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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medvis-338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКУШЕРСТВО И ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBSTETRICS AND GYNECOLOGY</subject></subj-group></article-categories><title-group><article-title>Особенности трофобластического кровотока у беременных на сроке с 7-й по 10-ю неделю с тромбофилией сложного генеза</article-title><trans-title-group xml:lang="en"><trans-title>Features of Trophoblastic Blood Flow in Pregnant Women in the Period from 7th to 10th Week of Thrombophilia Complex Origin</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Астафьева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Astafieva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, профессор кафедры лучевой диагностики,</p><p>350063 г. Краснодар, ул. Седина, д. 4</p></bio><bio xml:lang="en"><p>doct. of med. sci., professor at the Department of Radiology,</p><p>350063, Krasnodar, Sedina str., 4</p></bio><email xlink:type="simple">olga-astafeva2@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Асриянц</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Asriyants</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры лучевой диагностики,</p><p>г. Краснодар</p></bio><bio xml:lang="en"><p>graduate student at the Department of Radiology,</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО “Кубанский государственный медицинский университет” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University of the Ministry of Health Care of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2016</year></pub-date><volume>0</volume><issue>5</issue><fpage>114</fpage><lpage>119</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Астафьева О.В., Асриянц М.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Астафьева О.В., Асриянц М.А.</copyright-holder><copyright-holder xml:lang="en">Astafieva O.V., Asriyants M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/338">https://medvis.rdsmedia.ru/jour/article/view/338</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: выявить особенности трофобластического кровотока у беременных с тромбофилией в I триместре беременности по данным допплерометрии.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведено ультразвуковое исследование с применением метода допплерометрии и определением показателей кровотока в сосудах трофобласта у 80 беременных женщин в возрасте от 18 до 40 лет на сроке беременности с 7-й по 10-ю неделю. По данным ЦДК выделено 4 типа трофобластического кровотока у беременных на этом сроке. По данным импульсноволновой допплерометрии выделено 2 типа трофобластического кровотока.</p></sec><sec><title>Результаты</title><p>Результаты. У беременных с показателями высокорезистентного типа кровотока, а также с отсутствием локусов трофобластического кровотока отмечали высокую корреляцию показателей индекса резистентности в сосудах трофобласта с показателями анализа крови системы гемостаза. Проанализировано течение беременностей до конца I триместра. Было определено, что высокорезистентный тип, а также отсутствие локусов трофобластического кровотока являются прогностически неблагоприятным УЗ-признаком, а низкорезистентный кровоток – прогностически благоприятный УЗ-признак, процент благополучно протекающих беременностей у беременных с низкорезистентным трофобластическим кровотоком в 2 раза выше, чем в группе с высокорезистентным типом и отсутствием локусов трофобластического кровотока. Показана высокая специфичность и чувствительность допплерометрического исследования трофобластического кровотока.</p></sec><sec><title>Выводы</title><p>Выводы. Использование предложенного метода позволяет выявить группу риска для прогнозирования самопроизвольного выкидыша и замершей беременности в I триместре и своевременно назначить антикоагулянтную терапию. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To identify the features of trophoblastic blood flow in pregnant women with thrombophilia in the first trimester of pregnancy, according to doppler velocimetry.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. It was made ultrasound doppler velocimetry and the determination of parameters of blood flow in the vessels of the trophoblast in 80 pregnant women aged between 18 and 40 years on the stage of pregnancy from 7 th to 10 th weeks of gestation. According to the doppler velocimetry it was allocated 4 types of trophoblastic blood flow in pregnant women in this period. According to the pulse – wave doppler highlighted type 2 trophoblastic blood flow.</p></sec><sec><title>Results</title><p>Results. In pregnant women with indicators of highly resistant type of blood flow, as well as a lack of locus trophoblastic blood flow there is a high correlation between the resistance index in the vessels of the trophoblast with indicators of blood hemostasis analysis system. The course of pregnancy until the end of the first trimester. It was determined that: highly resistant type, as well as the absence of loci trophoblastic blood flow is poor prognostic ultrasound feature and lowe resistant blood flow – prognostically favorable US-sign percentage safely occurring pregnancies in women with lowe resistant trophoblastic blood flow in the two times higher than in the group with highly resistant type loci and absence trophoblastic circulation. It was show the high specificity and sensitivity of the doppler velocimetry study trophoblastic blood flow.</p></sec><sec><title>Conclusions</title><p>Conclusions. Using the proposed method allows to reveal risk to predict spontaneous abortion and missed abortion in the first trimester and assign anticoagulant therapy in a timely manner.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трофобласт</kwd><kwd>невынашивание</kwd><kwd>тромбофилия</kwd><kwd>допплерометрия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>trophoblast</kwd><kwd>miscarriage</kwd><kwd>thrombophilia</kwd><kwd>doppler velocimetry</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Озолиня Л.А., Лапина И.А., Нестерова А.О. Тромбофилия в акушерстве и гинекологии (обзор литературы). Вестник российского государственного медицинского университета. 2014; 4: 80–85.</mixed-citation><mixed-citation xml:lang="en">Ozolinja L.A., Lapin I.A., Nesterova S.A. Thrombophilia in obstetrics and gynecology (review). 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