7-921-595-05-63</p></bio><bio xml:lang="en"><p>Pavel Yu. Grishko – radiologist at the Department of Radiology </p><p>197758 Russian Federation, St. Petersburg, Pesochny, Leningradskaya str., 68.</p><p>Phone: 7-921-595-05-63</p></bio><email xlink:type="simple">dr.grishko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балясникова</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Balyasnikova</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Балясникова Светлана Сергеевна – канд. мед. наук, старший научный сотрудник научного отделения диагностической и интервенционной радиологии</p><p>Radiologist at the Department of Radiology </p></bio><bio xml:lang="en"><p>Svetlana S. Balyasnikova – cand. of med. sci., radiologist at the Department of Radiology </p><p>Radiologist at the Department of Radiology </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самсонов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Samsonov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="en"><p>Denis V. Samsonov – cand. of med. sci., oncologist at the Department of Abdominal Oncology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мищенко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mishchenko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мищенко Андрей Владимирович – доктор мед. наук, заведующий научным отделением диагностической и интервенционной радиологии</p><p>профессор НК и ОЦ “Лучевая диагностика и ядерная медицина” </p></bio><bio xml:lang="en"><p>Andrei V. Mishchenko – doct. of med. sci., Head of the Department of Diagnostic and Interventional radiology </p><p>Professor of the Scientific Clinical and Educational Center “Radiation Diagnostics and Nuclear Medicine”</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карачун</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Karachun</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карачун Алексей Михайлович – доктор мед. наук, заведующий хирургическим отделением абдоминальной онкологии, ведущий научный сотрудник научного отделения опухолей желудочно-кишечного тракта</p></bio><bio xml:lang="en"><p>Alexey M. Karachun – doct. of med. sci., Head of the Department of abdominal oncology, Leading researcher of the Department of Gastrointestinal Tumors</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Правосудов</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pravosudov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Правосудов Игорь Витальевич – доктор мед. наук, профессор, ведущий научный сотрудник научного отделения опухолей желудочнокишечного тракта</p><p>профессор кафедры онкологии медицинского факультета </p></bio><bio xml:lang="en"><p>Igor V. Pravosudov – doct. of med. sci., Professor, Leading researcher of the Department of Gastrointestinal Tumors</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НМИЦ онкологии имени Н.Н. Петрова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Oncology named after N. N. Petrov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НМИЦ онкологии имени Н.Н. Петрова; The Royal Marsden Hospital, NHS Foundation Trust, Downs Road; Imperial College London</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Oncology named after N. N. Petrov; The Royal Marsden Hospital, NHS Foundation Trust, Downs Road; Imperial College London</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>16</day><month>07</month><year>2019</year></pub-date><volume>0</volume><issue>2</issue><fpage>7</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гришко П.Ю., Балясникова С.С., Самсонов Д.В., Мищенко А.В., Карачун А.М., Правосудов И.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Гришко П.Ю., Балясникова С.С., Самсонов Д.В., Мищенко А.В., Карачун А.М., Правосудов И.В.</copyright-holder><copyright-holder xml:lang="en">Grishko P.Y., Balyasnikova S.S., Samsonov D.V., Mishchenko A.V., Karachun A.M., Pravosudov I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/766">https://medvis.rdsmedia.ru/jour/article/view/766</self-uri><abstract><p>В статье рассматриваются последние достижения лучевой диагностики при обследовании пациентов с предполагаемым и верифицированным раком прямой кишки на различных этапах лечебно-диагностического процесса. Показана высокая роль качественной визуализации в диагностике рака прямой кишки, подробно описываются возможности магнитно-резонансной томографии в первичной диагностике заболевания и при рестадировании опухоли после проведения неоадъювантного лечения, обсуждаются оптимальная методика проведения исследования и принципы интерпретации полученных данных в ежедневной практике.</p></abstract><trans-abstract xml:lang="en"><p>In this article are reviewed the most recent diagnostic methods for patients with probable and verified rectal cancer, in different stages of treatment. The importance of high quality visualization of rectal cancer, opportunities of magnetic resonance imaging in primary diagnosis and restaging of the disease after neoadjuvant chemotherapy, optimal examination methods and interpretation of images in routine are discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак прямой кишки</kwd><kwd>диагностика</kwd><kwd>оценка распространенности</kwd><kwd>неоадъювантное лечение</kwd><kwd>магнитно-резонансная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rectal cancer</kwd><kwd>diagnostics</kwd><kwd>disease extent assessment</kwd><kwd>neoadjuvant chemotherapy</kwd><kwd>magnetic resonance imaging</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Glynne-Jones R., Wyrwicz L., Tiret E., Brown G., Rodel C., Cervantes A., Arnold D., ESMO Guidelines Committee. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2017; 28 (Suppl. 4): 22–40. http://doi.org/10.1093/annonc/mdx224.</mixed-citation><mixed-citation xml:lang="en">Glynne-Jones R., Wyrwicz L., Tiret E., Brown G., Rodel C., Cervantes A., Arnold D., ESMO Guidelines Committee. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2017; 28 (Suppl. 4): 22–40. http://doi.org/10.1093/annonc/mdx224.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">American Cancer Society. Cancer Facts &amp; Figures. 2017. Available at: https://www.cancer.org/content/dam/ cancer-org/research/cancer-facts-and-statistics/ annual-cancer-facts-and-figures/2017/cancer-factsand-figures-2017.pdf (accessed August 12, 2018).</mixed-citation><mixed-citation xml:lang="en">American Cancer Society. Cancer Facts &amp; Figures. 2017. Available at: https://www.cancer.org/content/dam/ cancer-org/research/cancer-facts-and-statistics/ annual-cancer-facts-and-figures/2017/cancer-factsand-figures-2017.pdf (accessed August 12, 2018). (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2009 г. Вестник РОНЦ им. Н.Н. Блохина РАМН. 2011; 22 (3, Прил. 1) (85): 1–170.</mixed-citation><mixed-citation xml:lang="en">Davydov M.I., Aksel E.M. Cancer statistics in Russia and CIS in 2009. Journal of N.N. Blokhin Russian Cancer Research Center RAMS. 2011; 22 (3, Suppl. 1) (85): 1–170. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Каприн А.Д., Старинский В.В., Петрова Г.В. Состояние онкологической помощи населению России в 2017 году. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ “НМИЦ радиологии” Минздрава России, 2018. 250 с.</mixed-citation><mixed-citation xml:lang="en">Kaprin A.D., Starinskii V.V., Petrova G.V. The state of oncological care for the population of Russia in 2017. M.: MNIOI im. P.A. Gertzena – filial FGBU “NMITZ radiologii” Minzdrava Rossii, 2018. 250 p. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2016 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена – филиал ФГБУ “НМИЦ радиологии” Минздрава России, 2018. 250 с.</mixed-citation><mixed-citation xml:lang="en">Kaprin A.D., Starinskii V.V., Petrova G.V. Malignant neoplasms in Russia in 2016 (morbidity and mortality). M.: MNIOI im. P.A. Gertzena – filial FGBU “NMITZ radiologii” Minzdrava Rossii, 2018. 250 p. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Morson B. President's address. The polyp-cancer sequence in the large bowel. Proc. Royal Soc. Med. 1974; 67 (6): 451–457.</mixed-citation><mixed-citation xml:lang="en">Morson B. President's address. The polyp-cancer sequence in the large bowel. Proc. Royal Soc. Med. 1974; 67 (6): 451–457.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kang H., O'Connell J.B., Leonardi M.J., Maggard M.A., McGory M.L., Ko C.Y. Rare tumors of the colon and rectum: a national review. Int. J. Colorectal Dis. 2007; 22 (2): 183–189.</mixed-citation><mixed-citation xml:lang="en">Kang H., O'Connell J.B., Leonardi M.J., Maggard M.A., McGory M.L., Ko C.Y. Rare tumors of the colon and rectum: a national review. Int. J. Colorectal Dis. 2007; 22 (2): 183–189.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Union for International Cancer Control (UICC). Available at: https://www.hoofdhalskanker.info/wpavl/wp-content/ uploads/TNM-Classification-of-Malignant-Tumours-8thedition.pdf. (accessed August 12, 2018).</mixed-citation><mixed-citation xml:lang="en">Union for International Cancer Control (UICC). Available at: https://www.hoofdhalskanker.info/wpavl/wp-content/ uploads/TNM-Classification-of-Malignant-Tumours-8thedition.pdf. (accessed August 12, 2018). (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Balyasnikova S., Brown G. Imaging Advances in Colorectal Cancer. Curr. Colorectal Cancer Rep. 2016; 12 (3): 162–169. http://doi.org/10.1007/s11888-016-0321-x.</mixed-citation><mixed-citation xml:lang="en">Balyasnikova S., Brown G. Imaging Advances in Colorectal Cancer. Curr. Colorectal Cancer Rep. 2016; 12 (3): 162–169. http://doi.org/10.1007/s11888-016-0321-x.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Beets-Tan R.G.H., Lambregts D.M.J., Maas M., Bipat S., Barbaro B., Curvo-Semedo L., Fenlon H.M., Gollub M.J., Gourtsoyianni S., Halligan S., Hoeffel C., Kim S.H., Laghi A., Maier A., Rafaelsen S.R., Stoker J., Taylor S.A., Torkzad M.R., Blomqvist L. Magnetic resonance imaging for clinical management of rectal cancer: Updated recommendations from the 2016 European Society of Gastro intestinal and Abdominal Radiology (ESGAR) consensus meeting. Eur. Radiol. 2018; 28 (4): 1465–1475. http://doi.org/10.1007/s00330-017-5026-2.</mixed-citation><mixed-citation xml:lang="en">Beets-Tan R.G.H., Lambregts D.M.J., Maas M., Bipat S., Barbaro B., Curvo-Semedo L., Fenlon H.M., Gollub M.J., Gourtsoyianni S., Halligan S., Hoeffel C., Kim S.H., Laghi A., Maier A., Rafaelsen S.R., Stoker J., Taylor S.A., Torkzad M.R., Blomqvist L. Magnetic resonance imaging for clinical management of rectal cancer: Updated recommendations from the 2016 European Society of Gastro intestinal and Abdominal Radiology (ESGAR) consensus meeting. Eur. Radiol. 2018; 28 (4): 1465–1475. http://doi.org/10.1007/s00330-017-5026-2.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Peschaud F., Benoist S., Julie C., Penna C., Nordlinger B. The mesorectum: an anatomical entity that is difficult to evaluate with MRI. Morphologie: bulletin de l'Association des anatomistes. 2005; 89 (286): 126–130.</mixed-citation><mixed-citation xml:lang="en">Peschaud F., Benoist S., Julie C., Penna C., Nordlinger B. The mesorectum: an anatomical entity that is difficult to evaluate with MRI. Morphologie: bulletin de l'Association des anatomistes. 2005; 89 (286): 126–130.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rodel C., Sauer R., Fietkau R. The Role of Magnetic Resonance Imaging to Select Patients for Preoperative Treatment in Rectal Cancer. Strahlentherapie Onkol. 2009; 185 (8): 488–492. http://doi.org/10.1007/s00066-009-2043-3.</mixed-citation><mixed-citation xml:lang="en">Rodel C., Sauer R., Fietkau R. The Role of Magnetic Resonance Imaging to Select Patients for Preoperative Treatment in Rectal Cancer. Strahlentherapie Onkol. 2009; 185 (8): 488–492. http://doi.org/10.1007/s00066-009-2043-3.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Sukhni E., Milot L., Fruitman M., Beyene J., Victor J.C., Schmocker S., Brown G., McLeod R., Kennedy E. Diagnostic Accuracy of MRI for Assessment of T Category, Lymph Node Metastases, and Circumferential Resection Margin Involvement in Patients with Rectal Cancer: A Systematic Review and Meta-analysis. Ann. Surg. Oncol. 2012; 19 (7): 2212–2223. http://doi.org/10.1245/s10434-011-2210-5.</mixed-citation><mixed-citation xml:lang="en">Al-Sukhni E., Milot L., Fruitman M., Beyene J., Victor J.C., Schmocker S., Brown G., McLeod R., Kennedy E. Diagnostic Accuracy of MRI for Assessment of T Category, Lymph Node Metastases, and Circumferential Resection Margin Involvement in Patients with Rectal Cancer: A Systematic Review and Meta-analysis. Ann. Surg. Oncol. 2012; 19 (7): 2212–2223. http://doi.org/10.1245/s10434-011-2210-5.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Karatag O., Karatag G.Y., Ozkurt H., Degirmenci H.K., Avlanmis O., Basak M., Baykan A. The ability of phasedarray MRI in preoperative staging of primary rectal cancer: correlation with histopathological results. Diagn. Interv. Radiol. 2012; 18 (1): 20–26. http://doi.org/10.4261/1305-3825.DIR.3394-10.2.</mixed-citation><mixed-citation xml:lang="en">Karatag O., Karatag G.Y., Ozkurt H., Degirmenci H.K., Avlanmis O., Basak M., Baykan A. The ability of phasedarray MRI in preoperative staging of primary rectal cancer: correlation with histopathological results. Diagn. Interv. Radiol. 2012; 18 (1): 20–26. http://doi.org/10.4261/1305-3825.DIR.3394-10.2.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kim S.H., Lee J.M., Park H.S., Eun H.W., Han J.K., Choi B.I. Accuracy of MRI for Predicting the Circumferential Resection Margin, Mesorectal Fascia Invasion, and Tumor Response to Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer. J. Magn. Reson. Imaging. 2009; 29 (5): 1093–1101. http://doi.org/10.1002/jmri.21742.</mixed-citation><mixed-citation xml:lang="en">Kim S.H., Lee J.M., Park H.S., Eun H.W., Han J.K., Choi B.I. Accuracy of MRI for Predicting the Circumferential Resection Margin, Mesorectal Fascia Invasion, and Tumor Response to Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer. J. Magn. Reson. Imaging. 2009; 29 (5): 1093–1101. http://doi.org/10.1002/jmri.21742.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Koh D.M., Brown G., Temple L., Blake H., Raja A., Toomey P., Bett N., Farhat S., Norman A.R., Daniels I., Husband J.E. Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations. Eur. Radiol. 2005; 15 (8): 1650–1657. http://doi.org/10.1007/s00330-005-2751-8.</mixed-citation><mixed-citation xml:lang="en">Koh D.M., Brown G., Temple L., Blake H., Raja A., Toomey P., Bett N., Farhat S., Norman A.R., Daniels I., Husband J.E. Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations. Eur. Radiol. 2005; 15 (8): 1650–1657. http://doi.org/10.1007/s00330-005-2751-8.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Nougaret S., Reinhold C., Mikhael H.W., Rouanet P., Bibeau F., Brown G. The Use of MR Imaging in Treatment Planning for Patients with Rectal Carcinoma: Have You Checked the “DISTANCE”? Radiology. 2013; 268 (2): 329–343. http://doi.org/10.1148/radiol.13121361.</mixed-citation><mixed-citation xml:lang="en">Nougaret S., Reinhold C., Mikhael H.W., Rouanet P., Bibeau F., Brown G. The Use of MR Imaging in Treatment Planning for Patients with Rectal Carcinoma: Have You Checked the “DISTANCE”? Radiology. 2013; 268 (2): 329–343. http://doi.org/10.1148/radiol.13121361.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Patel U.B., Taylor F., Blomqvist L., George C., Evans H., Tekkis P., Quirke P., Sebag-Montefiore D., Moran B., Heald R., Guthrie A., Bees N., Swift I., Pennert K., Brown G. Magnetic Resonance Imaging-Detected Tumor Response for Locally Advanced Rectal Cancer Predicts Survival Outcomes: MERCURY Experience. J. Clin. Oncol. 2011; 29 (28): 3753–3760. http://doi.org/10.1200/JCO.2011.34.9068.</mixed-citation><mixed-citation xml:lang="en">Patel U.B., Taylor F., Blomqvist L., George C., Evans H., Tekkis P., Quirke P., Sebag-Montefiore D., Moran B., Heald R., Guthrie A., Bees N., Swift I., Pennert K., Brown G. Magnetic Resonance Imaging-Detected Tumor Response for Locally Advanced Rectal Cancer Predicts Survival Outcomes: MERCURY Experience. J. Clin. Oncol. 2011; 29 (28): 3753–3760. http://doi.org/10.1200/JCO.2011.34.9068.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Piippo U., Paakko E., Makinen M., Makela J. Local staging of rectal cancer using the black lumen magnetic resonance imaging technique. Scand. J. Surg. 2008; 97 (3): 237–242. http://doi.org/10.1177/145749690809700306.</mixed-citation><mixed-citation xml:lang="en">Piippo U., Paakko E., Makinen M., Makela J. Local staging of rectal cancer using the black lumen magnetic resonance imaging technique. Scand. J. Surg. 2008; 97 (3): 237–242. http://doi.org/10.1177/145749690809700306.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mulla M., Deb R., Singh R. MRI in T staging of rectal cancer: How effective is it? Indian J. Radiol. Imaging. 2010; 20 (2): 118–121. http://doi.org/10.4103/0971-3026.63055.</mixed-citation><mixed-citation xml:lang="en">Mulla M., Deb R., Singh R. MRI in T staging of rectal cancer: How effective is it? Indian J. Radiol. Imaging. 2010; 20 (2): 118–121. http://doi.org/10.4103/0971-3026.63055.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Vliegen R.F.A., Beets G.L., von Meyenfeldt M.F., Kessels A.G.H., Lemaire E., van Engelshoven J.M.A., Beets-Tan R.G.H. Rectal cancer: MR Imaging in local staging – Is gadolinium-based contrast material helpful? Radiology. 2005; 234 (1): 179–188. http://doi.org/10.1148/radiol.2341031403.</mixed-citation><mixed-citation xml:lang="en">Vliegen R.F.A., Beets G.L., von Meyenfeldt M.F., Kessels A.G.H., Lemaire E., van Engelshoven J.M.A., Beets-Tan R.G.H. Rectal cancer: MR Imaging in local staging – Is gadolinium-based contrast material helpful? Radiology. 2005; 234 (1): 179–188. http://doi.org/10.1148/radiol.2341031403.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Jao S.Y., Yang B.Y., Weng H.H., Yeh C.H., Lee L.W. Evaluation of gadolinium-enhanced T1-weighted magnetic resonance imaging in the preoperative assessment of local staging in rectal cancer. Colorectal Dis. 2010; 12 (11): 1139–1148. http://doi.org/10.1111/j.1463-1318.2009.01959.x.</mixed-citation><mixed-citation xml:lang="en">Jao S.Y., Yang B.Y., Weng H.H., Yeh C.H., Lee L.W. Evaluation of gadolinium-enhanced T1-weighted magnetic resonance imaging in the preoperative assessment of local staging in rectal cancer. Colorectal Dis. 2010; 12 (11): 1139–1148. http://doi.org/10.1111/j.1463-1318.2009.01959.x.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lambregts D.M.J., Vandecaveye V., Barbaro B., Bakers F.C.H., Lambrecht M., Maas M., Hauster mans K., Valentini V., Beets G.L., Beets-Tan R.G.H. Diffusionweighted MRI for selection of complete responders after chemoradiation for locally advanced rectal cancer: a multicenter study. Ann. Surg. Oncol. 2011; 18 (8): 2224–2231. http://doi.org/10.1245/s10434-011-1607-5.</mixed-citation><mixed-citation xml:lang="en">Lambregts D.M.J., Vandecaveye V., Barbaro B., Bakers F.C.H., Lambrecht M., Maas M., Hauster mans K., Valentini V., Beets G.L., Beets-Tan R.G.H. Diffusionweighted MRI for selection of complete responders after chemoradiation for locally advanced rectal cancer: a multicenter study. Ann. Surg. Oncol. 2011; 18 (8): 2224–2231. http://doi.org/10.1245/s10434-011-1607-5.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Foti P.V., Privitera G., Piana S., Palmucci S., Spatola C., Bevilacqua R., Raffaele L., Salamone V., Caltabiano R., Magro G., Destri G.L., Milone P., Ettorre G.C. Locally advanced rectal cancer: Qualitative and quantitative evaluation of diffusion-weighted MR imaging in the response assessment after neoadjuvant chemoradiotherapy. Eur. J. Radiol. Open. 2016; 3: 145–152. http://doi.org/10.1016/j.ejro.2016.06.003.</mixed-citation><mixed-citation xml:lang="en">Foti P.V., Privitera G., Piana S., Palmucci S., Spatola C., Bevilacqua R., Raffaele L., Salamone V., Caltabiano R., Magro G., Destri G.L., Milone P., Ettorre G.C. Locally advanced rectal cancer: Qualitative and quantitative evaluation of diffusion-weighted MR imaging in the response assessment after neoadjuvant chemoradiotherapy. Eur. J. Radiol. Open. 2016; 3: 145–152. http://doi.org/10.1016/j.ejro.2016.06.003.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Brown G. Thin section MRI in multidisciplinary preoperative decision making for patients with rectal cancer. Br. J. Radiol. 2005; 78: 117–127. http://doi.org/10.1259/bjr/15128198.</mixed-citation><mixed-citation xml:lang="en">Brown G. Thin section MRI in multidisciplinary preoperative decision making for patients with rectal cancer. Br. J. Radiol. 2005; 78: 117–127. http://doi.org/10.1259/bjr/15128198.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Dukes C.E. The classification of cancer of the rectum. The Journal of Pathology and Bacteriology. 1932; 35 (3): 323–332.</mixed-citation><mixed-citation xml:lang="en">Dukes C.E. The classification of cancer of the rectum. The Journal of Pathology and Bacteriology. 1932; 35 (3): 323–332.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Brown G. Staging rectal cancer: endoscopic ultrasound and pelvic MRI. Cancer Imaging. 2008; 8 (A): 43–45. http://doi.org/10.1102/1470-7330.2008.9008.</mixed-citation><mixed-citation xml:lang="en">Brown G. Staging rectal cancer: endoscopic ultrasound and pelvic MRI. Cancer Imaging. 2008; 8 (A): 43–45. http://doi.org/10.1102/1470-7330.2008.9008.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kikuchi R., Takano M., Takagi K., Fujimoto N., Nozaki R., Fujiyoshi T., Uchida Y. Management of early invasive colorectal-cancer – risk of recurrence and clinical guidelines. Dis. Colon. Rectum. 1995; 38 (12): 1286–1295.</mixed-citation><mixed-citation xml:lang="en">Kikuchi R., Takano M., Takagi K., Fujimoto N., Nozaki R., Fujiyoshi T., Uchida Y. Management of early invasive colorectal-cancer – risk of recurrence and clinical guidelines. Dis. Colon. Rectum. 1995; 38 (12): 1286–1295.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Puli S.R., Bechtold M.L., Reddy J.B.K., Choudhary A., Antillon M.R. Can Endoscopic Ultrasound Predict Early Rectal Cancers That Can Be Resected Endoscopically? A Meta-Analysis and Systematic Review. Dig. Dis. Sci. 2010; 55 (5): 1221–1229. http://doi.org/10.1007/s10620-009-0862-9.</mixed-citation><mixed-citation xml:lang="en">Puli S.R., Bechtold M.L., Reddy J.B.K., Choudhary A., Antillon M.R. Can Endoscopic Ultrasound Predict Early Rectal Cancers That Can Be Resected Endoscopically? A Meta-Analysis and Systematic Review. Dig. Dis. Sci. 2010; 55 (5): 1221–1229. http://doi.org/10.1007/s10620-009-0862-9.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Balyasnikova S., Read J., Wotherspoon A., Rasheed S., Tekkis P., Tait D., Cunningham D., Brown G. Diagnostic accuracy of high-resolution MRI as a method to predict potentially safe endoscopic and surgical planes in patients with early rectal cancer. BMJ Open Gastroenterol. 2017; 4 (1): e000151. http://doi.org/10.1136/bmjgast-2017-000151.</mixed-citation><mixed-citation xml:lang="en">Balyasnikova S., Read J., Wotherspoon A., Rasheed S., Tekkis P., Tait D., Cunningham D., Brown G. Diagnostic accuracy of high-resolution MRI as a method to predict potentially safe endoscopic and surgical planes in patients with early rectal cancer. BMJ Open Gastroenterol. 2017; 4 (1): e000151. http://doi.org/10.1136/bmjgast-2017-000151.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Brown G., Daniels I.R., Heald R.J., Quirke P., Blomqvist L., Sebag-Montefiore D., Moran B.J., Holm T., Strassbourg J., Peppercorn P.D., Fisher S.E., Mason B., Grp M.S. Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. Br. Med. J. 2006; 333 (7572): 779–782. http://doi.org/10.1136/bmj.38937.646400.55.</mixed-citation><mixed-citation xml:lang="en">Brown G., Daniels I.R., Heald R.J., Quirke P., Blomqvist L., Sebag-Montefiore D., Moran B.J., Holm T., Strassbourg J., Peppercorn P.D., Fisher S.E., Mason B., Grp M.S. Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. Br. Med. J. 2006; 333 (7572): 779–782. http://doi.org/10.1136/bmj.38937.646400.55.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kaur H., Choi H., You Y.N., Rauch G.M., Jensen C.T., Hou P., Chang G.J., Skibber J.M., Ernst R.D. MR imaging for preoperative evaluation of primary rectal cancer: practical considerations. Radiographics. 2012; 32 (2): 389–409. http://doi.org/10.1148/rg.322115122</mixed-citation><mixed-citation xml:lang="en">Kaur H., Choi H., You Y.N., Rauch G.M., Jensen C.T., Hou P., Chang G.J., Skibber J.M., Ernst R.D. MR imaging for preoperative evaluation of primary rectal cancer: practical considerations. Radiographics. 2012; 32 (2): 389–409. http://doi.org/10.1148/rg.322115122</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor F.G.M., Quirke P., Heald R.J., Moran B., Blomqvist L., Swift I., Sebag-Montefiore D.J., Tekkis P., Brown G., Grp M.S. Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone a prospective, multicenter, european study. Ann. Surg. 2011; 253 (4): 711–719. http://doi.org/10.1097/SLA.0b013e31820b8d52.</mixed-citation><mixed-citation xml:lang="en">Taylor F.G.M., Quirke P., Heald R.J., Moran B., Blomqvist L., Swift I., Sebag-Montefiore D.J., Tekkis P., Brown G., Grp M.S. Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone a prospective, multicenter, european study. Ann. Surg. 2011; 253 (4): 711–719. http://doi.org/10.1097/SLA.0b013e31820b8d52.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Benson A.B. 3rd, Venook A.P., Al-Hawary M.M., Cederquist L., Chen Y.-J., Ciombor K.K., Cohen S., Cooper H.S., Deming D., Engstrom P.F., Grem J.L., Grothey A., Hochster H.S., Hoffe S., Hunt S., Kamel A., Kirilcuk N., Krishnamurthi S., Messersmith W.A., Meyerhardt J., Mulcahy M.F., Murphy J.D., Nurkin S., Saltz L., Sharma S., Shibata D., Skibber J.M., Sofocleous C.T., Stoffel E.M., Stotsky-Himelfarb E., Willett C.G., Wuthrick E., Gregory K.M., Gurski L., Freedman-Cass D.A. Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. J. Natl. Compr. Canc. Netw. (JNCCN). 2018; 16 (7): 874–901. http://doi.org/10.6004/jnccn.2018.0061.</mixed-citation><mixed-citation xml:lang="en">Benson A.B. 3rd, Venook A.P., Al-Hawary M.M., Cederquist L., Chen Y.-J., Ciombor K.K., Cohen S., Cooper H.S., Deming D., Engstrom P.F., Grem J.L., Grothey A., Hochster H.S., Hoffe S., Hunt S., Kamel A., Kirilcuk N., Krishnamurthi S., Messersmith W.A., Meyerhardt J., Mulcahy M.F., Murphy J.D., Nurkin S., Saltz L., Sharma S., Shibata D., Skibber J.M., Sofocleous C.T., Stoffel E.M., Stotsky-Himelfarb E., Willett C.G., Wuthrick E., Gregory K.M., Gurski L., Freedman-Cass D.A. Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. J. Natl. Compr. Canc. Netw. (JNCCN). 2018; 16 (7): 874–901. http://doi.org/10.6004/jnccn.2018.0061.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Sukhni E., Milot L., Fruitman M., Brown G., Schmocker S., Kennedy E. User’s Guide for the Synoptic MRI Report for Rectal Cancer. Cancer Care Ontario. Canadian Cancer Society. Available at: http://www.osumcradiology. org/resources/High-Yield-Rad-info/Rectal-MRI.pdf (accessed August 12, 2018). (In Russian).</mixed-citation><mixed-citation xml:lang="en">Al-Sukhni E., Milot L., Fruitman M., Brown G., Schmocker S., Kennedy E. User’s Guide for the Synoptic MRI Report for Rectal Cancer. Cancer Care Ontario. Canadian Cancer Society. Available at: http://www.osumcradiology. org/resources/High-Yield-Rad-info/Rectal-MRI.pdf (accessed August 12, 2018). (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Moran M.R., James E.C., Rothenberger D.A., Goldberg S.M. Prognostic value of positive lymph-nodes in rectal-cancer. Dis. Colon. Rectum. 1992; 35 (6): 579–581.</mixed-citation><mixed-citation xml:lang="en">Moran M.R., James E.C., Rothenberger D.A., Goldberg S.M. Prognostic value of positive lymph-nodes in rectal-cancer. Dis. Colon. Rectum. 1992; 35 (6): 579–581.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Quirke P., Williams G. Minimum dataset for colorectal cancer histopathology reports. London: Royal College of Pathologists, 2000.</mixed-citation><mixed-citation xml:lang="en">Quirke P., Williams G. Minimum dataset for colorectal cancer histopathology reports. London: Royal College of Pathologists, 2000.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Bipat S., Glas A.S., Slors F.J.M., Zwinderman A.H., Bossuyt P.M.M., Stoker J. Rectal cancer: Local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging – A meta-analysis. Radiology. 2004; 232 (3): 773–783. http://doi.org/10.1148/radiol.2323031368.</mixed-citation><mixed-citation xml:lang="en">Bipat S., Glas A.S., Slors F.J.M., Zwinderman A.H., Bossuyt P.M.M., Stoker J. Rectal cancer: Local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging – A meta-analysis. Radiology. 2004; 232 (3): 773–783. http://doi.org/10.1148/radiol.2323031368.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Schnall M.D., Furth P.E.E., Rosato E.F., Kressel H.Y. Rectal tumor stage – correlation of endorectal MR-imaging and pathological findings. Radiology. 1994; 190 (3): 709–714. http://doi.org/10.1148/radiology.190.3.8115616.</mixed-citation><mixed-citation xml:lang="en">Schnall M.D., Furth P.E.E., Rosato E.F., Kressel H.Y. Rectal tumor stage – correlation of endorectal MR-imaging and pathological findings. Radiology. 1994; 190 (3): 709–714. http://doi.org/10.1148/radiology.190.3.8115616.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Brown G., Richards C.J., Bourne M.W., Newcombe R.G., Radcliffe A.G., Dallimore N.S., Williams G.T. Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histo pathologic comparison. Radiology. 2003; 227 (2): 371–377. http://doi.org/10.1148/radiol.2272011747.</mixed-citation><mixed-citation xml:lang="en">Brown G., Richards C.J., Bourne M.W., Newcombe R.G., Radcliffe A.G., Dallimore N.S., Williams G.T. Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histo pathologic comparison. Radiology. 2003; 227 (2): 371–377. http://doi.org/10.1148/radiol.2272011747.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kotanagi H., Fukuoka T., Shibata Y., Yoshioka T., Aizawa O., Saito Y., Tur G.E., Koyama K. The size of regional lymphnodes does not correlate with the presence or absence of metastasis in lymph-nodes in rectal-cancer. J. Surg. Oncol. 1993; 54 (4): 252–254.</mixed-citation><mixed-citation xml:lang="en">Kotanagi H., Fukuoka T., Shibata Y., Yoshioka T., Aizawa O., Saito Y., Tur G.E., Koyama K. The size of regional lymph nodes does not correlate with the presence or absence of metastasis in lymph-nodes in rectal-cancer. J. Surg. Oncol. 1993; 54 (4): 252–254.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Markl B., Rossle J., Arnholdt H.M., Schaller T., Krammer I., Cacchi C., Jahnig H., Schenkirsch G., Spatz H., Anthuber M. The clinical significance of lymph node size in colon cancer. Mod. Pathol. 2012; 25 (10): 1413–1422. http://doi.org/10.1038/modpathol.2012.92.</mixed-citation><mixed-citation xml:lang="en">Markl B., Rossle J., Arnholdt H.M., Schaller T., Krammer I., Cacchi C., Jahnig H., Schenkirsch G., Spatz H., Anthuber M. The clinical significance of lymph node size in colon cancer. Mod. Pathol. 2012; 25 (10): 1413–1422. http://doi.org/10.1038/modpathol.2012.92.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Smith N.J., Shihab O., Arnaout A., Swift R.I., Brown G. MRI for detection of extramural vascular invasion in rectal cancer. Am. J. Roentgenol. 2008; 191 (5): 1517–1522. http://doi.org/10.2214/AJR.08.1298.</mixed-citation><mixed-citation xml:lang="en">Smith N.J., Shihab O., Arnaout A., Swift R.I., Brown G. MRI for detection of extramural vascular invasion in rectal cancer. Am. J. Roentgenol. 2008; 191 (5): 1517–1522. http://doi.org/10.2214/AJR.08.1298.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Chand M., Swift R.I., Tekkis P.P., Chau I., Brown G. Extramural venous invasion is a potential imaging predictive biomarker of neoadjuvant treatment in rectal cancer. Br. J. Cancer. 2014; 110 (1): 19–25. http://doi.org/10.1038/bjc.2013.603.</mixed-citation><mixed-citation xml:lang="en">Chand M., Swift R.I., Tekkis P.P., Chau I., Brown G. Extramural venous invasion is a potential imaging predictive biomarker of neoadjuvant treatment in rectal cancer. Br. J. Cancer. 2014; 110 (1): 19–25. http://doi.org/10.1038/bjc.2013.603.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Chand M., Evans J., Swift R.I., Tekkis P.P., West N.P., Stamp G., Heald R.J., Brown G. The prognostic significance of postchemoradiotherapy high-resolution MRI and histopathology detected extramural venous invasion in rectal cancer. Ann. Surg. 2015; 261 (3): 473–479. http://doi.org/10.1097/SLA.0000000000000848.</mixed-citation><mixed-citation xml:lang="en">Chand M., Evans J., Swift R.I., Tekkis P.P., West N.P., Stamp G., Heald R.J., Brown G. The prognostic significance of postchemoradiotherapy high-resolution MRI and histopathology detected extramural venous invasion in rectal cancer. Ann. Surg. 2015; 261 (3): 473–479. http://doi.org/10.1097/SLA.0000000000000848.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Faes S., Gie O., Demartines N., Hahnloser D. Multidisciplinary treatment of locally advanced rectal cancer. Rev. Med. Suisse. 2016; 12 (523): 1185–1189. (In French)</mixed-citation><mixed-citation xml:lang="en">Faes S., Gie O., Demartines N., Hahnloser D. Multidisciplinary treatment of locally advanced rectal cancer. Rev. Med. Suisse. 2016; 12 (523): 1185–1189. (In French) 47. Miles W.E. A method of performing abdomino-perineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon. The Lancet. 1908; 172 (4451): 1812–1813.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Miles W.E. A method of performing abdomino-perineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon. The Lancet. 1908; 172 (4451): 1812–1813.</mixed-citation><mixed-citation xml:lang="en">Heald R.J. The holy plane of rectal surgery. J. R. Soc. Med. 1988; 81 (9): 503–508. PMID: 3184105. 49. Heald R.J., Moran B.J., Ryall R.D.H., Sexton R., MacFarlane J.K. Rectal cancer – the basingstoke experience of total mesorectal excision, 1978–1997. Arch. Surg. 1998; 133 (8): 894–898.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Heald R.J. The holy plane of rectal surgery. J. R. Soc. Med. 1988; 81 (9): 503–508. PMID: 3184105.</mixed-citation><mixed-citation xml:lang="en">Quirke P., Dixon M.F., Durdey P., Williams N.S. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection – histopathological study of lateral tumor spread and surgical excision. Lancet. 1986; 2 (8514): 996–999.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Heald R.J., Moran B.J., Ryall R.D.H., Sexton R., MacFarlane J.K. Rectal cancer – the basingstoke experience of total mesorectal excision, 1978–1997. Arch. Surg. 1998; 133 (8): 894–898.</mixed-citation><mixed-citation xml:lang="en">Taylor F.G.M., Quirke P., Heald R.J., Moran B.J., Blomqvist L., Swift I.R., Sebag-Montefiore D., Tekkis P., Brown G. Preoperative magnetic resonance imaging assessment of circumferential resection margin predicts disease-free survival and local recurrence: 5-year followup results of the MERCURY study. J. Clin. Oncol. 2014; 32 (1): 34–114. http://doi.org/10.1200/JCO.2012.45.3258.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Quirke P., Dixon M.F., Durdey P., Williams N.S. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection – histopathological study of lateral tumor spread and surgical excision. Lancet. 1986; 2 (8514): 996–999.</mixed-citation><mixed-citation xml:lang="en">Bown E.J., Lloyd G.M., Boyle KM., Miller A.S. Rectal cancer: prognostic indicators of long-term outcome in patients considered for surgery. Int. J. Colorectal. Dis. 2014; 29 (2): 147–155. http://doi.org/10.1007/s00384-013-1772-z.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor F.G.M., Quirke P., Heald R.J., Moran B.J., Blomqvist L., Swift I.R., Sebag-Montefiore D., Tekkis P., Brown G. Preoperative magnetic resonance imaging assessment of circumferential resection margin predicts disease-free survival and local recurrence: 5-year followup results of the MERCURY study. J. Clin. Oncol. 2014; 32 (1): 34–114. http://doi.org/10.1200/JCO.2012.45.3258.</mixed-citation><mixed-citation xml:lang="en">Zhao J., Du C.Z., Sun Y.S., Gu J. Patterns and prognosis of locally recurrent rectal cancer following multi disciplinary treatment. Wld J. Gastroenterol. 2012; 18 (47): 7015–7020. http://doi.org/10.3748/wjg.v18.i47.7015.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Bown E.J., Lloyd G.M., Boyle KM., Miller A.S. Rectal cancer: prognostic indicators of long-term outcome in patients considered for surgery. Int. J. Colorectal. Dis. 2014; 29 (2): 147–155. http://doi.org/10.1007/s00384-013-1772-z.</mixed-citation><mixed-citation xml:lang="en">Purkayastha S., Tekkis P.P., Athanasiou T., Tilney H.S., Darzi A.W., Heriot A.G. Diagnostic precision of magnetic resonance imaging for preoperative prediction of the circumferential margin involvement in patients with rectal cancer. Colorectal Dis. 2007; 9 (5): 402–411. http://doi.org/10.1111/j.1463-1318.2006.01104.x.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao J., Du C.Z., Sun Y.S., Gu J. Patterns and prognosis of locally recurrent rectal cancer following multi disciplinary treatment. Wld J. Gastroenterol. 2012; 18 (47): 7015–7020. http://doi.org/10.3748/wjg.v18.i47.7015.</mixed-citation><mixed-citation xml:lang="en">Taylor F.G.M., Quirke P., Heald R.J., Moran B., Blomqvist L., Swift I., St Rose S., Sebag-Montefiore D.J., Tekkis P., Brown G., Grp M.S. One millimetre is the safe cut-off for magnetic resonance imaging prediction of surgical margin status in rectal cancer. Br. J. Surg. 2011; 98 (6): 872–879. DOI: 10.1002/bjs.7458.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Purkayastha S., Tekkis P.P., Athanasiou T., Tilney H.S., Darzi A.W., Heriot A.G. Diagnostic precision of magnetic resonance imaging for preoperative prediction of the circumferential margin involvement in patients with rectal cancer. Colorectal Dis. 2007; 9 (5): 402–411. http://doi.org/10.1111/j.1463-1318.2006.01104.x.</mixed-citation><mixed-citation xml:lang="en">Rullier E., Denost Q., Vendrely V., Rullier A., Laurent C. Low rectal cancer: classification and standardization of surgery. Dis. Colon. Rectum. 2013; 56 (5): 560–567. http://doi.org/10.1097/DCR.0b013e31827c4a8c.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor F.G.M., Quirke P., Heald R.J., Moran B., Blomqvist L., Swift I., St Rose S., Sebag-Montefiore D.J., Tekkis P., Brown G., Grp M.S. One millimetre is the safe cut-off for magnetic resonance imaging prediction of surgical margin status in rectal cancer. Br. J. Surg. 2011; 98 (6): 872–879. DOI: 10.1002/bjs.7458.</mixed-citation><mixed-citation xml:lang="en">Perez R., Habr-Gama A., Camargo A., Souza S., Parmigiani R., Galante P., Salim A., Souza J., Quevedo B., Felicio N., Gama-Rodrigues J. Prediction of response to neoadjuvant chemoradiation therapy in patients with distal rectal cancer by gene expression using last generation sequencing. Dis. Colon. Rectum. 2011; 54 (5): Е7–E7.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Rullier E., Denost Q., Vendrely V., Rullier A., Laurent C. Low rectal cancer: classification and standardization of surgery. Dis. Colon. Rectum. 2013; 56 (5): 560–567. http://doi.org/10.1097/DCR.0b013e31827c4a8c.</mixed-citation><mixed-citation xml:lang="en">Chernikovskii I.L. Multidisciplinary approach in the diagnosis and treatment of resectable rectal cancer. Practical oncology. 2015; 16 (2): 69–76. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Perez R., Habr-Gama A., Camargo A., Souza S., Parmigiani R., Galante P., Salim A., Souza J., Quevedo B., Felicio N., Gama-Rodrigues J. Prediction of response to neoadjuvant chemoradiation therapy in patients with distal rectal cancer by gene expression using last generation sequencing. Dis. Colon. Rectum. 2011; 54 (5): Е7–E7.</mixed-citation><mixed-citation xml:lang="en">Sauer R., Becker H., Hohenberger W., Rodel C., Wittekind C., Fietkau R., Martus P., Tschmelitsch J., Hager E., Hess C.F., Karstens J.H., Liersch T., Schmidberger H., Raab R., German Rectal Cancer Study Group. Preoperative versus postoperative chemoradiotherapy for rectal cancer. New Engl. J. Med. 2004; 351 (17): 1731–1740. http://doi.org/10.1056/NEJMoa040694.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Черниковский И.Л. Мультидисциплинарный подход в диагностике и лечении резектабельного рака прямой кишки. Практическая онкология. 2015; 16 (2): 69–76.</mixed-citation><mixed-citation xml:lang="en">Hotker A.M., Tarlinton L., Mazaheri Y., Woo K.M., Gonen M., Saltz L.B., Goodman K.A., Garcia-Aguilar J., Gollub M.J. Multiparametric MRI in the assessment of response of rectal cancer to neoadjuvant chemo radiotherapy: A comparison of morphological, volumetric and functional MRI parameters. Eur. Radiol. 2016; 26 (12): 4303–4312. http://doi.org/10.1007/s00330-016-4283-9.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Sauer R., Becker H., Hohenberger W., Rodel C., Wittekind C., Fietkau R., Martus P., Tschmelitsch J., Hager E., Hess C.F., Karstens J.H., Liersch T., Schmidberger H., Raab R., German Rectal Cancer Study Group. Preoperative versus postoperative chemoradiotherapy for rectal cancer. New Engl. J. Med. 2004; 351 (17): 1731–1740. http://doi.org/10.1056/NEJMoa040694.</mixed-citation><mixed-citation xml:lang="en">Dworak O., Keilholz L., Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int. J. Colorectal Dis. 1997; 12 (1): 19–23.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Hotker A.M., Tarlinton L., Mazaheri Y., Woo K.M., Gonen M., Saltz L.B., Goodman K.A., Garcia-Aguilar J., Gollub M.J. Multiparametric MRI in the assessment of response of rectal cancer to neoadjuvant chemo radiotherapy: A comparison of morphological, volumetric and functional MRI parameters. Eur. Radiol. 2016; 26 (12): 4303–4312. http://doi.org/10.1007/s00330-016-4283-9.</mixed-citation><mixed-citation xml:lang="en">Camma C., Giunta M., Fiorica F., Pagliaro L., Craxi A., Cottone M. Preoperative radiotherapy for resectable rectal cancer – a meta-analysis. J. Am. Med. Ass. 2000; 284 (8): 1008–1015.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Dworak O., Keilholz L., Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int. J. Colorectal Dis. 1997; 12 (1): 19–23.</mixed-citation><mixed-citation xml:lang="en">Bhangu A., Ali S.M., Cunningham D., Brown G., Tekkis P. Comparison of long-term survival outcome of operative vs nonoperative management of recurrent rectal cancer. Colorectal Dis. 2013; 15 (2): 156–163. http://doi.org/10.1111/j.1463-1318.2012.03123.x.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Camma C., Giunta M., Fiorica F., Pagliaro L., Craxi A., Cottone M. Preoperative radiotherapy for resectable rectal cancer – a meta-analysis. J. Am. Med. Ass. 2000; 284 (8): 1008–1015.</mixed-citation><mixed-citation xml:lang="en">Tyuryaeva E.I. Chemoradiotherapy for rectal cancer. Practical oncology. 2008; 9 (1): 31–38. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Bhangu A., Ali S.M., Cunningham D., Brown G., Tekkis P. Comparison of long-term survival outcome of operative vs nonoperative management of recurrent rectal cancer. Colorectal Dis. 2013; 15 (2): 156–163. http://doi.org/10.1111/j.1463-1318.2012.03123.x.</mixed-citation><mixed-citation xml:lang="en">Keam S.J., Dunn C.J., Figgitt D.P. Oxaliplatin – in operable colorectal cancer. Drugs. 2005; 65 (1): 89–96. http://doi.org/10.2165/00003495-200565010-00005.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Тюряева Е.И. Химиолучевое лечение рака прямой кишки. Практическая онкология. 2008; 9 (1): 31–38.</mixed-citation><mixed-citation xml:lang="en">Hoetker A.M., Garcia-Aguilar J., Gollub M.J. Multiparametric MRI of rectal cancer in the assessment of response to therapy: a systematic review. Dis. Colon Rectum. 2014; 57 (6): 790–799. http://doi.org/10.1097/DCR.0000000000000127.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Keam S.J., Dunn C.J., Figgitt D.P. Oxaliplatin – in operable colorectal cancer. Drugs. 2005; 65 (1): 89–96. http://doi.org/10.2165/00003495-200565010-00005.</mixed-citation><mixed-citation xml:lang="en">Evans J., Tait D., Swift I., Pennert K., Tekkis P., Wotherspoon A., Chau I., Cunningham D., Brown G. Timing of surgery following preoperative therapy in rectal cancer: the need for a prospective randomized trial? Dis. Colon Rectum. 2011; 54 (10): 1251–1259. http://doi.org/10.1097/DCR.0b013e3182281f4b.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Hoetker A.M., Garcia-Aguilar J., Gollub M.J. Multiparametric MRI of rectal cancer in the assessment of response to therapy: a systematic review. Dis. Colon Rectum. 2014; 57 (6): 790–799. http://doi.org/10.1097/DCR.0000000000000127.</mixed-citation><mixed-citation xml:lang="en">Patel U.B., Brown G., Rutten H., West N., SebagMontefiore D., Glynne-Jones R., Rullier E., Peeters M., Van Cutsem E., Ricci S., Van de Velde C., Kjell P., Quirke P. Comparison of magnetic resonance imaging and histopathological response to chemoradiotherapy in locally advanced rectal cancer. Ann. Surg. Oncol. 2012; 19 (9): 2842–2852. http://doi.org/10.1245/s10434-012-2309-3.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Evans J., Tait D., Swift I., Pennert K., Tekkis P., Wotherspoon A., Chau I., Cunningham D., Brown G. Timing of surgery following preoperative therapy in rectal cancer: the need for a prospective randomized trial? Dis. Colon Rectum. 2011; 54 (10): 1251–1259. http://doi.org/10.1097/DCR.0b013e3182281f4b.</mixed-citation><mixed-citation xml:lang="en">Patel U.B., Brown G. MRI-based assessment of tumor regression in rectal cancer. Curr. Colorectal Cancer Rep. 2013; 9 (2): 136–145. http://doi.org/10.1007/s11888-013-0169-2.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Patel U.B., Brown G., Rutten H., West N., SebagMontefiore D., Glynne-Jones R., Rullier E., Peeters M., Van Cutsem E., Ricci S., Van de Velde C., Kjell P., Quirke P. Comparison of magnetic resonance imaging and histopathological response to chemoradiotherapy in locally advanced rectal cancer. Ann. Surg. Oncol. 2012; 19 (9): 2842–2852. http://doi.org/10.1245/s10434-012-2309-3.</mixed-citation><mixed-citation xml:lang="en">Sassen S., de Booij M., Sosef M., Berendsen R., Lammering G., Clarijs R., Bakker M., Beets-Tan R., Warmerdam F., Vliegen R. Locally advanced rectal cancer: is diffusion weighted MRI helpful for the identification of complete responders (ypT0N0) after neoadjuvant chemoradiation therapy? Eur. Radiol. 2013; 23 (12): 3440–3449. http://doi.org/10.1007/s00330-013-2956-1.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Patel U.B., Brown G. MRI-based assessment of tumor regression in rectal cancer. Curr. Colorectal Cancer Rep. 2013; 9 (2): 136–145. http://doi.org/10.1007/s11888-013-0169-2.</mixed-citation><mixed-citation xml:lang="en">Park M.J., Kim S.H., Lee S.J., Jang K.M., Rhim H. Locally advanced rectal cancer: added value of diffusion-weighted MR imaging for predicting tumor clearance of the mesorectal fascia after neoadjuvant chemotherapy and radiation therapy. Radiology. 2011; 260 (3): 771–780. http://doi.org/10.1148/radiol.11102135.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Sassen S., de Booij M., Sosef M., Berendsen R., Lammering G., Clarijs R., Bakker M., Beets-Tan R., Warmerdam F., Vliegen R. Locally advanced rectal cancer: is diffusion weighted MRI helpful for the identification of complete responders (ypT0N0) after neoadjuvant chemoradiation therapy? Eur. Radiol. 2013; 23 (12): 3440–3449. http://doi.org/10.1007/s00330-013-2956-1.</mixed-citation><mixed-citation xml:lang="en">Boone D., Taylor S.A., Halligan S. Diffusion weighted MRI: overview and implications for rectal cancer management. Colorectal Dis. 2013; 15 (6): 655–661. http://doi.org/10.1111/codi.12241.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Park M.J., Kim S.H., Lee S.J., Jang K.M., Rhim H. Locally advanced rectal cancer: added value of diffusion-weighted MR imaging for predicting tumor clearance of the mesorectal fascia after neoadjuvant chemotherapy and radiation therapy. Radiology. 2011; 260 (3): 771–780. http://doi.org/10.1148/radiol.11102135.</mixed-citation><mixed-citation xml:lang="en">Heijnen L.A., Lambregts D.M.J., Mondal D., Martens M.H., Riedl R.G., Beets G.L., Beets-Tan R.G.H. Diffusionweighted MR imaging in primary rectal cancer staging demonstrates but does not characterise lymph nodes. Eur. Radiol. 2013; 23 (12): 3354–3360. http://doi.org/10.1007/s00330-013-2952-5.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Boone D., Taylor S.A., Halligan S. Diffusion weighted MRI: overview and implications for rectal cancer management. Colorectal Dis. 2013; 15 (6): 655–661. http://doi.org/10.1111/codi.12241.</mixed-citation><mixed-citation xml:lang="en">Alberda W.J., Dassen H.P.N., Dwarkasing R.S., Willemssen F.E.J.A., van der Pool A.E.M., de Wilt J.H.W., Burger J.W. A., Verhoef C. Prediction of tumor stage and lymph node involvement with dynamic contrastenhanced MRI after chemoradiotherapy for locally advanced rectal cancer. Int. J. Colorectal Dis. 2013; 28 (4): 573–580. http://doi.org/10.1007/s00384-012-1576-6.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Heijnen L.A., Lambregts D.M.J., Mondal D., Martens M.H., Riedl R.G., Beets G.L., Beets-Tan R.G.H. Diffusionweighted MR imaging in primary rectal cancer staging demonstrates but does not characterise lymph nodes. Eur. Radiol. 2013; 23 (12): 3354–3360. http://doi.org/10.1007/s00330-013-2952-5.</mixed-citation><mixed-citation xml:lang="en">Hylton N. Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. J. Clin. Oncol. 2006; 24 (20): 3293–3298. http://doi.org/10.1200/JCO.2006.06.8080.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Alberda W.J., Dassen H.P.N., Dwarkasing R.S., Willemssen F.E.J.A., van der Pool A.E.M., de Wilt J.H.W., Burger J.W. A., Verhoef C. Prediction of tumor stage and lymph node involvement with dynamic contrastenhanced MRI after chemoradiotherapy for locally advanced rectal cancer. Int. J. Colorectal Dis. 2013; 28 (4): 573–580. http://doi.org/10.1007/s00384-012-1576-6.</mixed-citation><mixed-citation xml:lang="en">Fusco R., Sansone M., Petrillo M., Avallone A., Delrio P., Petrillo A. Dynamic Contrast Enhanced Magnetic Resonance Imaging in Rectal Cancer. Rectal Cancer-A Multidisciplinary Approach to Management / Giulio D., Santoro A. InTech. 2011; 75–98.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Hylton N. Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. J. Clin. Oncol. 2006; 24 (20): 3293–3298. http://doi.org/10.1200/JCO.2006.06.8080.</mixed-citation><mixed-citation xml:lang="en">Arya S., Das D., Engineer R., Saklani A. Imaging in rectal cancer with emphasis on local staging with MRI. Indian J. Radiol. Imaging. 2015; 25 (2): 148–161. http://doi.org/10.4103/0971-3026.155865.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Fusco R., Sansone M., Petrillo M., Avallone A., Delrio P., Petrillo A. Dynamic Contrast Enhanced Magnetic Resonance Imaging in Rectal Cancer. Rectal Cancer-A Multidisciplinary Approach to Management / Giulio D., Santoro A. InTech. 2011; 75–98.</mixed-citation><mixed-citation xml:lang="en">Fusco R., Sansone M., Petrillo M., Avallone A., Delrio P., Petrillo A. Dynamic Contrast Enhanced Magnetic Resonance Imaging in Rectal Cancer. Rectal Cancer-A Multidisciplinary Approach to Management / Giulio D., Santoro A. InTech. 2011; 75–98.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Arya S., Das D., Engineer R., Saklani A. Imaging in rectal cancer with emphasis on local staging with MRI. Indian J. Radiol. Imaging. 2015; 25 (2): 148–161. http://doi.org/10.4103/0971-3026.155865.</mixed-citation><mixed-citation xml:lang="en">Arya S., Das D., Engineer R., Saklani A. Imaging in rectal cancer with emphasis on local staging with MRI. Indian J. Radiol. Imaging. 2015; 25 (2): 148–161. http://doi.org/10.4103/0971-3026.155865.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
