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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-1504</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-1504</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МАЛЫЙ ТАЗ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SMALL PELVIS</subject></subj-group></article-categories><title-group><article-title>Магнитно-резонансная томография в диагностике метастатического поражения яичников</article-title><trans-title-group xml:lang="en"><trans-title>Magnetic resonance imaging in the diagnosis of metastatic ovarian lesions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2552-5754</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аксенова</surname><given-names>С. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Aksenova</surname><given-names>S. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аксенова Светлана Павловна – канд. мед. наук, научный сотрудник лаборатории рентгенорадиологии научно-исследовательского отдела комплексной диагностики заболеваний и радиотерапии ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России; ассистент кафедры онкологии и рентгенорадиологии им. В.П. Харченко ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России, Москва<ext-link xlink:href="https://orcid.org/0000-0003-2552-5754" ext-link-type="uri">https://orcid.org/0000-0003-2552-5754</ext-link>E-mail: fabella@mail.ru</p></bio><bio xml:lang="en"><p>Svetlana P. Aksenova – Cand. of Sci. (Med.), research fellow, Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation; Assistant Professor, Department of Oncology and Roentgenology named after V.P. Kharchenko, Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University), Moscow<ext-link xlink:href="https://orcid.org/0000-0003-2552-5754" ext-link-type="uri">https://orcid.org/0000-0003-2552-5754</ext-link>E-mail: fabella@mail.ru</p></bio><email xlink:type="simple">fabella@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5994-0468</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуднов</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nudnov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нуднов Николай Васильевич – доктор мед. наук, профессор, заместитель директора по научной работе, заведующий научно-исследовательским отделом комплексной диагностики заболеваний и радиотерапии ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России;профессор кафедры рентгенологии и радиологии ФГБОУ ДПО “Российская медицинская академия непрерывного профессионального образования” Минздрава России; профессор кафедры онкологии и рентгенорадиологии им. В.П. Харченко ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России, Москва<ext-link xlink:href="https://orcid.org/0000-0001-5994-0468." ext-link-type="uri">https://orcid.org/0000-0001-5994-0468</ext-link>E-mail: mailbox@rncrr.rssi.ru</p></bio><bio xml:lang="en"><p>Nikolay V. Nudnov – Doct. of Sci. (Med.),  Professor, Deputy Director for Scientific Work, Head of the Research Department for Complex Diagnostics of Diseases and Radiotherapy, Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation;Professor, Department of Roentgenoradiology and Radiology, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation;Professor, Department of Oncology and Radiology, Peoples' Friendship University of Russia named after Patrice Lumumba of the Ministry of Science and Higher Education of the Russian Federation, Moscow<ext-link xlink:href="https://orcid.org/0000-0001-5994-0468." ext-link-type="uri">https://orcid.org/0000-0001-5994-0468</ext-link>E-mail: mailbox@rncrr.rssi.ru</p></bio><email xlink:type="simple">nudnov@rncrr.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4147-1928</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеев</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeev</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергеев Николай Иванович – доктор мед. наук, заведующий лабораторией  рентгенорадиологии научно-исследовательского отдела комплексной диагностики заболеваний и радиотерапии ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России; профессор кафедры рентгенорадиологии ФДПО ФГАОУ ВО “Российский национальный исследовательский медицинский университет им. Н.И. Пирогова” Минздрава России, Москва<ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">https</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">://</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">orcid</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">.</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">org</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">/0000-0003-4147-1928</ext-link>E-mail: sergeevnickolay@yandex.ru</p></bio><bio xml:lang="en"><p>Nikolay I. Sergeev – Doct. of Sci. (Med.), Head of the Laboratory of X-ray Radiology of the Research Department of Complex Diagnostics of Diseases and Radiotherapy of the Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation; Professor of the Department Roentgenoradiology of FDPO of the Federal State Autonomous Educational Institution of Higher Education Pirogov Russian National Research Medical University, Moscow<ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">https</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">://</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">orcid</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">.</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">org</ext-link><ext-link xlink:href="https://orcid.org/0000-0003-4147-1928" ext-link-type="uri">/0000-0003-4147-1928</ext-link>E-mail: sergeevnickolay@yandex.ru</p></bio><email xlink:type="simple">sergeev_n@rncrr.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1641-6452</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солодкий</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solodky</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Солодкий Владимир Алексеевич – академик РАН, доктор мед. наук, профессор, директор ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России, Москва<ext-link xlink:href="https://orcid.org/0000-0002-1641-6452" ext-link-type="uri">https://orcid.org/0000-0002-1641-6452</ext-link></p></bio><bio xml:lang="en"><p>Vladimir A. Solodkiy – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Director of the Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation, Moscow<ext-link xlink:href="https://orcid.org/0000-0002-1641-6452" ext-link-type="uri">https://orcid.org/0000-0002-1641-6452</ext-link></p></bio><email xlink:type="simple">mailbox@rncrr.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-7535-8523</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шахвалиева</surname><given-names>Э. С.-А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shakhvalieva</surname><given-names>E. S.-A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шахвалиева Элина Саид-Аминовна – клинический ординатор по специальности “рентгенология” ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России; врач-кибернетик ГБУЗ города Москвы “Детская городская клиническая больница № 9 им. Г.Н. Сперанского ДЗ города Москвы”, Москва<ext-link xlink:href="https://orcid.org/0009-0000-7535-8523" ext-link-type="uri">https://orcid.org/0009-0000-7535-8523</ext-link>E-mail: shelina9558@gmail.com</p></bio><bio xml:lang="en"><p>Elina S-A. Shakhvalieva – clinical resident in the specialty “radiology” of the Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation; Cyberneticist, G.N. Speransky Children's City Clinical Hospital No. 9 of Moscow Healthcare Department,  Moscow<ext-link xlink:href="https://orcid.org/0009-0000-7535-8523" ext-link-type="uri">https://orcid.org/0009-0000-7535-8523</ext-link>E-mail: shelina9558@gmail.com</p></bio><email xlink:type="simple">shelina9558@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России; ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation; Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России; ФГАОУ ВО “Российский университет дружбы народов имени Патриса Лумумбы” Минобрнауки России; ФГБОУ ДПО “Российская медицинская академия непрерывного профессионального образования” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation; Peoples' Friendship University of Russia named after Patrice Lumumba (RUDN University); Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России; ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation; Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России; ГБУЗ города Москвы “Детская городская клиническая больница № 9 им. Г.Н. Сперанского ДЗ города Москвы”</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation; G.N. Speransky Children's City Clinical Hospital No. 9 of Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>28</day><month>11</month><year>2025</year></pub-date><volume>29</volume><issue>4</issue><fpage>94</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аксенова С.П., Нуднов Н.В., Сергеев Н.И., Солодкий В.А., Шахвалиева Э.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Аксенова С.П., Нуднов Н.В., Сергеев Н.И., Солодкий В.А., Шахвалиева Э.С.</copyright-holder><copyright-holder xml:lang="en">Aksenova S.P., Nudnov N.V., Sergeev N.I., Solodky V.A., Shakhvalieva E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/1504">https://medvis.rdsmedia.ru/jour/article/view/1504</self-uri><abstract><sec><title>Введение</title><p>Введение. На долю вторичного опухолевого поражения яичника (ВОЯ) приходится до 25% всех злокачественных новообразований яичников. Наиболее часто в яичник метастазируют опухоли желудочно-кишечного тракта, такие как рак желудка, толстой кишки, аппендикса, а также опухоли женской репродуктивной системы: рак молочной железы, рак эндометрия и шейки матки. Как известно, методом выбора для визуализации яичников являются ультразвуковое исследование и магнитно-резонансная томография (МРТ), позволяющая оценить размеры, структуру и перфузионные характеристика яичников.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: проанализировать и сравнить структуру, размеры и семиотические особенности метастатически измененных яичников при разных злокачественных новообразованиях с использованием метода МРТ.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включено 27 женщин с различными первичными злокачественными новообразованиями, у которых выявлено вторичное (метастатическое) поражение яичников. В исследование не включались пациентки с первичным раком яичников, доброкачественными образованиями яичников. Протокол МРТ органов малого таза соответствовал рекомендациям Европейского общества урогенитальных радиологов от 2020 г. (European Society of Urogenital Radiology, ESUR). Расчет статистических показателей производился в компьютерной программе для статистической обработки данных IBM SPSS Statistics 23.</p></sec><sec><title>Результаты</title><p>Результаты. У 27 пациенток суммарно выявлено 44 объемных образования яичников метастатического генеза. При анализе пациенток с ВОЯ одностороннее поражение яичника определялось в 10/27 наблюдениях (37%); двустороннее поражение яичников выявлялось в 17/27 наблюдениях (63%). При этом при одностороннем поражении отмечалось преимущественное (7/10, 70%) поражение левого яичника. Статистически значимых отличий по признаку одно- или двустороннего поражения в анализируемых подгруппах ВОЯ обнаружено не было (p-value = 0,115). По данным исследования выявлено, что объем метастатически измененных яичников при раке желудка, толстой кишки и эндометрия достоверно больше, чем при раке молочной железы и раке шейки матки (p &lt; 0,05). При этом наибольший объем метастатически измененных яичников наблюдается при раке толстой кишки (p &lt; 0,05). </p></sec><sec><title>Заключение</title><p>Заключение. В исследовании проводился анализ объемов и структуры яичников у пациенток с метастатическим поражением придатков матки при разных первичных нозологиях (рак желудка, прямой кишки, молочной железы, матки). В статье детально описаны семиотические МР-характеристики ВОЯ при разных первичных нозологиях, проанализированы размеры ВОЯ в разных подгруппах, приведены наглядные клинические примеры, что позволит улучшить диагностику патологий яичников и своевременно начать лечение основного заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>The aim</title><p>The aim: To analyze and compare the structure, size, and semiotic features of secondary tumors of the ovary (STO) in different primary malignant neoplasms using magnetic resonance imaging.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 27 women with various primary malignancies who had secondary (metastatic) ovarian lesion (OVA). The study did not include patients with primary ovarian cancer or benign ovarian tumors. The MRI protocol of the pelvic organs corresponded to the recommendations of the European Society of Urogenital Radiology from 2020 (European Society of Urogenital Radiology, ESUR). The statistical indicators were calculated in a computer program for statistical data processing IBM SPSS Statistics 23.</p></sec><sec><title>Results</title><p>Results. A total of 44 metastatic ovarian tumors (MOT, second ovarian tumors- SOT) were detected in 27 patients. In the analysis of patients with SOT, unilateral ovarian lesion was detected in 10/27 cases (37%); bilateral ovarian lesion was detected in 17/27 cases (63%). At the same time, with a unilateral lesion, a predominant (7/10, 70%) lesion of the left ovary was noted. There were no statistically significant differences in the sign of a single or bilateral lesion in the analyzed groups of SOT (p-value = 0.115). In the SOT subgroups, it was found that the volume of metastatically altered ovaries in gastric (GC), colon (CC) and endometrial (EC) cancers was significantly higher than in breast cancer (BC) and cervical cancer (p &lt; 0.05). At the same time, the largest volume of metastatically altered ovaries is observed in colon cancer (PK) (p &lt; 0.05).</p></sec><sec><title>Conclusions</title><p>Conclusions. The study analyzed the volumes and structure of the ovaries in patients with secondary tumors of the ovary in various primary nosologies (stomach cancer, colorectal cancer, breast cancer, uterine cancer). The article describes in detail the semiotic MR characteristics, analyzes the sizes of STO in different subgroups, provides illustrative clinical examples, which will improve the diagnosis of ovarian pathologies and which will allow timely initiation of treatment of the underlying disease. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>магнитно-резонансная томография</kwd><kwd>метастазы</kwd><kwd>вторичные опухоли яичников</kwd><kwd>опухоль Крукенберга</kwd><kwd>O-RADS</kwd></kwd-group><kwd-group xml:lang="en"><kwd>O-RADS MRI</kwd><kwd>magnetic resonance imaging</kwd><kwd>metastasis</kwd><kwd>Krukenberg tumor</kwd><kwd>secondary tumors of the ovary</kwd><kwd>metastatic ovarian cancer</kwd><kwd>оvarian metastases</kwd><kwd>Secondary Ovarian Tumour</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kubeček O., Laco J., Špaček J. et al. Clinicopathological Characteristics and Prognostic Factors in Ovarian Metastases from Right- and Left-Sided Colorectal Cancer. Curr Oncol. 2021; 28 (4): 2914–2927. http://doi.org/10.3390/curroncol28040255</mixed-citation><mixed-citation xml:lang="en">Kubeček O., Laco J., Špaček J. et al. Clinicopathological Characteristics and Prognostic Factors in Ovarian Metastases from Right- and Left-Sided Colorectal Cancer. Curr Oncol. 2021; 28 (4): 2914–2927. http://doi.org/10.3390/curroncol28040255</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bruls J., Simons M., Overbeek L.I. et al. A national population-based study provides insight in the origin of malignancies metastatic to the ovary. Virchows Arch. 2015; 467 (1): 79–86. http://doi.org/10.1007/s00428-015-1771-2</mixed-citation><mixed-citation xml:lang="en">Bruls J., Simons M., Overbeek L.I. et al. A national population-based study provides insight in the origin of malignancies metastatic to the ovary. Virchows Arch. 2015; 467 (1): 79–86. http://doi.org/10.1007/s00428-015-1771-2</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kubeček O., Laco J., Špaček J. et al. The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review. Clin. Exp. Metastasis. 2017; 34 (5): 295–307. http://doi.org/10.1007/s10585-017-9856-8</mixed-citation><mixed-citation xml:lang="en">Kubeček O., Laco J., Špaček J. et al. The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review. Clin. Exp. Metastasis. 2017; 34 (5): 295–307. http://doi.org/10.1007/s10585-017-9856-8</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Aziz M., Killeen R.B., Carlson K., Kasi A. Krukenberg Tumor. 2024. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. PMID: 29489206</mixed-citation><mixed-citation xml:lang="en">Aziz M., Killeen R.B., Carlson K., Kasi A. Krukenberg Tumor. 2024. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. PMID: 29489206</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Yakushiji M., Tazaki T., Nishimura H., Kato T. Krukenberg tumors of the ovary: a clinicopathologic analysis of 112 cases. Nihon Sanka Fujinka Gakkai Zasshi. 1987; 39 (3): 479–485. PMID: 3031182</mixed-citation><mixed-citation xml:lang="en">Yakushiji M., Tazaki T., Nishimura H., Kato T. Krukenberg tumors of the ovary: a clinicopathologic analysis of 112 cases. Nihon Sanka Fujinka Gakkai Zasshi. 1987; 39 (3): 479–485. PMID: 3031182</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Fujiwara K., Ohishi Y., Koike H. et al. Clinical implications of metastases to the ovary. Gynecol. Oncol. 1995; 59 (1): 124–128. http://doi.org/10.1006/gyno.1995.1278</mixed-citation><mixed-citation xml:lang="en">Fujiwara K., Ohishi Y., Koike H. et al. Clinical implications of metastases to the ovary. Gynecol. Oncol. 1995; 59 (1): 124–128. http://doi.org/10.1006/gyno.1995.1278</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Мустафин Р.Н., Халикова Л.В., Хуснутдинова Э.К. Особенности метастазирования рака яичника. Креативная хирургия и онкология. 2020; 10 (4): 319–329. https://doi.org/10.24060/2076-3093-2020-10-4-319-329</mixed-citation><mixed-citation xml:lang="en">Mustafin R.N., Khalikova L.V., Khusnutdinova E.K. Specific Features of Ovarian Cancer Metastasis. Creative Surgery and Oncology. 2020; 10 (4): 319–329. https://doi.org/10.24060/2076-3093-2020-10-4-319-329 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Сыркашев Е.М., Солопова А.Е. Сравнение информативности предоперационной диагностики распространенного рака яичников по данным МРТ и МСКТ. Акушерство и гинекология. 2020; 12: 137–142. https://dx.doi.org/10.18565/aig.2020.12.137-142</mixed-citation><mixed-citation xml:lang="en">Syrkashev E.M., Solopova A.E. Comparison of the diagnostic performance of MRI and MSCT in preoperative diagnosis of advanced ovarian cancer. Akusherstvo i Ginekologiya = Obstetrics and Gynecology. 2020; 12: 137–142. https://dx.doi.org/10.18565/aig.2020.12.137-142 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Meyniel J.P., Cottu P.H., Decraene C. et al. A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. BMC Cancer. 2010; 10: 222. http://doi.org/10.1186/1471-2407-10-222</mixed-citation><mixed-citation xml:lang="en">Meyniel J.P., Cottu P.H., Decraene C. et al. A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer. BMC Cancer. 2010; 10: 222. http://doi.org/10.1186/1471-2407-10-222</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Fujimoto D., Hirono Y., Goi T., Yamaguchi A. Sigmoid colonic metastasis by lymphatic spread occurring with unilateral Krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report. Oncol. Lett. 2016; 11 (1): 668–672. http://doi.org/10.3892/ol.2015.3919</mixed-citation><mixed-citation xml:lang="en">Fujimoto D., Hirono Y., Goi T., Yamaguchi A. Sigmoid colonic metastasis by lymphatic spread occurring with unilateral Krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report. Oncol. Lett. 2016; 11 (1): 668–672. http://doi.org/10.3892/ol.2015.3919</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Солопова А.Е., Терновой С.К., Мухаматуллина Э.З., Макацария А.Д. Методика комплексного магнитно-резонансного исследования в уточняющей диагностике образований яичника. Акушерство, гинекология и репродукция. 2016; 10 (4): 12–20. https://doi.org/10.17749/2313-7347.2016.10.4.012-020</mixed-citation><mixed-citation xml:lang="en">Solopova A.E., Ternovoy S.K., Mukhamatullina E.Z., Makatsaria A.D. Advanced magnetic resonance imaging technique in the diagnosis of ovarian lesions. Obstetrics, Gynecology and Reproduction. 2016; 10 (4): 12–20. https://doi.org/10.17749/2313-7347.2016.10.4.012-020 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Xu Y., Yang J., Zhang Z., Zhang G. MRI for discriminating metastatic ovarian tumors from primary epithelial ovarian cancers. J. Ovarian Res. 2015; 8: 61. http://doi.org/10.1186/s13048-015-0188-5</mixed-citation><mixed-citation xml:lang="en">Xu Y., Yang J., Zhang Z., Zhang G. MRI for discriminating metastatic ovarian tumors from primary epithelial ovarian cancers. J. Ovarian Res. 2015; 8: 61. http://doi.org/10.1186/s13048-015-0188-5</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">de Wall Y.R., Thomas C.M., Oei A.L. et al. Secondary ovarian malignancies: frequency, origin and characteristics. Int. J. Gynecol. Cancer. 2009; 19 (7): 1160–1165.</mixed-citation><mixed-citation xml:lang="en">de Wall Y.R., Thomas C.M., Oei A.L. et al. Secondary ovarian malignancies: frequency, origin and characteristics. Int. J. Gynecol. Cancer. 2009; 19 (7): 1160–1165.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Young R.H. From Krukenberg to today. The ever-present problem posed by metastatic tumor in the ovary: part 1. Historical perspective, general principles, mucinous tumors including the Krukenberg tumor. Adv. Anat. Pathol. 2006; 13 (5): 205–227.</mixed-citation><mixed-citation xml:lang="en">Young R.H. From Krukenberg to today. The ever-present problem posed by metastatic tumor in the ovary: part 1. Historical perspective, general principles, mucinous tumors including the Krukenberg tumor. Adv. Anat. Pathol. 2006; 13 (5): 205–227.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kiyokawa T., Young R.H., Scully R.E. Krukenberg tumors of the ovary: a clinicopathological analysis of 120 cases with emphasis on their variable pathological manifestations. Am. J. Pathol. 2006; 30 (3): 277–299. http://doi.org/10.1097/01.pas.0000190787.85024.cb</mixed-citation><mixed-citation xml:lang="en">Kiyokawa T., Young R.H., Scully R.E. Krukenberg tumors of the ovary: a clinicopathological analysis of 120 cases with emphasis on their variable pathological manifestations. Am. J. Pathol. 2006; 30 (3): 277–299. http://doi.org/10.1097/01.pas.0000190787.85024.cb</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kakushima N., Kamoshida T., Hirai S. et al. Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor. J. Gastroenterol. 2003; 38 (12): 1176–1180. http://doi.org/10.1007/s00535-003-1227-3</mixed-citation><mixed-citation xml:lang="en">Kakushima N., Kamoshida T., Hirai S. et al. Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor. J. Gastroenterol. 2003; 38 (12): 1176–1180. http://doi.org/10.1007/s00535-003-1227-3</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Roseland M.E., Millet J.D., Wasnik A.P. Imaging of Metastatic Disease to the Ovary/Adnexa. Magn. Reson. Imaging Clin. N. Am. 2023; 31 (1): 93–107. http://doi.org/10.1016/j.mric.2022.06.005</mixed-citation><mixed-citation xml:lang="en">Roseland M.E., Millet J.D., Wasnik A.P. Imaging of Metastatic Disease to the Ovary/Adnexa. Magn. Reson. Imaging Clin. N. Am. 2023; 31 (1): 93–107. http://doi.org/10.1016/j.mric.2022.06.005</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Shi S.Y., Li Y.A., Qiang J.W. Multiparametric MRI-based radiomics nomogram for differentiation of primary mucinous ovarian cancer from metastatic ovarian cancer. Abdom. Radiol. (NY). 2025; 50 (2): 1018–1028. http://doi.org/10.1007/s00261-024-04542-y</mixed-citation><mixed-citation xml:lang="en">Shi S.Y., Li Y.A., Qiang J.W. Multiparametric MRI-based radiomics nomogram for differentiation of primary mucinous ovarian cancer from metastatic ovarian cancer. Abdom. Radiol. (NY). 2025; 50 (2): 1018–1028. http://doi.org/10.1007/s00261-024-04542-y</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Gronwald J., Byrski T., Huzarski T. et al. Hereditary breast and ovarian cancer. Hered Cancer Clin. Pract. 2008; 6 (2): 88–98. http://doi.org/10.1186/1897-4287-6-2-88</mixed-citation><mixed-citation xml:lang="en">Gronwald J., Byrski T., Huzarski T. et al. Hereditary breast and ovarian cancer. Hered Cancer Clin. Pract. 2008; 6 (2): 88–98. http://doi.org/10.1186/1897-4287-6-2-88</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Casey L., Singh N. Metastases to the ovary arising from endometrial, cervical and fallopian tube cancer: recent advances. Histopathology. 2020; 76 (1): 37–51. http://doi.org/10.1111/his.13985</mixed-citation><mixed-citation xml:lang="en">Casey L., Singh N. Metastases to the ovary arising from endometrial, cervical and fallopian tube cancer: recent advances. Histopathology. 2020; 76 (1): 37–51. http://doi.org/10.1111/his.13985</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Ильина И.Ю., Бурдин Д.В., Нариманова М.Р., Ибрагимова Д.М. Генитальный эндометриоз: патогенез, диагностика и связь с онкологическими заболеваниями. РМЖ. Мать и дитя. 2021; 4 (4): 339–345. http://doi.org/10.32364/2618-8430-2021-4- 4-339-345</mixed-citation><mixed-citation xml:lang="en">Il’ina I.Yu., Burdin D.V., Narimanova M.R., Ibragimova D.M. Genital endometriosis: pathogenesis, diagnosis, and association with malignancies. Russian Journal of Woman and Child Health. 2021; 4 (4): 339–345. http://doi.org/10.32364/2618-8430-2021-4- 4-339-345 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Yamanishi Y., Koshiyama M., Ohnaka M. et al. Pathways of metastases from primary organs to the ovaries. Obstet. Gynecol. Int. 2011; 2011:612817. http://doi.org/10.1155/2011/612817</mixed-citation><mixed-citation xml:lang="en">Yamanishi Y., Koshiyama M., Ohnaka M. et al. Pathways of metastases from primary organs to the ovaries. Obstet. Gynecol. Int. 2011; 2011:612817. http://doi.org/10.1155/2011/612817</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Horn L.C., Höhn A.K., Stark S. et al. Endocervical adenocarcinoma in situ (AIS) with ovarian and pulmonary involvement: report of a case and review of the literature suggesting a “seed and soil hypothesis”. J. Cancer Res. Clin. Oncol. 2019; 145 (8): 2061–2069. http://doi.org/10.1007/s00432-019-02966-4</mixed-citation><mixed-citation xml:lang="en">Horn L.C., Höhn A.K., Stark S. et al. Endocervical adenocarcinoma in situ (AIS) with ovarian and pulmonary involvement: report of a case and review of the literature suggesting a “seed and soil hypothesis”. J. Cancer Res. Clin. Oncol. 2019; 145 (8): 2061–2069. http://doi.org/10.1007/s00432-019-02966-4</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Yachida N., Yoshihara K., Yamaguchi M. et al. How Does Endometriosis Lead to Ovarian Cancer? The Molecular Mechanism of Endometriosis-Associated Ovarian Cancer Development. Cancers (Basel). 2021; 13 (6): 1439. http://doi.org/10.3390/cancers13061439</mixed-citation><mixed-citation xml:lang="en">Yachida N., Yoshihara K., Yamaguchi M. et al. How Does Endometriosis Lead to Ovarian Cancer? The Molecular Mechanism of Endometriosis-Associated Ovarian Cancer Development. Cancers (Basel). 2021; 13 (6): 1439. http://doi.org/10.3390/cancers13061439</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Аксенова С.П., Нуднов Н.В., Сланская А.В., Солодкий В.А. В помощь практикующему врачу: визуализация образований яичников в соответствии с категориальной шкалой оценки рисков злокачественности образований яичников O-RADS MRI. Вестник рентгенологии и радиологии. 2023; 104 (3): 222–238. https://doi.org/10.20862/0042-4676-2023-104-3-222-238</mixed-citation><mixed-citation xml:lang="en">Aksenova S.P., Nudnov N.V., Slanskaya A.V., Solodkiy V.A. To Help the Practitioner: Imaging of Ovarian Masses According to the O-RADS MRI Ovarian Malignancy Categorical Risk Scale. Journal of Radiology and Nuclear Medicine. 2023; 104 (3): 222–238. https://doi.org/10.20862/0042-4676-2023-104-3-222-238 (In Russian)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
