medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-2017-2-120-130medvis-400Research ArticleМАЛЫЙ ТАЗSMALL PELVISМетоды визуализации рака шейки матки: современный взгляд на проблему (обзор литературы)Imaging of Uterine Cervical Cancer: a Modern View (Literature Review)ПлетнёваВ. Ю.PletnevaV. Yu.

Плетнёва Валерия Юрьевна – клинический ординатор отделения рентгенологии и магнитно-резонансных исследований  

Для корреспонденции: 117997 Москва, ул. Большая Серпуховская, д. 27. Институт хирургии им. А.В. Вишневского. 

Valeria Yu.Pletneva – resident of radiology department 

Contact: 117997 Moscow, Bolshaya Serpuhovskaya str., 27. 

leric51@yandex.ruПылёвА. Л.PylevA. L.

Andrei L.Pylev – cand. of med. sci., Deputy head physician for medical work

Moscow

МасловА. Л.MaslovA. L.

Aleksey L.Maslov – postgraduate student of radiology department of A.V. Vishnevsky Ministry of Health of theRussian Federation, radiologist of REMSI Diagnostics Rus

Moscow.

 

ФГБУ “Институт хирургии им. А.В. Вишневского”РоссияA.V. Vishnevsky Institute of SurgeryRussian FederationООО “Центр инновационных медицинских технологий”, Европейская клиникаРоссияCenter for the innovational medical technologiesRussian FederationФГБУ “Институт хирургии им. А.В. Вишневского”; ООО “РЭМСИ Диагностика Рус”РоссияA.V. Vishnevsky Institute of Surgery; “RAMSAY Diagnostics Rus”Russian Federation20172804201702120130Copyright © Плетнёва В.Ю., Пылёв А.Л., Маслов А.Л., 20172017Плетнёва В.Ю., Пылёв А.Л., Маслов А.Л.Pletneva V.Y., Pylev A.L., Maslov A.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/400

Рак шейки матки является 4-м по распространенности раком у женщин. Ранняя диагностика рака шейки матки остается клинической проблемой. Большая часть опубликованной литературы относится к оценке пациентов с макроскопически видимыми опухолями. В настоящее время использование последовательностей с динамическим контрастным усилением и диффузно-взвешенными изображениями при магнитно-резонансной томографии позволяет выявлять опухоли размером менее7 мм. Опубликован ряд работ по использованию трансвагинального ультразвукового исследования, указывающих на высокие данные чувствительности и специфичности, сопоставимые с МРТ. Компьютерная томография используется в основном для выявления метастатического поражения лимфатических узлов. В настоящем обзоре литературы рассмотрены вопросы точности и роли различных методов диагностики у пациентов с раком шейки матки, а также преимущества и недостатки используемых классификаций. 

Cervical cancer is the 4th most common cancer in women. Early diagnosis of cervical cancer remains a clinical problem. Most of the published literature refers to the evalu ation of patients with macroscopically visible tumors. Currently, the use of sequences with dynamic contrast enhancement (DCE) and diffusion-weighted images MRI allows for detection of tumors smaller than7 mm. Several articles on the use of transvaginal ultrasound have been published, indicating sensitivity and specificity comparable to MRI. Computed tomography is used primarily to detect metastases in the lymph nodes. In this review, we focus on the accuracy and role of various diagnostic methods in patients with cervical cancer, as well as advantages anddisadvantages of the most commonly used classifications.

рак шейки маткиКТМРТУЗИобзорcervical cancerCTMRIultrasoundreviewReferencesGLOBOCAN: http://globocan.iarc.fr/old/FactSheets/cancers/cervix-new.asp (дата обращения 12.01.2017 г.).GLOBOCAN: http://globocan.iarc.fr/old/FactSheets/cancers/cervix-new.asp (дата обращения 12.01.2017 г.).Злокачественные новообразования в России в 2015 году (заболеваемость и смертность); Под ред. Каприна А.Д., Старинского В.В., Петровой Г.В. – филиал ФГБУ “НМИРЦ” Минздрава России. М.: МНИОИ им. П.А. Герцена, 2017. 250 c.Malignant neoplasms in Russia in 2015 (morbidity and mortality); Eds Kaprin A.D., Starinsky V.V., Petrova G.V. – filial FGBU “NMIRTc” MinzdravaRossii. M.: MNIOI im. P.A. Gertcena, 2017. 250 p. (In Russian)Злокачественные новообразования в России в 2015 году (заболеваемость и смертность); Под ред. Каприна А.Д., Старинского В.В., Петровой Г.В. – филиал ФГБУ “НМИРЦ” Минздрава России. М.: МНИОИ им. П.А. Герцена, 2017. 250 c.Malignant neoplasms in Russia in 2015 (morbidity and mortality); Eds Kaprin A.D., Starinsky V.V., Petrova G.V. – filial FGBU “NMIRTc” MinzdravaRossii. M.: MNIOI im. P.A. Gertcena, 2017. 250 p. (In Russian)Féderation Internationale de Gynécologie et d’Obstétrique FIGO Committee on Gynecology Oncology. Revised FIGO staging for carcinoma of the vulva, cervix and endometrium. Int. J. Gynecol. Obstet. 2009; 105: 103–104.Féderation Internationale de Gynécologie et d’Obstétrique FIGO Committee on Gynecology Oncology. Revised FIGO staging for carcinoma of the vulva, cervix and endometrium. Int. J. Gynecol. Obstet. 2009; 105: 103–104.Reinhardt M.J., Ehritt-Braun C., Vogelgesang D., Ihling C., Högerle S., Mix M., Moser E., Krause T.M. Metastatic lymph nodes in patients with cervical cancer: detection with MR imaging and FDG PET. Radiology.2001; 218: 776–782. DOI: 10.1148/radiology.218.3.r01mr19776.Reinhardt M.J., Ehritt-Braun C., Vogelgesang D., Ihling C., Högerle S., Mix M., Moser E., Krause T.M. Metastatic lymph nodes in patients with cervical cancer: detection with MR imaging and FDG PET. Radiology.2001; 218: 776–782. DOI: 10.1148/radiology.218.3.r01mr19776.Chung H.H., Park N.H., Kim J.W., Song Y.S., Chung J.K., Kang S.B. Role of integrated PET-CT in pelvic lymph node staging of cervical cancer before radical hysterectomy. Gynecol. Obstet. Invest.2009; 67: 61–66. DOI: 10.1159/000162101.Chung H.H., Park N.H., Kim J.W., Song Y.S., Chung J.K., Kang S.B. Role of integrated PET-CT in pelvic lymph node staging of cervical cancer before radical hysterectomy. Gynecol. Obstet. Invest.2009; 67: 61–66. DOI: 10.1159/000162101.Кудреватых Е.В., Тер-Арутюнянц С.А., Мершина Е.А., Синицын В.Е. Магнитно-резонансная томография в диагностике и оценке результатов комбинированного и химиолучевого лечения рака шейки матки. Кубанский научный медицинский вестник.2010; 6: 65–69. Kudrevatykh E.V., Ter-Aratunyants S.A., MershinaE.A., SinitsinV.E. Application of magnetic resonance imaging in diagnostics and evaluation of results of combined and radiochemical cervical cancer therapy. Kubanskiy nauchnyi meditsinskii vestnik. 2010; 6: 65–69. (In Russian)Кудреватых Е.В., Тер-Арутюнянц С.А., Мершина Е.А., Синицын В.Е. Магнитно-резонансная томография в диагностике и оценке результатов комбинированного и химиолучевого лечения рака шейки матки. Кубанский научный медицинский вестник.2010; 6: 65–69. Kudrevatykh E.V., Ter-Aratunyants S.A., MershinaE.A., SinitsinV.E. Application of magnetic resonance imaging in diagnostics and evaluation of results of combined and radiochemical cervical cancer therapy. Kubanskiy nauchnyi meditsinskii vestnik. 2010; 6: 65–69. (In Russian)Han S.S., Lee S.H., Kim D.H., Kim J.W., Park N.H., Kang S.B., Song Y.S. Evaluation of preoperative criteria used to predict lymph node metastasis in endometrial cancer. Acta Obstet. Gynecol. 2010; 89: 168–174. DOI: 10.3109/00016340903370114.Han S.S., Lee S.H., Kim D.H., Kim J.W., Park N.H., Kang S.B., Song Y.S. Evaluation of preoperative criteria used to predict lymph node metastasis in endometrial cancer. Acta Obstet. Gynecol. 2010; 89: 168–174. DOI: 10.3109/00016340903370114.Kaji Y., Sugimura K., Kitao M., Ishida T. Histopathology of uterine cervical carcinoma: diagnostic comparison of endorectal surface coil and standard body coil MRI. J. Comput. Assist. Tomogr. 1994; 18 (5): 785–792.Kaji Y., Sugimura K., Kitao M., Ishida T. Histopathology of uterine cervical carcinoma: diagnostic comparison of endorectal surface coil and standard body coil MRI. J. Comput. Assist. Tomogr. 1994; 18 (5): 785–792.Кравец А., Кузнецов В.В., Морхов К.Ю., Нечушкина В.М., Хохлова С.В. Клинические рекомендации по диагностике и лечению рака шейки матки. М., 2014. 17 c. Kravets A., Kuznetcov V.V., Morkhov K.Iu., Nechushkina V.M., Khokhlova S.V. Guidelines for the diagnosis and treatment of cervical cancer. Moscow, 2014. 17 p. (In Russian)Кравец А., Кузнецов В.В., Морхов К.Ю., Нечушкина В.М., Хохлова С.В. Клинические рекомендации по диагностике и лечению рака шейки матки. М., 2014. 17 c. Kravets A., Kuznetcov V.V., Morkhov K.Iu., Nechushkina V.M., Khokhlova S.V. Guidelines for the diagnosis and treatment of cervical cancer. Moscow, 2014. 17 p. (In Russian)Colombo N., Carinelli S., Colombo A., Marini C., Rollo D., Sessa C. Cervical Cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2012; 23: 27–32. DOI: 10.1093/annonc/mds268.Colombo N., Carinelli S., Colombo A., Marini C., Rollo D., Sessa C. Cervical Cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2012; 23: 27–32. DOI: 10.1093/annonc/mds268.Saslow D., Solomon D., Lawson H.W., Killackey M., Kulasingam Sh.L., Cain J., Garcia F.A., Moriarty A.T., Waxman A.G., Wilbur D.C., Wentzensen N., Downs L.S., Spitzer M., Moscicki A., Franco E.L., Stoler M.H., Schiffman M., Castle Ph.E., Myers E.R. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology Screening Guidelines for the Prevention and Early Detection of Cervical Cancer. Am. J. Clin. Pathol. 2012; 62: 147–172. DOI: 10.1309/AJCPTGD94EVRSJCG.Saslow D., Solomon D., Lawson H.W., Killackey M., Kulasingam Sh.L., Cain J., Garcia F.A., Moriarty A.T., Waxman A.G., Wilbur D.C., Wentzensen N., Downs L.S., Spitzer M., Moscicki A., Franco E.L., Stoler M.H., Schiffman M., Castle Ph.E., Myers E.R. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology Screening Guidelines for the Prevention and Early Detection of Cervical Cancer. Am. J. Clin. Pathol. 2012; 62: 147–172. DOI: 10.1309/AJCPTGD94EVRSJCG.Mirpour S., Mhlanga J.C., Logeswaran P., Russo G., Mercier G., Subramaniam R.M. The role of PET/CT in the management of cervical cancer. Am. J. Roentgenol. 2013; 201:192–205. DOI:10.2214/AJR.12.9830.Mirpour S., Mhlanga J.C., Logeswaran P., Russo G., Mercier G., Subramaniam R.M. The role of PET/CT in the management of cervical cancer. Am. J. Roentgenol. 2013; 201:192–205. DOI:10.2214/AJR.12.9830.Тарачкова Е.В., Стрельцова О.Н., Ахвердиева Г.И., Базаева И.Я., Панов В.О., Тюрин И.Е. Методы лучевой диагностики и оценки лечения при раке шейки матки. Онкогинекология.2014; 3: 32–41.Tarachkova E.V., Streltsova O.N., Akhverdieva G.I., BazaevaI.Ya., Panov V.O., Tyurin I.E. Methods of radiation diagnostics and evaluation response of therapy of cervical cancer. Onkoginekologiya. 2014; 3: 32–41. (In Russian)Тарачкова Е.В., Стрельцова О.Н., Ахвердиева Г.И., Базаева И.Я., Панов В.О., Тюрин И.Е. Методы лучевой диагностики и оценки лечения при раке шейки матки. Онкогинекология.2014; 3: 32–41.Tarachkova E.V., Streltsova O.N., Akhverdieva G.I., BazaevaI.Ya., Panov V.O., Tyurin I.E. Methods of radiation diagnostics and evaluation response of therapy of cervical cancer. Onkoginekologiya. 2014; 3: 32–41. (In Russian)Fischerova D., Cibula D., Stenhova H., Vondrichova H., Calda P., Zikan M., Freitag P., Slama J., Dundr P., Belacek J. Transrectal ultrasound and magnetic resonance imaging in staging of early cervical cancer. Int. J. Gynecol. Cancer. 2008; 18: 766–772. DOI:10.1111/j.1525-1438.2007.01072.x.Fischerova D., Cibula D., Stenhova H., Vondrichova H., Calda P., Zikan M., Freitag P., Slama J., Dundr P., Belacek J. Transrectal ultrasound and magnetic resonance imaging in staging of early cervical cancer. Int. J. Gynecol. Cancer. 2008; 18: 766–772. DOI:10.1111/j.1525-1438.2007.01072.x.Moloney F., Ryan D., Twomey M., Hewitt M., Barry J. Comparison of MRI and high-resolution transvaginal sonography for the local staging of cervical cancer.J. Clin. Ultrasound. 2016; 44: 78-84.DOI:10.1002/jcu.22288.Moloney F., Ryan D., Twomey M., Hewitt M., Barry J. Comparison of MRI and high-resolution transvaginal sonography for the local staging of cervical cancer.J. Clin. Ultrasound. 2016; 44: 78-84.DOI:10.1002/jcu.22288.Van Nagell J.R., Roddick J.W., Lowin D.M. The staging of cervical cancer: inevitable discrepancies between clinical staging and pathologic findings. Am. J. Obstet. Gynecol. 1971; 110: 973-978. PMID:5558978.Van Nagell J.R., Roddick J.W., Lowin D.M. The staging of cervical cancer: inevitable discrepancies between clinical staging and pathologic findings. Am. J. Obstet. Gynecol. 1971; 110: 973-978. PMID:5558978.Novakoviс P., Mandiс A., Vujkov T., Tesi M., Rajoviс J., Zivaljeviс M., Popoviс M. Radical hysterectomy for stage IB1 cervical carcinoma: lymph node metastasis as a prognostic factor. JBUON.2002; 7: 247–250. PMID:17918796.Novakoviс P., Mandiс A., Vujkov T., Tesi M., Rajoviс J., Zivaljeviс M., Popoviс M. Radical hysterectomy for stage IB1 cervical carcinoma: lymph node metastasis as a prognostic factor. JBUON.2002; 7: 247–250. PMID:17918796.Liu M.T., Hsu J.C., Liu W.S., Wang A.Y., Huang W.T., Chang T.H., Pi C.P., Huang C.Y., Huang C.C., Chou P.H., Chen T.H. Prognostic factors affecting the outcome of early cervical cancer treated with radical hysterectomy and post-operative adjuvant therapy. Eur. J. Cancer Care. 2008; 17: 174–181. DOI:10.1111/j.1365-2354.2007.00831.x.Liu M.T., Hsu J.C., Liu W.S., Wang A.Y., Huang W.T., Chang T.H., Pi C.P., Huang C.Y., Huang C.C., Chou P.H., Chen T.H. Prognostic factors affecting the outcome of early cervical cancer treated with radical hysterectomy and post-operative adjuvant therapy. Eur. J. Cancer Care. 2008; 17: 174–181. DOI:10.1111/j.1365-2354.2007.00831.x.Morice P., Castaigne D., Pautier P., Rey A., Haie-Meder C., Leblanc M., Duvillard P. Interest of pelvic and paraaortic lymphadenectomy in patients with stage IB and II cervical carcinoma. Gynecol. Oncol. 1999; 73: 106–110. DOI: 10.1006/gyno.1998.5308.Morice P., Castaigne D., Pautier P., Rey A., Haie-Meder C., Leblanc M., Duvillard P. Interest of pelvic and paraaortic lymphadenectomy in patients with stage IB and II cervical carcinoma. Gynecol. Oncol. 1999; 73: 106–110. DOI: 10.1006/gyno.1998.5308.Lai C.-H., Hong J.-H., Hsueh S., Ng K.-K., Chang T.-C., Tseng C.-J., Chou H.-H., Huang K.-G. Preoperative prognostic variables and the impact of postoperative adjuvant therapy on the outcomes of stage IB or II cervical carcinoma patients with or without pelvic lymph node metastasis. Cancer. 1999; 85: 1537–1546. DOI: 10.1002/(SICI)1097-0142(19990401)85:7<1537::AID-CNCR15>3.0.CO;2-6.Lai C.-H., Hong J.-H., Hsueh S., Ng K.-K., Chang T.-C., Tseng C.-J., Chou H.-H., Huang K.-G. Preoperative prognostic variables and the impact of postoperative adjuvant therapy on the outcomes of stage IB or II cervical carcinoma patients with or without pelvic lymph node metastasis. Cancer. 1999; 85: 1537–1546. DOI: 10.1002/(SICI)1097-0142(19990401)85:7<1537::AID-CNCR15>3.0.CO;2-6.Yang W.T., Lam W.W., Yu M.Y., Cheung T.H., Metreweli C. Comparison of Dynamic Helical CT and Dynamic MR Imaging in the Evaluation of Pelvic Lymph Nodes in Cervical Carcinoma. Am. J. Obstet Gynecol. 2000; 175: 759–766. DOI: 10.2214/ajr.175.3.1750759.Yang W.T., Lam W.W., Yu M.Y., Cheung T.H., Metreweli C. Comparison of Dynamic Helical CT and Dynamic MR Imaging in the Evaluation of Pelvic Lymph Nodes in Cervical Carcinoma. Am. J. Obstet Gynecol. 2000; 175: 759–766. DOI: 10.2214/ajr.175.3.1750759.Patel S., Liyanage S.H., Sahdev A., Rockall A.G., Reznek R.H. Imaging of endometrial and cervical cancer. Insights Imaging. 2010; 1: 309–328. DOI: 10.1007/s13244-010-0042-7.Patel S., Liyanage S.H., Sahdev A., Rockall A.G., Reznek R.H. Imaging of endometrial and cervical cancer. Insights Imaging. 2010; 1: 309–328. DOI: 10.1007/s13244-010-0042-7.Sakuragi N., Satoh Ch., Takeda N., Hareyama H., Takeda M., Yamamoto R., Fujimoto T., Oikawa M., Fujino T., Fujimoto S. Incidence and distribution pattern of pelvic and paraaortic lymph node metastasis in stages IB, IIA and IIB cervical carcinoma treated with radical hysterectomy. Cancer. 1999; 85: 1547–1554. DOI:10.1002/(SICI)1097-0142(19990401)85:7.Sakuragi N., Satoh Ch., Takeda N., Hareyama H., Takeda M., Yamamoto R., Fujimoto T., Oikawa M., Fujino T., Fujimoto S. Incidence and distribution pattern of pelvic and paraaortic lymph node metastasis in stages IB, IIA and IIB cervical carcinoma treated with radical hysterectomy. Cancer. 1999; 85: 1547–1554. DOI:10.1002/(SICI)1097-0142(19990401)85:7.Lindsay R., Paul J., Siddiqui N., Davis J., Gaffney D.K. Survey on the management of early cervical cancer among members of the GCIG. Int. J. Gynecol. Cancer. 2012; 22(9): 1617–1623. DOI:10.1097/IGC.0b013e31826fd66b.Lindsay R., Paul J., Siddiqui N., Davis J., Gaffney D.K. Survey on the management of early cervical cancer among members of the GCIG. Int. J. Gynecol. Cancer. 2012; 22(9): 1617–1623. DOI:10.1097/IGC.0b013e31826fd66b.Thomeer M.G., Gerestein C., Spronk S., van Doorn H.C., van der Ham E., Hunink M.G. Clinical examination versus magnetic resonance imaging in the pretreatment staging of cervical carcinoma: systematic review and metaanalysis. Eur. J. Radiol.2013; 23: 2005–2018. DOI:10.1007/s00330-013-2783-4.Thomeer M.G., Gerestein C., Spronk S., van Doorn H.C., van der Ham E., Hunink M.G. Clinical examination versus magnetic resonance imaging in the pretreatment staging of cervical carcinoma: systematic review and metaanalysis. Eur. J. Radiol.2013; 23: 2005–2018. DOI:10.1007/s00330-013-2783-4.Bourgioti C., Koutoulidis V., Chatoupis K., Rodolakis A., Koureas A., Thomakos N., Moulopoulos L.A. MRI findings before and after abdominal radical trachelectomy (ART) for cervical cancer: a prospective study and review of the literature. Clin. Radiol. 2014; 69: 678-686. DOI: 10.1016/j.crad.2014.02.001.Bourgioti C., Koutoulidis V., Chatoupis K., Rodolakis A., Koureas A., Thomakos N., Moulopoulos L.A. MRI findings before and after abdominal radical trachelectomy (ART) for cervical cancer: a prospective study and review of the literature. Clin. Radiol. 2014; 69: 678-686. DOI: 10.1016/j.crad.2014.02.001.Bourgioti C., Chatoupis K., Moulopoulos L.A. Current imaging strategies for the evaluation of uterine cervical cancer. Wld J. Radiol.2016; 8 (4): 342–354. DOI: 10.4329/wjr.v8.i4.342.Bourgioti C., Chatoupis K., Moulopoulos L.A. Current imaging strategies for the evaluation of uterine cervical cancer. Wld J. Radiol.2016; 8 (4): 342–354. DOI: 10.4329/wjr.v8.i4.342.Рубцова Н.А., Новикова Е.Г., Пузаков К.Б., Антипов В.А. Магнитно-ренозансная томография в диагностике рака шейки матки. Российский онкологический журнал. 2012; 2: 39–45.Rubtsova N.A., Novikova E.G., Puzakov K.B., Antipov V.A. Role of magnetic resonance imaging in the diagnosis of cancer of the cervix uteri. Rossiiskii onkologicheskii zhurnal.2012; 2: 39–45. (In Russian)Рубцова Н.А., Новикова Е.Г., Пузаков К.Б., Антипов В.А. Магнитно-ренозансная томография в диагностике рака шейки матки. Российский онкологический журнал. 2012; 2: 39–45.Rubtsova N.A., Novikova E.G., Puzakov K.B., Antipov V.A. Role of magnetic resonance imaging in the diagnosis of cancer of the cervix uteri. Rossiiskii onkologicheskii zhurnal.2012; 2: 39–45. (In Russian)Mitchell D.G., Snyder B., Coakley F., Reinhold C., Thomas G., Amendola M., Schwartz L.H., Woodward P., Pannu H., Hricak H. Early invasive cervical cancer: tumor delineation by magnetic resonance imaging, computed tomography, and clinical examination, verified by pathologic results, in the ACRIN 6651/GOG 183 Intergroup Study. J. Clin. Oncol. 2006; 24: 5687–5694. DOI: 10.1200/JCO.2006.07.4799.Mitchell D.G., Snyder B., Coakley F., Reinhold C., Thomas G., Amendola M., Schwartz L.H., Woodward P., Pannu H., Hricak H. Early invasive cervical cancer: tumor delineation by magnetic resonance imaging, computed tomography, and clinical examination, verified by pathologic results, in the ACRIN 6651/GOG 183 Intergroup Study. J. Clin. Oncol. 2006; 24: 5687–5694. DOI: 10.1200/JCO.2006.07.4799.Charles-Edwards E.M., Messiou C., Morgan V.A., De Silva S.S., McWhinney N.A., Katesmark M., Attygalle A.D., DeSouza N.M. Diffusion-weighted imaging in cervical cancer with an endovaginal technique: potential value for improving tumor detection in stage Ia and Ib1 disease. Radiology. 2008; 249: 541–550. DOI: 10.1148/radiol.2491072165.Charles-Edwards E.M., Messiou C., Morgan V.A., De Silva S.S., McWhinney N.A., Katesmark M., Attygalle A.D., DeSouza N.M. Diffusion-weighted imaging in cervical cancer with an endovaginal technique: potential value for improving tumor detection in stage Ia and Ib1 disease. Radiology. 2008; 249: 541–550. DOI: 10.1148/radiol.2491072165.Terminologia Anatomica. International anatomical terminology/Federative Committee on Anatomical Terminology (FCAT). Stuttgart/New York: Thieme, 1998. 300 p.Terminologia Anatomica. International anatomical terminology/Federative Committee on Anatomical Terminology (FCAT). Stuttgart/New York: Thieme, 1998. 300 p.Sala E., Wakely S., Senior E., Lomas D. MRI of Malignant Neoplasms of the Uterine Corpus and Cervix. Am. J.Sala E., Wakely S., Senior E., Lomas D. MRI of Malignant Neoplasms of the Uterine Corpus and Cervix. Am. J.Roentgenol.2007; 188 (6): 1577–1587. DOI: 10.2214/AJR.06.1196.Roentgenol.2007; 188 (6): 1577–1587. DOI: 10.2214/AJR.06.1196.Valentini A.L., Gui B., Micco M., Giuliani M., Rodolfino E., Ninivaggi V., Iacobucci M., Marino M., Gambacorta M.A., Testa A.C., Zannoni G.F., Bonomo L. MRI anatomy of parametrial extension to better identify local pathways of disease spread in cervical cancer. Diagn. Intervent. Radiol. 2016; 22: 319–325. DOI:10.5152/dir.2015.15282.Valentini A.L., Gui B., Micco M., Giuliani M., Rodolfino E., Ninivaggi V., Iacobucci M., Marino M., Gambacorta M.A., Testa A.C., Zannoni G.F., Bonomo L. MRI anatomy of parametrial extension to better identify local pathways of disease spread in cervical cancer. Diagn. Intervent. Radiol. 2016; 22: 319–325. DOI:10.5152/dir.2015.15282.Рубцова Н.А., Новикова Е.Г. Ошибки магнитно-резонансной томографии в диагностике рака шейки матки и эндометрия. Лучевая диагностика и терапия. 2013; 3: 71–76.Rubtsova N.A., Novikova E.G. Errors of magnetic resonance imaging in diagnostics of cervical and endometrial carcinoma. Luchevaia diagnostika i terapiya. 2013; 3: 71–76. (In Russian)Рубцова Н.А., Новикова Е.Г. Ошибки магнитно-резонансной томографии в диагностике рака шейки матки и эндометрия. Лучевая диагностика и терапия. 2013; 3: 71–76.Rubtsova N.A., Novikova E.G. Errors of magnetic resonance imaging in diagnostics of cervical and endometrial carcinoma. Luchevaia diagnostika i terapiya. 2013; 3: 71–76. (In Russian)Papadopoulou I., Stewart V., Barwick T.D., Park W.H., Soneji N., Rockall A.G., Bharwani N. Post-Radiation Therapy Imaging Appearances in Cervical Carcinoma. RadioGraphics. 2016; 36 (2): 538–553. DOI: 10.1148/rg.2016150117.Papadopoulou I., Stewart V., Barwick T.D., Park W.H., Soneji N., Rockall A.G., Bharwani N. Post-Radiation Therapy Imaging Appearances in Cervical Carcinoma. RadioGraphics. 2016; 36 (2): 538–553. DOI: 10.1148/rg.2016150117.Haie-Meder C., Pötter R., Van Limbergen E., Briot E., De Brabandere M., Dimopoulos J., Dumas I., Hellebust T.P., Kirisits C., Lang S., Muschitz S., Nevinson J., Nulens A., Petrow P., Wachter-Gerstner N.; Gynaecological (GYN) GEC-ESTRO Working Group. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group. Concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother. Oncol.2005; 74 (3): 235–245.Haie-Meder C., Pötter R., Van Limbergen E., Briot E., De Brabandere M., Dimopoulos J., Dumas I., Hellebust T.P., Kirisits C., Lang S., Muschitz S., Nevinson J., Nulens A., Petrow P., Wachter-Gerstner N.; Gynaecological (GYN) GEC-ESTRO Working Group. Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group. Concepts and terms in 3D image based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV. Radiother. Oncol.2005; 74 (3): 235–245.Viswanathan A.N., Thomadsen B.; American Brachytherapy Society Cervical Cancer Recommendations Committee; American Brachytherapy Society. American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. General principles. Brachytherapy. 2012; 11 (1): 33–46. DOI:10.1016/j.radonc.2004.12.015.Viswanathan A.N., Thomadsen B.; American Brachytherapy Society Cervical Cancer Recommendations Committee; American Brachytherapy Society. American Brachytherapy Society consensus guidelines for locally advanced carcinoma of the cervix. General principles. Brachytherapy. 2012; 11 (1): 33–46. DOI:10.1016/j.radonc.2004.12.015.Park J.J., Kim C.K., Park S.Y., Simonetti A.W., Kim E., Park B.K., Huh S.J. Assessment of early response to concurrent chemoradiotherapy in cervical cancer: value of diffusion-weighted and dynamic contrastenhanced MR imaging. Magn. Reson. Imaging. 2014; 32 (8): 993–1000. DOI: 10.1016/j.mri.2014.05.009.Park J.J., Kim C.K., Park S.Y., Simonetti A.W., Kim E., Park B.K., Huh S.J. Assessment of early response to concurrent chemoradiotherapy in cervical cancer: value of diffusion-weighted and dynamic contrastenhanced MR imaging. Magn. Reson. Imaging. 2014; 32 (8): 993–1000. DOI: 10.1016/j.mri.2014.05.009.Balleyguier C., Sala E., Da Cunha T., Bergman A , Brkljacic B., Danza F., Forstner R., Hamm B., KubikHuch R., Lopez C., Manfredi R., McHugo J., Oleaga L., Togashi K., Kinkel K. Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology. Eur. Radiol.2011; 21 (5): 1102–1110. DOI: 10.1007/s00330-010-1998-x .Balleyguier C., Sala E., Da Cunha T., Bergman A , Brkljacic B., Danza F., Forstner R., Hamm B., KubikHuch R., Lopez C., Manfredi R., McHugo J., Oleaga L., Togashi K., Kinkel K. Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology. Eur. Radiol.2011; 21 (5): 1102–1110. DOI: 10.1007/s00330-010-1998-x .

The authors declare that there are no conflicts of interest present.