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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-1358</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-1358</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЕРДЦЕ И СОСУДЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEART AND VESSELS</subject></subj-group></article-categories><title-group><article-title>Роль эхокардиографии в диагностике сердечной недостаточности с сохраненной фракцией выброса левого желудочка</article-title><trans-title-group xml:lang="en"><trans-title>Role of echocardiography in heart failure with preserved ejection fraction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5389-0973</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солдатова</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Soldatova</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Солдатова Анна Михайловна – доктор мед. наук, старший научный сотрудник лаборатории инструментальной диагностики научного отдела инструментальных методов исследования</p><p>625026 Тюмень, ул. Мельникайте, д. 111</p><p>тел.: 8-922-267-77-78</p></bio><bio xml:lang="en"><p>Anna M. Soldatova – Doct. of Sci. (Med.), Senior Scientific Researcher of the Laboratory of Instrumental Diagnostics of the Scientific Division of Instrumental Research Methods</p><p>111, Melnikaite str., Tyumen 625026</p><p>Phone: 8-922-267-77-78</p></bio><email xlink:type="simple">amsoldatova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4325-2633</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Широков</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Shirokov</surname><given-names>N. Е.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Широков Никита Евгеньевич – канд. мед. наук, научный сотрудник лаборатории инструментальной диагностики научного отдела инструментальных методов исследования</p><p>625026 Тюмень, ул. Мельникайте, д. 111</p></bio><bio xml:lang="en"><p>Nikita Е. Shirokov – Cand. of Sci. (Med.), Scientific Researcher of the Laboratory of Instrumental Diagnostics of the Scientific Division of Instrumental Research Methods</p><p>111, Melnikaite str., Tyumen 625026</p></bio><email xlink:type="simple">shirokovne@infarkta.net</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1436-8853</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ярославская</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yaroslavskay</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ярославская Елена Ильинична – доктор мед. наук, профессор, ведущий научный сотрудник, заведующий лабораторией инструментальной диагностики научного отдела инструментальных методов исследования, врач ультразвуковой диагностики</p><p>625026 Тюмень, ул. Мельникайте, д. 111</p></bio><bio xml:lang="en"><p>Elena I. Yaroslavskaya – Doct. of Sci. (Med.), Professor, Leading Scientific Researcher, Head of the Laboratory of Instrumental Diagnosticsf the Scientific Division of Instrumental Research Methods</p><p>111, Melnikaite str., Tyumen 625026</p></bio><email xlink:type="simple">yaroslavskaya@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тюменский кардиологический научный центр – филиал Томского национального исследовательского медицинского центра Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen Cardiology Research Center – Branch of Tomsk National Research Medical Center, Russian Academy of Science</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>12</month><year>2023</year></pub-date><volume>28</volume><issue>2</issue><fpage>10</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Солдатова А.М., Широков Н.Е., Ярославская Е.И., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Солдатова А.М., Широков Н.Е., Ярославская Е.И.</copyright-holder><copyright-holder xml:lang="en">Soldatova A.M., Shirokov N.Е., Yaroslavskay E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/1358">https://medvis.rdsmedia.ru/jour/article/view/1358</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: изучить и проанализировать данные о роли эхокардиографического обследования в оценке диастолической функции левого желудочка и диагностике сердечной недостаточности с сохраненной фракцией выброса (СНсФВ).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведен поиск научных публикаций и клинических рекомендаций в информационно-аналитических системах PubMed и Google Scholar за 2016–2022 гг. по следующим ключевым словам: диастолическая дисфункция, диастолический стресс-тест, сердечная недостаточность с сохраненной фракцией выброса, эхокардиография. Дополнительно проведен анализ списков литературы для обнаружения статей, соответствующих критериям поиска.</p></sec><sec><title>Результаты</title><p>Результаты. Проанализировано 140 статей, 27 из которых использованы для составления обзора. Из списков литературы дополнительно включено 11 статей за 2003–2015 гг. Результаты поиска: созданы блоки статей, внутри которых статьи анализировали для изучения роли эхокардиографического обследования в оценке диастолической функции левого желудочка и диагностике СНсФВ.</p></sec><sec><title>Заключение</title><p>Заключение. Эхокардиографическое обследование дает важную информацию о структуре и функции сердца и показано всем пациентам с подозрением на СНсФВ. По результатам рутинной оценки показателей тканевой допплерографии врачами ультразвуковой диагностики при выявлении снижения скорости расслабления левого желудочка клинический кардиолог имеет возможность принять решение о необходимости разворачивания алгоритма диагностики СНсФВ методом диастолического стресс-теста. Результаты диастолического стресс-теста в связи с его ограничениями следует интерпретировать в соответствии с клиническим сценарием или вероятностью наличия СНсФВ. Снижение диастолического резерва (E/e &gt; 15) – краеугольный камень подтверждения СНсФВ. Ключевой задачей ближайших клинических испытаний является более четкое выделение различных клинических фенотипов СНсФВ, что позволит улучшить лечение каждого конкретного пациента с СНсФВ.</p></sec></abstract><trans-abstract xml:lang="en"><p>This study aimed to investigate and analyze data regarding the role of echocardiographic examination in assessing the diastolic function of the left ventricle and diagnosing heart failure with preserved ejection fraction (HFpEF).</p><sec><title>Materials and methods</title><p>Materials and methods. A search of scientific publications and clinical recommendations was conducted in the PubMed and Google Scholar information-analytical systems for the years 2016–2022, using keywords such as diastolic dysfunction, diastolic stress test, heart failure with preserved ejection fraction, and echocardiography. Additionally, literature lists were analyzed to identify articles meeting the search criteria.</p></sec><sec><title>Results</title><p>Results. A total of 140 articles were analyzed, with 27 of them utilized in composing the review. Eleven additional articles from 2003–2015 were included from literature lists. The search results were organized into article blocks, within which articles were analyzed to study the role of echocardiographic examination in assessing the diastolic function of the left ventricle and diagnosing HFpEF.</p></sec><sec><title>Conclusion</title><p>Conclusion: Echocardiographic examination provides crucial information about the structure and function of the heart and is recommended for all patients with suspected HFpEF. Based on routine assessment of tissue Doppler imaging parameters, ultrasound diagnostic physicians can decide on the need to initiate the diagnostic algorithm for HFpEF using the diastolic stress test method. Results of the diastolic stress test, considering its limitations, should be interpreted in accordance with the clinical scenario or the probability of the presence of HFpEF. A reduction in diastolic reserve (E/e &gt; 15) is a cornerstone for confirming HFpEF. The key task of upcoming clinical trials is to better differentiate various clinical phenotypes of HFpEF, thereby improving the treatment of each specific patient with HFpEF.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>диастолическая дисфункция</kwd><kwd>диастолический стресс-тест</kwd><kwd>сердечная недостаточность с сохраненной фракцией выброса</kwd><kwd>эхокардиография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diastolic dysfunction</kwd><kwd>diastolic stress test</kwd><kwd>heart failure with preserved ejection fraction</kwd><kwd>echocardiography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nagueh S.F., Smiseth O.A., Appleton C.P. et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J. Am. Soc. Echocardiogr. 2016; 29 (4): 277–314. http://doi.org/10.1016/j.echo.2016.01.011</mixed-citation><mixed-citation xml:lang="en">Nagueh S.F., Smiseth O.A., Appleton C.P. et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J. Am. Soc. Echocardiogr. 2016; 29 (4): 277–314. http://doi.org/10.1016/j.echo.2016.01.011</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Pieske B., Tschöpe C., de Boer R.A. et al. How to diagnose heart failure with preserved ejection fraction: the HFAPEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur. Heart J. 2019; 40 (40): 3297–3317. http://doi.org/10.1093/eurheartj/ehz641</mixed-citation><mixed-citation xml:lang="en">Pieske B., Tschöpe C., de Boer R.A. et al. How to diagnose heart failure with preserved ejection fraction: the HFAPEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur. Heart J. 2019; 40 (40): 3297–3317. http://doi.org/10.1093/eurheartj/ehz641</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Хроническая сердечная недостаточность. Клинические рекомендации 2020. Российский кардиологический журнал. 2020; 25 (11): 4083. http://doi.org/10.15829/1560-4071-2020-4083</mixed-citation><mixed-citation xml:lang="en">Clinical practice guidelines for Chronic heart failure. Russian Journal of Cardiology. 2020; 25 (11): 4083. http://doi.org/10.15829/1560-4071-2020-4083 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Paulus W.J., Tschope C., Sanderson J.E. et al. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur. Heart J. 2007; 28 (20): 2539–2550.</mixed-citation><mixed-citation xml:lang="en">Paulus W.J., Tschope C., Sanderson J.E. et al. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur. Heart J. 2007; 28 (20): 2539–2550.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Овчинников А.Г., Арефьева Т.И., Потехина А.В., Филатова А.Ю., Агеев Ф.Т., Бойцов С.А. Молекулярные и клеточные механизмы, ассоциированные с микрососудистым воспалением в патогенезе сердечной недостаточности с сохраненной фракцией выброса. Acta Naturae. 2020; 12 (2): 40–51. http://doi.org/10.32607/actanaturae.10990</mixed-citation><mixed-citation xml:lang="en">Ovchinnikov A.G., Arefieva T.I., Potekhina A.V. et al. The Molecular and Cellular Mechanisms Associated with a Microvascular Inflammation in the Pathogenesis of Heart Failure with Preserved Ejection Fraction. Acta Naturae. 2020; 12 (2): 40–51. http://doi.org/10.32607/actanaturae.10990 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Овчинников А.Г., Агеев Ф.Т., Алехин М.Н., Беленков Ю.Н., Васюк Ю.А., Галявич А.С., Гиляревский С.Р., Лопатин Ю.М., Мареев В.Ю., Мареев Ю.В., Митьков В.В., Потехина А.В., Простакова Т.С., Рыбакова М.К., Саидова М.А., Хадзегова А.Б., Чернов М.Ю., Ющук Е.Н., Бойцов С.А. Диастолическая трансторакальная стресс-эхокардиография с дозированной физической нагрузкой в диагностике сердечной недостаточности с сохраненной фракцией выброса: показания, методология, интерпретация результатов. Ультразвуковая и функциональная диагностика. 2020; 2: 60–90. http://doi.org/10.24835/1607-0771-2020-2-60-90</mixed-citation><mixed-citation xml:lang="en">Ovchinnikov A.G., Ageev F.T., Alekhin M.N. et al. Diastolic transthoracic stress echocardiography with incremental workload in the evaluation of heart failure with preserved ejection fraction: indications, methodology, interpretation. Ultrasound and Functional Diagnostics. 2020; 2: 60–90. http://doi.org/10.24835/1607-0771-2020-2-60-90 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Мрикаев Д.В. Диастолическая дисфункция левого желудочка у больных c сердечной недостаточностью. Креативная кардиология. 2017; 11 (2): 145–158. http://dx.doi.org/10.24022/1997-3187-2017-11-2-145-158</mixed-citation><mixed-citation xml:lang="en">Mrikaev D.V. Left ventricular diastolic dysfunction in patients with heart failure. Kreativnaya kardiologiya = Creative Cardiology, Russian Journal. 2017; 11 (2): 145–158. http://dx.doi.org/10.24022/1997-3187-2017-11-2-145-158 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nagueh S.F. Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography. JACC Cardiovasc. Imaging. 2020; 228–244. http://doi.org/10.1016/j.jcmg.2018.10.038</mixed-citation><mixed-citation xml:lang="en">Nagueh S.F. Left Ventricular Diastolic Function: Understanding Pathophysiology, Diagnosis, and Prognosis With Echocardiography. JACC Cardiovasc. Imaging. 2020; 228–244. http://doi.org/10.1016/j.jcmg.2018.10.038</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Almeida J.G., Fontes-Carvalho R., Sampaio F. et al. Impact of the 2016 ASE/EACVI recommendations on the prevalence of diastolic dysfunction in general population. Eur. Heart J. Cardiovasc. Imaging. 2018; 19 (4): 380–386. http://doi.org/10.1093/ehjci/jex252</mixed-citation><mixed-citation xml:lang="en">Almeida J.G., Fontes-Carvalho R., Sampaio F. et al. Impact of the 2016 ASE/EACVI recommendations on the prevalence of diastolic dysfunction in general population. Eur. Heart J. Cardiovasc. Imaging. 2018; 19 (4): 380–386. http://doi.org/10.1093/ehjci/jex252</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Caballero L., Kou S., Dulgheru R. et al. Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study. Eur. Heart J. Cardiovasc. Imaging. 2015; 16 (9): 1031–1041. http://doi.org/10.1093/ehjci/jev083</mixed-citation><mixed-citation xml:lang="en">Caballero L., Kou S., Dulgheru R. et al. Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study. Eur. Heart J. Cardiovasc. Imaging. 2015; 16 (9): 1031–1041. http://doi.org/10.1093/ehjci/jev083</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Oh J.K., Miranda W.R., Bird J.G. et al. The 2016 Diastolic Function Guideline: Is it Already Time to Revisit or Revise Them? JACC Cardiovasc. Imaging. 2020; 13 (1 Pt 2): 327–335. http://doi.org/10.1016/j.jcmg.2019.12.004</mixed-citation><mixed-citation xml:lang="en">Oh J.K., Miranda W.R., Bird J.G. et al. The 2016 Diastolic Function Guideline: Is it Already Time to Revisit or Revise Them? JACC Cardiovasc. Imaging. 2020; 13 (1 Pt 2): 327–335. http://doi.org/10.1016/j.jcmg.2019.12.004</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">McDonagh T.A., Metra M., Adamo M. et al. 2021 ESC Guidelines for the diagnosis and treat ment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contri bution of the Heart Failure Association (HFA) of the ESC. Eur. J. Heart Failure. 2022; 24 (1): 4–131. http://doi.org/10.1002/ejhf.2333</mixed-citation><mixed-citation xml:lang="en">McDonagh T.A., Metra M., Adamo M. et al. 2021 ESC Guidelines for the diagnosis and treat ment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contri bution of the Heart Failure Association (HFA) of the ESC. Eur. J. Heart Failure. 2022; 24 (1): 4–131. http://doi.org/10.1002/ejhf.2333</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Smiseth O.A., Morris D.A., Cardim N. et al.; Reviewers: This document was reviewed by members of the 2018–2020 EACVI Scientific Documents Committee. Multimodality imaging in patients with heart failure and preserved ejection fraction: an expert consensus document of the European Association of Cardiovascular Imaging. Eur. Heart J. Cardiovasc. Imaging. 2022; 23 (2): e34–e61. http://doi.org/10.1093/ehjci/jeab154</mixed-citation><mixed-citation xml:lang="en">Smiseth O.A., Morris D.A., Cardim N. et al.; Reviewers: This document was reviewed by members of the 2018–2020 EACVI Scientific Documents Committee. Multimodality imaging in patients with heart failure and preserved ejection fraction: an expert consensus document of the European Association of Cardiovascular Imaging. Eur. Heart J. Cardiovasc. Imaging. 2022; 23 (2): e34–e61. http://doi.org/10.1093/ehjci/jeab154</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Opdahl A., Remme E.W., Helle-Valle T. et al. Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load. Circulation. 2009; 119 (19): 2578–2586. http://doi.org/10.1161/CIRCULATIONAHA.108.791681</mixed-citation><mixed-citation xml:lang="en">Opdahl A., Remme E.W., Helle-Valle T. et al. Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load. Circulation. 2009; 119 (19): 2578–2586. http://doi.org/10.1161/CIRCULATIONAHA.108.791681</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Graham R.J., Gelman J.S., Donelan L. et al. Effect of preload reduction by haemodialysis on new indices of diastolic function. Clin. Sci. (Lond.). 2003; 105: 499–506. http://doi.org/10.1042/CS20030059</mixed-citation><mixed-citation xml:lang="en">Graham R.J., Gelman J.S., Donelan L. et al. Effect of preload reduction by haemodialysis on new indices of diastolic function. Clin. Sci. (Lond.). 2003; 105: 499–506. http://doi.org/10.1042/CS20030059</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">von Bibra H., Paulus W.J., St John Sutton M. et al. Quantification of diastolic dysfunction via the age dependence of diastolic function – impact of insulin resistance with and without type 2 diabetes. Int. J. Cardiol. 2015; 182: 368–374. http://doi.org/10.1016/j.ijcard.2014.12.005</mixed-citation><mixed-citation xml:lang="en">von Bibra H., Paulus W.J., St John Sutton M. et al. Quantification of diastolic dysfunction via the age dependence of diastolic function – impact of insulin resistance with and without type 2 diabetes. Int. J. Cardiol. 2015; 182: 368–374. http://doi.org/10.1016/j.ijcard.2014.12.005</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kasner M., Westermann D., Lopez B. et al. Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction. J. Am. Coll. Cardiol. 2011; 57: 977–985. http://doi.org/10.1016/j.jacc.2010.10.024</mixed-citation><mixed-citation xml:lang="en">Kasner M., Westermann D., Lopez B. et al. Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction. J. Am. Coll. Cardiol. 2011; 57: 977–985. http://doi.org/10.1016/j.jacc.2010.10.024</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Donal E., Galli E., Fraser A.G. Non-invasive estimation of left heart filling pressures: another nail in the coffin for E/e’? Eur. J. Heart Fail. 2017; 19 (2): 1661–1663. http://doi.org/10.1002/ejhf.944</mixed-citation><mixed-citation xml:lang="en">Donal E., Galli E., Fraser A.G. Non-invasive estimation of left heart filling pressures: another nail in the coffin for E/e’? Eur. J. Heart Fail. 2017; 19 (2): 1661–1663. http://doi.org/10.1002/ejhf.944</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mitter S.S., Shah S.J., Thomas J.D. A test in context: E/A and E/e’ to assess diastolic dysfunction and LV filling pressure. J. Am. Coll. Cardiol. 2017; 69 (11): 1451–1464. http://doi.org/10.1016/j.jacc.2016.12.037</mixed-citation><mixed-citation xml:lang="en">Mitter S.S., Shah S.J., Thomas J.D. A test in context: E/A and E/e’ to assess diastolic dysfunction and LV filling pressure. J. Am. Coll. Cardiol. 2017; 69 (11): 1451–1464. http://doi.org/10.1016/j.jacc.2016.12.037</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Naamani N., Preston I.R., Paulus J.K. et al. Pulmonary arterial capacitance is an important predictor of mortality in heart failure with a preserved ejection fraction. JACC Heart Fail. 2015; 3 (6): 467–474. http://doi.org/10.1016/j.jchf.2015.01.013</mixed-citation><mixed-citation xml:lang="en">Al-Naamani N., Preston I.R., Paulus J.K. et al. Pulmonary arterial capacitance is an important predictor of mortality in heart failure with a preserved ejection fraction. JACC Heart Fail. 2015; 3 (6): 467–474. http://doi.org/10.1016/j.jchf.2015.01.013</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Aschauer S., Zotter-Tufaro C., Duca F. et al. Modes of death in patients with heart failure and preserved ejection fraction. Int. J. Cardiol. 2017; 228: 422–426. http://doi.org/10.1016/j.ijcard.2016.11.154</mixed-citation><mixed-citation xml:lang="en">Aschauer S., Zotter-Tufaro C., Duca F. et al. Modes of death in patients with heart failure and preserved ejection fraction. Int. J. Cardiol. 2017; 228: 422–426. http://doi.org/10.1016/j.ijcard.2016.11.154</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Gorter T.M., van Veldhuisen D.J., Bauersachs J. et al. Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur. J. Heart Fail. 2018; 20 (1): 16–37. http://doi.org/10.1002/ejhf.1029</mixed-citation><mixed-citation xml:lang="en">Gorter T.M., van Veldhuisen D.J., Bauersachs J. et al. Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur. J. Heart Fail. 2018; 20 (1): 16–37. http://doi.org/10.1002/ejhf.1029</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kasner M., Westermann D., Steendijk P. et al. Left ventricular dysfunction induced by nonsevere idiopathic pulmonary arterial hypertension: a pressure-volume relationship study. Am. J. Respir. Crit. Care Med. 2012; 186 (2): 181–189. http://doi.org/10.1164/rccm.201110-1860OC</mixed-citation><mixed-citation xml:lang="en">Kasner M., Westermann D., Steendijk P. et al. Left ventricular dysfunction induced by nonsevere idiopathic pulmonary arterial hypertension: a pressure-volume relationship study. Am. J. Respir. Crit. Care Med. 2012; 186 (2): 181–189. http://doi.org/10.1164/rccm.201110-1860OC</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Nagueh S.F., Chang S.M., Nabi F. et al. Cardiac imaging in patients with heart failure and preserved ejection fraction. Circ. Cardiovasc. Imaging. 2017; 10 (9): e006547. http://doi.org/10.1161/CIRCIMAGING.117.006547</mixed-citation><mixed-citation xml:lang="en">Nagueh S.F., Chang S.M., Nabi F. et al. Cardiac imaging in patients with heart failure and preserved ejection fraction. Circ. Cardiovasc. Imaging. 2017; 10 (9): e006547. http://doi.org/10.1161/CIRCIMAGING.117.006547</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Lang R.M., Badano L.P., Mor-Avi V. et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J. Am. Soc. Echocardiogr. 2015; 28 (1): 1–39. e14. http://doi.org/10.1016/j.echo.2014.10.003</mixed-citation><mixed-citation xml:lang="en">Lang R.M., Badano L.P., Mor-Avi V. et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J. Am. Soc. Echocardiogr. 2015; 28 (1): 1–39. e14. http://doi.org/10.1016/j.echo.2014.10.003</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Morris D.A., Belyavskiy E., Aravind-Kumar R. et al. Potential Usefulness and Clinical Relevance of Adding Left Atrial Strain to Left Atrial Volume Index in the Detection of Left Ventricular Diastolic Dysfunction. JACC Cardiovasc. Imaging. 2018; 11 (10): 1405–1415. http://doi.org/10.1016/j.jcmg.2017.07.029</mixed-citation><mixed-citation xml:lang="en">Morris D.A., Belyavskiy E., Aravind-Kumar R. et al. Potential Usefulness and Clinical Relevance of Adding Left Atrial Strain to Left Atrial Volume Index in the Detection of Left Ventricular Diastolic Dysfunction. JACC Cardiovasc. Imaging. 2018; 11 (10): 1405–1415. http://doi.org/10.1016/j.jcmg.2017.07.029</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue K., Khan F.H., Remme E.W. et al. Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure. Eur. Heart J. Cardiovasc. Imaging. 2021; 23 (1): 61–70. http://doi.org/10.1093/ehjci/jeaa415</mixed-citation><mixed-citation xml:lang="en">Inoue K., Khan F.H., Remme E.W. et al. Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure. Eur. Heart J. Cardiovasc. Imaging. 2021; 23 (1): 61–70. http://doi.org/10.1093/ehjci/jeaa415</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Cameli M., Sparla S., Losito M. et al. Correlation of left atrial strain and Doppler measurements with invasive measurement of left ventricular end-diastolic pressure in patients stratified for different values of ejection fraction. Echocardiography. 2016; 33 (3): 398–405. http://doi.org/10.1111/echo.13094</mixed-citation><mixed-citation xml:lang="en">Cameli M., Sparla S., Losito M. et al. Correlation of left atrial strain and Doppler measurements with invasive measurement of left ventricular end-diastolic pressure in patients stratified for different values of ejection fraction. Echocardiography. 2016; 33 (3): 398–405. http://doi.org/10.1111/echo.13094</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Potter E., Marwick T.H. Assessment of left ventricular function by echocardiography: the case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovasc. Imaging. 2018; 11 (2, Pt 1): 260–274. http://doi.org/10.1016/j.jcmg.2017.11.017</mixed-citation><mixed-citation xml:lang="en">Potter E., Marwick T.H. Assessment of left ventricular function by echocardiography: the case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovasc. Imaging. 2018; 11 (2, Pt 1): 260–274. http://doi.org/10.1016/j.jcmg.2017.11.017</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Zile M.R., Gottdiener J.S., Hetzel S.J. et al. Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction. Circulation. 2011; 124 (23): 2491–2501. http://doi.org/10.1161/CIRCULATIONAHA.110.011031</mixed-citation><mixed-citation xml:lang="en">Zile M.R., Gottdiener J.S., Hetzel S.J. et al. Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction. Circulation. 2011; 124 (23): 2491–2501. http://doi.org/10.1161/CIRCULATIONAHA.110.011031</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Shah A.M., Cikes M., Prasad N. et al. Echocardiographic features of patients with heart failure and preserved left ventricular ejection fraction. J. Am. Coll. Cardiol. 2019; 74 (23): 2858–2873. http://doi.org/10.1016/j.jacc.2019.09.063</mixed-citation><mixed-citation xml:lang="en">Shah A.M., Cikes M., Prasad N. et al. Echocardiographic features of patients with heart failure and preserved left ventricular ejection fraction. J. Am. Coll. Cardiol. 2019; 74 (23): 2858–2873. http://doi.org/10.1016/j.jacc.2019.09.063</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kraigher-Krainer E., Shah A.M., Gupta D.K. et al. Impaired systolic function by strain imaging in heart failure with preserved ejection fraction. J. Am. Coll. Cardiol. 2014; 63 (5): 447–456. http://doi.org/10.1016/j.jacc.2013.09.052</mixed-citation><mixed-citation xml:lang="en">Kraigher-Krainer E., Shah A.M., Gupta D.K. et al. Impaired systolic function by strain imaging in heart failure with preserved ejection fraction. J. Am. Coll. Cardiol. 2014; 63 (5): 447–456. http://doi.org/10.1016/j.jacc.2013.09.052</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lancellotti P., Pellikka P.A., Budts W. et al. The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur. Heart J. Cardiovasc. Imaging. 2016; 17 (11): 1191–1229. http://doi.org/10.1093/ehjci/jew190</mixed-citation><mixed-citation xml:lang="en">Lancellotti P., Pellikka P.A., Budts W. et al. The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur. Heart J. Cardiovasc. Imaging. 2016; 17 (11): 1191–1229. http://doi.org/10.1093/ehjci/jew190</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Prasad S.B., Holland D.J., Atherton J.J. Diastolic stress echocardiography: from basic principles to clinical applications. Heart. 2018; 104 (21): 1739–1748. http://doi.org/10.1136/heartjnl-2017-312323</mixed-citation><mixed-citation xml:lang="en">Prasad S.B., Holland D.J., Atherton J.J. Diastolic stress echocardiography: from basic principles to clinical applications. Heart. 2018; 104 (21): 1739–1748. http://doi.org/10.1136/heartjnl-2017-312323</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Uijl A., Savarese G., Vaartjes I. et al. Identification of distinct phenotypic clusters in heart failure with preserved ejection fraction. Eur. J. Heart. Fail. 2021; 23 (6): 973–982. http://doi.org/10.1002/ejhf.2169</mixed-citation><mixed-citation xml:lang="en">Uijl A., Savarese G., Vaartjes I. et al. Identification of distinct phenotypic clusters in heart failure with preserved ejection fraction. Eur. J. Heart. Fail. 2021; 23 (6): 973–982. http://doi.org/10.1002/ejhf.2169</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hagendorff A., Stöbe S., Kandels J. et al. Diagnostic role of echocardiography for patients with heart failure symptoms and preserved left ventricular ejection fraction. Herz. 2022; 47 (4): 293–300. http://doi.org/10.1007/s00059-022-05118-6</mixed-citation><mixed-citation xml:lang="en">Hagendorff A., Stöbe S., Kandels J. et al. Diagnostic role of echocardiography for patients with heart failure symptoms and preserved left ventricular ejection fraction. Herz. 2022; 47 (4): 293–300. http://doi.org/10.1007/s00059-022-05118-6</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Kobayashi M., Huttin O., Magnusson M. et al.; STANISLAS Study Investigators. Machine Learning-Derived Echocardiographic Phenotypes Predict Heart Failure Incidence in Asymptomatic Individuals. JACC Cardiovasc. Imaging. 2022; 15 (2): 193–208. http://doi.org/10.1016/j.jcmg.2021.07.004</mixed-citation><mixed-citation xml:lang="en">Kobayashi M., Huttin O., Magnusson M. et al.; STANISLAS Study Investigators. Machine Learning-Derived Echocardiographic Phenotypes Predict Heart Failure Incidence in Asymptomatic Individuals. JACC Cardiovasc. Imaging. 2022; 15 (2): 193–208. http://doi.org/10.1016/j.jcmg.2021.07.004</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Агеев Ф.Т., Овчинников А.Г. Лечение пациентов с сердечной недостаточностью и сохраненной фракцией выброса: опора на клинические фенотипы. Кардиология. 2022; 62 (7): 44–53.</mixed-citation><mixed-citation xml:lang="en">Ageev F.T., Ovchinnikov А.G. Treatment of patients with heart failure and preserved ejection fraction: reliance on clinical phenotypes. Kardiologiia. 2022; 62 (7): 44–53. (In Russian)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
