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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-2018-1-47-51</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-506</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГРУДНАЯ КЛЕТКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>THORAX</subject></subj-group></article-categories><title-group><article-title>ДВУХЭНЕРГЕТИЧЕСКАЯ КТ С ИНЕРТНЫМ ГАЗОМ КСЕНОНОМ У ПАЦИЕНТОВ С ПАТОЛОГИЕЙ ЛЕГКИХ. ПЕРВЫЕ ДАННЫЕ</article-title><trans-title-group xml:lang="en"><trans-title>DUAL-ENERGY CT WITH XENON IN PATIENTS WITH LUNG PATHOLOGY. FIRST DATA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпов</surname><given-names>О. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpov</surname><given-names>O. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпов Олег Эдуардович – член-корр. РАН, доктор медицинских наук, профессор, генеральный директор.</p><p>Москва</p></bio><bio xml:lang="en"><p>Oleg E. Karpov – corresponding member of RAS, professor, doсt. of med. sci., Director.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бронов</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bronov</surname><given-names>O. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бронов Олег Юрьевич – кандидат медицинских наук, доцент, заведующий отделением рентгенологии.</p><p>105203 Москва, Нижняя Первомайская, д. 70, +7-499-464-42-54, +7-916-024-19-34</p></bio><bio xml:lang="en"><p>Oleg Yu. Bronov – cand. of med. sci., head of the radiology department.</p><p>105203 Nizhnyaya Pervomaiskaya, 70, Moscow, +7-499-464-42-54, +7-916-024-19-34</p></bio><email xlink:type="simple">bronovOU@pirogov-center.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Китаев</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kitaev</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Китаев Вячеслав Михайлович – доктор медицинских наук, профессор, главный специалист по лучевой диагностике.</p><p>Москва</p></bio><bio xml:lang="en"><p>Vyacheslav M. Kitaev – doсt. of med. sci., professor, Chief specialist in radiology.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ветшев</surname><given-names>П. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vetshev</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ветшев Петр Сергеевич – доктор медицинских наук, профессор, советник по клинической и научной работе.</p><p>Москва</p></bio><bio xml:lang="en"><p>Petr S. Vetshev – doсt. of med. sci., professor, vice director.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пихута</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pikhuta</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пихута Дмитрий Александрович – кандидат медицинских наук, врач-рентгенолог.</p><p>Москва</p></bio><bio xml:lang="en"><p>Dmitriy A. Pikhuta – cand. of med. sci., radiologist of radiology department.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппов</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fillippov</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филиппов Юрий Андреевич – ординатор кафедры рентгенологии с курсом клинической радиологии ИУВ.</p><p>Москва</p></bio><bio xml:lang="en"><p>Yury A. Fillippov – resident of radiology department.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Национальный медико-хирургический центр им. Н.И. Пирогова” Минздрава Росси</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov’s National Medical Surgical Center</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2018</year></pub-date><volume>0</volume><issue>1</issue><fpage>47</fpage><lpage>51</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карпов О.Э., Бронов О.Ю., Китаев В.М., Ветшев П.С., Пихута Д.А., Филиппов Ю.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Карпов О.Э., Бронов О.Ю., Китаев В.М., Ветшев П.С., Пихута Д.А., Филиппов Ю.А.</copyright-holder><copyright-holder xml:lang="en">Karpov O.E., Bronov O.Y., Kitaev V.M., Vetshev P.S., Pikhuta D.A., Fillippov Y.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/506">https://medvis.rdsmedia.ru/jour/article/view/506</self-uri><abstract><p>Возможность прогнозирования вентиляционной функции легких перед и после оперативного вмешательства является достаточно острой проблемой. Традиционные методы диагностики имеют известные ограничения. В связи с этим было проведено исследование возможности двухэнергетической компьютерной томографии (ДЭКТ) с использованием ксенона для оценки вентиляционной функции легких.</p><sec><title>Цель исследования</title><p>Цель исследования: отработать методику исследования больных с легочной патологией, оценить возможность обоснования объема оперативного вмешательства и прогнозирования послеоперационной функции легких на основе полученных гибридных изображений.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Для исследования были отобраны  12 пациентов с различной легочной патологией (хроническая обструктивная болезнь легких – 5, новообразования легких – 4, бронхоэктатическая болезнь – 3).</p></sec><sec><title>Результаты</title><p>Результаты. Первые данные позволили предположить, что применение ДЭКТ с ксеноном более точно отражает функциональное состояние легочной ткани в сравнении с иными применяемыми методами.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные данные дают предпосылки для планирования оперативного вмешательства и введения метода в современные протоколы предоперационной подготовки.</p></sec></abstract><trans-abstract xml:lang="en"><p>Routine diagnostic methods have limitations in terms of predicting the ventilation function of the lungs before and after surgery. It was decided to investigate the possibilities of dual-energy CT (DECT) using xenon in assessment of lung ventilation function.</p><sec><title>Objective</title><p>Objective: to master the methods of examination of patients with pulmonary pathology, evaluate the possibility of justifying the volume of operative intervention and prediction of postoperative lung function based on the hybrid images.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. For the study, 12 patients with different pulmonary pathologies were selected (COPD – 5, lung cancer – 4, bronchiectasis – 3). Results. It was found that the use of DECT with xenon reflects the functional state of lung tissue.</p></sec><sec><title>Conclusions</title><p>Conclusions. DECT with xenon have potential for planning surgical intervention and introducing the method into modern protocols of preoperative preparation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>двухэнергетическая компьютерная томография</kwd><kwd>ДЭКТ</kwd><kwd>ксенон</kwd><kwd>патология легких</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dual energy computed tomography</kwd><kwd>DECT</kwd><kwd>xenon</kwd><kwd>lung pathology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Milne S., King G.G. Advanced imaging in COPD: insights into pulmonary pathophysiology. J. Thorac Dis. 2014; 6 (11): 1570–1585. DOI:10.3978/j.issn.2072-1439.2014.11.30.</mixed-citation><mixed-citation xml:lang="en">Milne S., King G.G. Advanced imaging in COPD: insights into pulmonary pathophysiology. J. Thorac Dis. 2014; 6 (11): 1570–1585.  DOI:10.3978/j.issn.2072-1439.2014.11.30.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Зубовский Г.А., Черногорцев А.В., Назаров А.А. Пневмосцинтиграфия: перспективы применения в клинической практике. Вестник РНЦРР. 2004; 3: 33–36.</mixed-citation><mixed-citation xml:lang="en">Zubovskiy G.A., Chernogortsev A.V., Nazarov A.A., Pneumocystography: prospects of application in clinical practice. Vestnik RNCRR. 2004; 3: 33–36.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Буров Н.Е., Корниенко Л., Арзамасцев Е., Коротич А., Голубых В. Изучение токсичности ксенона в условиях субхронического эксперимента. Анестезиология и реаниматология. 1998; 3: 58–60.</mixed-citation><mixed-citation xml:lang="en">(In Russian) 3.  Burov N.E., Kornienko L., Arzamastsev E., Korotich A., Golubyh V. The study of xenon toxicity in a subchronic experiment. Anesteziologiya i reanimatologiya. 1998; 3: 58–60. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Park E.A., Goo J.M., Park S.J. Chronic obstructive pulmonary disease: quantitative and visual ventilation pattern analysis at xenon ventilation CT performed by using a dual-energy technique. Radiol. J. 2010; 256 (3): 985–997. DOI: 10.1148/radiol.10091502.</mixed-citation><mixed-citation xml:lang="en">Park E.A., Goo J.M., Park S.J. Chronic obstructive pulmonary disease: quantitative and visual ventilation pattern analysis at xenon ventilation CT performed by using a dual-energy technique. Radiol. J. 2010; 256 (3): 985–997. DOI: 10.1148/radiol.10091502.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Honda N., Osada H., Watanabe W., Nakayama M., Nishimura K., Krauss B., Otani K. Imaging of ventilation with dual-energy CT during breath hold after single vitalcapacity inspiration of stable xenon. Radiology. 2012; 262 (1): 262–268. DOI: 10.1148/radiol.11110569.</mixed-citation><mixed-citation xml:lang="en">Honda N., Osada H., Watanabe W., Nakayama M., Nishimura K., Krauss B., Otani K. Imaging of ventilation with dual-energy CT during breath hold after single vitalcapacity inspiration of stable xenon. Radiology. 2012; 262 (1): 262–268. DOI: 10.1148/radiol.11110569.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kyoyama H., Hirata Y., Kikuchi S. Evaluation of pulmonary function using singlebreath-hold dual-energy computed tomography with xenon. Medicine (Baltimore). 2017; 96 (3): 21–26. DOI: 10.1097/MD.0000000000005937.</mixed-citation><mixed-citation xml:lang="en">Kyoyama H., Hirata Y., Kikuchi S. Evaluation of pulmonary function using singlebreath-hold dual-energy computed tomography with xenon. Medicine (Baltimore). 2017; 96 (3): 21–26. DOI: 10.1097/MD.0000000000005937.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lee S.M., Seo J.B., Hwang H.J., Kim N., Oh S.Y., Lee J.S., Lee S.W, Oh Y.-M., Kim T.H. Assessment of regional emphysema, air-trapping and Xenon-ventilation using dual-energy computed tomography in chronic obstructive pulmonary disease patients. Eur. Radiol. 2017; 27 (7): 2818–2827. DOI: 10.1007/s00330-016-4657-z.</mixed-citation><mixed-citation xml:lang="en">Lee S.M., Seo J.B., Hwang H.J., Kim N., Oh S.Y., Lee J.S., Lee S.W, Oh Y.-M., Kim T.H. Assessment of regional emphysema, air-trapping and Xenon-ventilation using dual-energy computed tomography in chronic obstructive pulmonary disease patients. Eur. Radiol. 2017; 27 (7): 2818–2827. DOI: 10.1007/s00330-016-4657-z.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lee S.W., Lee S.M., Shin S.Y., Park T.S., Oh S.Y., Kim N., Hong Y., Lee J.S., Oh Y.-M., Lee S.-D., Seo J.B., Improvement in Ventilation-Perfusion Mismatch after Bronchoscopic Lung Volume Reduction. Radiology. 2017; 285 (1): 250–260. DOI: 10.1148/radiol.2017162148.</mixed-citation><mixed-citation xml:lang="en">Lee S.W., Lee S.M., Shin S.Y., Park T.S., Oh S.Y., Kim N., Hong Y., Lee J.S., Oh Y.-M., Lee S.-D., Seo J.B., Improvement in Ventilation-Perfusion Mismatch after Bronchoscopic Lung Volume Reduction. Radiology. 2017; 285 (1): 250–260. DOI: 10.1148/radiol.2017162148.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ohno Y., Yoshikawa T., Takenaka D., Fujisawa Y., Sugihara N., Kishida Y., Seki S., Koyama H., Sugimura K. Xenon-enhanced CT using subtraction CT: Basic and preliminaryclinical studies for comparison of its efficacy with that of dual-energy CT and ventilation SPECT/CT to assess regional ventilation and pulmonary functional loss in smokers. Eur. J. Radiol. 2017; 86: 41–51. DOI: 10.1016/j.ejrad.2016.10.035.</mixed-citation><mixed-citation xml:lang="en">Ohno Y., Yoshikawa T., Takenaka D., Fujisawa Y., Sugihara N., Kishida Y., Seki S., Koyama H., Sugimura K. Xenon-enhanced CT using subtraction CT: Basic and preliminaryclinical studies for comparison of its efficacy with that of dual-energy CT and ventilation SPECT/CT to assess regional ventilation and pulmonary functional loss in smokers. Eur. J. Radiol. 2017; 86: 41–51.  DOI: 10.1016/j.ejrad.2016.10.035.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
