medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.medvis-246Research ArticleБРЮШНАЯ ПОЛОСТЬ И ЗАБРЮШИННОЕ ПРОСТРАНСТВОABDOMEN AND RETROPERITONEALКонтрастная МРТ с эффектом переноса намагниченности при исследовании метастатического поражения печениContrast-Enhanced MRI with Magnetization Transfer Effect in the Imaging of Liver Metastatic LesionsБородинОлег ЮрьевичBorodinOleg Yurievichoyborodin@yandex.ruЕрмаковаАнастасия АлександровнаErmakovaAnastasiya Aleksandrovnanoemail@neicon.ruСенькоАнна АндреевнаSenkoAnna Andreevnanoemail@neicon.ruСанниковМаксим ЮрьевичSannikovMaksim Yurievichnoemail@neicon.ruОГАУЗ “Томский областной онкологический диспансер”; ГБОУ ВПО “Сибирский государственный медицинский университет” Минздрава РоссииРоссияTomsk Regional Oncology Center; Siberian State Medical UniversityRussian FederationГБОУ ВПО “Сибирский государственный медицинский университет” Минздрава РоссииРоссияSiberian State Medical UniversityRussian FederationОГАУЗ “Томский областной онкологический диспансер”РоссияTomsk Regional Oncology CenterRussian Federation201628022016015462Copyright © Бородин О.Ю., Ермакова А.А., Сенько А.А., Санников М.Ю., 20162016Бородин О.Ю., Ермакова А.А., Сенько А.А., Санников М.Ю.Borodin O.Y., Ermakova A.A., Senko A.A., Sannikov M.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/246

Цель исследования: разработка оптимальной импульсной последовательности с использованием эффекта переноса намагниченности для выявления метастазов в печени малых размеров (до 1 см). Материал и методы. Пилотные испытания проведены с использованием жиро- и контрастсодержащих фантомов, сканированных со смещением резонансной частоты в диапазоне от -1200 до +1200 Гц и отклонением угла от 0 до 800°. Клинические исследования брюшной полости (n = 13) выполнены в режимах T1-FatSat field-echo (FE) и Т1-turbo-spin-echo (TSE) Magnetization Transfer Contrast (МТС) у пациентов с метастатическим очаговым поражением печени (n = 103). Результаты. Была разработана импульсная последовательность Т1-TSE-MTC с параметрами импульса: Offset Frequency = -210 Гц и FA = 600°. При клиническом испытании протокола с Т1 TSE MTC показано значимое увеличение отношения контраст/шум (p < 0,001) и коэффициента усиления (р < 0,05) между очаговыми изменениями и размером (n = 103) и окружающей тканью печени в сравнении с протоколом T1-FE-FatSat и преимущественно за счет лучшей визуализации очагов до 1 см. Выявлено значимое (р < 0,02) повышение показателей чувствительности при использовании Т1-TSE-MTC. Выводы. Использование Т1-взвешенных изображений с использованием импульсной последовательности Т1-TSE с эффектом переноса намагниченности повышает контрастность и интенсивность контрастирования очаговых метастатических поражений печени.

Purpose: to develop optimal pulse sequence with magnetization transfer effect to detect metastases smaller than 1 cm diameter in the liver. Materials and Methods. Pilot tests were carried out using fat containing and contrast containing phantoms, which were scanned with the offset resonance frequency in the range from -1200 Hz to +1200 Hz and the flip angle from 0 to 800. Clinical studies (n = 13) of hepatoduodenal area were carried out with patients who have metastatic focal liver lesions (n = 103) in the T1-FatSat field-echo (T1-FE-FatSat) mode and in T1-turbo-spin-echo mod with Magnetization Transfer Contrast (T1-TSE-MTC) mode. Results. It was developed pulse sequence T1-TSE-MTC with parameters: offset frequency = -210 Hz and flip angle = 600. Using the protocol with T1-TSE-MTC, a significant increase of Contrast to Noise ratio (CNR) (p < 0.001) and contrast ratio (p < 0.05) between the focal changes up to 1 cm (n = 103) and the surrounding tissue of the liver has been shown as compared to the protocol T1-FE and predominantly due to better visualization of foci of up to 1 cm. A significant (p < 0.02) increase in sensitivity using T1-TSE MTC was also revealed. Conclusion. The use of T1-weighted images using the pulse sequence T1-TSE with the effect of the magnetization transfer increases the contrast and intensity of foci of liver metastatic lesions.

МРТперенос намагниченностиконтрастностьпоражения печениметастазыMRImagnetization transfercontrastliver lesionsmetastasesReferencesCoenegrachts K. Magnetic resonance imaging of the liver: New imaging strategies for evaluating focal liver lesions. Wld J. Radiol. 2009; 1 (1): 72-85.Coenegrachts K. Magnetic resonance imaging of the liver: New imaging strategies for evaluating focal liver lesions. Wld J. Radiol. 2009; 1 (1): 72-85.Alzahrani N., Ung L., Valle S.J. et al. Synchronous Liver Resection with Cytoreductive Surgery for the Treatment of Liver and Peritoneal Metastases from Colon Cancer: Results from an Australian Centre. J. Gastrointest. Dig. Syst. 2015; 5: 264.Alzahrani N., Ung L., Valle S.J. et al. Synchronous Liver Resection with Cytoreductive Surgery for the Treatment of Liver and Peritoneal Metastases from Colon Cancer: Results from an Australian Centre. J. Gastrointest. Dig. Syst. 2015; 5: 264.Xue S., Qiao J., Pu F. et al. Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2013; 5 (2): 163-179.Xue S., Qiao J., Pu F. et al. Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2013; 5 (2): 163-179.Pedrassa B.C., da Rocha E.L., Kierszenbaum M.L. et al. Uncommon hepatic tumors: iconographic essay-Part 1. Radiologia Brasileira. 2014; 47 (5): 310-316.Pedrassa B.C., da Rocha E.L., Kierszenbaum M.L. et al. Uncommon hepatic tumors: iconographic essay-Part 1. Radiologia Brasileira. 2014; 47 (5): 310-316.Cyran C.C., Sennino B., Fu Y., Rogut V. et al. Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF). Eur. J. Radiol. 2012; 81 (5): 891-896.Cyran C.C., Sennino B., Fu Y., Rogut V. et al. Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF). Eur. J. Radiol. 2012; 81 (5): 891-896.Cyran C.C., Schwarz B., Paprottka P.M. et al. In vivo monitoring of sorafenib therapy effects on experimental prostate carcinomas using dynamic contrast-enhanced MRI and macromolecular contrast media. Cancer Imaging. 2013; 13 (4): 557.Cyran C.C., Schwarz B., Paprottka P.M. et al. In vivo monitoring of sorafenib therapy effects on experimental prostate carcinomas using dynamic contrast-enhanced MRI and macromolecular contrast media. Cancer Imaging. 2013; 13 (4): 557.Cyran C.C., Fu Y., Rogut V. et al. Evaluation of a Novel Macromolecular Cascade-Polymer Contrast Medium for Dynamic Contrast-Enhanced MRI Monitoring of Anti- angiogenic Bevacizumab Therapy in a Human Melanoma Model. Acad. Radiol. 2013; 20 (10): 1256-1263.Cyran C.C., Fu Y., Rogut V. et al. Evaluation of a Novel Macromolecular Cascade-Polymer Contrast Medium for Dynamic Contrast-Enhanced MRI Monitoring of Anti- angiogenic Bevacizumab Therapy in a Human Melanoma Model. Acad. Radiol. 2013; 20 (10): 1256-1263.Wolff S. D., Balaban R. S. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn. Resonance Med. 1989; 10 (1): 135-144.Wolff S. D., Balaban R. S. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn. Resonance Med. 1989; 10 (1): 135-144.Losseff N.A., Wang L., Lai H.M. et al. Progressive cerebral atrophy in multiple sclerosis: a serial MRI study. Brain. 1996; 119 (6): 2009-2019.Losseff N.A., Wang L., Lai H.M. et al. Progressive cerebral atrophy in multiple sclerosis: a serial MRI study. Brain. 1996; 119 (6): 2009-2019.Shimizu H., Matsushima S., Kinosada Y. et al. Evaluation of parotid gland function using equivalent cross-relaxation rate imaging applied magnetization transfer effect. J. Rad. Res. 2012; 53 (1): 138-144.Shimizu H., Matsushima S., Kinosada Y. et al. Evaluation of parotid gland function using equivalent cross-relaxation rate imaging applied magnetization transfer effect. J. Rad. Res. 2012; 53 (1): 138-144.Vainio H., Coleman M., Wilbourn J. Carcinogenicity evaluations and ongoing studies: the IARC databases. Environm. Health Perspect. 1991; 96; 5-9.Vainio H., Coleman M., Wilbourn J. Carcinogenicity evaluations and ongoing studies: the IARC databases. Environm. Health Perspect. 1991; 96; 5-9.Aisen A.M., Doi K., Swanson S.D. et al. Detection of liver fibrosis with magnetic cross relaxation. Magn. Resonance Med. 1994; 31 (5): 551-556.Aisen A.M., Doi K., Swanson S.D. et al. Detection of liver fibrosis with magnetic cross relaxation. Magn. Resonance Med. 1994; 31 (5): 551-556.De Boer R.W. Magnetization transfer contrast. Part. 1995; 2: 74-83.De Boer R.W. Magnetization transfer contrast. Part. 1995; 2: 74-83.Morrison C., Henkelman R.M. A model for magnetization transfer in tissues. Magn. Resonance Med. 1995; 33 (4): 475-482.Morrison C., Henkelman R.M. A model for magnetization transfer in tissues. Magn. Resonance Med. 1995; 33 (4): 475-482.Zhang H., Xie Y. Dynamics of paramagnetic agents by offresonance rotating frame technique. J. Magn. Resonance. 2006; 183 (2): 213-227.Zhang H., Xie Y. Dynamics of paramagnetic agents by offresonance rotating frame technique. J. Magn. Resonance. 2006; 183 (2): 213-227.Dixon T.W., Engels H., Castillo M., Shardashti M. Incidental Magnetization Transfer Contrast in Standard Multislice Imaging. Magn. Resonance Imaging. 1990; 8: 417-422.Dixon T.W., Engels H., Castillo M., Shardashti M. Incidental Magnetization Transfer Contrast in Standard Multislice Imaging. Magn. Resonance Imaging. 1990; 8: 417-422.D'Ippolito G., Appezzato L.F., Ribeiro A.C.R. et al. Unusual presentations of hepatocellular carcinoma: an icono graphic essay. Radiol. Brasileira. 2006; 39 (2): 137-143.D'Ippolito G., Appezzato L.F., Ribeiro A.C.R. et al. Unusual presentations of hepatocellular carcinoma: an icono graphic essay. Radiol. Brasileira. 2006; 39 (2): 137-143.Francisco F.A.F., Araújo A.L.E., Neto J.A.O. et al. Hepatobiliary contrast agents: differential diagnosis of focal hepatic lesions, pitfalls and other indications. Radiol. Brasileira. 2014; 47 (5): 301-309.Francisco F.A.F., Araújo A.L.E., Neto J.A.O. et al. Hepatobiliary contrast agents: differential diagnosis of focal hepatic lesions, pitfalls and other indications. Radiol. Brasileira. 2014; 47 (5): 301-309.Henkelman R.M., Stanisz G.J., Graham S.J. et al. Magnetization transfer in MRI: a review. NMR Biomed. 2001; 14 (2): 57-64.Henkelman R.M., Stanisz G.J., Graham S.J. et al. Magnetization transfer in MRI: a review. NMR Biomed. 2001; 14 (2): 57-64.Куприянов Д.А. Метод кросс-релаксационной спектроскопии в магнитно-резонансной томографии головного мозга: Автореф. дис. … канд. физ.-мат. наук. М., 2002. 18 с.Куприянов Д.А. Метод кросс-релаксационной спектроскопии в магнитно-резонансной томографии головного мозга: Автореф. дис. … канд. физ.-мат. наук. М., 2002. 18 с.Арасланова Л.В. МРТ в ранней диагностике и мониторинге рассеянного склероза: Автореф. дис. … канд. мед. наук. М., 2004. 25 с.Арасланова Л.В. МРТ в ранней диагностике и мониторинге рассеянного склероза: Автореф. дис. … канд. мед. наук. М., 2004. 25 с.Серков С.В., Пронин И.Н., Корниенко В.Н. МРТ в диагностике врожденной лейкоэнцефалопатии (обзор). Журнал неврологии и психиатрии им. С.С. Корсакова. 2011; 9 (2): 95-112.Серков С.В., Пронин И.Н., Корниенко В.Н. МРТ в диагностике врожденной лейкоэнцефалопатии (обзор). Журнал неврологии и психиатрии им. С.С. Корсакова. 2011; 9 (2): 95-112.Hughes K.S., Simon R., Songhorabodi S. et al. Resection of the liver for colorectal carcinoma metastases: a multiinstitutional study of patterns of recurrence. Surgery. 1986; 100 (2): 278-284.Hughes K.S., Simon R., Songhorabodi S. et al. Resection of the liver for colorectal carcinoma metastases: a multiinstitutional study of patterns of recurrence. Surgery. 1986; 100 (2): 278-284.Alkhalili E., Berber E. Laparoscopic liver resection for malignancy: A review of the literature. Wld J. Gastroenterol. 2014; 20 (37): 13599.Alkhalili E., Berber E. Laparoscopic liver resection for malignancy: A review of the literature. Wld J. Gastroenterol. 2014; 20 (37): 13599.Du S., Wang Z., Sang X. et al. Surgical Resection Improves the Outcome of the Patients With Neuroendocrine Tumor Liver Metastases: Large Data From Asia. Medicine. 2015; 94 (2): e388.Du S., Wang Z., Sang X. et al. Surgical Resection Improves the Outcome of the Patients With Neuroendocrine Tumor Liver Metastases: Large Data From Asia. Medicine. 2015; 94 (2): e388.Coenegrachts K., Orlent H., ter Beek L. et al. Improved focal liver lesion detection: Comparison of single shot spinecho echoplanar and superparamagnetic iron oxide (SPIO) enhanced MRI. J. Magn. Reson. Imaging. 2008; 27 (1): 117-124.Coenegrachts K., Orlent H., ter Beek L. et al. Improved focal liver lesion detection: Comparison of single shot spinecho echoplanar and superparamagnetic iron oxide (SPIO) enhanced MRI. J. Magn. Reson. Imaging. 2008; 27 (1): 117-124.Loevblad K.O., Anzalone N., Dörfler A. et al. MR imaging in multiple sclerosis: review and recommendations for current practice. Am. J. Neuroradiol. 2010; 31 (6): 983-989.Loevblad K.O., Anzalone N., Dörfler A. et al. MR imaging in multiple sclerosis: review and recommendations for current practice. Am. J. Neuroradiol. 2010; 31 (6): 983-989.Stacul F., van der Molen A.J., Reimer P. et al. Contrast induced nephropathy: updated ESUR contrast media safety committee guidelines. Eur. Radiol. 2011; 21 (12): 2527-2541.Stacul F., van der Molen A.J., Reimer P. et al. Contrast induced nephropathy: updated ESUR contrast media safety committee guidelines. Eur. Radiol. 2011; 21 (12): 2527-2541.

The authors declare that there are no conflicts of interest present.