medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.medvis-186Research ArticleКОНТРАСТНЫЕ СРЕДСТВАCONTRAST MEDIAСравнительная характеристика радиофармацевтических препаратов для визуализации воспалительных и инфекционных процессов методом эмиссионной томографииComparative Analysis of Radiopharmaceuticals for Imaging of Inflammation and Infection using Emission TomographyЛунёвАлександр СергеевичLunyovAlexander Sergeevichl5h33@rambler.ruЛысенкоНиколай ПетровичLysenkoNikolay Petrovichnoemail@neicon.ruПетросоваКристина АндреевнаPetrosovaKristina Andreevnanoemail@neicon.ruФГБОУ ВПО” Московская государственная академия ветеринарной медицины и биотехнологии им. К.И. Скрябина”РоссияMoscow State Academy of Veterinary Medicine and BiotechnologyRussian FederationФГБУ ГНЦ “Федеральный медицинский биофизический центр им. А.И. Бурназяна” ФМБА РоссииРоссияBurnasyan Federal Medical Biophysical Center FMBA of RussiaRussian Federation201528022015018393Copyright © Лунёв А.С., Лысенко Н.П., Петросова К.А., 20152015Лунёв А.С., Лысенко Н.П., Петросова К.А.Lunyov A.S., Lysenko N.P., Petrosova K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/186

Визуализация и радионуклидная диагностика воспалительных и инфекционных процессов методами эмиссионной томографии, основывающейся на локальных физико-химических изменениях в пораженной ткани, позволяет отразить функциональный статус патологии, тогда как другие современные методы визуализации (КТ, МРТ, УЗИ) опираются на морфологические изменения в тканях, что лишает возможности оценить патологию на ранней стадии развития. К сожалению, на сегодняшний день нет “идеального” радиофармпрепарата, отвечающего определенным критериям, поэтому многолетний мировой опыт использования меченых агентов для визуализации воспалений и их конкретные позитивные результаты явились основанием в предоставлении достаточного количества препаратов для независимого выбора применения того или иного агента.

Emission imaging and radionuclide diagnostics of inflammation and infection are based on local physical and chemical changes of affected tissue. Emission imaging allows demonstrating functional status of pathology while other modern methods (CT, USG and MRI) are based on morphological changes. Imaging using radiopharmaceutical allows estimating foci of early development stage. Unfortunately, nowadays there is no “ideal” radiopharmaceutical (fast accumulation in inflammation, fast excretion, low toxicity, discrimination between inflammation and infection, low cost). Therefore, the world experience of radiopharmaceutical using for inflammation imaging and their positive results were providing foundation of sufficient number of radiopharmaceuticals for independent select of using different labeled agents.

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The authors declare that there are no conflicts of interest present.