<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-2017-5-18-28</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-470</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГОЛОВА И ШЕЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEAD AND NECK</subject></subj-group></article-categories><title-group><article-title>ПЭТ/КТ с 18F-фторэтилтирозином в диагностике лучевого некроза в височной доле головного мозга после лучевого лечения рака носоглотки (клиническое наблюдение)</article-title><trans-title-group xml:lang="en"><trans-title>PET/CT with 18F-Fluoroethyl-L-Tyrosine in Diagnosis of Radiation Necrosis of the Temporal Lobe after Radiotherapy for Nasopharyngeal Carcinoma (Clinical Case)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Люосев</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyuosev</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник отделения позитронной эмиссионной томографии НИИ КиЭР ФГБУ “НМИЦ онкологии им. Н.Н. Блохина” МЗ РФ, Москва</p><p>115478 Москва, Каширское шоссе, д. 23. Отделение позитронной эмиссионной томографии НИИ КиЭР ФГБУ “НМИЦ онкологии им. Н.Н. Блохина” МЗ РФ. Тел.: +7-909-626-82-81</p></bio><bio xml:lang="en"><p>medical doctor of PET department of N.N. Blokhin NMRCO, Moscow</p><p>115478 Moscow, Kashirskoe shosse, 23. Department of positronemission tomography of N.N. Blokhin NMRCO. Phone: +7-909-626-82-81</p></bio><email xlink:type="simple">v24seven@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгушин</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgushin</surname><given-names>M. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, профессор, заведующий отделением позитронной эмиссионной томографии НИИ КиЭР ФГБУ “НМИЦ онкологии им. Н.Н. Блохина” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>doct. of med. sci., head of PET department of N.N. Blokhin NMRCO, Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пронин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pronin</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник отделения позитронной эмиссионной томографии НИИ КиЭР ФГБУ “НМИЦ онкологии им. Н.Н. Блохина” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>medical doctor of PET department of N.N. Blokhin NMRCO, Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Назаренко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nazarenko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, заведующий радиологическим отделением НИИ КиЭР ФГБУ “НМИЦ онкологии им. Н.Н. Блохина” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>cand. of med. sci., head of Radiological department of N.N. Blokhin NMRCO, Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мещерякова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Meshcheriakova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-рентгенолог отделения позитронной эмиссионной томографии НИИ КиЭР ФГБУ “НМИЦ онкологии им. Н.Н. Блохина” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>medical doctor of PET department of N.N. Blokhin NMRCO, Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Невзоров</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Nevzorov</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>инженер-радиохимик отделения позитронной эмиссионной томографии НИИ КиЭР ФГБУ “НМИЦ онкологии им. Н.Н. Блохина» МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>engineer radiochemist of PET department ofN.N. Blokhin NMRCO, Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алиева</surname><given-names>С. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Alieva</surname><given-names>S. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, ведущий научный сотрудник отделения радиологического НИИ КиЭР ФГБУ “НМИЦ онкологии им. Н.Н. Блохина” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>doct. of med. sci., Radiological department of N.N. Blokhin NMRCO, Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSBI “N.N. Blokhin Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2017</year></pub-date><volume>0</volume><issue>5</issue><fpage>18</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Люосев А.С., Долгушин М.Б., Пронин А.И., Назаренко А.В., Мещерякова Н.А., Невзоров Д.И., Алиева С.Б., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Люосев А.С., Долгушин М.Б., Пронин А.И., Назаренко А.В., Мещерякова Н.А., Невзоров Д.И., Алиева С.Б.</copyright-holder><copyright-holder xml:lang="en">Lyuosev A.S., Dolgushin M.B., Pronin A.I., Nazarenko A.V., Meshcheriakova N.A., Nevzorov D.I., Alieva S.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/470">https://medvis.rdsmedia.ru/jour/article/view/470</self-uri><abstract><p>Представлено клиническое наблюдение больного раком носоглотки после  стереотаксического радиохирургического лечения по поводу продолженного роста рака  носоглотки после химиолучевой терапии. В анализ были включены диагностические  данные, полученные после проведенных ПЭТ/КТ с 18F-фторэтилтирозином (18F-ФЭТ) и МРТ  с внутривенным контрастированием головы и шеи. Проанализирован случай дифференциальной диагностики  изменений в височной доле головного мозга после стереотаксической лучевой терапии рака  носоглотки при помощи ПЭТ/КТ с 18F-ФЭТ. Определена высокая диагностическая точность  метода в дифференциальной диагностике отсроченных изменений в головном мозге  (опухолевые или лучевой некроз) после проведенной повторной лучевой терапии рака носоглотки.</p></abstract><trans-abstract xml:lang="en"><p>Clinical case of the patient with nasopharyngeal carcinomaafter stereotactic radiosurgical treatment for the persistent disease after chemoradiotherapyare presented. The diagnostic data of PET/CTwith  18F-Fluoroethyl-Ltyrosine (18F-FET)and MRI with intravenous contrastof head and neck were included in analysis. There was  analyzeda clinical case of differential diagnosis of changes in thetemporal lobe of the brain after stereotactic radiation therapy of  nasopharyngeal carcinoma using PET/CT with 18F-FET. Identified high  diagnostic accuracy in the differential diagnosis of delayed changes in  the brain (tumor or radiation necrosis) after radiation therapy  ofnasopharyngeal carcinoma.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ПЭТ/КТ</kwd><kwd>18F-ФЭТ</kwd><kwd>МРТ</kwd><kwd>головной мозг</kwd><kwd>некроз</kwd><kwd>стереотаксическая радиохирургия</kwd><kwd>лучевая терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>PET/CT</kwd><kwd>18F-FET</kwd><kwd>MRI</kwd><kwd>brain</kwd><kwd>necrosis</kwd><kwd>stereotactic radiosurgery</kwd><kwd>radiation therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J., Dassarath M., Yin Z., Liu H., Yang K., Wu G. Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management. Radiation Oncology. 2011; 6: 128. DOI: 10.1186/1748-717X-6-128.</mixed-citation><mixed-citation xml:lang="en">Chen J., Dassarath M., Yin Z., Liu H., Yang K., Wu G. Radiation induced temporal  lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in  its management. Radiation Oncology. 2011; 6: 128. DOI: 10.1186/1748-717X-6-128.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">De Salvo M.N. Radiation necrosis of the pons after radiotherapy for nasopharyngeal carcinoma: diagnosis and treatment. J. Radiol. Case Rep. 2012; 6 (7): 9–16. DOI: 10.3941/jrcr.v6i7.1108.</mixed-citation><mixed-citation xml:lang="en">De Salvo M.N. Radiation necrosis of the pons after radiotherapy for  nasopharyngeal carcinoma: diagnosis and treatment. J. Radiol. Case Rep. 2012; 6 (7):  9–16. DOI: 10.3941/jrcr.v6i7.1108.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hsu Y.-C., Wang L.-F., Lee K.-W., Ho K.-Y., Huang C.-J., Kuo W.-R. Сerebral radionecrosis in patients with nasopharyngeal carcinoma. Kaohsiung J. Med. Sci. 2005; 21 (10): 452–459. DOI: 10.1016/S1607-551X(09)70150-0.</mixed-citation><mixed-citation xml:lang="en">Hsu Y.-C., Wang L.-F., Lee K.-W., Ho K.-Y., Huang C.-J., Kuo W.-R. Сerebral  radionecrosis in patients with nasopharyngeal carcinoma. Kaohsiung J. Med. Sci.  2005; 21 (10): 452–459. DOI: 10.1016/S1607-551X(09)70150-0.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sheline G.E., Wara W.M., Smith V. Therapeutic irradiation and brain injury. Int. J. Radiat. Oncol. Biol. Phys. 1980; 6: 1215–1228.</mixed-citation><mixed-citation xml:lang="en">Sheline G.E., Wara W.M., Smith V. Therapeutic irradiation and brain injury. Int.  J. Radiat. Oncol. Biol. Phys. 1980; 6: 1215–1228.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Qin D.X., Hu Y.H., Yan J.H., Xu G.Z., Cai W.M., Wu X.L., Cao D.X., Gu X.Z. Analysis of 1379 patients with nasopharyngeal carcinoma treated by radiation. Cancer. 1988; 61: 1117–1124.</mixed-citation><mixed-citation xml:lang="en">Qin D.X., Hu Y.H., Yan J.H., Xu G.Z., Cai W.M., Wu X.L., Cao D.X., Gu X.Z.  Analysis of 1379 patients with nasopharyngeal carcinoma treated by radiation.  Cancer. 1988; 61: 1117–1124.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lee A.W., Ng S.H., Ho J.H., Tse V.K., Poon Y.F., Tse C.C., Au G.K., O S.K., Lau W.H., Foo W.W. Clinical diagnosis of late temporal lobe necrosis following radiation therapy for nasopharyngeal carcinoma. Cancer. 1988; 61: 1535–1542.</mixed-citation><mixed-citation xml:lang="en">Lee A.W., Ng S.H., Ho J.H., Tse V.K., Poon Y.F., Tse C.C., Au G.K., O S.K., Lau  W.H., Foo W.W. Clinical diagnosis of late temporal lobe necrosis following radiation  therapy for nasopharyngeal carcinoma. Cancer. 1988; 61: 1535–1542.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fischer A.W., Holfelder H. Lokales Amyloid in Gehirn. Einespatfolge von rontgenbestrahlungen. Dtsch. Z. Chir. 1930; 227: 475–483.</mixed-citation><mixed-citation xml:lang="en">Fischer A.W., Holfelder H. Lokales Amyloid in Gehirn. Einespatfolge von  rontgenbestrahlungen. Dtsch. Z. Chir. 1930; 227: 475–483.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Glass J.P.,Hwang T.L., Leavens M.E., Libshitz H.I. Cerebral radiation necrosis following treatment of extracranial malignancies. Cancer. 1984; 54: 1966–1972.</mixed-citation><mixed-citation xml:lang="en">Glass J.P.,Hwang T.L., Leavens M.E., Libshitz H.I. Cerebral radiation necrosis  following treatment of extracranial malignancies. Cancer. 1984; 54: 1966–1972.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">MarksJ. E., Wong J. The risk of cerebral radionecrosis in relation to dose, time and fractionation: a follow-up study. Prog. Exp. Tumor Res. 1985; 29: 210–218.</mixed-citation><mixed-citation xml:lang="en">MarksJ. E., Wong J. The risk of cerebral radionecrosis in relation to dose, time  and fractionation: a follow-up study. Prog. Exp. Tumor Res. 1985; 29: 210–218.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ruben J.D., Dally М., Bailey М., Smith R., McLean C.A., Fedele P. Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2006; 65: 499–508. DOI: 10.1016/j.ijrobp.2005.12.002.</mixed-citation><mixed-citation xml:lang="en">Ruben J.D., Dally М., Bailey М., Smith R., McLean C.A., Fedele P. Cerebral  radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Савинцева Ж.И., Скворцова Т.Ю., Бродская З.Л. Современные методы нейровизуализации в дифференциальной диагностике лучевых поражений головного мозга у больных с церебральными опухолями. Лучевая диагностика и терапия. 2012; 1 (3): 15–23.</mixed-citation><mixed-citation xml:lang="en">parameters and chemotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2006; 65: 499–508. DOI: 10.1016/j.ijrobp.2005.12.002.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Крячок И.А. Новый подход к лечению пациентов с пострадиационным некрозом головного мозга. Онкология. 2010; 12 (3): 261–262.</mixed-citation><mixed-citation xml:lang="en">Savintseva Zh.I., Skvortsova T.Yu., Brodskaya Z.L. Modern neuroimaging  techniques in the differential diagnosis of radiation injuries of the brain in  patients with cerebral tumors. Luchevaya diagnostic i therapiya. 2012; 1 (3): 15–23. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Burger Р.С., Boyko O.B. The pathology of central nervous system radiation injury. Radiation injury to the nervous system. Eds Gutin P.H., Leibel S.A., Sheline G.E. New York: Raven, 1991: 191–208.</mixed-citation><mixed-citation xml:lang="en">Kryachok I.A. A new approach to the treatment of patients with radiation  necrosis of the brain. Oncologia. 2010; 12 (3): 261–262. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Castel J.C., Caille J.M. Imaging of irradiated brain tumors: value of magnetic resonance imaging. J. Neuradiol. 1989; 16: 81–132.</mixed-citation><mixed-citation xml:lang="en">Burger Р.С., Boyko O.B. The pathology of central nervous system radiation  injury. Radiation injury to the nervous system. Eds Gutin P.H., Leibel S.A., Sheline  G.E. New York: Raven, 1991: 191–208.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sawaya R. The fibrinolytic enzymes in the biology of brain tumors. Sawaya M. D. (ed). Fibrilysis and the central nerv system. Philadelphia, Pa: Harnley and Belfus, 1990: 106–126.</mixed-citation><mixed-citation xml:lang="en">Castel J.C., Caille J.M. Imaging of irradiated brain tumors: value of magnetic  resonance imaging. J. Neuradiol. 1989; 16: 81–132.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y.Q., Chen P., Haimovitz-Friedman A., Reilly R.M., Wong C.S. Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation. Cancer Res. 2003; 63 (18): 5950–5956.</mixed-citation><mixed-citation xml:lang="en">Sawaya R. The fibrinolytic enzymes in the biology of brain tumors. Sawaya M. D.  (ed). Fibrilysis and the central nerv system. Philadelphia, Pa: Harnley and Belfus,  1990: 106–126.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкина Л.В. Патологическая анатомия осложнений у нейроонкологических больных после лучевой терапии: Автореф. дисс. … канд. мед. наук. М., 1988. 18 с.</mixed-citation><mixed-citation xml:lang="en">Li Y.Q., Chen P., Haimovitz-Friedman A., Reilly R.M., Wong C.S. Endothelial  apoptosis initiates acute blood-brain barrier disruption after ionizing radiation.  Cancer Res. 2003; 63 (18): 5950–5956.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Никитин К.В., Шишкина Л.В., Пронин И.Н., Ильялов С.Р., Костюченко В.В., Голанов А.В. Лучевой некроз после стереотаксической радиохирургии доброкачественной глиомы: описание случая. Вопросы нейро хирургии им. Н.Н. Бурденко. 2009; 3: 37–42.</mixed-citation><mixed-citation xml:lang="en">Shishkina L.V. Morbid anatomy complications in neurooncological patients after  radiotherapy: Avtoref. diss. … cand. of med. sci. Moscow. 1988. 18 p. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Monje M.L., Toda H., Palmer T.D. Inflammatory blockade restores adult hippocampal neurogenesis. Science. 2003; 302 (5651): 1760–1765. DOI: 10.1126/science.1088417.</mixed-citation><mixed-citation xml:lang="en">Nikitin K.V., Shishkina L.V., Pronin I.N., Ilyalov S.R., Kostyuchenko V.V.,  Golanov A.V. Radiation necrosis after stereotactic radiosurgery of benign glioma:  case report. Voprosi neirokhirurgii im. N.N. Burdenko. 2009; 3: 37–42. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson C.M., Gaber M.W., Sabek O.M., Zawaski J.A., Merchant T.E. Radiation-induced astrogliosis and bloodbrain barrier damage can be abrogated using anti-TNF treatment. Int. J. Radiat. Oncol. Biol. Phys. 2009; 74 (3): 934–941. DOI: 10.1016/j.ijrobp.2009.02.035.</mixed-citation><mixed-citation xml:lang="en">Monje M.L., Toda H., Palmer T.D. Inflammatory blockade restores adult  hippocampal neurogenesis. Science. 2003; 302 (5651): 1760–1765. DOI:  10.1126/science.1088417.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou H., Liu Z., Liu J., Zhou D., Zhao Z., Xiao S., Tao E., Suo W.Z. Fractionated radiation- induced acute encephalopathy in a young rat model: cognitive dysfunction and histologic findings. Am. J .Neuroradiol. 2011; 32 (10): 1795–1800. DOI: 10.3174/ajnr.A2643.</mixed-citation><mixed-citation xml:lang="en">Wilson C.M., Gaber M.W., Sabek O.M., Zawaski J.A., Merchant T.E. Radiation- induced astrogliosis and bloodbrain barrier damage can be abrogated using anti-TNF treatment. Int. J. Radiat. Oncol. Biol. Phys. 2009; 74 (3): 934–941. DOI: 10.1016/j.ijrobp.2009.02.035.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Safdari Н., Fuentes J.M. Dubois J.B., Alirezai M., Castan P., Vlahovitch B. Radiation necrosis of the brain: Time of onset and incidence related to total dose and fractionation of radiation. Neuroradiology. 1985; 27: 44–47.</mixed-citation><mixed-citation xml:lang="en">Zhou H., Liu Z., Liu J., Zhou D., Zhao Z., Xiao S., Tao E., Suo W.Z.  Fractionated radiation-induced acute encephalopathy in a young rat model: cognitive  dysfunction and histologic findings. Am. J .Neuroradiol. 2011; 32 (10): 1795–1800. DOI: 10.3174/ajnr.A2643.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lee A.W.M., Law S.C.K., Ng S.H., Chan D.K., Poon Y.F., Foo W., Tung S.Y., Cheung F.K., Ho J.H. Retrospective analysis of nasopharyngeal carcinoma treated during 1976-1985: late complications following megavoltage irradiation. Br. J. Radiol. 1992; 65: 918–928. DOI: 10.1259/0007-1285-65-778-918.</mixed-citation><mixed-citation xml:lang="en">Safdari Н., Fuentes J.M. Dubois J.B., Alirezai M., Castan P., Vlahovitch B.  Radiation necrosis of the brain: Time of onset and incidence related to total dose  and fractionation of radiation. Neuroradiology. 1985; 27: 44–47.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Chong V.F., Fan Y.F., Mukherji K.S. Radiation-Induced Temporal Lobe Changes: CT and MR Imaging Characteristics. Am. J. Roentgenol. 2000; 175: 431–436. DOI: 10.2214/ajr.175.2.1750431.</mixed-citation><mixed-citation xml:lang="en">Lee A.W.M., Law S.C.K., Ng S.H., Chan D.K., Poon Y.F., Foo W., Tung S.Y., Cheung  F.K., Ho J.H. Retrospective analysis of nasopharyngeal carcinoma treated during 1976-1985: late complications following megavoltage irradiation. Br. J. Radiol.  1992; 65: 918–928. DOI: 10.1259/0007-1285-65-778-918.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Lee A.W., Foo W., Chappell R., Fowler J.F., Sze W.M., Poon Y.F., Law S.C., Ng S.H., O S.K., Tung S.Y., Lau W.H., Ho J.H. Effect of time, dose, and fractionation on temporal lobe necrosis following radiotherapy for nasopharyngeal carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 1998; 40: 35–42.</mixed-citation><mixed-citation xml:lang="en">Chong V.F., Fan Y.F., Mukherji K.S. Radiation-Induced Temporal Lobe Changes: CT  and MR Imaging Characteristics. Am. J. Roentgenol. 2000; 175: 431–436. DOI: 10.2214/ajr.175.2.1750431.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Tandon N., Vollmer D., New P., Hevezi J.M., Herman T., Kagan-Hallet K., West G.A. Fulminant radiation-induced necrosis after stereotactic radiation therapy to the posterior fossa. Case report and review of the literature. J. Neurosurg. 2001; 95: 507–512. DOI: 10.3171/jns.2001.95.3.0507.</mixed-citation><mixed-citation xml:lang="en">Lee A.W., Foo W., Chappell R., Fowler J.F., Sze W.M., Poon Y.F., Law S.C., Ng  S.H., O S.K., Tung S.Y., Lau W.H., Ho J.H. Effect of time, dose, and fractionation  on temporal lobe necrosis following radiotherapy for nasopharyngeal carcinoma. Int.  J. Radiat. Oncol. Biol. Phys. 1998; 40: 35–42.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Chin L.S., Ma L., DiBiase S. Radiation necrosis following gamma knife surgery: a case- controlled comparison of treatment parameters and long-term clinical follow up. J. Neurosurg. 2001; 94: 899–904. DOI: 10.3171/jns.2001.94.6.0899.</mixed-citation><mixed-citation xml:lang="en">Tandon N., Vollmer D., New P., Hevezi J.M., Herman T., Kagan-Hallet K., West  G.A. Fulminant radiation-induced necrosis after stereotactic radiation therapy to  the posterior fossa. Case report and review of the literature. J. Neurosurg. 2001; 95: 507–512. DOI: 10.3171/jns.2001.95.3.0507.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Chen H., Burnett M., Huse J., Lustig R.A., Bagley L.J., Zager E.L. Recurrent late cerebral necrosis with aggressive characteristics after radiosurgical treatment of an arteriovenous malformation. Casereport J. Neurosurg. 2006; 105: 455–460. DOI: 10.3171/jns.2006.105.3.455.</mixed-citation><mixed-citation xml:lang="en">Chin L.S., Ma L., DiBiase S. Radiation necrosis following gamma knife surgery: a  case-controlled comparison of treatment parameters and long-term clinical follow up.J. Neurosurg. 2001; 94: 899–904. DOI: 10.3171/jns.2001.94.6.0899.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng K.M., Chan C.M., Fu Y.T., Ho L.C., Tsang Y.W., Lee M.K., Cheung Y.L., Law C.K. Brain abscess formation in radiation necrosis of the temporal lobe following radiation therapy for nasopharyngeal carcinoma. Acta Neurochir. (Wien). 2000; 142: 435–440.</mixed-citation><mixed-citation xml:lang="en">Chen H., Burnett M., Huse J., Lustig R.A., Bagley L.J., Zager E.L. Recurrent  late cerebral necrosis with aggressive characteristics after radiosurgical treatment  of an arteriovenous malformation. Casereport J. Neurosurg. 2006; 105: 455–460. DOI:  10.3171/jns.2006.105.3.455.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng K.M., Chan C.M., Fu Y.T., Ho L.C., Cheung F.C., Law C.K. Acute hemorrhage in late radiation necrosis of the temporal lobe: report of five cases and review of the literature. J. Neurooncol. 2001; 51: 143–150.</mixed-citation><mixed-citation xml:lang="en">Cheng K.M., Chan C.M., Fu Y.T., Ho L.C., Tsang Y.W., Lee M.K., Cheung Y.L., Law  C.K. Brain abscess formation in radiation necrosis of the temporal lobe following  radiation therapy for nasopharyngeal carcinoma. Acta Neurochir. (Wien). 2000; 142: 435–440.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Giglio P., Gilbert M. Cerebral Radiation Necrosis. The Neurologist. 2003; 9: 180–188. DOI: 10.1097/01.nrl.0000080951.78533.c4.</mixed-citation><mixed-citation xml:lang="en">Cheng K.M., Chan C.M., Fu Y.T., Ho L.C., Cheung F.C., Law C.K. Acute hemorrhage  in late radiation necrosis of the temporal lobe: report of five cases and review of  the literature. J. Neurooncol. 2001; 51: 143–150.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Dooms G.C., Hecht S., Brant-Zawadzki M., Berthiaume Y., Norman D., Newton T.H. Brain radiation lesions: MR imaging. Radiology. 1986; 158: 149–155. DOI: 10.1148/radiology.158.1.3940373.</mixed-citation><mixed-citation xml:lang="en">Giglio P., Gilbert M. Cerebral Radiation Necrosis. The Neurologist. 2003; 9:  180–188. DOI: 10.1097/01.nrl.0000080951.78533.c4.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Galldiks N., Stoffels G., Filss C., Piroth M.D., Sabel M., Ruge M.I., Herzog H., Shah N.J., Fink G.R., Coenen H.H., Langen K.J. Role of O-(2-18F-Fluoroethyl)-L-Tyrosine PET for Differentiation of Local Recurrent Brain Metastasis from Radiation Necrosis. J. Nuclear Med. 2012; 53 (9): 1367–1374. DOI: 10.2967/jnumed.112.103325.</mixed-citation><mixed-citation xml:lang="en">Dooms G.C., Hecht S., Brant-Zawadzki M., Berthiaume Y., Norman D., Newton T.H.  Brain radiation lesions: MR imaging. Radiology. 1986; 158: 149–155. DOI: 10.1148/radiology.158.1.3940373.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Скворцова Т.Ю., Бродская З.Л., Савинцева Ж.И., Гурчин А.Ф. Современные проблемы мониторинга лече ния церебральных глиом и возможности повышения точности диагностики при помощи ПЭТ с [11С]метионином. Лучевая диагностика и терапия. 2014; 2 (5): 5–16. http://dx.doi.org/10.22328/2079-5343-2014-2-5-16.</mixed-citation><mixed-citation xml:lang="en">Galldiks N., Stoffels G., Filss C., Piroth M.D., Sabel M., Ruge M.I., Herzog H.,  Shah N.J., Fink G.R., Coenen H.H., Langen K.J. Role of O-(2-18F-Fluoroethyl)-L- Tyrosine PET for Differentiation of Local Recurrent Brain Metastasis from Radiation  Necrosis. J. Nuclear Med. 2012; 53 (9): 1367–1374. DOI: 10.2967/jnumed.112.103325.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Kreth F.W., Muacevic A., Medele R., Bise K., Meyer T., Reulen H.J. The risk of haemorrhage after image guided stereotactic biopsy of intra-axial brain tumours- a pro spective study. Acta Neurochirurgica. 2001; 143 (6): 539–546.</mixed-citation><mixed-citation xml:lang="en">Skvortsova T.Yu., Brodskaya Z.L., SavintsevaZh.I. Modern problems with  monitoring of treatment of cerebral gliomas and the possibility of improving the  accuracy of diagnosis using PET with [11C]methionine. Luchevaya diagnostica i therapiya. 2014; 2 (5): 5–16. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Heper A.O., Erden E., Savas A., Ceyhan K., Erden I., Akyar S., Kanpolat Y. An analysis of stereotactic biopsy of brain tumors and nonneoplastic lesions: a prospective clinicopathologic study. Surg. Neurol. 2005; 30; 64: 82–88. DOI: 10.1016/j.surneu.2005.07.055.</mixed-citation><mixed-citation xml:lang="en">Kreth F.W., Muacevic A., Medele R., Bise K., Meyer T., Reulen H.J. The risk of  haemorrhage after image guided stereotactic biopsy of intra-axial brain tumours- a  pro spective study. Acta Neurochirurgica. 2001; 143 (6): 539–546.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Grosu A.L., Astner S.T., Riedel E., Nieder C., Wiedenmann N., Heinemann F., Schwaiger M., Molls M., Wester H.J., Weber W.A. An Interindividual Comparison of O-(2- [18F] Fluoroethyl)- L-Tyrosine (FET)-and L-[Methyl-11C] Methionine (MET)-PET in Patients With Brain Gliomas and Metastases. Int. J. Radiat. Oncol. Biol. Phys. 2011; 81 (4): 1049–1058. DOI: 10.1016/j.ijrobp.2010.07.002.</mixed-citation><mixed-citation xml:lang="en">Heper A.O., Erden E., Savas A., Ceyhan K., Erden I., Akyar S., Kanpolat Y. An  analysis of stereotactic biopsy of brain tumors and nonneoplastic lesions: a  prospective clinicopathologic study. Surg. Neurol. 2005; 30; 64: 82–88. DOI: 10.1016/j.surneu.2005.07.055.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Palumbo B., Buresta T., Nuvoli S., Spanu A., Schillaci O., Fravolini M.L., Palumbo I. SPECT and PET serve as molecular imaging techniques and in Vivo biomarkers for brain metastases. Int. J. Molec. Sci. 2014; 15 (6): 9878–9893. DOI: 10.3390/ijms15069878.</mixed-citation><mixed-citation xml:lang="en">Grosu A.L., Astner S.T., Riedel E., Nieder C., Wiedenmann N., Heinemann F.,  Schwaiger M., Molls M., Wester H.J., Weber W.A. An Interindividual Comparison of O- (2- [18F] Fluoroethyl)-L-Tyrosine (FET)-and L-[Methyl-11C] Methionine (MET)-PET in  Patients With Brain Gliomas and Metastases. Int. J. Radiat. Oncol. Biol. Phys. 2011;  81 (4): 1049–1058. DOI: 10.1016/j.ijrobp.2010.07.002.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Stöber B., Tanase U., Herz M., Seidl C., Schwaiger M., Senekowitsch-Schmidtke R. Differentiation of tumour and inflammation: characterisation of [methyl-3H] methionine (MET) and O-(2-[18F] fluoroethyl)-L-tyrosine (FET) uptake in human tumour and inflammatory cells. Eur. J Nucl. Med. Molec. Imaging. 2006; 33 (8): 932–939. DOI: 10.1007/s00259-005-0047-5.</mixed-citation><mixed-citation xml:lang="en">Palumbo B., Buresta T., Nuvoli S., Spanu A., Schillaci O., Fravolini M.L.,  Palumbo I. SPECT and PET serve as molecular imaging techniques and in Vivo  biomarkers for brain metastases. Int. J. Molec. Sci. 2014; 15 (6): 9878– 9893. DOI: 10.3390/ijms15069878.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Hanakawa K., Ikeda H., Ishii K., Asamoto S., Iwata T., Matsumoto K. High uptake on 11C methionine PET scan in the pituitary gland of a patient with cerebral glioma after surgical abortion. No To Shinkei. 1998; 50 (6): 573–577.</mixed-citation><mixed-citation xml:lang="en">Stöber B., Tanase U., Herz M., Seidl C., Schwaiger M., Senekowitsch-Schmidtke R.  Differentiation of tumour and inflammation: characterisation of [methyl-3H]  methionine (MET) and O-(2-[18F] fluoroethyl)-L-tyrosine (FET) uptake in human tumour  and inflammatory cells. Eur. J Nucl. Med. Molec. Imaging. 2006; 33 (8): 932–939. DOI: 10.1007/s00259-005-0047-5.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Позитронная эмиссионная томография: Руководство для врачей; Под ред. А.М. Гранова и Л.А. Тютина. М.: Фолиант, 2008. 610 c.</mixed-citation><mixed-citation xml:lang="en">Hanakawa K., Ikeda H., Ishii K., Asamoto S., Iwata T., Matsumoto K. High uptake  on 11C methionine PET scan in the pituitary gland of a patient with cerebral glioma  after surgical abortion. No To Shinkei. 1998; 50 (6): 573–577.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Карташев А.В., Виноградов В.М., Киселева Л.Н.. Злокачественные глиомы головного мозга. Lambert Academic Publishing. 2011; 166–168.</mixed-citation><mixed-citation xml:lang="en">Positronemission tomography: a guide for physicians. Eds A.M. Granov, L.A.  Tyutin. M.: Foliant., 2008. 610 p. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Pöpperl G., Götz C., Rachinger W., Gildehaus F.J., Tonn J.C., Tatsch K.Value of O-(2-[18F] fluoroethyl)-Ltyrosine PET for the diagnosis of recurrent glioma. Eur. J. Nucl. Med. Molec. Imaging. 2004; 31 (11): 1464–1470. DOI: 10.1007/s00259-004-1590-1.</mixed-citation><mixed-citation xml:lang="en">Kartashev A.V., Vinogradov V.M., Kiseleva L.N. Malignant gliomas of the brain.  Lambert Academic Publishing. 2011; 166–168. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Langen K.J., Hamacher K., Weckesser M., Floeth F., Stoffels G., Bauer D., Coenen H.H., Pauleit D. O-(2-[18F] fluoroethyl)-L-tyrosine: uptake mechanisms and clinical applications. Nucl. Med. Biol. 2006; 33 (3): 287–294. DOI: 10.1016/j.nucmedbio.2006.01.002.</mixed-citation><mixed-citation xml:lang="en">Pöpperl G., Götz C., Rachinger W., Gildehaus F.J., Tonn J.C., Tatsch K.Value of  O-(2-[18F] fluoroethyl)- L-tyrosine PET for the diagnosis of recurrent glioma. Eur. J. Nucl. Med. Molec. Imaging. 2004; 31 (11): 1464–1470. DOI: 10.1007/s00259-004-1590-1.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Jensen M.L. Image Analysis of FET PET scans performed during Chemo-Radiotherapy of Glioblastoma Multiforme. DTU Informatics. 2012: 8–14.</mixed-citation><mixed-citation xml:lang="en">Langen K.J., Hamacher K., Weckesser M., Floeth F., Stoffels G., Bauer D., Coenen  H.H., Pauleit D. O-(2-[18F] fluoroethyl)-L-tyrosine: uptake mechanisms and clinical applications. Nucl. Med. Biol. 2006; 33 (3): 287–294. DOI: 10.1016/j.nucmedbio.2006.01.002.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Juhász C., Dwivedi S., Kamson D.O., Michelhaugh S.K., Mittal S. Comparison of amino acid positron emission tomographic radiotracers for molecular imaging of primary and metastatic brain tumors. Molec. Imaging. 2014; 13 (6): 7290–2014.</mixed-citation><mixed-citation xml:lang="en">Jensen M.L. Image Analysis of FET PET scans performed during Chemo-Radiotherapy  of Glioblastoma Multiforme. DTU Informatics. 2012: 8–14.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Pöpperl G., Kreth F.W., Herms J., Koch W., Mehrkens J.H., Gildehaus F.J., Kretzschmar H.A., Tonn J.C., Tatsch K. Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods? J. Nucl. Med. 2006; 47 (3): 393–403.</mixed-citation><mixed-citation xml:lang="en">Juhász C., Dwivedi S., Kamson D.O., Michelhaugh S.K., Mittal S. Comparison of  amino acid positron emission tomographic radiotracers for molecular imaging of  primary and metastatic brain tumors. Molec. Imaging. 2014; 13 (6): 7290–2014.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Piroth M.D., Liebenstund S., Galldiks N., Stoffels G., ShahN. J., EbleM. J., Coenen H.H., Langen K.J. Monitoring of Radiochemotherapy in Patients with Glioblastoma Using O-(2- [18F] Fluoroethyl)-L-Tyrosine Positron Emission Tomography: Is Dynamic Imaging Helpful? Molec. Imaging. 2013; 12 (6): 7290–2013.</mixed-citation><mixed-citation xml:lang="en">Pöpperl G., Kreth F.W., Herms J., Koch W., Mehrkens J.H., Gildehaus F.J.,  Kretzschmar H.A., Tonn J.C., Tatsch K. Analysis of 18F-FET PET for grading of  recurrent gliomas: is evaluation of uptake kinetics superior to standard methods? J.  Nucl. Med. 2006; 47 (3): 393–403.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Di Chiro G., De LaPaz R.L., Brooks R.A., Sokoloff L., Kornblith P.L., Smith B.H., Patronas N.J., Kufta C.V., Kessler R.M., Johnston G.S., Manning R.G., Wolf A.P. Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography. eurology. 1982; 32 (12): 1323.</mixed-citation><mixed-citation xml:lang="en">Piroth M.D., Liebenstund S., Galldiks N., Stoffels G., ShahN. J., EbleM. J.,  Coenen H.H., Langen K.J. Monitoring of Radiochemotherapy in Patients with  Glioblastoma Using O-(2-[18F] Fluoroethyl)-L-Tyrosine Positron Emission Tomography:  Is Dynamic Imaging Helpful? Molec. Imaging. 2013; 12 (6): 7290–2013.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Bělohlávek O., Šimonová G., Kantorová I., Novotný J. Jr., Liscák R. Brain metastases after stereotactic radiosurgery using the Leksell gamma knife: can FDG PET help to differentiate radionecrosis from tumour progression? Eur. J. Nucl. Med. Molec. Imaging. 2003; 30 (1): 96– 100. DOI: 10.1007/s00259-002-1011-2.</mixed-citation><mixed-citation xml:lang="en">Di Chiro G., De LaPaz R.L., Brooks R.A., Sokoloff L., Kornblith P.L., Smith  B.H., Patronas N.J., Kufta C.V., Kessler R.M., Johnston G.S., Manning R.G., Wolf  A.P. Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose  and positron emission tomography. Neurology. 1982; 32 (12): 1323.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Lee H.Y., Chung J.K., Jeong J.M., Lee D.S., Kim D.G., Jung H.W., Lee M.C. Comparison of FDG-PET findings of brain metastasis from non-small-cell lung cancer and small-cell lung cancer. Ann. Nucl. Med. 2008 ; 22 (4): 281–286. DOI: 10.1007/s12149-007-0104-1.</mixed-citation><mixed-citation xml:lang="en">Bělohlávek O., Šimonová G., Kantorová I., Novotný J. Jr., Liscák R. Brain  metastases after stereotactic radiosurgery using the Leksell gamma knife: can FDG  PET help to differentiate radionecrosis from tumour progression? Eur. J. Nucl. Med.  Molec. Imaging. 2003; 30 (1): 96–100. DOI: 10.1007/s00259-002-1011-2.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Трофимова Т.Н., Трофимов Е.А. Современные стратегии лучевой диагностики при первичных опухолях головного мозга. Практическая онкология. 2013; 14 (3): 141–147.</mixed-citation><mixed-citation xml:lang="en">Lee H.Y., Chung J.K., Jeong J.M., Lee D.S., Kim D.G., Jung H.W., Lee M.C.  Comparison of FDG-PET findings of brain metastasis from non-small-cell lung cancer  and small-cell lung cancer. Ann. Nucl. Med. 2008 ; 22 (4): 281–286. DOI: 10.1007/s12149-007-0104-1.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Molecular anatomic imaging: PET-CT and SPECT-CT integrated modality imaging. Ed. Von Schulthess G.K. Lippincott Williams &amp; Wilkins, 2007: 150–152.</mixed-citation><mixed-citation xml:lang="en">Trofimova T.N., Trofimov E.A. Modern strategies for radiation diagnosis in  primary brain tumors. Practical Oncology. 2013; 14 (3): 141–147. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Hutterer M., Nowosielski M., Putzer D., Jansen N.L., Seiz M., Schocke M., McCoy M., Göbel G., laFougère C., Virgolini I.J., Trinka E., Jacobs A.H., Stockham mer G. [18F]-fluoro- ethyl-L-tyrosine PET: a valuable diagnostic tool in neuro-oncology, but not all that glitters is glioma. Neurooncology. 2013; 341–351. DOI: 10.1093/neuonc/nos300.</mixed-citation><mixed-citation xml:lang="en">Molecular anatomic imaging: PET-CT and SPECT-CT integrated modality imaging. Ed.  Von Schulthess G.K. Lippincott Williams &amp; Wilkins, 2007: 150–152.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Unterrainer M., Schweisthal F., Suchorska B., Wenter V., Schmid-Tannwald C., Fendler W.P., Schüller U., Bartenstein P., Tonn J.C., Albert N.L. Serial 18F-FET PET imaging of primarily 18F-FET-negative glioma – does it make sense? J. Nucl. Med. 2016; 57: 1177–1182. DOI: 10.2967/jnumed.115.171033.</mixed-citation><mixed-citation xml:lang="en">Hutterer M., Nowosielski M., Putzer D., Jansen N.L., Seiz M., Schocke M., McCoy  M., Göbel G., laFougère C., Virgolini I.J., Trinka E., Jacobs A.H., Stockham mer G. [18F]-fluoro-ethyl-L-tyrosine PET: a valuable diagnostic tool in neuro-oncology, but  not all that glitters is glioma. Neurooncology. 2013; 341–351. DOI: 10.1093/neuonc/nos300.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Weckesser M., Matheja P., Rickert C., Löttgen J., Palkovic S., Riemann B., Paulus W., Wassmann H., Schober O. Evaluation of the extension of cerebral gliomas by scintigraphy. Strahlenther. Onkol. 2000; 176 (4): 180–185.</mixed-citation><mixed-citation xml:lang="en">Unterrainer M., Schweisthal F., Suchorska B., Wenter V., Schmid-Tannwald C.,  Fendler W.P., Schüller U., Bartenstein P., Tonn J.C., Albert N.L. Serial 18F-FET PET imaging of primarily 18F-FET-negative glioma – does it make sense? J. Nucl. Med.  2016; 57: 1177–1182. DOI: 10.2967/jnumed.115.171033.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">del Amo E.M., Urtti A., Yliperttula M. Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. Eur. J. Pharmaceut. Sci. 2008; 35 (3): 161–174. DOI: 10.1016/j.ejps.2008.06.015.</mixed-citation><mixed-citation xml:lang="en">Weckesser M., Matheja P., Rickert C., Löttgen J., Palkovic S., Riemann B.,  Paulus W., Wassmann H., Schober O. Evaluation of the extension of cerebral gliomas  by scintigraphy. Strahlenther. Onkol. 2000; 176 (4): 180–185.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">del Amo E.M., Urtti A., Yliperttula M. Pharmacokinetic role of L-type amino acid  transporters LAT1 and LAT2. Eur. J. Pharmaceut. Sci. 2008; 35 (3): 161–174. DOI: 10.1016/j.ejps.2008.06.015.</mixed-citation><mixed-citation xml:lang="en">del Amo E.M., Urtti A., Yliperttula M. Pharmacokinetic role of L-type amino acid  transporters LAT1 and LAT2. Eur. J. Pharmaceut. Sci. 2008; 35 (3): 161–174. DOI: 10.1016/j.ejps.2008.06.015.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
