medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.medvis-326Research ArticleГОЛОВА И ШЕЯHEAD AND NECKДиффузионно-куртозисная МРТ в оценке Ki-67/MIB-1 LI глиальных опухолейDiffusionkurtosis MRI in assesment of Ki-67/MIB-1 LI in GliomasПронинИ. Н.ProninI. N.

академик РАН, заведующий отделением рентгеновских и радиоизотопных методов диагностики, заместитель директора,

Москва

academician of the Russian Academy of Sciences, Deputy Director,

Moscow

ТоноянА. С.TonoyanA. S.

младший научный сотрудник отделения рентгеновских и радиоизотопных методов диагностики,

Москва

neuroradiologist of the Department of Neuroradiology,

Moscow

ШульцЕ. И.ShultsE. I.

врач-рентгенолог отделения рентгеновских и радиоизотопных методов диагностики,

125047 Москва, ул. 4-я Тверская-Ямская, д. 16

neuroradiologist of the Department of Neuroradiology,

125047 Moscow, 4-ya Tverskaya-Yamskaya str., 16

eshults@nsi.ruФадееваЛ. М.FadeevaL. M.

ведущий инженер отделения рентгеновских и радиоизотопных методов диагностики,

Москва

engineer of the Department of Neuroradiology,

Moscow

ЗахароваН. Е.ZakharovaN. E.

доктор мед. наук, ведущий научный сотрудник отделения рентгеновских и радиоизотопных методов диагностики,

Москва

doct. of med. sci., Leading Research Fellow of the Department of Neuroradiology,

Moscow

ГоряйновС. А.GoryainovS. A.

канд. мед. наук, научный сотрудник отделения нейроонкологии,

Москва

cand. of med. sci., Neurosurgeon of the Department of Neurooncology,

Moscow

БыкановА. Е.BykanovA. E.

канд. мед. наук, младший научный сотрудник отделения нейроонкологии,

Москва

cand. of med. sci., Neurosurgeon of the Department of Neurooncology,

Moscow

ПицхелауриД. И.PitskhelauriD. I.

доктор мед. наук, профессор, заведующий отделением нейроонкологии,

Москва

professor, Head of Neurooncology Department,

Moscow

ПотаповА. А.PotapovA. A.

доктор мед. наук, профессор, академик РАН, директор,

Москва

Full Мember of the Russian Academy of Sciences, Director,

Moscow

ФГАУ “Научно-исследовательский институт нейрохирургии им. акад. Н.Н. Бурденко” Минздрава РоссииРоссияN.N. Burdenko Neurosurgery InstituteRussian Federation20162810201605617Copyright © Пронин И.Н., Тоноян А.С., Шульц Е.И., Фадеева Л.М., Захарова Н.Е., Горяйнов С.А., Быканов А.Е., Пицхелаури Д.И., Потапов А.А., 20162016Пронин И.Н., Тоноян А.С., Шульц Е.И., Фадеева Л.М., Захарова Н.Е., Горяйнов С.А., Быканов А.Е., Пицхелаури Д.И., Потапов А.А.Pronin I.N., Tonoyan A.S., Shults E.I., Fadeeva L.M., Zakharova N.E., Goryainov S.A., Bykanov A.E., Pitskhelauri D.I., Potapov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/326Цель исследования

Цель исследования: оценить корреляцию Ki-67/ MIB-1 LI и степень злокачественности глиом головного мозга с параметрами диффузионно-куртозисной МРТ (ДК-МРТ) в опухоли.

Материал и методы

Материал и методы. В исследование включено 84 пациента с супратенториальными глиомами головного мозга (35 глиом низкой, 20 глиом III и 29 глиом IV степени злокачественности). Оценена корреляционная связь абсолютных и нормализованных параметров диффузионного тензора (средняя, аксиальная и радиальная диффузия (MD, AD, RD), фракционной и относительной анизотропии (FA и RA)), диффузион ного куртозиса (средний, аксиальный и радиальный куртозис (MK, AK, RK), куртозисной анизотропии (KA)) с Ki-67/MIB-1 LI и степенью злокачественности глиом в их наиболее злока чественных участках (p < 0,05, коэффициент Спирмена).

Результаты

Результаты. Параметры ДК-МРТ показали статистически значимую корреляцию с Ki-67/MIB-1 LI и степенью злокачественности глиом. Наличие олигодендроглиального компонента в глиомах (в олигодендроглиомах (ОлДГ) и олигоастроцитомах (ОлАСЦ)) не повлияло на корреляцию параметров ДК-МРТ с Ki-67/MIB-1 LI, однако повлияло на корреляцию параметров ДК-МРТ со степенью злокачественности глиом. При изучении корреляции параметров ДК-МРТ с Ki-67/MIB-1 LI у глиом grade IV максимальная корреляция была найдена у нормализованной куртозисной анизотропии.

Заключение

Заключение. ДК-МРТ показала высокую чувствительность в выявлении структурных изменений в глиомах, которые наблюдаются при изменении степени злокачественности и Ki-67/MIB-1 LI опухоли. Параметры ДК-МРТ зависят от степени злокачественностии Ki-67/ MIB-1 LI глиом. Наличие олигодендроглиального компонента в глиомах не влияет на корреляцию параметров ДК-МРТ с Ki-67/MIB-1 LI, однако влияет на корреляцию параметров ДК-МРТ со степенью злокачественности глиом. Комплексный анализ параметров ДК-МРТ в глиомах с учетом степени злокачественности, Ki-67/MIB-1 LI и наличия олигодендроглиального компонента в опухоли, проведенный в нашей работе, позволил углубленно изучить параметры ДК-МРТ при различных патологических процессах, развивающихся в опухоли.

Purpose

Purpose: to assess correlation between Ki-67/MIB-1 LI and WHO grade brain gliomas and parameters of diffusion kurtosis MRI (DK-MRI) in the tumor.

Patients and methods

Patients and methods. The study includes 84 patients with supratentorial brain gliomas (35 gliomas with low grade malignancy, 20 gliomas with the 3-rd grade and 29 gliomas with the 4-th grade of malignancy). The study appraised correlation links between absolute and normalized parameters of diffusion tensor (mean, axial and radial (MD, AD, RD), fractional and relative anisotropy (FA and RA) and diffusion kurtosis (mean, axial and radial (MK, AK, RK), kurtosis anisotropy (KA)) with Ki-67/MIB-1 LI and WHO glioma grade in the most malignant regions (p < 0.05, Spirman coefficient).

Results

Results. DK-MRI parameters showed statistically significant correlation with Ki-67/MIB-1 LI and WHO glioma grades. Presence of oligodendroglioma (ODG) component in gliomas and oligoastrocytomas (OASs) did not affect the correlation between DK-MRI parameters and Ki-67/MIB-1 LI. However it affected correlation between DK-MRI parameters and WHO glioma grades. When studying correlation between parameters of DK-MRI and Ki-67/MIB-1 LI in IV grade gliomas maximum correlation was detected in case of normalised kurtosis anisotropy (KA).

Conclusion

Conclusion. DK-MRI proved high sensitivity in detecting structural changes in gliomas, which are observed when WHO grade and Ki-67/MIB-1 LI tumors change. DK-MRI parameters depend on WHO grade and Ki-67/MIB-1 LI gliomas. Presence of oligodendroglioma component in gliomas does not affect the correlation between DK-MRI parameters and Ki-67/MIB-1 LI, but affect the correlation between DK-MRI parameters and WHO glioma grade. Complex analysis of DK-MRI parameters in gliomas with due account for WHO glioma grade, Ki-67/MIB-1 LI and presence of oligodendroglioma component in the tumor carried out in our study made it possible to study in depth the dynamics of DK-MRI parameters during various pathological processes developing in the tumor.

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The authors declare that there are no conflicts of interest present.