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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medvis-362</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БРЮШНАЯ ПОЛОСТЬ И ЗАБРЮШИННОЕ ПРОСТРАНСТВО</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ABDOMEN AND RETROPERITONEAL</subject></subj-group></article-categories><title-group><article-title>Опыт применения эхоконтрастного препарата Соновью в дифференциальной диагностике опухолей почки. Часть 2</article-title><trans-title-group xml:lang="en"><trans-title>Experience of the use of Sonovyu Ultrasound Contrast Agents in Differential Diagnosis of Kidney Tumours. Part 2</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанова</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanova</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, старший научный сотрудник отела лучевых методов диагностики и лечения ФГБУ “Институт хирургии им. А.В. Вишневского” МЗ РФ; профессор кафедры лучевой диагностики ИПО ФГБОУ ВО Первый МГМУ им. И.М. Сеченова, Москва</p><p>117997 Москва, ул. Б. Серпуховская, 27. Отдел лучевых методов диагностики и лечения Института хирургии им. А.В. Вишневского. Тел.: 7-499-236-44-14</p></bio><bio xml:lang="en"><p>doct. of med. sci., the senior research of radiology methods of diagnostics and treatment department of A.V. Vishnevsky Institute of Surgery; professor of radiology department of IPE of I.M. Sechenov First Moscow state medical university, Moscow</p><p>117997 Moscow, Bol. Serpukhovskaya str., 27. A.V. Vishnevsky Institute of Surgery. Phone: +7-499-236-44-14</p></bio><email xlink:type="simple">stepanovaua@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимина</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Timina</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, заведующая отделением ультразвуковых методов диагностики и лечения ФГБУ “Институт хирургии им. А.В. Вишневского” МЗ РФ; профессор кафедры лучевой диагностики ИПО ФГБОУ ВО Первый МГМУ им. И.М. Сеченова, Москва</p></bio><bio xml:lang="en"><p>doct. of med. sci., Head of ultrasound diagnostics department of A.V. Vishnevsky Institute of Surgery; professor of radiology department of IPE of I.M. Sechenov First Moscow state medical university, Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Теплов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Teplov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, профессор, заместитель директора ФГБУ “Институт хирургии им. А.В. Вишневского” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>doct. of med. sci., professor, Deputy Director of A.V. Vishnevsky Institute of Surgery, Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чехоева</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chekhoyeva</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник отделения ультразвуковых методов диагностики и лечения ФГБУ “Институт хирургии им. А.В. Вишневского” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>junior researcher of ultrasound diagnostics department of A.V. Vishnevsky Institute of Surgery, Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры лучевой диагностики ИПО ФГБОУ ВО Первый МГМУ им. И.М. Сеченова, Москва</p></bio><bio xml:lang="en"><p>postgraduate student of radiology department of IPE of I.M. Sechenov First Moscow state medical university, Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грицкевич</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gritskevich</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, старший научный сотрудник отделения урологии ФГБУ “Институт хирургии им. А.В. Вишневского” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>cand. of med. sci., the senior research of the Urology department of A.V. Vishnevsky Institute of Surgery, Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пьяникин</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pyanikin</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник отделения урологии ФГБУ “Институт хирургии им. А.В. Вишневского” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>junior researcher of the Urology department of A.V. Vishnevsky Institute of Surgery, Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калинин</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalinin</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, заведующий отделением патологической анатомии ФГБУ “Институт хирургии им. А.В. Вишневского” МЗ РФ, Москва</p></bio><bio xml:lang="en"><p>cand. of med. sci., Head of Pathology Department of A.V. Vishnevsky Institute of Surgery, Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Институт хирургии им. А.В. Вишневского” Минздрава России&#13;
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ФГБОУ ВО Первый МГМУ им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky Institute of Surgery&#13;
&#13;
I.M. Sechenov First Moscow state medical university</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ “Институт хирургии им. А.В. Вишневского” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky Institute of Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО Первый МГМУ им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow state medical university</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>6</issue><fpage>69</fpage><lpage>83</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Степанова Ю.А., Тимина И.Е., Теплов А.А., Чехоева О.А., Морозова М.В., Грицкевич А.А., Пьяникин С.С., Калинин Д.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Степанова Ю.А., Тимина И.Е., Теплов А.А., Чехоева О.А., Морозова М.В., Грицкевич А.А., Пьяникин С.С., Калинин Д.В.</copyright-holder><copyright-holder xml:lang="en">Stepanova Y.A., Timina I.E., Teplov A.A., Chekhoyeva O.A., Morozova M.V., Gritskevich A.A., Pyanikin S.S., Kalinin D.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/362">https://medvis.rdsmedia.ru/jour/article/view/362</self-uri><abstract><p>В настоящее время в мире накоплен достаточный опыт дифференциальной диагностики очаговых образований почек по данным ультразвукового контрастного исследования, однако только собственный опыт применения данного препарата дает возможность накопления соответствующих знаний и навыков.</p><sec><title>Цель исследования</title><p>Цель исследования: оценить возможности применения контрастного препарата Соновью (SonoVue) для дифференциальной ультразвуковой диагностики очаговых образований почек и сопоставить полученные данные с результатами морфологического исследования.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В период с марта 2015 г. по сентябрь 2016 г. в Институте хирургии им. А.В. Вишневского были обследованы и прошли хирургическое лечение 47 пациентов с очаговыми образованиями почек. В исследование вошло 27 (57,4%) мужчин и 20 (42,6%) женщин в возрасте от 19 до 66 лет. Всем больным выполняли ультразвуковое исследование (УЗИ) в В-режиме, в режиме дуплексного сканирования, при необходимости выполняли трехмерную реконструкцию ультразвукового изображения, а также выполняли исследование с контрастным усилением препаратом Соновью (SonoVue). Все образования морфологически верифицировали: светлоклеточный рак – 34 (72,4%); папиллярный рак – 5 (10,6%); хромофобный рак – 1 (2,1%); юкстагломерулярная опухоль – 1 (2,1%); онкоцитома – 1 (2,1%); аденома – 2 (4,3%); хронический воспалительный инфильтрат – 1 (2,1%); киста – 2 (4,3%). Считаем целесообразным отдельно осветить вопросы диагностики светлоклеточного рака и редких форм опухолей почки.</p></sec><sec><title>Результаты</title><p>Результаты. Часть 2. Представлены наблюдения УЗИ с контрастным усилением редких морфологических форм доброкачественных и злока чественных опухолей почки в сопоставлении с результатами морфоло гических исследований, которые позволяют более детально изучить характер кровоснабжения опухолей, что дает возможность их дифференциации. Целесообразны дальнейшее накопление материала и анализ большего массива данных для выработки собст венной позиции относительно возможностей верификации редких опухолей почки по данным УЗИ с контрастным усилением.</p></sec><sec><title>Заключение</title><p>Заключение. УЗИ с конт растным усилением относительно недорого, не несет лучевой нагрузки на пациента и не является нефротоксичным, вследствие чего его целесообразно включить в протокол обследования пациентов с подозрением на рак почки.</p></sec></abstract><trans-abstract xml:lang="en"><p>Sufficient experience of differential diagnostics of focal renal lesions according to contrast-enhanced ultrasound is accumulated in the world now, however, only the own experience of use of this agent gives the chance of accumulation of the corresponding knowledge and skills.</p><sec><title>Objective</title><p>Objective: to estimate the possibilities of SonoVue contrast agent for differential ultrasonic diagnostics of focal renal lesions and to compare the obtained data with results of morphology.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. During the period from March, 2015 to September, 2016 at A.V. Institute of surgery 47 patient with focal renal lesdions have been surveyed and were operated on. There were 27 (57.4%) men and 20 (42.6%) women aged from 19 up to 66 years. All patient carried out ultrasonography in B-mode, duplex scanning, three-dimensional reconstruction of the ultrasonic image, and contrast-enhanced research with SonoVue agent was carried out also. All neoplasms were morphologically verified: clear cell carcinoma – 34 (72.4%); papillary cancer – 5 (10.6%); chromophobe cancer – 1 (2.1%); juxtaglomerular cell tumor – 1 (2.1%); oncocytoma – 1 (2.1%); adenoma – 2 (4.3%); chronic inflammatory infiltrate – 1 (2.1%); a cyst – 2 (4.3%). We consider to take up expedient separately questions of diagnosis of light-cellular cancer and rare forms of kidney and cellular cancer.</p></sec><sec><title>Results</title><p>Results. Part 2. Observations of US with contrastenhanced of rare morphological forms of benign and malignant renal tumors of in comparison to results of morphological researches are presented. It allows to study the nature of tumors bloodsupply in more detail, that gives the chance to provide their differentiation. Further accumulating of material and the analysis of bigger data array for development of own line item concerning opportunities of verification of rare renal tumors according to US with contrastenhanced are reasonably.</p></sec><sec><title>Conclusion</title><p>Conclusion. Contrast-enhanced ultrasonography with SonoVue agent is rather cheap, doesn't bear beam load of the patient and isn't nephrotoxic owing to what it is expedient to include it in the protocol of inspection of patients with suspicion of renal cancer.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>очаговые образования почек</kwd><kwd>ультразвуковое исследование с контрастным препаратом</kwd><kwd>дифференциальная диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>focal renal lesions</kwd><kwd>contrast-enhanced ultrasound</kwd><kwd>differential diagnostics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ignee A., Straub B., Schuessler G. et al. Contrast enhanced ultrasound of renal masses. Wld J. Radiol. 2010; 2: 15–31.</mixed-citation><mixed-citation xml:lang="en">Ignee A., Straub B., Schuessler G. et al. Contrast enhanced ultrasound of renal masses. Wld J. 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