medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-1524medvis-1524Research ArticleБРЮШНАЯ ПОЛОСТЬ И ЗАБРЮШИННОЕ ПРОСТРАНСТВОABDOMEN AND RETROPERITONEALСложности оценки местной распространенности рака поджелудочной железы с помощью компьютерной томографии после проведения неоадъювантного химиотерапевтического лечения (серия клинических наблюдений и обзор)Difficulties in assessing the local prevalence of pancreatic ductal adenocarcinoma using computed tomography after neoadjuvant chemotherapeutic treatmenthttps://orcid.org/0000-0001-8117-6670ЖариковаА. В.ZharikovaA. V.

Жарикова Александра Витальевна – врач-рентгенолог ГБУЗ города Москвы “Городская клиническая больница им. С.С. Юдина” ДЗ города Москвы; соискатель ФГБУ “НМИЦ хирургии им. А.В. Вишневского” Минздрава России, Москва.

https://orcid.org/0000-0001-8117-6670

E-mail: zha-vit@yandex.ru

Alexandra V. Zharikova – radiologist, Yudin Moscow State Clinical Hospital; applicant, A.V. Vishnevsky National Medical Research Centre of Surgery, Moscow

https://orcid.org/0000-0001-8117-6670.

E-mail: zha-vit@yandex.ru

zha-vit@yandex.ruhttps://orcid.org/0000-0002-1950-2188БорискинаК. П.BoriskinaK. P.

Борискина Ксения Петровна – врач-рентгенолог ГБУЗ города Москвы “Городская клиническая больница им. С.С. Юдина” ДЗ города Москвы, Москва

https://orcid.org/0000-0002-1950-2188

Kseniya P. Boriskina – radiologist, Yudin Moscow State Clinical Hospital; applicant, A.V. Vishnevsky National Medical Research Centre of Surgery, Moscow.

https://orcid.org/0000-0002-1950-2188

yakimovichkse@gmail.comhttps://orcid.org/0000-0001-7070-3391КондратьевЕ. В.KondratyevE. V.

Кондратьев Евгений Валерьевич – канд. мед. наук, заведующий отдела лучевых методов диагностики и лечения ФГБУ “НМИЦ хирургии им. А.В. Вишневского” Минздрава России, Москва

https://orcid.org/0000-0001-7070-3391.

E-mail: evgenykondratiev@gmail.com

Evgeny V. Kondratyev – Cand. of Sci. (Med.), Heаd of the Diagnostic Rаdiology Depаrtment at the А.V. Vishnevsky Nаtionаl Mediсаl Reseаrсh Сenter of Surgery Moscow.

https://orcid.org/0000-0001-7070-3391

E-mail: evgenykondratiev@gmail.com

evgenykondratiev@gmail.comhttps://orcid.org/0000-0003-4539-9943СидоровД. В.SidorovD. V.

Сидоров Дмитрий Владимирович – доктор мед. наук, заведующий онкологическим отделением №7, врач-онколог ГБУЗ города Москвы “Городская клиническая больница им. С.С. Юдина” ДЗ города Москвы, Москва

https://orcid.org/0000-0002-8282-9351

Dmitry V. Sidorov – Doct. of Sci. (Med.), Head of Oncology Department No. 7, Oncologist, Yudin Moscow State Clinical Hospital; applicant, A.V. Vishnevsky National Medical Research Centre of Surgery, Moscowhttps://orcid.org/0000-0002-8282-9351

dvsidorov_65@mail.ruhttps://orcid.org/0000-0002-6716-5593НечаевВ. А.NechaevV. A.

Нечаев Валентин Александрович – канд. мед. наук, заведующий центром комплексной диагностики, врач-рентгенолог ГБУЗ города Москвы “Городская клиническая больница им. С.С. Юдина” ДЗ города Москвы, Москваhttps://orcid.org/0000-0002-6716-5593

Valentin A. Nechaev – Cand. of Sci. (Med.), Head of the Center for Comprehensive Diagnostics, Radiologist, Yudin Moscow State Clinical Hospital; applicant, A.V. Vishnevsky National Medical Research Centre of Surgery, Moscowhttps://orcid.org/0000-0002-6716-5593

dfkz2005@gmail.comГБУЗ города Москвы “Городская клиническая больница им. С.С. Юдина” ДЗ города Москвы; ФГБУ “Национальный медицинский исследовательский центр хирургии им. А.В. Вишневского” Минздрава РоссииРоссияYudin Moscow State Clinical Hospital; A.V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Healthcare of the Russian FederationRussian FederationГБУЗ города Москвы “Городская клиническая больница им. С.С. Юдина” ДЗ города МосквыРоссияYudin Moscow State Clinical HospitalRussian FederationФГБУ “Национальный медицинский исследовательский центр хирургии им. А.В. Вишневского” Минздрава РоссииРоссияA.V. Vishnevsky National Medical Research Center of Surgery of the Ministry of Healthcare of the Russian FederationRussian Federation2025300420252925159Copyright © Жарикова А.В., Борискина К.П., Кондратьев Е.В., Сидоров Д.В., Нечаев В.А., 20252025Жарикова А.В., Борискина К.П., Кондратьев Е.В., Сидоров Д.В., Нечаев В.А.Zharikova A.V., Boriskina K.P., Kondratyev E.V., Sidorov D.V., Nechaev V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/1524Цель исследования

Цель исследования: продемонстрировать сложности оценки местной распространенности протоковой аденокарциномы поджелудочной железы с помощью компьютерной томографии после проведения неоадъювантного химиотерапевтического лечения на примере серии клинических наблюдений.

Материал и методы

Материал и методы. Проведен поиск научных публикаций и клинических рекомендаций в информационно-аналитической системе PubMed с использованием ключевых слов “pancreatic ductal adenocarcinoma”, “resectable and borderline resectable”, “locally advanced cancer”, “neoadjuvant therapy response”, “post-chemotherapy computed tomography”, “radiomics” за последние 10 лет.

Результаты

Результаты. Из найденных 30 источников для обзора отобрано 23.

Заключение

Заключение. Компьютерная томография остается основным методом оценки местной распространенности протоковой аденокарциномы поджелудочной железы, однако, в ряде случаев не позволяет дифференцировать опухолевые, фиброзные и воспалительные изменения после неоадъювантного химиотерапевтического лечения.

Aim

Aim: to demonstrate the difficulties of assessing the local prevalence of pancreatic ductal adenocarcinoma using computed tomography (CT) after neoadjuvant chemotherapeutic treatment using the example of a series of clinical observations.

Materials and methods

Materials and methods. A search was conducted for scientific publications and clinical recommendations in the PubMed information and analytical system using the keywords “pancreatic ductal adenocarcinoma”, “resectable and borderline resectable”, “locally advanced cancer”, “neoadjuvant therapy response”, “post-chemotherapy computed tomography”, “radiomics” over the past 10 years.

Results

Results. From 30 sources found, 23 were selected for review.

Conclusion

Conclusion. Computed tomography remains the main method of assessing the local prevalence of ductal adenocarcinoma of the pancreas, however, in some cases it does not allow differentiating tumor, fibrous and inflammatory changes after neoadjuvant chemotherapeutic treatment.

протоковая аденокарцинома поджелудочной железырезектабельная и погранично-резектабельная опухольместнораспространенная опухольоценка ответа на неоадювантную химиотерапиюкомпьютерная томография после химиотерапиирадиомикаpancreatic ductal adenocarcinomaresectable and borderline resectable tumorlocally advanced tumorassessment of response to neoadjuvant chemotherapypost-chemotherapy computed tomographyradiomicsРабота выполнена по инициативе авторов без привлечения финансирования.ReferencesSaad A.M., Turk T., Al-Husseini M.J., Abdel-Rahman O. Trends in pancreatic adenocarcinoma incidence and mortality in the United States in the last four decades; a SEER-based study. BMC Cancer. 2018; 18 (1): 688. http://doi.org/10.1186/s12885-018-4610-4Saad A.M., Turk T., Al-Husseini M.J., Abdel-Rahman O. Trends in pancreatic adenocarcinoma incidence and mortality in the United States in the last four decades; a SEER-based study. 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The authors declare that there are no conflicts of interest present.