medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-1415medvis-1415Research ArticleТЕХНОЛОГИИ ЛУЧЕВОЙ ДИАГНОСТИКИRADIOLOGICAL TECHNOLOGIESВозможности применения бесконтрастной МР-перфузии в дифференциальной диагностике опухоли мягких тканейPossibility of contrast-free MR-perfusion using in differential diagnosis of soft tissue tumorhttps://orcid.org/0009-0009-3897-7267БогомоловД. Ю.BogomolovD. Y.

Богомолов Даниил Юрьевич – главный специалист по применению медицинского оборудования, отдел клинического применения медицинского оборудования

115054 Москва, ул. Валовая, д. 26

Daniil Y. Bogomolov – M.D., Key Application Specialist of Application Department

26, Valovaya str., Moscow 115054

https://orcid.org/0009-0009-6665-7148МозокинаК. С.MozokinaK. S.

Мозокина Ксения Сергеевна – специалист по применению медицинского оборудования, отдел клинического применения медицинского оборудования

115054 Москва, ул. Валовая, д. 26

Ksenia S. Mozokina – M.D. Application Specialist of Application Department 

26, Valovaya str., Moscow 115054

https://orcid.org/0000-0002-2770-2200МухаматуллинаЭ. З.MukhamatullinaE. Z.

Мухаматуллина Эльвира Зилауровна – руководитель отдела применения медицинского оборудования

115054 Москва, ул. Валовая, д. 26

Elvira Z. Mukhamatullina – M.D., Head of Application Department 

26, Valovaya str., Moscow 115054

https://orcid.org/0000-0002-3771-1354КапустинВ. В.KapustinV. V.

Капустин Владимир Викторович – доктор мед. наук, доцент, профессор кафедры лучевой диагностики ФГБОУ ВО “Московский государственный медико-стоматологический университет имени А.И. Евдокимова” Минздрава России; руководитель отдела научно-практического сотрудничества ООО “АрПи Канон Медикал Системз”

115054 Москва, ул. Валовая, д. 26127473 Москва, ул. Делегатская, д. 20, стр. 1

Vladimir V. Kapustin – Doct. of Sci. (Med.), Assistant Professor, Professor, Division of Radiology, Yevdokimov Moscow State University of Medicine and Dentistry; Head of Scientific and Practical Collaboration Department of RP Canon Medical Systems

26, Valovaya str., Moscow 11505420/1, Delegatskaya str., Moscow 127473

wwkapustin@yandex.ruООО “АрПи Канон Медикал Системз”РоссияRP Canon Medical Systems, LLCRussian FederationООО “АрПи Канон Медикал Системз”; ФГБОУ ВО “Московский государственный медико-стоматологический университет имени А.И. Евдокимова” Минздрава РоссииРоссияRP Canon Medical Systems, LLC; A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian FederationRussian Federation202307122023274179185Copyright © Богомолов Д.Ю., Мозокина К.С., Мухаматуллина Э.З., Капустин В.В., 20232023Богомолов Д.Ю., Мозокина К.С., Мухаматуллина Э.З., Капустин В.В.Bogomolov D.Y., Mozokina K.S., Mukhamatullina E.Z., Kapustin V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/1415

Бесконтрастная МР-перфузия “меченых спинов артериальной крови” (“ASL-перфузия”) – это МР-технология качественной и количественной оценки перфузионных свойств тканей, основанная на маркировке спинов протонов артериальной крови радиочастотными импульсами и последующем их измерении при прохождении через зону интереса. Наибольший клинический опыт применения ASL-перфузии накоплен в диагностике заболеваний центральной нервной системы, однако в последние годы появились работы, показывающие эффективность использования данной методики в оценке перфузии скелетных мышц и диагностике опухолей мягких тканей.

Представлены два клинических наблюдения (опухоль мягких тканей и посттравматические неопухолевые изменения), демонстрирующие возможности применения указанной методики для бесконтрастной оценки характера васкуляризации патологических изменений в мягких тканях бедра.

Contrast-free MR-perfusion of "labeled arterial blood spins" ("ASL-perfusion") is an MR-technology for qualitative and quantitative assessment of tissue perfusion properties based on of arterial blood proton spins labeling by radiofrequency pulses and their subsequent measurement when passing through the area of interest. The most of ASL-perfusion application clinical data referred to central nervous system diseases diagnostics, but some works showing the effectiveness of this technique in assessment of skeletal muscle perfusion and diagnostics of soft tissue tumors appeared recently.

Two presented clinical cases (soft tissue tumor and post-traumatic benign changes) demonstrate the possibility of this technique usage to assess vascularization of pathological changes in hip soft tissues.

опухоли мягких тканеймультипараметрическая магнитно-резонансная томографияASL-перфузияsoft tissue tumorsmultiparametric magnetic resonance imagingASL-perfusionReferencesLin C.H., Hsieh, T.J., Chou Y.C., Chen C.K.H. Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay. Diagnostics. 2022; 12: 2450. https://doi.org/10.3390/diagnostics12102450Lin C.H., Hsieh, T.J., Chou Y.C., Chen C.K.H. Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling Delay. Diagnostics. 2022; 12: 2450. https://doi.org/10.3390/diagnostics12102450Barrett T., Brechbiel M., Bernardo M., Choyke P.L. MRI of tumor angiogenesis. J. Magn. Reson. Imaging. 2007; 26: 235–249. https://doi.org/10.1002/jmri.20991Barrett T., Brechbiel M., Bernardo M., Choyke P.L. MRI of tumor angiogenesis. J. Magn. Reson. Imaging. 2007; 26: 235–249. https://doi.org/10.1002/jmri.20991Sujlana P., Skrok J., Fayad L.M. Review of dynamic contrast-enhanced MRI: Technical aspects and applications in the musculoskeletal system. J. Magn. Reson. Imaging. 2018; 47: 875–890. https://doi.org/10.1002/jmri.25810Sujlana P., Skrok J., Fayad L.M. Review of dynamic contrast-enhanced MRI: Technical aspects and applications in the musculoskeletal system. J. Magn. Reson. Imaging. 2018; 47: 875–890. https://doi.org/10.1002/jmri.25810Ferréa J.C., Bannierb E. Raoulta H. et al. Arterial spin labeling (ASL) perfusion: Techniques and clinical use. Diagnostic Interventional. Imaging. 2013; 94: 1211–1223.Ferréa J.C., Bannierb E. Raoulta H. et al. Arterial spin labeling (ASL) perfusion: Techniques and clinical use. Diagnostic Interventional. Imaging. 2013; 94: 1211–1223.Watts J.M., Whitlow C.T., Maldjian J.A. Clinical applications of arterial spin labeling. NMR Biomed. 2013; 26: 892–900. https://doi.org/10.1002/nbm.2904Watts J.M., Whitlow C.T., Maldjian J.A. Clinical applications of arterial spin labeling. NMR Biomed. 2013; 26: 892–900. https://doi.org/10.1002/nbm.2904Madhuranthakam A.J., Yuan Q., Pedrosa I. Quantitative Methods in Abdominal MRI: Perfusion Imaging. Top Magn. Reson. Imaging. 2017; 26 (6): 251–258. https://doi.org/10.1097/RMR.0000000000000145Madhuranthakam A.J., Yuan Q., Pedrosa I. Quantitative Methods in Abdominal MRI: Perfusion Imaging. Top Magn. Reson. Imaging. 2017; 26 (6): 251–258. https://doi.org/10.1097/RMR.0000000000000145Warmuth C., Gunther M., Zimmer C. Quantification of blood flow in brain tumors: Comparison of arterial spin labeling and dynamic susceptibility-weighted contrastenhanced MR imaging. Radiology. 2003; 228: 523–532. https://doi.org/10.1148/radiol.2282020409Warmuth C., Gunther M., Zimmer C. Quantification of blood flow in brain tumors: Comparison of arterial spin labeling and dynamic susceptibility-weighted contrastenhanced MR imaging. Radiology. 2003; 228: 523–532. https://doi.org/10.1148/radiol.2282020409Duyn J.H., van Gelderen P., Talagala L., Koretsky A., de Zwart J.A. Technological advances in MRI measurement of brain perfusion. J. Magn. Reson. Imaging. 2005; 22 (6): 751–753. https://doi.org/10.1002/jmri.20450Duyn J.H., van Gelderen P., Talagala L., Koretsky A., de Zwart J.A. Technological advances in MRI measurement of brain perfusion. J. Magn. Reson. Imaging. 2005; 22 (6): 751–753. https://doi.org/10.1002/jmri.20450Kawashima M., Katada Y., Shukuya T. et al. MR perfusion imaging using the arterial spin labeling technique for breast cancer. J. Magn. Reson. Imaging. 2012; 35: 436–440. https://doi.org/10.1002/jmri.22882Kawashima M., Katada Y., Shukuya T. et al. MR perfusion imaging using the arterial spin labeling technique for breast cancer. J. Magn. Reson. Imaging. 2012; 35: 436–440. https://doi.org/10.1002/jmri.22882Li X., Metzger G.J. Feasibility of Measuring Prostate Perfusion with Arterial Spin Labeling NMR Biomed. 2013; 26 (1): 51–57. https://doi.org/10.1002/nbm.2818Li X., Metzger G.J. Feasibility of Measuring Prostate Perfusion with Arterial Spin Labeling NMR Biomed. 2013; 26 (1): 51–57. https://doi.org/10.1002/nbm.2818Cai W., Li F., Wang J. et al. A comparison of arterial spin labeling perfusion MRI and DCE-MRI in human prostate cancer. NMR Biomed. 2014; 27 (7): 817–825. https://doi.org/10.1002/nbm.3124Cai W., Li F., Wang J. et al. A comparison of arterial spin labeling perfusion MRI and DCE-MRI in human prostate cancer. NMR Biomed. 2014; 27 (7): 817–825. https://doi.org/10.1002/nbm.3124Fujima N., Kudo K., Tsukahara A. et al. Measurement of tumor blood flow in head and neck squamous cell carcinoma by pseudo-continuous arterial spin labeling: Comparison with dynamic contrast-enhanced MRI. J. Magn. Reson. Imaging. 2015; 41 (4): 983–991. https://doi.org/10.1002/jmri.24885Fujima N., Kudo K., Tsukahara A. et al. Measurement of tumor blood flow in head and neck squamous cell carcinoma by pseudo-continuous arterial spin labeling: Comparison with dynamic contrast-enhanced MRI. J. Magn. Reson. Imaging. 2015; 41 (4): 983–991. https://doi.org/10.1002/jmri.24885Winter J.D., St Lawrence K.S., Cheng, H.L. Quantification of renal perfusion: Comparison of arterial spin labeling and dynamic contrast-enhanced MRI. J. Magn. Reson. Imaging. 2011; 34 (3): 608–615. https://doi.org/10.1002/jmri.22660Winter J.D., St Lawrence K.S., Cheng, H.L. Quantification of renal perfusion: Comparison of arterial spin labeling and dynamic contrast-enhanced MRI. J. Magn. Reson. Imaging. 2011; 34 (3): 608–615. https://doi.org/10.1002/jmri.22660Nery F., Buchanan C.E., Harteveld A.A. et al. Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magnetic Resonance Materials in Phys., Biol. and Med. 2020; 33: 141–161. https://doi.org/10.1007/s10334-019-00800-zNery F., Buchanan C.E., Harteveld A.A. et al. Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magnetic Resonance Materials in Phys., Biol. and Med. 2020; 33: 141–161. https://doi.org/10.1007/s10334-019-00800-zEnglund E.K., Rodgers Z.B., Langham M.C. et al. Measurement of Skeletal Muscle Perfusion Dynamics With Pseudo-Continuous Arterial Spin Labeling (pCASL): Assessment of Relative Labeling Efficiency at Rest and During Hyperemia, and Comparison to Pulsed Arterial Spin Labeling (PASL). Magn. Reson. Imaging. 2016; 44 (4): 929–939. https://doi.org/10.1002/jmri.25247Englund E.K., Rodgers Z.B., Langham M.C. et al. Measurement of Skeletal Muscle Perfusion Dynamics With Pseudo-Continuous Arterial Spin Labeling (pCASL): Assessment of Relative Labeling Efficiency at Rest and During Hyperemia, and Comparison to Pulsed Arterial Spin Labeling (PASL). Magn. Reson. Imaging. 2016; 44 (4): 929–939. https://doi.org/10.1002/jmri.25247Baligand C., Hirschler L., Veeger T.T.J. et al. A split-label design for simultaneous measurements of perfusion in distant slices by pulsed arterial spin labeling. Magn. Reson. Med. 2021; 86: 2441–2453.Baligand C., Hirschler L., Veeger T.T.J. et al. A split-label design for simultaneous measurements of perfusion in distant slices by pulsed arterial spin labeling. Magn. Reson. Med. 2021; 86: 2441–2453.Xu L., Xu L., Zhu H. Evaluation of three-dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors. Exp. Ther. Med. 2018; 15 (6); 5029–5034. https://doi.org/10.3892/etm.2018.6030Xu L., Xu L., Zhu H. Evaluation of three-dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors. Exp. Ther. Med. 2018; 15 (6); 5029–5034. https://doi.org/10.3892/etm.2018.6030Lin C.H., Hsieh, T.J., Chou Y.C., Chen C.K.H. Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling. Delay. Diagnostics. 2022; 12 (10): 2450. https://doi.org/10.3390/diagnostics12102450Lin C.H., Hsieh, T.J., Chou Y.C., Chen C.K.H. Feasibility of Arterial Spin Labeling Magnetic Resonance Imaging for Musculoskeletal Tumors with Optimized Post-Labeling. Delay. Diagnostics. 2022; 12 (10): 2450. https://doi.org/10.3390/diagnostics12102450

The authors declare that there are no conflicts of interest present.