medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-1376medvis-1376Research ArticleТЕХНОЛОГИИ ЛУЧЕВОЙ ДИАГНОСТИКИRADIOLOGICAL TECHNOLOGIESНеинвазивное измерение метаболизма кислорода, часть 2: новые методики в ПЭТ и МРТNon-Invasive Measurement of Oxygen Metabolism. Part 2: New Techniques in PET and MRIhttps://orcid.org/0000-0003-2504-2090ПостновА. А.PostnovAndrey A.

Постнов Андрей Александрович – канд. физ.-мат. наук, научный сотрудник отделения рентгеновских и радиоизотопных методов диагностики ФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава России; доцент Национального исследовательского ядерного университета “МИФИ”; научный сотрудник Физического института им. П.Н. Лебедева РАН, Москва.

Andrey A. Postnov – Cand. of Sci. (Phys.-Math.), researcher of Department of X-ray and Radioisotope Diagnostic Methods, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of Russia; Assistant Professor of National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); researcher of P.N. Lebedev Physical Institute of the Russian Academy of Sciences, Moscow

postnov.email@gmail.comhttps://orcid.org/0000-0001-8719-2225КалаеваД. Б.KalaevaDiana B.

Калаева Диана Борисовна – медицинский физик отделения рентгеновских и радиоизотопных методов диагностики ФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава России; аспирант Национального исследовательского ядерного университета “МИФИ”, Москва

Diana B. Kalaeva – Medical physicist of the Department of X-ray and Radioisotope Diagnostic Methods, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of Russia; graduate student of National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow

dkalaeva@nsi.ruhttps://orcid.org/0000-0002-3666-0911БалахоновА. Б.BalakhonovAnton B.

Балахонов Антон Борисович – ведущий инженер отделения рентгеновских и радиоизотопных методов диагностики ФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава России, Москва

Anton B. Balakhonov – Lead Engineer of the Department of X-ray and Radioisotope Diagnostic Methods, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of Russia, Moscow

ABalakhonov@nsi.ruhttps://orcid.org/0000-0002-4480-0275ПронинИ. Н.ProninIgor’ N.

Пронин Игорь Николаевич – академик РАН, доктор мед. наук, профессор, заведующий отделением рентгеновских и радиоизотопных методов диагностики ФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава России, Москва

Igor’ N. Pronin – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Head of the Department of X-ray and Radioisotope Diagnostic Methods, N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of Russia, Moscow

pronin@nsi.ruФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава России; 125047 Москва, 4-я Тверская-Ямская ул., д.16, Российская Федерация Национальный исследовательский ядерный университет “МИФИ”; 115409 Москва, Каширское ш., 31, Российская Федерация 115230 Москва, Варшавское шоссе, д. 46, Российская Федерация Физический институт им. П.Н. Лебедева РАН; 119991 Москва, Ленинский пр-т, д. 53, Российская ФедерацияРоссияN.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; 16, 4rd Tverskaya-Yamskaya str., Moscow 125047, Russian Federation National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); 115230, Moscow, Kashirskoe shosse, 31, Russian Federation P.N. Lebedev Physical Institute of the Russian Academy of Sciences; 53, Leninsky prospect, Moscow 119991, Russian FederationRussian FederationФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава России; 125047 Москва, 4-я Тверская-Ямская ул., д.16, Российская Федерация Национальный исследовательский ядерный университет “МИФИ”; 115409 Москва, Каширское ш., 31, Российская ФедерацияРоссияN.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; 16, 4rd Tverskaya-Yamskaya str., Moscow 125047, Russian Federation National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); 115230, Moscow, Kashirskoe shosse, 31, Russian FederationRussian FederationФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава России; 125047 Москва, 4-я Тверская-Ямская ул., д.16, Российская ФедерацияРоссияN.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; 16, 4rd Tverskaya-Yamskaya str., Moscow 125047, Russian FederationRussian Federation202417122023282145152Copyright © Постнов А.А., Калаева Д.Б., Балахонов А.Б., Пронин И.Н., 20242024Постнов А.А., Калаева Д.Б., Балахонов А.Б., Пронин И.Н.Postnov A.A., Kalaeva D.B., Balakhonov A.B., Pronin I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/1376

Метаболизм кислорода является ключевым фактором жизни живого организма. Статья является второй частью обзора методов измерения метаболизма кислорода.

Цель исследования

Цель исследования: Дать представление о новых методиках измерения перфузии, основанных на МРТ и КТ, сравнить их точность с «золотым стандартом» - измерениями на основе ПЭТ с H215O, а также описать их роль в клинической практике.

Материалы и методы

Материалы и методы. Проанализировано более 200 работ из базы научных публикаций Pubmed по ключевым словам «perfusion, MRI, CT, ASL, oxygen metabolism», также изучались релевантные ссылки в данных публикациях, не содержащие указанных ключевых слов, либо содержащие их в иной формулировке.

Результаты

Результаты. В рамках данного обзора была отобраны 42 публикации, описывающие КТ- и МР- перфузию с использованием контрастирующих препаратов и МР ASL перфузию. Приведены примеры использования описанных методик в фундаментальных исследованиях и прикладной медицине.

Заключение

Заключение. Результаты, полученные с помощью новых неинвазивных методик молекулярной визуализации в большинстве случаев сопоставимы с данными ПЭТ с H215O, что позволяет шире применять МРТ и КТ исследования метаболизма кислорода в клинической практике.

Oxygen metabolism is a key factor in the life of a living organism. The article is the second part of a review of methods for measuring oxygen metabolism.

Purpose

Purpose. The aim of this review is to provide an insight into newly developed perfusion measurement techniques based on MRI and CT comparing their accuracy with the “gold standard” H215O PET measurements and describing their role in today’s clinical practice.

Materials and methods

Materials and methods. More than 200 Pubmed publications were analyzed for the keywords “perfusion, MRI, CT, ASL, oxygen metabolism”. Relevant publications that do not contain these keywords or contain them in a different wording were also studied.

Results

Results. This review selected 49 publications describing CT and MR perfusion using contrast agents and MR ASL perfusion. Examples of the use of the described methods in fundamental research and applied medicine are given.

Conclusion

Conclusion. The quantitative results obtained using novel non-invasive molecular imaging techniques are in most cases comparable to H215O PET data, which opens the way for broad use of MRI and CT perfusion and oxygen metabolism measurements in clinical practice.

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The authors declare that there are no conflicts of interest present.