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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-1533</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-1533</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОПОРНО-ДВИГАТЕЛЬНЫЙ АППАРАТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SUPPORTING MOTOR SYSTEM</subject></subj-group></article-categories><title-group><article-title>Магнитно-резонансная томография в дифференциальной диагностике липом и липосарком мягких тканей</article-title><trans-title-group xml:lang="en"><trans-title>Magnetic resonance imaging in differential diagnosis lipomas and liposarcomas of soft tissues</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5994-0468</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуднов</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nudnov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нуднов Николай Васильевич – доктор мед. наук, профессор, заместитель директора по научной работе, заведующий научно-исследовательским отделом комплексной диагностики заболеваний и радиотерапии ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России;</p><p>профессор кафедры онкологии и рентгенорадиологии им. В.П. Харченко ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России, Москва<ext-link xlink:href="https://orcid.org/0000-0001-5994-0468" ext-link-type="uri">https://orcid.org/0000-0001-5994-0468</ext-link>E-mail: mailbox@rncrr.rssi.ru</p></bio><bio xml:lang="en"><p>Nikolay V. Nudnov – Doct. of Sci. (Med.),  Professor, Deputy Director for Scientific Work, Head of the Research Department for Complex Diagnostics of Diseases and Radiotherapy, Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation;Professor, Department of Oncology and Roentgenology named after V.P. Kharchenko, Peoples' Friendship University of Russia named after Patrice Lumumba of the Ministry of Science and Higher Education of the Russian Federation, Moscow<ext-link xlink:href="https://orcid.org/0000-0001-5994-0468" ext-link-type="uri">https://orcid.org/0000-0001-5994-0468</ext-link></p></bio><email xlink:type="simple">nudnov55@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5352-492X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харченко</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kharchenko</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Харченко Наталья Владимировна – доктор мед. наук, профессор, профессор кафедры онкологии и рентгенорадиологии им. В.П. Харченко ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России, Москваhttps://orcid.org/0000-0002-5352-492X</p></bio><bio xml:lang="en"><p>Natalia V. Kharchenko – Doct. of Sci. (Med.),  Professor, professor of the Department of Oncology and Roentgenology named after V.P. Kharchenko, Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University), Moscow<ext-link xlink:href="https://orcid.org/0000-0002-5352-492X" ext-link-type="uri">https://orcid.org/0000-0002-5352-492X</ext-link></p></bio><email xlink:type="simple">docsemi@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2552-5754</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аксенова</surname><given-names>С. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Aksenova</surname><given-names>S. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аксенова Светлана Павловна – канд. мед. наук, научный сотрудник лаборатории рентгенорадиологии научно-исследовательского отдела комплексной диагностики заболеваний и радиотерапии ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России; ассистент кафедры онкологии и рентгенорадиологии им. В.П. Харченко ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России, Москва<ext-link xlink:href="https://orcid.org/0000-0003-2552-5754" ext-link-type="uri">https://orcid.org/0000-0003-2552-5754</ext-link>E-mail: fabella@mail.ru</p></bio><bio xml:lang="en"><p>Svetlana P. Aksenova – Cand. of Sci. (Med.), research fellow, Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation; Assistant Professor, Department of Oncology and Roentgenology named after V.P. Kharchenko, Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University), Moscow<ext-link xlink:href="https://orcid.org/0000-0003-2552-5754" ext-link-type="uri">https://orcid.org/0000-0003-2552-5754</ext-link>E-mail: fabella@mail.ru</p></bio><email xlink:type="simple">fabella@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-8226-2449</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уразов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Urazov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уразов Александр Викторович – аспирант кафедры онкологии и рентгенорадиологии им. В.П. Харченко ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России, Москва<ext-link xlink:href="https://orcid.org/0009-0004-8226-2449" ext-link-type="uri">https://orcid.org/0009-0004-8226-2449</ext-link></p></bio><bio xml:lang="en"><p>Alexandr V. Urazov – graduate student of the Department of Oncology and Roentgenology named after V.P. Kharchenko, Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University), Moscow<ext-link xlink:href="https://orcid.org/0009-0004-8226-2449" ext-link-type="uri">https://orcid.org/0009-0004-8226-2449</ext-link></p></bio><email xlink:type="simple">urazov_av@pfur.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1641-6452</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солодкий</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solodky</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Солодкий Владимир Алексеевич – академик РАН, доктор мед. наук, профессор, заслуженный врач РФ, директор ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России, Москва<ext-link xlink:href="https://orcid.org/0000-0002-1641-6452" ext-link-type="uri">https://orcid.org/0000-0002-1641-6452</ext-link></p></bio><bio xml:lang="en"><p>Vladimir A. Solodkiy – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Director of the Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation, Moscow<ext-link xlink:href="https://orcid.org/0000-0002-1641-6452" ext-link-type="uri">https://orcid.org/0000-0002-1641-6452</ext-link></p></bio><email xlink:type="simple">director@rncrr.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8784-8415</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каприн</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaprin</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каприн Андрей Дмитриевич – академик РАН, доктор мед. наук, профессор, генеральный директор ФГБУ “НМИЦ радиологии” Минздрава России, директор МНИОИ имени П.А. Герцена – филиала ФГБУ “НМИЦ радиологии” Минздрава России, главный внештатный специалист-онколог (ПФО, ЦФО, СКФО, ЛНР, ДНР) Минздрава России; заведующий кафедрой онкологии и рентгенорадиологии им. В.П. Харченко ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России, Москва<ext-link xlink:href="https://orcid.org/0000-0001-87848415" ext-link-type="uri">https://orcid.org/0000-0001-87848415</ext-link></p></bio><bio xml:lang="en"><p>Andrey D. Kaprin – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.),  Professor, Director General of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Head of the Department of Oncology and Roentgenology named after V.P. Kharchenko, Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University), Moscow<ext-link xlink:href="https://orcid.org/0000-0001-87848415" ext-link-type="uri">https://orcid.org/0000-0001-87848415</ext-link></p></bio><email xlink:type="simple">contact@nmicr.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России; ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation; Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ “Национальный медицинский исследовательский центр радиологии” Минздрава России; ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>04</month><year>2025</year></pub-date><volume>29</volume><issue>2</issue><fpage>72</fpage><lpage>87</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нуднов Н.В., Харченко Н.В., Аксенова С.П., Уразов А.В., Солодкий В.А., Каприн А.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Нуднов Н.В., Харченко Н.В., Аксенова С.П., Уразов А.В., Солодкий В.А., Каприн А.Д.</copyright-holder><copyright-holder xml:lang="en">Nudnov N.V., Kharchenko N.V., Aksenova S.P., Urazov A.V., Solodky V.A., Kaprin A.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/1533">https://medvis.rdsmedia.ru/jour/article/view/1533</self-uri><abstract><sec><title>Введение</title><p>Введение. За последние 5 лет заболеваемость липосаркомами мягких тканей, включая их локализацию в области конечностей, остается на прежнем уровне и составляет 1 случай на 100 тыс. человек в год. Несмотря на это, липосаркомы отличаются высоким риском рецидивирования и метастазирования, что обусловливает необходимость мультидисциплинарного подхода к их лечению. Диагностика данных злокачественных новообразований сохраняет свою сложность из-за их морфологического разнообразия и выраженного сходства с доброкачественными липомами, даже в условиях совершенствования методов лучевой визуализации.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: выявить семиотические характеристики липом и липосарком по данным мультипараметрической магнитно-резонансной томографии (МРТ), позволяющие дифференцировать данные гистологические типы опухолей между собой.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование было включено 75 пациентов с гистологически верифицированными липоматозными опухолями мягких тканей (28 мужчин и 47 женщин) в возрасте от 30 до 82 лет (средний возраст 58 лет). Всем пациентам проводилась мультипараметрическая МРТ мягких тканей до начала лечения на томографе с напряженностью магнитного поля 1,5 Тл.</p></sec><sec><title>Результаты</title><p>Результаты. В исследование включены 32 пациента с гистологически верифицированной липосаркомой и 43 пациента с липомой мягких тканей. Морфологически липосаркомы были представлены следующими типами: атипичная липоматозная опухоль (ALT/WDLS), дедифференцированная липосаркома (DDLPS), миксоидная липосаркома (MLPS), плеоморфная липосаркома (PLPS). В исследовании выявлен ряд МР-критериев, отличающих липомы и липосаркомы между собой (форма опухоли, расположение опухоли относительно компартмента, количество и толщина перегородок, наличие солидной ткани, МР-сигнал на импульсной последовательности с подавлением сигнала от жировой ткани (p &lt; 0,05).</p></sec><sec><title>Заключение</title><p>Заключение. МРТ позволяет не только выявить липоматозные опухоли, но и дифференцировать доброкачественные липомы от злокачественных липосарком на основе их морфологических характеристик. Это делает МРТ незаменимым инструментом в диагностике и планировании лечения таких опухолей.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Over the past 5 years, the incidence of soft tissue liposarcomas, including their localization in the extremities, has remained at the same level and amounts to 1 case per 100 thousand people per year. Despite this, liposarcoma is characterized by a high risk of recurrence and metastasis, which necessitates multidisciplinary treatment for each of them. The diagnosis of these malignant neoplasms remains complex due to their morphological diversity and pronounced similarity to benign lipomas, even with the improvement of radiation imaging methods.</p></sec><sec><title>The aim</title><p>The aim: To identify the semiotic characteristics of lipomas and liposarcomas according to multi-parametric magnetic resonance imaging, allowing these histological types of tumors to be differentiated from each other.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 75 patients with histologically verified lipomatous tumors of soft tissues (28 men and 47 women) aged from 30 to 82 years (average age 58 years). All patients underwent multiparametric MRI of soft tissues before treatment on a tomograph with a magnetic field strength of 1.5 T.</p></sec><sec><title>Results</title><p>Results. The study included 32 patients with histologically verified liposarcoma and 43 patients with soft tissue lipoma. Morphologically, liposarcoma was represented by the following types: atypical lipomatous tumor (ALT/WDLS), dedifferentiated liposarcoma (DDLPS), myxoid liposarcoma (MLPS), pleomorphic liposarcoma (PLPS). The study identified a number of MR criteria that distinguish lipomas and liposarcomas from each other (tumor shape, location of the tumor relative to the compartment, number and thickness of septa, presence of solid tissue, MR signal on IP with suppression of the signal from adipose tissue (p &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>Conclusion. MRI allows not only to detect lipomatous tumors, but also to differentiate benign lipomas from malignant liposarcomas based on their morphological characteristics. This makes MRI an indispensable tool in the diagnosis and treatment planning of such tumors.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>липосаркома</kwd><kwd>липома</kwd><kwd>атипичная липоматозная опухоль</kwd><kwd>магнитно-резонансная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liposarcoma</kwd><kwd>lipoma</kwd><kwd>atypical lipomatous tumor</kwd><kwd>magnetic resonance imaging</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gadgeel S.M., Harlan L.C., Zeruto C.A. et al. Patterns of care in a population based sample of soft tissue sarcoma patients in the United States. 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