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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-1322</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-1322</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БРЮШНАЯ ПОЛОСТЬ И ЗАБРЮШИННОЕ ПРОСТРАНСТВО</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ABDOMEN AND RETROPERITONEAL</subject></subj-group></article-categories><title-group><article-title>Роль ультразвуковой оценки коэффициента массы селезенки в динамике наблюдения детей с хронической формой ВЭБ-инфекцией</article-title><trans-title-group xml:lang="en"><trans-title>The role of ultrasound assessment of the spleen mass coefficient in the observation dynamics in children with chronic EBV virus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1083-2807</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Первишко</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pervishko</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Первишко Олеся Валерьевна – канд. мед. наук, доцент кафедры детских инфекционных болезней,</p><p>350063 Краснодар, ул. им. М. Седина, д. 4</p></bio><bio xml:lang="en"><p>Olesya V. Pervishko – Cand. of Sci. (Med.), Associate Professor of the Department of Childhood Infectious Diseases, </p><p>4, M. Sedin str., Krasnodar 350063</p></bio><email xlink:type="simple">ole-pervishko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2421-9918</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Возгомент</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vozgoment</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Возгомент Ольга Викторовна – доктор мед. наук, профессор, ведущий научный сотрудник, 119021 Москва, ул. Тимура Фрунзе, д.16;</p><p>профессор кафедры лучевой диагностики детского возраста, 125993 Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Olga V. Vozgoment – Doct. of Sci. (Med.), Professor, Leading Researcher, 16, Timur Frunze str., Moscow 119021;</p><p>Professor of the Department of Childhood Radiation Diagnostics, 2/1 bld. 1, Barrikadnaya str., Moscow 125993</p></bio><email xlink:type="simple">vozgom@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3731-6263</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пыков</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pykov</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пыков Михаил Иванович – доктор мед. наук, профессор, заведующий кафедрой лучевой диагностики детского возраста,</p><p>125993 Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Mikhail I. Pykov – Doct. of Sci. (Med.), Professor, Head of the Department of Childhood Radiation Diagnostics, </p><p>2/1 bld. 1, Barrikadnaya str., Moscow 125993</p></bio><email xlink:type="simple">pykov@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3793-1135</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Астафьева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Astafyeva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астафьева Ольга Викторовна – доктор мед. наук, профессор, профессор кафедры лучевой диагностики №1,</p><p>350063 Краснодар, ул. им. М. Седина, д. 4</p></bio><bio xml:lang="en"><p>Olga V. Astafyeva – Doct. of Sci. (Med.), Professor, Professor of the Department of Radiation Diagnostics No. 1, </p><p>4, M. Sedin str., Krasnodar 350063</p></bio><email xlink:type="simple">ole-pervishko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2021-0465</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слинин</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Slinin</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Слинин Алексей Сергеевич – заведующий отделом по работе с регионами, </p><p>117997 Москва, ул. Саморы Машела, д. 1</p></bio><bio xml:lang="en"><p>Alexey S. Slinin – Head of the Department for Work with Regions, </p><p>1, Samory Mashela str., Moscow 117997</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1911-3841</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сурмач</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Surmach</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сурмач Полина Альбертовна – студентка педиатрического факультета, </p><p>350063 Краснодар, ул. им. М. Седина, д. 4</p></bio><bio xml:lang="en"><p>Polina A. Surmach – student of the Pediatric Faculty, </p><p>4, M. Sedin str., Krasnodar 350063</p></bio><email xlink:type="simple">rugaleva.p@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9919-2537</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Северина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Severina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Северина Елизавета Алексеевна – студентка педиатрического факультета,</p><p>350063 Краснодар, ул. им. М. Седина, д. 4</p></bio><bio xml:lang="en"><p>Elizaveta A. Severina – student of the Pediatric Faculty, </p><p>4, M. Sedin str., Krasnodar 350063</p></bio><email xlink:type="simple">elizavetaseverena889@mail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8887-0593</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бондаренко</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bondarenko</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бондаренко Светлана Александровна – студентка педиатрического факультета, </p><p>350063 Краснодар, ул. им. М. Седина, д. 4</p></bio><bio xml:lang="en"><p>Svetlana A. Bondarenko – student of the Pediatric Faculty, </p><p>4, M. Sedin str., Krasnodar 350063</p></bio><email xlink:type="simple">svetlanabondarenko516@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО “Кубанский государственный медицинский университет” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ НМИЦ “Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии”&#13;
Минздрава России; &#13;
ФГБОУ ДПО “Российская медицинская академия непрерывного профессионального образования” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Research Institute of Dentistry and Maxillofacial Surgery of the Ministry of Healthcare of the Russian Federation;&#13;
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ДПО “Российская медицинская академия непрерывного профессионального образования” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ “Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии&#13;
им. Дмитрия Рогачева” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2023</year></pub-date><volume>27</volume><issue>4</issue><fpage>115</fpage><lpage>123</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Первишко О.В., Возгомент О.В., Пыков М.И., Астафьева О.В., Слинин А.С., Сурмач П.А., Северина Е.А., Бондаренко С.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Первишко О.В., Возгомент О.В., Пыков М.И., Астафьева О.В., Слинин А.С., Сурмач П.А., Северина Е.А., Бондаренко С.А.</copyright-holder><copyright-holder xml:lang="en">Pervishko O.V., Vozgoment O.V., Pykov M.I., Astafyeva O.V., Slinin A.S., Surmach P.A., Severina E.A., Bondarenko S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/1322">https://medvis.rdsmedia.ru/jour/article/view/1322</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: показать значимость ультразвуковой диагностики  в оценке динамики коэффициента массы селезенки у детей различных возрастных групп на фоне хронической формы ВЭБ - инфекции.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включили 146 детей в возрасте от 3 до 18 лет с хронической формой ВЭБ - инфекции. В зависимости от возраста, дети были разделены на 3 группы. В 1-ю группу вошло 63 пациента от 3 до 7 лет; 2 – ю группу составили 28 детей с 8 до 11 лет; 3 – ю группу - 55 детей от 12 до 18 лет. Проводили клиническое, лабораторное и ультразвуковое обследование, включая ультразвуковое исследование селезенки с определением коэффициента массы (КМС).</p></sec><sec><title>Результаты</title><p>Результаты. В остром периоде ВЭБ инфекции дети всех возрастных групп имели увеличение КМС, при этом максимальное увеличение отмечалось у детей от 3 до 7 лет и колебалось в диапазоне от 4,9 до 9,2. При наличии полного клинико-лабораторного выздоровления у данного возрастного контингента КМС оставался на уровне 4,2-5,8 и не достигал средних значений здоровых детей данного возраста. Динамика наблюдения в течение 15-18 месяцев выявляла нормализацию КМС до средневозрасных значений здоровых пациентов у детей 12 лет и старше.</p></sec><sec><title>Выводы</title><p>Выводы. Дети в группе от 3 до 7 лет имели максимальное значение коэффициента массы селезенки, как в остром периоде, так и после полного клинико - лабораторного выздоровления. Применение ультразвуковой методики с оценкой коэффициента массы селезенки при хроническом течении ВЭБ-инфекции позволяет расширить и определить контингент детей для дальнейшего динамического наблюдения с целью профилактики возможных осложнений.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose of the study</title><p>Purpose of the study: to show the significance of ultrasound diagnostics in assessing the dynamics of the spleen mass coefficient in children of various age against the background of a chronic form of EBV virus.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study was performed on 146 children aged 3 to 18 years suffering from chronic EBV virus. Depending on age, the children were divided into 3 groups. Group 1 included 63 patients aged 3 to 7 years; Group 2 consisted of 28 children aged 8 to 11 years; Group 3 included 55 children aged 12 to 18 years. The clinical, laboratory and ultrasound examination was conducted including ultrasound of the spleen with the further determination of its mass coefficient (SMC).</p></sec><sec><title>Results</title><p>Results. In the acute period of EBV virus, children of all age groups revealed an increase in SMC, while the maximum increase was observed in children aged 3 to 7 years and amounted to 6,88. Against the background of a complete clinical and laboratory recovery in this age group, the SMC remained at the level of 4.66 and did not reach the average values of healthy children of the same age. The follow-up dynamics for 15–18 months demonstrated the normalization of the SMC to the average values of healthy patients in accordance with their age (in children aged 12 years and older).</p></sec><sec><title>Findings</title><p>Findings. Children in the age group from 3 to 7 years old had the maximum value of the spleen mass coefficient, both in the acute period and after complete clinical and laboratory recovery. The use of ultrasound technique with the assessment of the spleen mass coefficient in the chronic course of EBV virus allows expanding and determining the children contingent for further dynamic monitoring for prevention of possible complications.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>коэффициент массы селезенки</kwd><kwd>дети</kwd><kwd>хроническая ВЭБ-инфекция.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>spleen mass coefficient</kwd><kwd>children</kwd><kwd>chronic EBV virus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Иванова B.B., Железникова Г.Ф., Aксенов О.A. Инфекционный мононуклеоз: клиника, патогенез, новое в диагностике и терапии. Инфекционные болезни. 2004; 4: 5–12.</mixed-citation><mixed-citation xml:lang="en">Ivanova B.B., Zheleznikova G.F., Aksenov O.A. Infectious mononucleosis: clinic, pathogenesis, new in diagnosis and therapy. 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