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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medvis-336</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БРЮШНАЯ ПОЛОСТЬ И ЗАБРЮШИННОЕ ПРОСТРАНСТВО</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ABDOMEN AND RETROPERITONEAL</subject></subj-group></article-categories><title-group><article-title>Опыт применения эхоконтрастного препарата Соновью в дифференциальной диагностике опухолей почки. Часть 1</article-title><trans-title-group xml:lang="en"><trans-title>Experience of the use of Sonovyu Ultrasound Contrast Agents in Differential Diagnosis of Kidney Tumours. Part 1</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанова</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanova</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, старший научный сотрудник отдела лучевых методов диагностики и лечения, 117997 Москва, ул. Бол. Серпуховская, 27;</p><p>профессор кафедры лучевой диагностики ИПО</p></bio><bio xml:lang="en"><p>doct. of med. sci., the senior research of radiology methods of diagnostics and treatment department, 117997, Moscow, Bol. Serpukhovskaya str., 27;</p><p>professor of radiology department of IPE</p></bio><email xlink:type="simple">stepanovaua@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимина</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Timina</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, заведующая отделением ультразвуковых методов диагностики и лечения;</p><p>профессор кафедры лучевой диагностики ИПО,</p><p>Москва</p></bio><bio xml:lang="en"><p>doct. of med. sci., Head of ultrasound diagnostics department;</p><p>professor of radiology department of IPE,</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Теплов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Teplov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, профессор, заместитель директора,</p><p>Москва</p></bio><bio xml:lang="en"><p>doct. of med. sci., professor, Deputy Director,</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чехоева</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chekhoyeva</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник отделения ультразвуковых методов диагностики и лечения,</p><p>Москва</p></bio><bio xml:lang="en"><p>junior researcher of ultrasound diagnostics department,</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры лучевой диагностики ИПО,</p><p>Москва</p></bio><bio xml:lang="en"><p>postgraduate student of radiology department of IPE,</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грицкевич</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gritskevich</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, старший научный сотрудник отделения урологии,</p><p>Москва</p></bio><bio xml:lang="en"><p>cand. of med. sci., the senior research of the Urology department,</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пьяникин</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pyanikin</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник отделения урологии,</p><p>Москва</p></bio><bio xml:lang="en"><p>junior researcher of the Urology department,</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калинин</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalinin</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, заведующий отделением патологической анатомии,</p><p>Москва</p></bio><bio xml:lang="en"><p>cand. of med. sci., Head of Pathology Department,</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Институт хирургии им. А.В. Вишневского” Минздрава России;&#13;
ФГБОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky Institute of Surgery;&#13;
I.M. Sechenov First Moscow state medical university</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ “Институт хирургии им. А.В. Вишневского” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky Institute of Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow state medical university</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2016</year></pub-date><volume>0</volume><issue>5</issue><fpage>97</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Степанова Ю.А., Тимина И.Е., Теплов А.А., Чехоева О.А., Морозова М.В., Грицкевич А.А., Пьяникин С.С., Калинин Д.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Степанова Ю.А., Тимина И.Е., Теплов А.А., Чехоева О.А., Морозова М.В., Грицкевич А.А., Пьяникин С.С., Калинин Д.В.</copyright-holder><copyright-holder xml:lang="en">Stepanova Y.A., Timina I.E., Teplov A.A., Chekhoyeva O.A., Morozova M.V., Gritskevich A.A., Pyanikin S.S., Kalinin D.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/336">https://medvis.rdsmedia.ru/jour/article/view/336</self-uri><abstract><p>В настоящее время в мире накоплен достаточный опыт дифференциальной диагностики очаговых образований почек по данным ультразвукового контрастного исследования, однако только собственный опыт применения данного препарата дает возможность накопления соответствующих знаний и навыков.</p><sec><title>Цель исследования</title><p>Цель исследования: оценить возможности применения контрастного препарата Соновью (SonoVue) для дифференциальной ультразвуковой диагностики очаговых образований почек и сопоставить полученные данные с результатами морфологического исследования.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В период с марта 2015 г. по сентябрь 2016 г. в Институте хирургии были обследованы и прошли хирургическое лечение 47 пациентов с очаговыми образованиями почек. В исследование вошло 27 (57,4%) мужчин и 20 (42,6%) женщин в возрасте от 19 до 66 лет. Всем больным выполняли ультразвуковое исследование в В-режиме, в режиме дуплексного сканирования, при необходимости выполняли трехмерную реконструкцию ультразвукового изображения, а также выполняли исследование с контрастным усилением препаратом Соновью (SonoVue). Все образования морфологически верифицировали: светлоклеточный рак – 34 (72,4%); папиллярный рак – 4 (8,5%); хромофобный рак – 1 (2,1%); юкстагломерулярная опухоль – 1 (2,1%); онкоцитома – 1 (2,1%); нейрогенная опухоль – 1 (2,1%); аденома – 2 (4,3%); хронический воспалительный инфильтрат – 1 (2,1%); киста – 2 (4,3%). Считаем целесообразным отдельно осветить вопросы диагностики светлоклеточного рака и редких форм почечно-клеточного рака.</p></sec><sec><title>Результаты</title><p>Результаты. Часть 1. Оценка возможностей контрастного препарата Соновью при дифференциальной диагностике светлоклеточного рака почки. Ультразвуковое исследование в В-режиме, режимах дуплексного сканирования и трехмерной реконструкции не всегда позволяет получить четкую информацию о локализации опухоли почки, а также о характере очагового образования, поэтому применяли исследование с введением контрастного препарата Соновью. Чувствительность, специфичность и точность эхоконтрастного исследования при диагностике светлоклеточного рака почки составили 92, 100, 92% соответственно.</p></sec><sec><title>Заключение</title><p>Заключение. Ультразвуковое исследование с контрастным усилением относительно недорого, не несет лучевую нагрузку на пациента и не является нефротоксичным, вследствие чего его целесообразно включить в протокол обследования пациентов с подозрением на рак почки.</p></sec></abstract><trans-abstract xml:lang="en"><p>Sufficient experience of differential diagnostics of focal renal lesions according to contrast-enhanced ultrasound is accumulated in the world now, however, only the own experience of use of this agent gives the chance of accumulation of the corresponding knowledge and skills.</p><sec><title>Objective</title><p>Objective: to estimate the possibilities of SonoVue contrast agent for differential ultrasonic diagnostics of focal renal lesions and to compare the obtained data with results of morphology.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. During the period from March, 2015 to September, 2016 at A.V. Vishnevsky Institute of surgery 47 patient with focal renal lesdions have been surveyed and were operated on. There were 27 (57.4%) men and 20 (42.6%) women aged from 19 up to 66 years. All patient carried out ultrasonography in B-mode, duplex scanning, threedimensional reconstruction of the ultrasonic image, and contrast-enhanced research with SonoVue agent was carried out also. All neoplasms were morphologically verified: clear cell carcinoma – 34 (72.4%); papillary cancer – 4 (8.5%); chromophobe cancer – 1 (2.1%); juxtaglomerular cell tumor – 1 (2.1%); oncocytoma – 1 (2.1%); neurogenic tumor – 1 (2.1%); adenoma – 2 (4.3%); chronic inflammatory infiltrate – 1 (2.1%); a cyst – 2 (4.3%). We consider to take up expedient separately questions of diagnosis of lightcellular cancer and rare forms of kidney and cellular cancer.</p></sec><sec><title>Results</title><p>Results. Part 1. Assessment of opportunities of SonoVue contrast agent at differential diagnosis of renal clear cell carcinoma. Ultrasonography in the B-mode, duplex scanning, three-dimensional reconstruction, doesn’t always allow to obtain accurate information on localization of renal tumor, and the nature of the lesion, therefore contrastenhanced ultrasonography with SonoVue agent was applied. Sensitivity, specificity and accuracy of сontrast-enhanced ultrasonography at diagnosis of renal clear cell carcinoma were 92%, 100%, 92%, respectively.</p></sec><sec><title>Conclusion</title><p>Conclusion. Contrast-enhanced ultrasonography with SonoVue agent is rather cheap, doesn't bear beam load of the patient and isn't nephrotoxic owing to what it is expedient to include it in the protocol of inspection of patients with suspicion of renal cancer.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>очаговые образования почек</kwd><kwd>ультразвуковое исследование с контрастным препаратом</kwd><kwd>дифференциальная диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>focal renal lesions</kwd><kwd>contrast-enhanced ultrasound</kwd><kwd>differential diagnostics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Фомина С.В., Завадовская В.Д., Юсубов М.С. и др. Контрастные препараты для ультразвукового исследования. Бюллетень сибирской медицины. 2011; 6: 137–142.</mixed-citation><mixed-citation xml:lang="en">Фомина С.В., Завадовская В.Д., Юсубов М.С. и др. 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