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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-2018-2-18-24</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-538</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГОЛОВА И ШЕЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEAD AND NECK</subject></subj-group></article-categories><title-group><article-title>ПСЕВДОПРОГРЕССИЯ У БОЛЬНОГО С АНАПЛАСТИЧЕСКОЙ ЭПЕНДИМОМОЙ ПОСЛЕ ЛУЧЕВОЙ ТЕРАПИИ</article-title><trans-title-group xml:lang="en"><trans-title>PSEUDOPROGRESSION IN A PATIENT WITH ANAPLASTIC EPENDYMOMA AFTER RADIATION THERAPY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуднов</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nudnov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нуднов Николай Васильевич – доктор мед. наук, профессор, заместитель директора по научной работе ФГБУ “РНЦРР” Минздрава России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Nikolay V. Nudnov – doct. of med. sci., professor of FSBI “RSCRR” Ministry of healthcare of Russia.</p><p>Moscow.</p></bio><email xlink:type="simple">nudnov@rncrr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Желудкова</surname><given-names>О. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Zheludkova</surname><given-names>O. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Желудкова Ольга Григорьевна – доктор мед. наук, профессор, главный научный сотрудник лаборатории комплексных методов лечения онкологических заболеваний у детей ФГБУ “РНЦРР” Минздрава России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Olga G. Zheludkova – doct. of med. sci., professor of FSBI “RSCRR” Ministry of healthcare of Russia.</p><p>Moscow. </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мнацаканова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mnatsakanova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мнацаканова Ирина Владимировна – клинический ординатор по специальности “рентгенология” ФГБУ “РНЦРР” Минздрава России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Irina V. Mnatsakanova – a clinical resident on the specialty in radiology FSBI “RSCRR” Ministry of healthcare of Russia.</p><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидорова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidorova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сидорова Елена Владимировна – клинический ординатор по специальности “рентгенология” ФГБУ “РНЦРР” Минздрава России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Еlena V. Sidorova – a clinical resident on the specialty in radiology FSBI “RSCRR” Ministry of healthcare of Russia.</p><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Подоксенова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Podoksenova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Подоксенова Татьяна Валерьевна – клинический ординатор по специальности “онкология” ФГБУ “РНЦРР” Минздрава России.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Tatiana V. Podoksenova – a clinical resident on the specialty in oncology FSBI “RSCRR” Ministry of healthcare of Russia.</p><p>Moscow. </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шевцов</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Shevtsov</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шевцов Андрей Игоревич – врач-радиотерапевт, аспирант ФГБОУ ВПО “Российский университет дружбы народов” Министерства образования и науки России.</p><p>Москва</p></bio><bio xml:lang="en"><p>Andrey I. Shevtsov – doctor-radiation therapist, post-graduate student of the Russian Peoples Friendship University of the Ministry of Education and Science of Russia.</p><p>Moscow. </p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВПО “Российский университет дружбы народов” Министерства образования и науки России.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Peoples Friendship University of the Ministry of Education and Science of Russia.</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2018</year></pub-date><volume>0</volume><issue>2</issue><fpage>18</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нуднов Н.В., Желудкова О.Г., Мнацаканова И.В., Сидорова Е.В., Подоксенова Т.В., Шевцов А.И., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Нуднов Н.В., Желудкова О.Г., Мнацаканова И.В., Сидорова Е.В., Подоксенова Т.В., Шевцов А.И.</copyright-holder><copyright-holder xml:lang="en">Nudnov N.V., Zheludkova O.G., Mnatsakanova I.V., Sidorova E.V., Podoksenova T.V., Shevtsov A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/538">https://medvis.rdsmedia.ru/jour/article/view/538</self-uri><abstract><p>Эпендимома – опухоль головного мозга, развивающаяся из эпендимальных клеток, которые выстилают изнутри все желудочки мозга. Эпендимомы в 2 раза чаще появляются в области задней черепной ямки. Псевдопрогрессия – это изменения, которые развиваются после проведенного хирургического и/или химиолучевого лечения, обусловленные сосудистыми изменениями, ведущими к транзиторному увеличению проницаемости гематоэнцефалического барьера. Эти изменения совпадают с ранними отсроченными реакциями на лучевую терапию и рассматривается как подострая реакция мозга. При МРТ наблюдается преходящее появление очагов, накапливающих контраст в течение от нескольких недель до 6 мес и более после химиолучевой терапии. При динамическом контроле отмечается улучшение, что подтверждает отсутствие истинного роста опухоли. Изменения проходят без специфичного лечения. В статье представлено редкое клиническое наблюдение, которое показывает важность и эффективность динамического МР-контроля в дифференциальной диагностике.</p></abstract><trans-abstract xml:lang="en"><p>Ependymoma is a brain tumor that develops from ependemic cells that lining the inside of all the ventricles of the brain. Ependymomas are twice as likely to appear in the region of the posterior cranial fossa. Pseudoprogression is a change that develops after surgical and/or chemoradiotherapy, caused by vascular changes leading to a transient increase in the permeability of the BBB. These changes coincide with early delayed reactions to radiotherapy and are considered as a subacute reaction of the brain. On MRI, there is a transient occurrence of foci that accumulate contrast for several weeks to 6 months or more after chemoradiotherapy. Dynamic control shows an improvement, which confirms the absence of true tumor growth. Changes take place without specific treatment. In the article, we give a rare clinical observation that shows the importance and effectiveness of dynamic MRI monitoring in differential diagnosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>анапластическая эпендимома</kwd><kwd>псевдопрогресссия</kwd><kwd>гематоэнцефалический барьер</kwd><kwd>МРТ</kwd><kwd>постконтрастное усиление</kwd><kwd>ПЭТ</kwd><kwd>лучевая терапия</kwd><kwd>полихимиотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>anaplastic ependymoma</kwd><kwd>pseudoprogression</kwd><kwd>BBB</kwd><kwd>MRI</kwd><kwd>post-contrast enhancement</kwd><kwd>PET</kwd><kwd>radiotherapy</kwd><kwd>polychemotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hygino da Cruz L.C., Rodriguez I., Domingues R.C., Gasparetto E.L., Sorrensen A.G. Pseudoprogression and pseudoresponse: imaging challenges in the assessment of posttreatment glioma. Am. J. 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