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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-1706</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-1706</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БРЮШНАЯ ПОЛОСТЬ И ЗАБРЮШИННОЕ ПРОСТРАНСТВО</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ABDOMEN AND RETROPERITONEAL</subject></subj-group></article-categories><title-group><article-title>Методика выполнения чрескожной таргетной биопсии опухолей поджелудочной железы под ультразвуковым контролем с применением данных низкодозной перфузионной КТ в качестве навигации в режиме fusion (методические рекомендации)</article-title><trans-title-group xml:lang="en"><trans-title>A technique for performing ultrasound-guided percutaneous targeted biopsy of pancreatic tumors using low-dose perfusion CT data for fusion-mode navigation (methodological recommendations)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0731-921X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джигкаева</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhigkaeva</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джигкаева Марина Михайловна – врач-рентгенолог отделения рентгеновской диагностики с кабинетами рентгеновской и магнитно-резонансной компьютерной томографии ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России, Москва<ext-link xlink:href="https://orcid.org/0000-0003-0731-921X" ext-link-type="uri">https://orcid.org/0000-0003-0731-921X</ext-link></p></bio><bio xml:lang="en"><p>Marina M. Dzhigkaeva – Radiologist, Department of X-Ray Diagnostics with X-Ray and Magnetic Resonance Computed Tomography Rooms, Russian Scientific Center of Roentgenoradiology, Moscow<ext-link xlink:href="https://orcid.org/0000-0003-0731-921X" ext-link-type="uri">https://orcid.org/0000-0003-0731-921X</ext-link></p></bio><email xlink:type="simple">dzhigkaeva.mm@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9732-7170</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лагкуева</surname><given-names>И. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Lagkueva</surname><given-names>I. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лагкуева Ирина Джабраиловна – канд. мед. наук, заведующая отделением рентгеновской диагностики с кабинетами рентгеновской и магнитно-резонансной компьютерной томографии ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России, Москва<ext-link xlink:href="https://orcid.org/0000-0001-9732-7170" ext-link-type="uri">https://orcid.org/0000-0001-9732-7170</ext-link></p></bio><bio xml:lang="en"><p>Irina D. Lagkueva – Cand. of Sci. (Med.), Head of Department of X-Ray Diagnostics with X-Ray and Magnetic Resonance Computed Tomography Rooms, Russian Scientific Center of Roentgenoradiology, Moscow<ext-link xlink:href="https://orcid.org/0000-0001-9732-7170" ext-link-type="uri">https://orcid.org/0000-0001-9732-7170</ext-link></p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5002-3521</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рагимов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ragimov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рагимов Вадим Абдурагимович – канд. мед. наук, научный сотрудник лаборатории хирургических технологий в онкологии научно-исследовательского отдела хирургии, урологии, гинекологии и инвазивных технологий в онкологии ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России, Москва<ext-link xlink:href="https://orcid.org/0000-0002-5002-3521" ext-link-type="uri">https://orcid.org/0000-0002-5002-3521</ext-link></p></bio><bio xml:lang="en"><p>Vadim A. Ragimov – Cand. of Sci. (Med.), Laboratory of Surgical Technologies in Oncology, Research Department of Surgery, Urology, Gynecology and Invasive Technologies in Oncology, Russian Scientific Center of Roentgenoradiology, Moscow<ext-link xlink:href="https://orcid.org/0000-0002-5002-3521" ext-link-type="uri">https://orcid.org/0000-0002-5002-3521</ext-link></p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5994-0468</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуднов</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nudnov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нуднов Николай Васильевич – доктор мед. наук, профессор, заместитель директора по научной работе ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России, Москва<ext-link xlink:href="https://orcid.org/0000-0001-5994-0468" ext-link-type="uri">https://orcid.org/0000-0001-5994-0468</ext-link></p></bio><bio xml:lang="en"><p>Nikolay V. Nudnov – Doct. of Sci. (Med.), Professor, Deputy Director for Scientific Work, Russian Scientific Center of Roentgenoradiology, Moscow<ext-link xlink:href="https://orcid.org/0000-0001-5994-0468" ext-link-type="uri">https://orcid.org/0000-0001-5994-0468</ext-link></p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1641-6452</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солодкий</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solodkiy</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Солодкий Владимир Алексеевич – академик РАН, доктор мед. наук, профессор, заслуженный врач РФ, директор ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России, Москва<ext-link xlink:href="https://orcid.org/0000-0002-1641-6452" ext-link-type="uri">https://orcid.org/0000-0002-1641-6452</ext-link></p></bio><bio xml:lang="en"><p>Vladimir A. Solodkiy – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor,  Honored Doctor of the Russian Federation, Director of the Russian Scientific Center of Roentgenoradiology, Moscow<ext-link xlink:href="https://orcid.org/0000-0002-1641-6452" ext-link-type="uri">https://orcid.org/0000-0002-1641-6452</ext-link></p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>01</day><month>10</month><year>2026</year></pub-date><volume>30</volume><issue>3</issue><fpage>64</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Джигкаева М.М., Лагкуева И.Д., Рагимов В.А., Нуднов Н.В., Солодкий В.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Джигкаева М.М., Лагкуева И.Д., Рагимов В.А., Нуднов Н.В., Солодкий В.А.</copyright-holder><copyright-holder xml:lang="en">Dzhigkaeva M.M., Lagkueva I.D., Ragimov V.A., Nudnov N.V., Solodkiy V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/1706">https://medvis.rdsmedia.ru/jour/article/view/1706</self-uri><abstract><p>Компьютерная томография с внутривенным контрастным усилением (КТ с в/в КУ) является “золотым стандартом” в диагностике образований поджелудочной железы. Дополнение стандартного протокола КТ с в/в КУ перфузионной программой существенно расширяет ее диагностические возможности, в частности в выявлении наиболее информативных структурных участков для забора морфологического материала на основании внутриопухолевых показателей кровотока. Практическое применение данных низкодозной перфузионной компьютерной томографии (ндПКТ) при чрескожной биопсии образований поджелудочной железы, подозрительных на злокачественный процесс, позволяет снизить число ложноотрицательных результатов. В статье представлены методика выполнения ндПКТ поджелудочной железы, постпроцессинговая обработка полученных данных, а также технические аспекты выполнения чрескожной таргетной биопсии образований поджелудочной железы с ориентацией на данные ндПКТ под ультразвуковым контролем в режиме fusion.</p><sec><title>Цель исследования</title><p>Цель исследования: методическое описание техники выполнения и параметрического анализа данных низкодозной перфузионной компьютерной томографии для последующего использования полученных данных в качестве навигации при чрескожной таргетной биопсии под ультразвуковым контролем в режиме fusion подозрительных на рак образований поджелудочной железы.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В основу методических рекомендаций вошли результаты собственных исследований, выполненных 34 пациентам с образованиями поджелудочной железы, находившимся в стационарном отделении хирургических методов лечения и противоопухолевой лекарственной терапии абдоминальной онкологии с койками абдоминальной ФГБУ “РНЦРР” Минздрава России в период 2023–2026 гг.</p></sec></abstract><trans-abstract xml:lang="en"><p>Computed tomography with intravenous contrast enhancement (CT with IV-CE) is the “gold standard” for diagnosing pancreatic lesions. Supplementing standard CT with IV-CE with a perfusion scanning protocol significantly enhances the diagnostic capabilities of imaging techniques in identifying the most informative intratumoral biopsy sites based on blood flow measurements, which in turn reduces the number of false-negative results in suspected pancreatic malignancy. This article presents the methodology for performing NDPCT of pancreatic lesions, post-processing of the obtained results, as well as the technical aspects of performing percutaneous targeted biopsy of pancreatic lesions based on NDPCT data under ultrasound control in fusion mode.</p><sec><title>Objective</title><p>Objective: A detailed description of the methodology for performing and parametrically analyzing the results of low-dose perfusion computed tomography for the subsequent use of the obtained data for navigation during percutaneous targeted biopsy under ultrasound control in fusion mode of pancreatic tumors suspicious for cancer.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. These methodological guidelines are based on the results of original research conducted on 34 patients with pancreatic lesions who were treated between 2023 and 2026 at the Department of Surgical Treatment and Antitumor Drug Therapy for Abdominal Malignancies (incorporating abdominal surgery beds) of the Russian Scientific Center of Radiology and Surgical Technologies (RNCRR) of the Ministry of Health of Russia.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>рак поджелудочной железы</kwd><kwd>чрескожная таргетная биопсия</kwd><kwd>ультразвуковое исследование</kwd><kwd>низкодозная перфузионная компьютерная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pancreatic cancer</kwd><kwd>percutaneous targeted biopsy</kwd><kwd>ultrasound</kwd><kwd>low-dose perfusion computed tomography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sung H., Filho A.M., Laversanne M. et al. 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