medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-2018-2-84-93medvis-550Research ArticleБРЮШНАЯ ПОЛОСТЬABDOMENМАЛИГНИЗИРОВАННАЯ ГЕПАТОЦЕЛЛЮЛЯРНАЯ АДЕНОМА У МУЖЧИНЫHEPATOCELLULAR ADENOMA WITH MALIGNANT TRANSFORMATION IN MALE PATIENTЛомовцеваК. Х.LomovtsevaK. Kh.

Ломовцева Карина Хусаиновна – аспирант кафедры лучевой диагностики Института профессионального образования.

Москва. 

Karina Kh. Lomovtseva – resident of Radiology Department. 

Moscow.

lomovtsevakarina@gmail.comГальчинаЮ. С.Gal’chinaYu. S.

Гальчина Юлия Сергеевна – аспирант отделения рентгенологии и магнитно-резонансных исследований. 

Москва. 

Yulia S. Galchina – resident of radiology department. 

Moscow.

ГлотовА. В.GlotovA. V.

Глотов Андрей Вячеславович – врач-патологоанатом патологоанатомического отделения. 

Москва. 

Andrey V. Glotov – pathologist of Pathology department.

Moscow.

КалининД. В.KalininD. V.

Калинин Дмитрий Валерьевич – канд. мед. наук, руководитель патологоанатомического отделения. 

Москва. 

Dmitriy V. Kalinin – cand. of med. sci., chief of Pathology department. 

Moscow.

ЧжаоА. В.ChzhaoA. V.

Чжао Алексей Владимирович – доктор мед. наук, профессор, заместитель директора по научной и клинической работе. 

Москва. 

Alexey V. Chzhao – doct. of med. sci., professor, deputy director for scientific and clinical work. 

Moscow.

КоваленкоА. Ю.KovalenkoYu. A.

Коваленко Юрий Алексеевич – канд. мед. наук, старший научный сотрудник отделения хирургии печени, желчных протоков и поджелудочной железы.

Москва. 

Yury A. Kovalenko – cand. of med. sci., senior research of Department of liver, bile ducts and pancreas surgery. 

Moscow.

КармазановскийГ. Г.KarmazanovskyG. G.

Кармазановский Григорий Григорьевич – член-корр. РАН, доктор мед. наук, профессор, заведующий отделением лучевой диагностики; профессор кафедры лучевой диагностики. 

 Москва. 

Grigory G. Karmazanovsky – corresponding member of RAS, doct. of med. sci., professor, chief of the Radiology Department;   professor of Department of Radiology in Institute of professional education. 

Moscow.

ФГАОУ ВО Первый МГМУ им. И.М.Сеченова Минздрава России (Сеченовский Университет).РоссияI.M. Sechenov 1st MSMU (Sechenov University).Russian FederationФГБУ “Институт хирургии им. А.В.Вишневского” Минздрава России.РоссияA.V. Vishnevsky Institute of Surgery.Russian FederationФГАОУ ВО Первый МГМУ им. И.М.Сеченова Минздрава России (Сеченовский Университет); ФГБУ “Институт хирургии им. А.В.Вишневского” Минздрава России.РоссияI.M. Sechenov 1st MSMU (Sechenov University); A.V. Vishnevsky Institute of Surgery.Russian Federation201828042018028493Copyright © Ломовцева К.Х., Гальчина Ю.С., Глотов А.В., Калинин Д.В., Чжао А.В., Коваленко А.Ю., Кармазановский Г.Г., 20182018Ломовцева К.Х., Гальчина Ю.С., Глотов А.В., Калинин Д.В., Чжао А.В., Коваленко А.Ю., Кармазановский Г.Г.Lomovtseva K.K., Gal’china Y.S., Glotov A.V., Kalinin D.V., Chzhao A.V., Kovalenko Y.A., Karmazanovsky G.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/550

Гепатоцеллюлярная аденома (ГЦА) – редкая первичная доброкачественная опухоль печени, которая наиболее часто встречается у женщин на фоне приема оральных контрацептивов. У мужчин ГЦА развивается редко и обычно ассоциирована с приемом анаболических стероидов, гликогенозом I, III типов. Описаны случаи развития ГЦА, индуцированные приемом противоэпилептических препаратов. Одним из осложнений ГЦА является озлокачествление опухоли, которое в 10 раз чаще встречается у мужчин, чем у женщин. В представленном наблюдении у пациента 23 лет, длительно принимавшего противоэпилептические препараты, было выявлено образование III сегмента печени. По данным магнитнорезонансной томографии с гепатобилиарным контрастным препаратом был заподозрен гепатоцеллюлярный рак (ГЦР), не исключалась аденома печени. Пациенту была выполнена резекция III сегмента печени. При гистологическом и иммуногистохимическом исследованиях опухоль была представлена β-катенин активированной ГЦА с трансформацией в пределах опухоли в очаг высокодифференцированного ГЦР. В статье представлены клиническое наблюдение и краткий обзор литературы по данной теме.

Hepatocellular adenoma (HCA) is a rare primary benign tumor of the liver that generally occurs in women taking oral contraceptives. HCA in men is rare, and it is usually associated with anabolic steroid intake, glycogen storage disease I, III. There are some instances where HCA is induced by antiepileptic drugs. Malignant transformation is one of the complications of HCA, and it is 10 times more often in men than in women. We present a case, where a man, 23 years old, was taking antiepileptic drugs for a long time. The lesion in third liver segment was revealed under routine examination. MRI with hepatobiliary contrast agent was performed. Hepatocellular cancer (HCC) was suspected, however HCA was not excluded. The patient underwent resection of third liver segment. Histological and immunohistochemical examinations revealed that the tumor was β-catenin activated HCA with focus of well differentiated HCC. The article describes the clinical case and provides a brief literature review on this subject.

гепатоцеллюлярная аденомамалигнизациямагнитно-резонансная томографиягепатобилиарный контрастный препаратhepatocellular adenomamalignant transformationmagnetic resonance imaginghepatobiliary contrast agentReferencesСурков А.Н., Намазова-Баранова Л.С., Потапов А.С., Савостьянов К.В., Пушков А.А., Никитин А.Г., Полякова С.И., Рязанов М.В., Кустова О.В., Барский В.И., Степанян М.Ю. Случай множественных аденом печени у подростка с тяжелым течением гликогеновой болезни типа Ib. Вестник РАМН. 2014; 11–12: 54–59.Surkov А.N., Namazova-Baranova L.S., Potapov А.S., Savost’yanov К.V., Pushkov А.А., Nikitin А.G., Polyakova S.I., Ryazanov M.V., Kustova О.V., Barskii V.I., Stepanyan М.Yu. History сase of multiple hepatic adenomas in adolescent with severe course of glycogen storage disease type 1b. Annals of the Russian Academy of Medical Sciences. 2014; 11–12: 54–59. (In Russian)Vijay A., Elaffandi A., Khalaf H. Hepatocellular adenoma: An update. Wld J. Hepatol. 2015; 7 (25): 2603.Vijay A., Elaffandi A., Khalaf H. Hepatocellular adenoma: An update. Wld J. Hepatol. 2015; 7 (25): 2603.Mamada Y., Onda M., Tajiri T., Akimaru K., Yoshida H., Taniai N., Mineta S., Hirakata A., Hirose Y. Liver cell adenoma in a 26-year-old man. J. Nippon Med. School. 2001; 68 (6): 516–519.Mamada Y., Onda M., Tajiri T., Akimaru K., Yoshida H., Taniai N., Mineta S., Hirakata A., Hirose Y. Liver cell adenoma in a 26-year-old man. J. Nippon Med. School. 2001; 68 (6): 516–519.Herman P., Pugliese V., Machado M. A., Montagnini A. L., Salem M. Z., Bacchella T., D’Albuquerque L. A., Saad W.A., Machado M. C., Pinotti H. W. Hepatic adenoma and focal nodular hyperplasia: differential diagnosis and treatment. Wld J. Surg. 2000; 24 (3): 372–376.Herman P., Pugliese V., Machado M. A., Montagnini A. L., Salem M. Z., Bacchella T., D’Albuquerque L. A., Saad W. A., Machado M. C., Pinotti H. W. Hepatic adenoma and focal nodular hyperplasia: differential diagnosis and treatment. Wld J. Surg. 2000; 24 (3): 372–376.Toso C., Majno P., Andres A., Rubbia-Brandt L., Berney T., Buhler L., Morel P., Mentha G. Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors. Wld J. Gastroenterol. 2005; 11 (36): 56–91.Toso C., Majno P., Andres A., Rubbia-Brandt L., Berney T., Buhler L., Morel P., Mentha G. Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors. Wld J. Gastroenterol. 2005; 11 (36): 56–91.Dokmak S., Paradis V., Vilgrain V., Sauvanet A., Farges O., Valla D., Bedossa P., Belghiti J. A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas. Gastroenterology. 2009; 137 (5): 1698–1705. DOI: 10.1053/j.gastro.2009.07.061.Dokmak S., Paradis V., Vilgrain V., Sauvanet A., Farges O., Valla D., Bedossa P., Belghiti J. A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas. Gastroenterology. 2009; 137 (5): 1698–1705. DOI: 10.1053/j.gastro.2009.07.061.Stoot J.H., Coelen R.J., De Jong M.C., Dejong C.H. Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases. HPB. 2010; 12 (8): 509–522. DOI: 10.1111/j.1477-2574.2010.00222.x.Stoot J.H., Coelen R.J., De Jong M.C., Dejong C.H. Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases. HPB. 2010; 12 (8): 509–522. DOI: 10.1111/j.1477-2574.2010.00222.x.Farges O., Ferreira N., Dokmak S., Belghiti J., Bedossa P., Paradis V. Changing trends in malignant transformation of hepatocellular adenoma. Gut. 2011; 60 (1): 85–89. DOI: 10.1136/gut.2010.222109.Farges O., Ferreira N., Dokmak S., Belghiti J., Bedossa P., Paradis V. Changing trends in malignant transformation of hepatocellular adenoma. Gut. 2011; 60 (1): 85–89. DOI: 10.1136/gut.2010.222109.Zucman Rossi J., Jeannot E., Van Nhieu J. T., Scoazec J. Y., Guettier C., Rebouissou S., Bacq Y., Leteurtre E., Paradis V., Michalak S., Wendum D., Chiche L., Fabre M., Mellottee L., Laurent C., Partensky C., Castaing D., Zafrani E.S., Laurent-Puig P., Balabaud C., Bioulac-Sage P. Genotype–phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology. 2006; 43 (3): 515–524. DOI: 10.1002/hep.21068.Zucman Rossi J., Jeannot E., Van Nhieu J. T., Scoazec J. Y., Guettier C., Rebouissou S., Bacq Y., Leteurtre E., Paradis V., Michalak S., Wendum D., Chiche L., Fabre M., Mellottee L., Laurent C., Partensky C., Castaing D., Zafrani E.S., Laurent-Puig P., Balabaud C., Bioulac-Sage P. Genotype–phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology. 2006; 43 (3): 515–524. DOI: 10.1002/hep.21068.Lade A.G., Monga S.P. Beta-catenin signaling in hepatic development and progenitors: Which way does the WNT blow? Developmental Dynamics. 2011; 240 (3): 486–500. DOI: 10.1002/dvdy.22522.Lade A.G., Monga S.P. Beta-catenin signaling in hepatic development and progenitors: Which way does the WNT blow? Developmental Dynamics. 2011; 240 (3): 486–500. DOI: 10.1002/dvdy.22522.Bioulac-Sage P., Balabaud C., Zucman-Rossi J. Subtype classification of hepatocellular adenoma. Digest. Surg. 2010; 27 (1): 39–45. DOI: 10.1159/000268406.Bioulac-Sage P., Balabaud C., Zucman-Rossi J. Subtype classification of hepatocellular adenoma. Digest. Surg. 2010; 27 (1): 39–45. DOI: 10.1159/000268406.Toiyama Y., Inoue Y., Yasuda H., Yoshiyama S., Araki T., Miki C., Kusunoki M. Hepatocellular adenoma containing hepatocellular carcinoma in a male patient with familial adenomatous polyposis coli: Report of a case. Surg. Today. 2011; 41 (10): 1442. DOI: 10.1007/s00595-010-4451-5.Toiyama Y., Inoue Y., Yasuda H., Yoshiyama S., Araki T., Miki C., Kusunoki M. Hepatocellular adenoma containing hepatocellular carcinoma in a male patient with familial adenomatous polyposis coli: Report of a case. Surg. Today. 2011; 41 (10): 1442. DOI: 10.1007/s00595-010-4451-5.Nault J.C., Bioulac-Sage P., Zucman-Rossi J. Hepatocellular benign tumors – from molecular classification to personalized clinical care. Gastroenterology. 2013; 144 (5): 888–902. DOI: 10.1053/j.gastro.2013.02.032.Nault J.C., Bioulac-Sage P., Zucman-Rossi J. Hepatocellular benign tumors – from molecular classification to personalized clinical care. Gastroenterology. 2013; 144 (5): 888–902. DOI: 10.1053/j.gastro.2013.02.032.Bioulac Sage P., Laumonier H., Couchy G., Le Bail B., Sa Cunha A., Rullier A., Laurent C., Blanc J.F., Cubel G., Trillaud H., Zucman Rossi J., Balabaud C., Saric J. Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology. 2009; 50 (2): 481–489. DOI: 10.1002/hep.22995.Bioulac Sage P., Laumonier H., Couchy G., Le Bail B., Sa Cunha A., Rullier A., Laurent C., Blanc J.F., Cubel G., Trillaud H., Zucman Rossi J., Balabaud C., Saric J. Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology. 2009; 50 (2): 481–489. DOI: 10.1002/hep.22995.Bioulac-Sage P., Sempoux C., Balabaud C. Hepatocellular adenoma: classification, variants and clinical relevance. Seminars in Diagn. Pathol. 2017; 34 (20): 112–125. DOI: 10.1053/j.semdp.2016.12.007.Bioulac-Sage P., Sempoux C., Balabaud C. Hepatocellular adenoma: classification, variants and clinical relevance. Seminars in Diagn. Pathol. 2017; 34 (20): 112–125. DOI: 10.1053/j.semdp.2016.12.007.Ronald M., Woodfield J., McCall J., Koea J. Hepatic adenomas in male patients. HPB. 2004; 6 (1): 25–27. DOI: 10.1080/13651820310020846.Ronald M., Woodfield J., McCall J., Koea J. Hepatic adenomas in male patients. HPB. 2004; 6 (1): 25–27. DOI: 10.1080/13651820310020846.Vázquez J.J., Marigil M.A. Liver-cell adenoma in an epileptic man on barbiturates. Histol. Histopathol. 1989; 4 (3): 301–303.Vázquez J.J., Marigil M.A. Liver-cell adenoma in an epileptic man on barbiturates. Histol. Histopathol. 1989; 4 (3): 301–303.Tazawa K., Yasuda M., Ohtani Y., Makuuchi H., Osamura R.Y. Multiple hepatocellular adenomas associated with long-term carbamazepine. Histopathology. 1999; 35 (1): 92–94. DOI: 10.1046/j.1365-2559.1999.0728g.x.Tazawa K., Yasuda M., Ohtani Y., Makuuchi H., Osamura R.Y. Multiple hepatocellular adenomas associated with long-term carbamazepine. Histopathology. 1999; 35 (1): 92–94. DOI: 10.1046/j.1365-2559.1999.0728g.x.Ferko A., Bedrna J., Nozicka J. Pigmented hepatoc ellular adenoma of the liver caused by long-term use of phenobarbital. Rozhl chir. 2003; 82 (4): 192–195.Ferko A., Bedrna J., Nozicka J. Pigmented hepatoc ellular adenoma of the liver caused by long-term use of phenobarbital. Rozhl chir. 2003; 82 (4): 192–195.Seki A., Inoue T., Maegaki Y., Sugiura C., Toyoshima M., Akaboshi S., Ohno K. Polycystic ovary syndrome and hepatocellular adenoma related to long-term use of sodium valproate in a young woman. No to hattatsu. 2006; 38 (3): 205–208.Seki A., Inoue T., Maegaki Y., Sugiura C., Toyoshima M., Akaboshi S., Ohno K. Polycystic ovary syndrome and hepatocellular adenoma related to long-term use of sodium valproate in a young woman. No to hattatsu. 2006; 38 (3): 205–208.Lautz T.B., Finegold M.J., Chin A.C., Superina R.A. Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy. J. Pediatr. Surg. 2008; 43 (4): 751–754. DOI: 10.1016/j.jpedsurg.2007.11.036.Lautz T.B., Finegold M.J., Chin A.C., Superina R.A. Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy. J. Pediatr. Surg. 2008; 43 (4): 751–754. DOI: 10.1016/j.jpedsurg.2007.11.036.Lee P.U., Roberts L.R., Kaiya J.K., Lee C.U. Hepatic adenomas associated with anti-epileptic drugs: a case series and imaging review. Abdom. Imaging. 2010; 35 (2): 208–211.Lee P.U., Roberts L.R., Kaiya J.K., Lee C.U. Hepatic adenomas associated with anti-epileptic drugs: a case series and imaging review. Abdom. Imaging. 2010; 35 (2): 208–211.Bioulac-Sage P., Sempoux C., Possenti L., Frulio N., Laumonier H., Laurent C., Chiche L., Blanc J. F., Saric J., Trillaud H., Le Bail B., Balabaud C. Pathological diagnosis of hepatocellular cellular adenoma according to the clinical context. Int. J. Hepatol. 2013; 2013: 253261. DOI: 10.1155/2013/253261.Bioulac-Sage P., Sempoux C., Possenti L., Frulio N., Laumonier H., Laurent C., Chiche L., Blanc J. F., Saric J., Trillaud H., Le Bail B., Balabaud C. Pathological diagnosis of hepatocellular cellular adenoma according to the clinical context. Int. J. Hepatol. 2013; 2013: 253261. DOI: 10.1155/2013/253261.Davis M., Portmann B., Searle M., Wright R., Williams R. Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives. Br. Med J. 1975; 4 (5995): 496–498.Davis M., Portmann B., Searle M., Wright R., Williams R. Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives. Br. Med J. 1975; 4 (5995): 496–498.Deneve J. L., Pawlik T. M., Cunningham S., Clary B., Reddy S., Scoggins C. R., Martin C.G. Angelica M., Staley C.A., Choti M.A., Jarnagin, W. R., Schulick R.D. Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy. Ann. Surg. Oncol. 2009; 16 (3): 640–648. DOI: 10.1245/s10434-008-0275-6.Deneve J. L., Pawlik T. M., Cunningham S., Clary B., Reddy S., Scoggins C. R., Martin C.G. Angelica M., Staley C.A., Choti M.A., Jarnagin, W. R., Schulick R.D. Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy. Ann. Surg. Oncol. 2009; 16 (3): 640–648. DOI: 10.1245/s10434-008-0275-6.Farges O., Dokmak S. Malignant transformation of liver adenoma: an analysis of the literature. Digest. Surg. 2010; 27 (1): 32–38. DOI: 10.1159/000268405.Farges O., Dokmak S. Malignant transformation of liver adenoma: an analysis of the literature. Digest. Surg. 2010; 27 (1): 32–38. DOI: 10.1159/000268405.An S. L., Wang L. M., Rong W. Q., Wu F., Sun W., Yu, W. B., Feng L., Liu F.Q., Tian F., Wu J. X. Hepatocellular adenoma with malignant transformation in male patients with non-cirrhotic livers. Chinese J. Cancer. 2015; 34 (3): 17. DOI: 10.1186/s40880-015-0014-x.An S. L., Wang L. M., Rong W. Q., Wu F., Sun W., Yu, W. B., Feng L., Liu F.Q., Tian F., Wu J. X. Hepatocellular adenoma with malignant transformation in male patients with non-cirrhotic livers. Chinese J. Cancer. 2015; 34 (3): 17. DOI: 10.1186/s40880-015-0014-x.Micchelli S.T., Vivekanandan P., Boitnott J.K., Pawlik T.M., Choti M.A., Torbenson M. Malignant transformation of hepatic adenomas. Modern Pathol. 2008; 21 (4): 491. DOI: 10.1038/modpathol.2008.8.Micchelli S.T., Vivekanandan P., Boitnott J.K., Pawlik T.M., Choti M.A., Torbenson M. Malignant transformation of hepatic adenomas. Modern Pathol. 2008; 21 (4): 491. DOI: 10.1038/modpathol.2008.8.Laumonier H., Bioulac-Sage P., Laurent C., ZucmanRossi J., Balabaud C., Trillaud H. Hepatocellular aden omas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology. 2008; 48 (3): 808–818. DOI: 10.1002/hep.22417.Laumonier H., Bioulac-Sage P., Laurent C., ZucmanRossi J., Balabaud C., Trillaud H. Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology. 2008; 48 (3): 808–818. DOI: 10.1002/hep.22417.van Aalten S.M., Thomeer M.G., Terkivatan T., Dwarkasing R.S., Verheij J., de Man R., Ijzermans J.N. Hepatocellular adenomas: correlation of MR imaging findings with pathologic subtype classification. Radiology. 2011; 261 (1): 172–181. DOI: 10.1148/radiol.11110023.van Aalten S.M., Thomeer M.G., Terkivatan T., Dwarkasing R.S., Verheij J., de Man R., Ijzermans J.N. Hepatocellular adenomas: correlation of MR imaging findings with pathologic subtype classification. Radiology. 2011; 261 (1): 172–181. DOI: 10.1148/radiol.11110023.Ronot M., Bahrami S., Calderaro J., Valla D.C., Bedossa P., Belghti J., Vilgrain V., Paradis, V. Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification. Hepatology. 2011; 53 (4): 1182–1191. DOI: 10.1002/hep.24147.Ronot M., Bahrami S., Calderaro J., Valla D.C., Bedossa P., Belghti J., Vilgrain V., Paradis, V. Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification. Hepatology. 2011; 53 (4): 1182–1191. DOI: 10.1002/hep.24147.Лукьянченко А.Б., Медведева Б.М. Современные возможности лучевой диагностики гепатоцеллюлярных аденом (обзор литературы и собственные наблюдения). Медицинская визуализация. 2013; (1): 33–43.Lukianchenko A.B., Medvedeva B.M. The current approaches to the diagnosis of hepatocellular adenomas (Literature review аnd clinical cases). Medical Visualization. 2013; (1): 33–43. (In Russian)Yoneda N., Matsui O., Kitao A., Kozaka K., Kobayashi S., Sasaki M. Yoshida K., Inoue D., Minami T., Gabata, T. Benign Hepatocellular Nodules: Hepatobiliary Phase of Gadoxetic Acid-enhanced MR Imaging Based on Molecular Background. Radiographics. 2016; 36 (7): 2010–2027. DOI: 10.1148/rg.2016160037.Yoneda N., Matsui O., Kitao A., Kozaka K., Kobayashi S., Sasaki M. Yoshida K., Inoue D., Minami T., Gabata, T. Benign Hepatocellular Nodules: Hepatobiliary Phase of Gadoxetic Acid-enhanced MR Imaging Based on Molecular Background. Radiographics. 2016; 36 (7): 2010–2027. DOI: 10.1148/rg.2016160037.Agarwal S., Fuentes-Orrego J. M., Arnason T., Misdraji J., Jhaveri K.S., Harisinghani M., Hahn P. F. Inflammatory hepatocellular adenomas can mimic focal nodular hyperplasia on gadoxetic acid–enhanced MRI. Am. J. Roentgenol. 2014; 203 (4): 408–414. DOI: 10.2214/AJR.13.12251.Agarwal S., Fuentes-Orrego J. M., Arnason T., Misdraji J., Jhaveri K.S., Harisinghani M., Hahn P. F. Inflammatory hepatocellular adenomas can mimic focal nodular hyperplasia on gadoxetic acid–enhanced MRI. Am. J. Roentgenol. 2014; 203 (4): 408–414. DOI: 10.2214/AJR.13.12251.Fukusato T., Soejima Y., Kondo F., Inoue M., Watanabe M., Takahashi Y., Aso T., Uozaki H., Sano K., Sanada Y., Niki T. Preserved or enhanced OATP1B3 expression in hepatocellular adenoma subtypes with nuclear accumulation of β-catenin. Hepatol. Res. 2015; 45 (10). DOI: 10.1111/hepr.12453.Fukusato T., Soejima Y., Kondo F., Inoue M., Watanabe M., Takahashi Y., Aso T., Uozaki H., Sano K., Sanada Y., Niki T. Preserved or enhanced OATP1B3 expression in hepatocellular adenoma subtypes with nuclear accumulation of β-catenin. Hepatol. Res. 2015; 45 (10). DOI: 10.1111/hepr.12453.Kwok W.Y., Hagiwara S., Nishida N., Watanabe T., Sakurai T., Ida H., Minami Y.,Takita M., Minami T., Iwanishi M., Chishina H., Kono M., Ueshima K., Komeda Y., Arizumi T., Enoki E., Nakai T., Kumabe T., Nakashima O., Kondo F., Kudo M. Malignant transformation of hepatocellular adenoma. Oncology. 2017; 92(1): 16–28. DOI: 10.1159/000451012.Kwok W.Y., Hagiwara S., Nishida N., Watanabe T., Sakurai T., Ida H., Minami Y.,Takita M., Minami T., Iwanishi M., Chishina H., Kono M., Ueshima K., Komeda Y., Arizumi T., Enoki E., Nakai T., Kumabe T., Nakashima O., Kondo F., Kudo M. Malignant transformation of hepatocellular adenoma. Oncology. 2017; 92(1): 16–28. DOI: 10.1159/000451012.Agnello F., Ronot M., Valla D.C., Sinkus R., Van Beers B.E., Vilgrain V. High-b-value diffusion-weighted MR imaging of benign hepatocellular lesions: quantitative and qualitative analysis. Radiology. 2012; 262 (2): 511–519. DOI: 10.1148/radiol.11110922.Agnello F., Ronot M., Valla D.C., Sinkus R., Van Beers B.E., Vilgrain V. High-b-value diffusion-weighted MR imaging of benign hepatocellular lesions: quantitative and qualitative analysis. Radiology. 2012; 262 (2): 511–519. DOI: 10.1148/radiol.11110922.Lee S.A., Lee .H., Jung W.Y., Lee ., Choi J.W., Kim K.A, Park C.M. Paradoxical high signal intensity of hepatocellular carcinoma in the hepatobiliary phase of Gd-EOBDTPA enhanced MRI: initial experience. Magn. Reson. Imaging. 2011; 29(1): 83–90. DOI: 10.1016/j.mri.2010.07.019.Lee S.A., Lee .H., Jung W.Y., Lee ., Choi J.W., Kim K.A, Park C.M. Paradoxical high signal intensity of hepatocellular carcinoma in the hepatobiliary phase of Gd-EOBDTPA enhanced MRI: initial experience. Magn. Reson. Imaging. 2011; 29(1): 83–90. DOI: 10.1016/j.mri.2010.07.019.Descottes B., Glineur D., Lachachi F., Valleix D., Paineau J., Hamy A., Morino M., Bismuth H., Castaing D., Savier E., Honore P., Detry O., Legrand M., Azagra J.S., Goergen M., Ceuterick M., Marescaux J., Mutter D., Hemptinne B., Troisi R., Weerts J., Dallemagne B., Jehaes C., Gelin M., Donckier V., Aerts R., Topal B., Bertrand C., Mansvelt B., Van Krunckelsven L., Herman D., Kint M., Totte E., Schockmel R., GigoT J.F. Laparoscopic liver resection of benign liver tumors. Surg. Endosc. Intervent. Techn. 2003; 17 (1): 23–30. DOI: 10.1007/s00464-002-9047-8.Descottes B., Glineur D., Lachachi F., Valleix D., Paineau J., Hamy A., Morino M., Bismuth H., Castaing D., Savier E., Honore P., Detry O., Legrand M., Azagra J.S., Goergen M., Ceuterick M., Marescaux J., Mutter D., Hemptinne B., Troisi R., Weerts J., Dallemagne B., Jehaes C., Gelin M., Donckier V., Aerts R., Topal B., Bertrand C., Mansvelt B., Van Krunckelsven L., Herman D., Kint M., Totte E., Schockmel R., GigoT J.F. Laparoscopic liver resection of benign liver tumors. Surg. Endosc. Intervent. Techn. 2003; 17 (1): 23–30. DOI: 10.1007/s00464-002-9047-8.Khanna M., Ramanathan S., Fasih N., Schieda N., Virmani V., McInnes M.D. Current updates on the molecular genetics and magnetic resonance imaging of focal nodular hyperplasia and hepatocellular adenoma. Insights into imaging. 2015; 6 (3): 347–362. DOI: 10.1007/s13244-015-0399-8.Khanna M., Ramanathan S., Fasih N., Schieda N., Virmani V., McInnes M.D. Current updates on the molecular genetics and magnetic resonance imaging of focal nodular hyperplasia and hepatocellular adenoma. Insights into imaging. 2015; 6 (3): 347–362. DOI: 10.1007/s13244-015-0399-8.

The authors declare that there are no conflicts of interest present.