Цель исследования

medvis

Медицинская визуализация

Medical Visualization

1607-07632408-9516

RDS-Media Ltd.

10.24835/1607-0763-1297

medvis-1334

Research Article

ТЕХНОЛОГИИ ЛУЧЕВОЙ ДИАГНОСТИКИ

RADIOLOGICAL TECHNOLOGIES

Неинвазивное измерение метаболизма кислорода. Часть 1: исторический обзор и современное состояние

Non-invasive measurement of oxygen metabolism. Part 1: Historical review and state of the art

https://orcid.org/0000-0003-2504-2090

Постнов

А. А.

Postnov

A. A.

Постнов Андрей Александрович – канд. физ.-мат. наук, научный сотрудник отделения рентгеновских и радиоизотопных методов диагностики; доцент; руководитель проекта; научный сотрудник

125047 Москва, 4-я Тверская-Ямская ул., д.16; 115409 Москва, Каширское шоссе, 31;115230 Москва, Варшавское шоссе, д. 46;119991 Москва, Ленинский проспект, д. 53

Andrey A. Postnov – Cand. of Sci. (Phys.-Math.), researcher of Department of X-ray and Radioisotope Diagnostic Methods; assistant professor; project leader; researcher

16, 4rd Tverskaya-Yamskaya str., Moscow 125047;31, Kashirskoe shosse, Moscow 115230;46, Varshavskoe shosse, Moscow 115230;53, Leninsky prospect, Moscow 119991

postnov.email@gmail.com

Калаева

Д. Б.

Kalaeva

D. B.

Калаева Диана Борисовна – медицинский физик отделения рентгеновских и радиоизотопных методов диагностики; аспирант

125047 Москва, 4-я Тверская-Ямская ул., д.16; 115409 Москва, Каширское шоссе, 31

Diana B. Kalaeva – Medical physicist of the Department of X-ray and Radioisotope Diagnostic Methods; graduate student

16, 4rd Tverskaya-Yamskaya str., Moscow 125047;31, Kashirskoe shosse, Moscow 115230

https://orcid.org/0000-0002-3666-0911

Балахонов

А. Б.

Balakhonov

A. B.

Балахонов Антон Борисович – ведущий инженер отделения рентгеновских и радиоизотопных методов диагностики

125047 Москва, 4-я Тверская-Ямская ул., д.16

Anton B. Balakhonov – Lead Engineer of the Department of X-ray and Radioisotope Diagnostic Methods

16, 4rd Tverskaya-Yamskaya str., Moscow 125047

ABalakhonov@nsi.ru

https://orcid.org/0000-0002-4480-0275

Пронин

И. Н.

Pronin

I. N.

Пронин Игорь Николаевич – академик РАН, доктор мед. наук, профессор, заведующий отделением рентгеновских и радиоизотопных методов диагностики

125047 Москва, 4-я Тверская-Ямская ул., д.16

Igor’ N. Pronin – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Head of the Department of X-ray and Radioisotope Diagnostic Methods

16, 4rd Tverskaya-Yamskaya str., Moscow 125047

pronin@nsi.ru

ФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава России; Национальный исследовательский ядерный университет “МИФИ”; АО “Научно-исследовательский институт технической физики и автоматизации”; Физический институт им. П.Н. Лебедева РАНРоссияN.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute); Research Institute of Technical Physics and Automation (“NIITFA”); P.N. Lebedev Physical Institute of the Russian Academy of SciencesRussian Federation

ФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава России; Национальный исследовательский ядерный университет “МИФИ”РоссияN.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian Federation; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)Russian Federation

ФГАУ “НМИЦ нейрохирургии им. акад. Н.Н. Бурденко” Минздрава РоссииРоссияN.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Healthcare of the Russian FederationRussian Federation

2023

08022023

274138149

2023

Постнов А.А., Калаева Д.Б., Балахонов А.Б., Пронин И.Н.

Postnov A.A., Kalaeva D.B., Balakhonov A.B., Pronin I.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://medvis.rdsmedia.ru/jour/article/view/1334

Метаболизм кислорода является ключевым фактором жизни живого организма. Статья является первой частью обзора методов измерения метаболизма кислорода.

Цель исследования

Цель исследования: дать представление об истории развития методов измерения метаболизма кислорода, перехода от глобального измерения перфузии головного мозга к локальному, описать роль изотопа 15O как основы “золотого стандарта” измерения метаболизма кислорода с помощью позитронно-эмиссионной томографии (ПЭТ), а также привести примеры использования методики.

Материал и методы

Материал и методы. Проанализировано более 200 работ из базы научных публикаций Pubmed по ключевым словам “positron emission tomography + O-15”, также изучались релевантные ссылки в данных публикациях, не содержащих указанных ключевых слов либо содержащих их в иной формулировке. Приведен пример измерения перфузии опухоли головного мозга методом КТ-перфузии, МР-ASL и ПЭТ с H215O из собственной практики.

Результаты

Результаты. Для иллюстрации эволюции методов измерения перфузии и метаболизма кислорода процитированы 57 работ, описывающих ключевые достижения в технологиях измерения. Приведены примеры использования ПЭТ с H215O в фундаментальных исследованиях и клинической практике.

Заключение

Заключение. Очевидная ценность данных, полученных ПЭТ с изотопом кислорода, сочетается с инвазивностью (в некоторых случаях), технической сложностью и высокой стоимостью процедуры. Вторая часть обзора будет посвящена альтернативным методам измерения метаболизма кислорода, которые развиваются в XXI веке и которые предназначены для широкого клинического применения.

Oxygen metabolism is a key factor in the life of a living organism. The article is the first part of a review of methods for measuring oxygen metabolism.

Purpose

Purpose. The aim of this review is to present an insight into the evolution of methods for measuring oxygen metabolism in a way from global to local measurement of brain perfusion. The role of the 15O isotope as the “gold standard” for measuring oxygen metabolism using positron emission tomography (PET) is described. We also provide a case report of brain tumor perfusion measurements from our clinic.

Materials and methods

Materials and methods. More than 200 Pubmed publications were studied with the keywords “positron emission tomography + O-15”. Relevant publications that do not contain these keywords or contain them in a different wording were also analyzed. A clinical case of a brain tumor perfusion using CT perfusion, MR-ASL and PET with H215O is provided.

Results

Results. The evolution of methods for measuring perfusion, oxygen extraction, and oxygen metabolism, is described. More than 50 papers are cited depicting key advances in measurement technologies. Examples of the use of PET with H215O in fundamental research and clinical practice are given.

Conclusion

Conclusion. The obvious value of oxygen-isotope PET data is combined with the invasiveness (in some cases), technical complexity and high cost of the procedure. The second part of the review will be devoted to alternative methods for measuring oxygen metabolism, which are developing in the 21st century and which are intended for wide clinical use.

метаболизм кислородаПЭТ с 15-Oперфузия

oxygen metabolism15-O PETperfusion

Исследование выполнено за счет гранта Российского научного фонда (проект № 22-25-00201).

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Grüner J.M., Paamand R., Kosteljanetz M., Broholm H. Brain perfusion CT compared with 15O-H2O PET in patients with primary brain tumours. Eur. J. Nucl. Med. Mol. Imaging. 2012; 39: 1691–1701. https://doi.org/10.1007/s00259-012-2173-1

The authors declare that there are no conflicts of interest present.