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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medvis-204</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОНТРАСТНЫЕ СРЕДСТВА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CONTRAST MEDIA</subject></subj-group></article-categories><title-group><article-title>История развития контрастного усиления при ультразвуковом исследовании</article-title><trans-title-group xml:lang="en"><trans-title>History of Development of Contrast-Enhanced Imaging at Ultrasound</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кармазановский</surname><given-names>Григорий Григорьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Karmazanovsky</surname><given-names>Grigoriy Grigoriyevich</given-names></name></name-alternatives><email xlink:type="simple">karmazanovsky@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанова</surname><given-names>Юлия Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanova</surname><given-names>Yulia Aleksandrovna</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аскерова</surname><given-names>Нурия Нураддиновна</given-names></name><name name-style="western" xml:lang="en"><surname>Askerova</surname><given-names>Nuriya Nuraddinovna</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Институт хирургии им. А.В. Вишневского” Минздрава России; ГБОУ ВПО “Первый Московский государственный медицинский университет им. И.М. Сеченова” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky Institute of Surgery; I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ “Институт хирургии им. А.В. Вишневского” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A.V. Vishnevsky Institute of Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2015</year></pub-date><volume>0</volume><issue>2</issue><fpage>110</fpage><lpage>119</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кармазановский Г.Г., Степанова Ю.А., Аскерова Н.Н., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Кармазановский Г.Г., Степанова Ю.А., Аскерова Н.Н.</copyright-holder><copyright-holder xml:lang="en">Karmazanovsky G.G., Stepanova Y.A., Askerova N.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/204">https://medvis.rdsmedia.ru/jour/article/view/204</self-uri><abstract><p>УЗИ является неотъемлемой составной частью современной лучевой диагностики и в отечественной клинической медицине относится к наиболее широко используемым методам медицинской визуализации. На сегодняшний день в мировой клинической практике использование эхоконтрастных препаратов при УЗИ стало обязательным условием исследований больных любого клинического профиля при постоянном совершенствовании и разработке новых эхоконтрастных препаратов. В обзоре освещены основные физико-технические принципы контрастной ультразвуковой диагностики, достоинства и недостатки применяемых эхоконстрастных препаратов.</p></abstract><trans-abstract xml:lang="en"><p>Ultrasonic research is the integral component of modern radiodiagnosis and in domestic clinical medicine belongs to the most widely used methods of medical visualization. Use the contrast agents at ultrasonic research became an indispensable condition of researches of patients of any clinical profile at continuous improvement and development new the contrast agents in world clinical practice today. The basic physics and technology principles of contrast ultrasonic diagnostics, merits and demerits of the preparations applied the contrast agents are covered in the review.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ультразвуковое исследование</kwd><kwd>контрастное усиление</kwd><kwd>история развития</kwd><kwd>ultrasound</kwd><kwd>contrast enhancement</kwd><kwd>history of development</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Фомина С.В., Завадовская В.Д., Юсубов М.С. и др. Контрастные препараты для ультразвукового исследования. Бюллетень сибирской медицины. 2011; 6: 137-142.</mixed-citation><mixed-citation xml:lang="en">Фомина С.В., Завадовская В.Д., Юсубов М.С. и др. Контрастные препараты для ультразвукового исследования. 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