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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-1231</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-1231</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЕРДЦЕ И СОСУДЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEART AND VESSELS</subject></subj-group></article-categories><title-group><article-title>Кинетическая энергия, как фактор оценки работы сердца у пациентов с аортальным стенозом</article-title><trans-title-group xml:lang="en"><trans-title>Kinetic energy as a factor in assessing the work of the heart in patients with aortic stenosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1535-5982</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сандриков</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sandrikov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сандриков Валерий Александрович – академик РАН, доктор мед. наук, профессор, руководитель отдела клинической физиологии инструментальной и лучевой диагностики,</p><p>119991 Москва, ГСП-1, Абрикосовский пер., д. 2</p></bio><bio xml:lang="en"><p>Valery A. Sandrikov – Academician of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Head of the Department of Clinical Physiology of Instrumental and Radiation Diagnostics,</p><p>2, Abrikosovsky lane, Moscow 119991</p></bio><email xlink:type="simple">sandrikov@med.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6165-6474</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулагина</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulagina</surname><given-names>T. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кулагина Татьяна Юрьевна – доктор мед. наук, заведующая лабораторией нагрузочных тестов отдела клинической физиологии, инструментальной и лучевой диагностики,</p><p>119991 Москва, ГСП-1, Абрикосовский пер., д. 2</p></bio><bio xml:lang="en"><p>Tatiana Yu. Kulagina – Doct. of Sci. (Med.), Head of the Laboratory of Stress Tests of the Department of Clinical Physiology of Instrumental and Radiation Diagnostics,</p><p>2, Abrikosovsky lane, Moscow 119991</p></bio><email xlink:type="simple">takula@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4716-4814</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимова</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimova</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Максимова Анастасия Юрьевна – врач лаборатории нагрузочных тестов отдела клинической физиологии инструментальной и лучевой диагностики,</p><p>119991 Москва, ГСП-1, Абрикосовский пер., д. 2</p></bio><bio xml:lang="en"><p>Anastasia Yu. Maksimova – doctor of the laboratory of stress tests of the Clinical Physiology of Instrumental and Radiation Diagnostics,</p><p>2, Abrikosovsky lane, Moscow 119991</p></bio><email xlink:type="simple">nastyanastuhamax@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0143-9053</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузнецова Людмила Митрофановна – доктор мед. наук, главный научный сотрудник лаборатории нагрузочных тестов отдела клинической физиологии инструментальной и лучевой диагностики,</p><p>119991 Москва, ГСП-1, Абрикосовский пер., д. 2</p></bio><bio xml:lang="en"><p>Lyudmila M. Kuznetsova – Doct. of Sci. (Med.), Chief Researcher of the Laboratory of Stress Tests of the Department of Clinical Physiology of Instrumental and Radiation Diagnostics,</p><p>2, Abrikosovsky lane, Moscow 119991</p></bio><email xlink:type="simple">aristova@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4488-1597</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попов</surname><given-names>С. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Popov</surname><given-names>S. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попов Сергей Олегович – канд. мед. наук, врач сердечно-сосудистой хирургии,</p><p>119991 Москва, ГСП-1, Абрикосовский пер., д. 2</p></bio><bio xml:lang="en"><p>Sergey O. Popov – Cand. of Sci. (Med.), Doctor of Cardiovascular Surgery,</p><p>2, Abrikosovsky lane, Moscow 119991</p></bio><email xlink:type="simple">popov@med.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ “Российский научный центр хирургии им. акад. Б.В. Петровского”</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Petrovsky Russian Research Center of Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>14</day><month>06</month><year>2023</year></pub-date><volume>27</volume><issue>3</issue><fpage>68</fpage><lpage>75</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сандриков В.А., Кулагина Т.Ю., Максимова А.Ю., Кузнецова Л.М., Попов С.О., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Сандриков В.А., Кулагина Т.Ю., Максимова А.Ю., Кузнецова Л.М., Попов С.О.</copyright-holder><copyright-holder xml:lang="en">Sandrikov V.A., Kulagina T.Y., Maksimova A.Y., Kuznetsova L.M., Popov S.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/1231">https://medvis.rdsmedia.ru/jour/article/view/1231</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: проанализировать эволюцию силы сокращения миокарда через оценку кинетической энергии (КЭ) у пациентов с аортальным стенозом, основываясь на внутрижелудочковых потоках крови.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В соответствии с критериями отбора обследован 21 здоровый доброволец (средний возраст 34 ± 3 года) и 105 пациентов с аортальным стенозом (средний возраст 62 ± 4 года) до и после операции на 7–10-й день. Выполняли трансторакальную эхокардиографию на аппарате Vivid E9 в 2-, 3- и 4-камерных позициях с регистрацией внутрижелудочковых потоков крови, расчетом скорости изменения объема и КЭ в зависимости от КДО левого желудочка (ЛЖ), градиента давления (ΔР) на аортальном клапане, с оценкой смещения контура эндокарда ЛЖ, основанной на технологии слежения за спеклами ультразвуковых изображений в программе Мультивокс.</p></sec><sec><title>Результаты</title><p>Результаты. Мы ставили своей целью количественное определение КЭ в течение всего сердечного цикла ЛЖ с помощью эхокардиографии. Одной из основных сильных сторон, выявленных в этих исследованиях, является высокая воспроизводимость кровотока и гемодинамики ЛЖ, средний коэффициент вариабельности 7 ± 2% для оценки функции ЛЖ. Исследования показали повышенную диагностическую достоверность без затрат дополнительного времени. Графически KЭ регистрировалась в систолу и диастолу. В систолу КЭ до операции в ЛЖ была выше нормальных значений (0,62–0,78 Дж). После операции КЭ приближалась к норме, составив в среднем 0,55 Дж.</p></sec><sec><title>Заключение</title><p>Заключение. Изменения внутрижелудочкового кровотока у пациентов с перегрузкой сердца давлением демонстрируют более высокую систолическую энергию по сравнению с контрольной группой. Различные временные значения энергии в систолу и диастолу, наблюдаемые у пациентов до операции, представляют объективный подход в оценке работы сердца. Анализ энергии отражает более ранние признаки механических нарушений миокарда по сравнению с фракцией выброса и, возможно, позволяет предсказать развитие ремоделирования сердца. Адекватная коррекция порока нормализует работу сердца уже в раннем послеоперационном периоде.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Goal</title><p>Goal. To analyze the evolution of the myocardial contraction force through the assessment of kinetic energy in patients with aortic stenosis based on intraventricular blood flows</p></sec><sec><title>Material and methods</title><p>Material and methods. According to the selection criteria, 21 healthy volunteers (age 34 ± 3) and 105 patients with aortic stenosis (age 62 ± 4) were examined before and after surgery for 7–10 days. Transthoracic echocardiography was performed on a Vivid E9 device in 2, 3 and 4 chamber positions with registration of intraventricular blood flows, calculation of the rate of change in volume and kinetic energy depending on the left ventricular EDV, pressure gradient (ΔP) on the aortic valve with an assessment of the displacement of the left ventricular endocardium contour, based on technologies for tracking speckles of ultrasonic images in the MultiVox program.</p></sec><sec><title>Results</title><p>Results. Our goal was to quantify kinetic energy (KE) during the entire cardiac cycle of the left ventricle (LV) using echocardiography. One of the main strengths identified in these studies is the high reproducibility of the assessment of LV blood flow and hemodynamics the average coefficient of variability 7 ± 2% for assessing LV function. Studies have shown increased diagnostic reliability without spending additional time. In systole, the KE before the LV operation was higher than normal values (0.62–0.78 J) after the operation, the KE approached the norm, averaging 0.55 J.</p></sec><sec><title>Conclusion</title><p>Conclusion. Changes in intraventricular blood flow in patients with pressure overload of the heart demonstrate higher systolic energy compared to the control group. Different time values of energy in systole and diastole, observed in patients before surgery, represent an objective approach to assessing the work of the heart. The energy analysis reflects earlier signs of mechanical myocardial disorders, compared with the ejection fraction and, possibly, predict the development of cardiac remodeling. Adequate correction of the defect normalizes the work of the heart already in the early postoperative period.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>механика сердца</kwd><kwd>внутрижелудочковый кровоток</kwd><kwd>кинетическая энергия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart mechanics</kwd><kwd>intraventricular blood flow</kwd><kwd>kinetic energy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vallelonga F., Airale G., Pedrizzetti G. et al. Introduction in hemodynamic forces analysis moving into the new frontier of cardiac deformation analysis. J. Am. Heart Assoc. 2021; 10 (24): e023417. http://doi.org/10.1161/JAHA.121.023417</mixed-citation><mixed-citation xml:lang="en">Vallelonga F., Airale G., Pedrizzetti G. et al. Introduction in hemodynamic forces analysis moving into the new frontier of cardiac deformation analysis. J. Am. Heart Assoc. 2021; 10 (24): e023417. http://doi.org/10.1161/JAHA.121.023417</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Zajac J., Eriksson J., Dyverfeldt P. et al. Turbulent kinetic energy in normal and myopathic left ventricles. J. Magn. Reson. Imaging. 2015; 41 (4): 1021–1029. http://doi.org/10.1002/jmri.24633</mixed-citation><mixed-citation xml:lang="en">Zajac J., Eriksson J., Dyverfeldt P. et al. Turbulent kinetic energy in normal and myopathic left ventricles. J. Magn. Reson. Imaging. 2015; 41 (4): 1021–1029. http://doi.org/10.1002/jmri.24633</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Eriksson J., Dyverfeldt P., Engvall J. et al. Quantification of presystolic blood flow organization and energetics in the human left ventricle. Am. J. Physiol. Heart Circ. Physiol. 2011 Jun; 300 (6): H2135–2141. http://doi.org/10.1152/ajpheart.00993.2010</mixed-citation><mixed-citation xml:lang="en">Eriksson J., Dyverfeldt P., Engvall J. et al. Quantification of presystolic blood flow organization and energetics in the human left ventricle. Am. J. Physiol. Heart Circ. Physiol. 2011 Jun; 300 (6): H2135–2141. http://doi.org/10.1152/ajpheart.00993.2010</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Dweck M.R., Joshi S., Murigu T. et al. Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 2012; 14 (1): 50. http://doi.org/10.1186/1532-429X-14-50</mixed-citation><mixed-citation xml:lang="en">Dweck M.R., Joshi S., Murigu T. et al. Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 2012; 14 (1): 50. http://doi.org/10.1186/1532-429X-14-50</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Сандриков В.А., Кулагина Т.Ю. Эхокардиография в кардиохирургии. Векторный анализ и внутрижелудочковые потоки крови. М.: Наш мир, 2022. 607 с. ISBN: 978-5-907549-17-3</mixed-citation><mixed-citation xml:lang="en">Sandrikov V.A., Kulagina T.Yu. Echocardiography in cardiac surgery. Vector analysis and intraventricular blood flows. Moscow: Our World, 2022. 607 p. ISBN: 978-5-907549-17-3 (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Pedrizzetti G., La Canna G., Alfieri O., Tonti G. The vortex – an early predictor of cardiovascular outcome? Nat. Rev. Cardiol. 2014; 11 (9): 545–553. http://doi.org/10.1038/nrcardio.2014.75</mixed-citation><mixed-citation xml:lang="en">Pedrizzetti G., La Canna G., Alfieri O., Tonti G. The vortex – an early predictor of cardiovascular outcome? Nat. Rev. Cardiol. 2014; 11 (9): 545–553. http://doi.org/10.1038/nrcardio.2014.75</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Crandon S., Westenberg J.J.M., Swoboda P.P. et al. Impact of Age and Diastolic Function on Novel, 4D flow CMR Biomarkers of Left Ventricular Blood Flow Kinetic Energy. Sci. Rep. 2018; 8 (1): 14436. http://doi.org/10.1038/s41598-018-32707-5</mixed-citation><mixed-citation xml:lang="en">Crandon S., Westenberg J.J.M., Swoboda P.P. et al. Impact of Age and Diastolic Function on Novel, 4D flow CMR Biomarkers of Left Ventricular Blood Flow Kinetic Energy. Sci. Rep. 2018; 8 (1): 14436. http://doi.org/10.1038/s41598-018-32707-5</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dweck M.R., Joshi S., Murigu T. et al. Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 2012; 14 (1): 50. http://doi.org/10.1186/1532-429X-14-50</mixed-citation><mixed-citation xml:lang="en">Dweck M.R., Joshi S., Murigu T. et al. Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 2012; 14 (1): 50. http://doi.org/10.1186/1532-429X-14-50</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Arvidsson P.M., Töger J., Pedrizzetti G. et al. Hemodynamic forces using four-dimensional flow MRI: an independent biomarker of cardiac function in heart failure with left ventricular dyssynchrony? Am. J. Physiol. Heart Circ. Physiol. 2018; 315 (6): H1627–H1639. http://doi.org/10.1152/ajpheart.00112.2018</mixed-citation><mixed-citation xml:lang="en">Arvidsson P.M., Töger J., Pedrizzetti G. et al. Hemodynamic forces using four-dimensional flow MRI: an independent biomarker of cardiac function in heart failure with left ventricular dyssynchrony? Am. J. Physiol. Heart Circ. Physiol. 2018; 315 (6): H1627–H1639. http://doi.org/10.1152/ajpheart.00112.2018</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Eriksson J., Dyverfeldt P., Engvall J. et al. Quantification of presystolic blood flow organization and energetics in the human left ventricle. Am. J. Physiol. Heart Circ. Physiol. 2011; 300 (6): H2135–2141. http://doi.org/10.1152/ajpheart.00993.2010</mixed-citation><mixed-citation xml:lang="en">Eriksson J., Dyverfeldt P., Engvall J. et al. Quantification of presystolic blood flow organization and energetics in the human left ventricle. Am. J. Physiol. Heart Circ. Physiol. 2011; 300 (6): H2135–2141. http://doi.org/10.1152/ajpheart.00993.2010</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lund O., Flø C., Jensen F.T. et al. Left ventricular systolic and diastolic function in aortic stenosis. Prognostic value after valve replacement and underlying mechanisms. Eur. Heart J. 1997; 18 (12): 1977–1987. https://doi.org/10.1093/oxfordjournals.eurheartj.a015209</mixed-citation><mixed-citation xml:lang="en">Lund O., Flø C., Jensen F.T. et al. Left ventricular systolic and diastolic function in aortic stenosis. Prognostic value after valve replacement and underlying mechanisms. Eur. Heart J. 1997; 18 (12): 1977–1987. https://doi.org/10.1093/oxfordjournals.eurheartj.a015209</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
