medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-1127medvis-1266Research ArticleГОЛОВАHEADМагнитно-резонансная томография в оценке цереброваскулярной реактивностиMagnetic resonance imaging for cerebrovascular reactivity assessmenthttps://orcid.org/0000-0002-4517-1351НикогосоваА. К.NikogosovaA. K.

Никогосова Анаит Карэновна – научный сотрудник, врач-рентгенолог 

117513 Москва, ул. Островитянова, 1, стр. 10Тел.: +7-926-538-16-80

Anait K. Nikogosova – researcher, radiologist, Scientific and research center of radiology and clinical physiology

1-10, Ostrivityanova str., Moscow 117513Phone: +7-926-538-16-80

gazanchyan.anait@gmail.comhttps://orcid.org/0000-0001-8428-8037ЛелюкС. Э.LelyukS. E.

Лелюк Светлана Эдуардовна – доктор медицинских наук, профессор, профессор кафедры ультразвуковой диагностики

125993 Москва, ул. Баррикадная, д. 2/1, стр. 1

Svetlana E. Lelyuk – Doct. of Sci. (Med.), Professor, Professor of the Department of Ultrasound Diagnostics

2/1 bld. 1, Barrikadnaya str., Moscow 125993

https://orcid.org/0000-0002-9690-8325ЛелюкВ. Г.LelyukV. G.

Лелюк Владимир Геннадьевич – доктор медицинских наук, профессор, руководитель НИЦ радиологии и клинической физиологии

117513 Москва, ул. Островитянова, 1, стр. 10

Vladimir G. Lelyuk – Doct. of Sci. (Med.), Professor, Head of Scientific and research center of radiology and clinical physiology

1-10, Ostrivityanova str., Moscow 117513

ФГБУ “Федеральный центр мозга и нейротехнологий” ФМБА РоссииРоссияFederal center for brain and neurotechnologies of the Federal Medical and Biological AgencyRussian FederationФГБОУ ДПО “Российская медицинская академия непрерывного профессионального образования” Минздрава РоссииРоссияRussian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationRussian Federation2023211020222722335Copyright © Никогосова А.К., Лелюк С.Э., Лелюк В.Г., 20232023Никогосова А.К., Лелюк С.Э., Лелюк В.Г.Nikogosova A.K., Lelyuk S.E., Lelyuk V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/1266Цель исследования

Цель исследования: анализ литературы, касающейся методики проведения МРТ-картирования цереброваскулярной реактивности.

Материал и методы

Материал и методы. Проанализировано 75 публикаций (4 отечественные, 71 зарубежная), вышедших в свет в период с 1960 по 2021 г. Более половины работ было опубликовано в последнее десятилетие, 26 работ — в период с 2016 по 2021 г.

Результаты

Результаты. В статье систематизированы способы оценки цереброваскулярной реактивности и подходы к оценке цереброваскулярной реактивности методом МРТ. Подробно изложена методика проведения бесконтрастного МРТ-картирования цереброваскулярной реактивности с гиперкапнической пробой; также рассмотрены альтернативные вазоактивные стимулы. Обсуждены вопросы, связанные с обработкой данных и оценкой результатов исследования.

Заключение

Заключение. Нарушения цереброваскулярной реактивности играют важную роль в патогенезе сосудистых заболеваний головного мозга. На протяжении последних десятилетий для оценки цереброваскулярной реактивности широко использовались различные радионуклидные и ультразвуковые методы. В последние годы значительно возрос интерес исследователей к МРТ как методу картирования цереброваскулярной реактивности. Неинвазивность, безопасность, отсутствие лучевой нагрузки и хорошая переносимость являются безусловными преимуществами МРТ-картирования перед другими способами оценки цереброваскулярной реактивности. Однако разнообразие методологических подходов к МРТ-картированию цереброваскулярной реактивности обусловливает значительную вариабельность результатов исследования. Стандартизация процедуры должна являться первым шагом на пути внедрения МРТ-картирования цереброваскулярной реактивности в клиническую практику.

Purpose

Purpose. To analyze the publications related to the technique of MRI mapping of cerebrovascular reactivity.

Materials and methods

Materials and methods. We have analyzed 75 publications (4 Russian, 71 foreign), published in the period from 1960 to 2021 years. More than half of these articles were published in the last ten years, with 26 studies – in the period from 2016 to 2021 years.

Results

Results. The article systematizes methods for assessing cerebrovascular reactivity and approaches to assessing cerebrovascular reactivity by MRI. The technique of non-enhanced MRI mapping of cerebrovascular reactivity with a hypercapnic challenge is described in detail; alternative vasoactive stimuli are also considered. Issues related to data processing and evaluation of research results were discussed.

Conclusion

Conclusion. Impairment of cerebrovascular reactivity plays an important role in the pathogenesis of cerebrovascular diseases. Over the past decades, various radionuclide and ultrasound methods have been widely used to assess cerebrovascular reactivity. In recent years the interest of researchers in MRI as a method of mapping cerebrovascular reactivity has increased significantly. Noninvasiveness, safety, absence of radiation exposure, and good tolerability are the absolute advantages of MRI mapping over other methods of assessing cerebrovascular reactivity. However, the variety of methodological approaches to MRI mapping of cerebrovascular reactivity causes significant variability in the results of the study. Standardization of the procedure should be the first step toward the introduction of MRI mapping of cerebrovascular reactivity into clinical practice.

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The authors declare that there are no conflicts of interest present.