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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-1109</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-1109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЕРДЦЕ И СОСУДЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEART AND VESSELS</subject></subj-group></article-categories><title-group><article-title>Роль радионуклидной диагностики в комплексном обследовании ВИЧ-инфицированных пациентов с ишемической болезнью сердца</article-title><trans-title-group xml:lang="en"><trans-title>The role of molecular imaging in the comprehensive examination of HIV-patients with ischemic heart disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8196-6661</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гладких</surname><given-names>П. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gladkikh</surname><given-names>P. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гладких Павел Геннадиевич – врач-рентгенолог, ассистент кафедры лучевой диагностики и терапии МБФ,</p><p>117997 Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Pavel G. Gladkikh – Radiologist, assistant of the Radiology Department,</p><p>house 1, Ostrivityanova str., Moscow 117997 </p></bio><email xlink:type="simple">PAVEL-170@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8317-4097</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мосин</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Mosin</surname><given-names>D. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мосин Дмитрий Юрьевич – научный сотрудник, врач-радиолог НКЦ №2, 119991 Москва, ГСП-1, Абрикосовский пер., д. 2; </p><p>ассистент кафедры рентгенорадиологии, 117997 Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Dmitry Yu. Mosin – Radiologist, researcher; assistant of the Rentgenoradiologi Department, 2, Abrikosovsky lane, Moscow 119991; </p><p>assistant of the Rentgenoradiologi Department, house 1, Ostrivityanova str., Moscow 117997 </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4277-1957</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудрявцев</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudryavtsev</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кудрявцев Антон Денисович – научный сотрудник,</p><p>119991 Москва, ГСП-1, Абрикосовский пер., д. 2</p></bio><bio xml:lang="en"><p>Anton D. Kudryavtsev – Researcher,</p><p>2, Abrikosovsky lane, Moscow 119991</p></bio><email xlink:type="simple">Kudryavtsev95@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0305-6723</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Знаменский</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Znamenskiy</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Знаменский Игорь Альбертович – доктор мед. наук, врач-радиолог, заведующий отделением радионуклидных методов диагностики НКЦ №2, 119991 Москва, ГСП-1, Абрикосовский пер., д. 2; </p><p>профессор кафедры лучевой диагностики и терапии МБФ, 117997 Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Igor A. Znamenskiy – Doct. of Sci. (Med.), Radiologist, Head of the Department of Radionuclide Diagnostic Methods, 2, Abrikosovsky lane, Moscow 119991; </p><p>Professor of the Department of Radiation Diagnostics and Therapy, house 1, Ostrivityanova str., Moscow 117997 </p></bio><email xlink:type="simple">Doc551@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харина</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kharina</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Харина Дина Сергеевна – канд. мед. наук, научный сотрудник, врач-радиолог,</p><p>119991 Москва, ГСП-1, Абрикосовский пер., д. 2</p></bio><bio xml:lang="en"><p>Dina S. Kharina – Cand. of Sci. (Med.), Researcher, Radiologist,</p><p>2, Abrikosovsky lane, Moscow 119991</p></bio><email xlink:type="simple">sardina.sl@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1641-6452</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солодкий</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solodkiy</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Солодкий Владимир Алексеевич – академик РАН, доктор мед. наук, профессор, директор,</p><p>117997 Москва, ул. Профсоюзная, д. 86</p></bio><bio xml:lang="en"><p>Vladimir A. Solodkiy – Full Member of the Russian Academy of Sciences, Doct. of Sci. (Med.), Professor, Director,</p><p>86, Profsoyusnaya str., Moscow 117997</p></bio><email xlink:type="simple">mailbox@rncrr.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5994-0468</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуднов</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nudnov</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нуднов Николай Васильевич – доктор мед. наук, профессор, заместитель директора по научной работе, заведующий НИО комплексной диагностики заболеваний и радиотерапии,</p><p>117997 Москва, ул. Профсоюзная, д. 86</p></bio><bio xml:lang="en"><p>Nikolai V. Nudnov – Doct. of Sci. (Med.), Professor, Deputy Director for scientific work of FSBI, Head of the Research Institute of Complex Diagnostics of Diseases and Radiotherapy,</p><p>86, Profsoyusnaya str., Moscow 117997</p></bio><email xlink:type="simple">nudnov@rncrr.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-5056-8042</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гладких</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gladkikh</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гладких Анастасия Александровна – студент ,</p><p>117997 Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Anastasia A. Gladkikh – student,</p><p>house 1, Ostrivityanova str., Moscow 117997 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2570-5758</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Созыкин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sozykin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Созыкин Алексей Викторович – доктор мед. наук, заведующий отделением рентгенохирургических методов диагностики и лечения,</p><p>119991 Москва, ГСП-1, Абрикосовский пер., д. 2</p></bio><bio xml:lang="en"><p>Aleksey V. Sozykin – Doct. of Sci. (Med.), Head of the Department of endovascular surgery,</p><p>2, Abrikosovsky lane, Moscow 119991</p></bio><email xlink:type="simple">ckb@ckbran.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7284-4737</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдин</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Yudin</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юдин Андрей Леонидович – доктор мед. наук, профессор, заведующий кафедрой лучевой диагностики и терапии МБФ,</p><p>117997 Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Andrei L. Yudin – Doct. of Sci. (Med.), Professor, Head of the Radiology Department,</p><p>house 1, Ostrivityanova str., Moscow 117997 </p></bio><email xlink:type="simple">rsmu@rsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО “Российский национальный исследовательский медицинский университет им. Н.И. Пирогова” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НКЦ №2 ФГБНУ “Российский научный центр хирургии им. акад. Б.В. Петровского” Минздрава России; &#13;
ФГАОУ ВО “Российский национальный исследовательский медицинский университет им. Н.И. Пирогова” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Petrovsky Russian Research Center of Surgery of the Ministry of Healthcare of the Russian Federation; &#13;
Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>НКЦ №2 ФГБНУ “Российский научный центр хирургии им. акад. Б.В. Петровского” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Petrovsky Russian Research Center of Surgery of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ “Российский научный центр рентгенорадиологии” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Scientific Center of Roentgenoradiology of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>29</day><month>06</month><year>2023</year></pub-date><volume>27</volume><issue>3</issue><fpage>41</fpage><lpage>52</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гладких П.Г., Мосин Д.Ю., Кудрявцев А.Д., Знаменский И.А., Харина Д.С., Солодкий В.А., Нуднов Н.В., Гладких А.А., Созыкин А.В., Юдин А.Л., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Гладких П.Г., Мосин Д.Ю., Кудрявцев А.Д., Знаменский И.А., Харина Д.С., Солодкий В.А., Нуднов Н.В., Гладких А.А., Созыкин А.В., Юдин А.Л.</copyright-holder><copyright-holder xml:lang="en">Gladkikh P.G., Mosin D.Y., Kudryavtsev A.D., Znamenskiy I.A., Kharina D.S., Solodkiy V.A., Nudnov N.V., Gladkikh A.A., Sozykin A.V., Yudin A.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/1109">https://medvis.rdsmedia.ru/jour/article/view/1109</self-uri><abstract><p>Наиболее частой причиной смертности во всем мире являются сердечно-сосудистые заболевания, среди которых ведущее место занимает ишемическая болезнь сердца (ИБС). В группу с наиболее высоким риском развития ИБС входят пациенты с ВИЧ-инфекцией.</p><sec><title>Цель исследования</title><p>Цель исследования: оценка возможности применения методов молекулярной визуализации в комплексном обследовании пациентов с ВИЧ-инфекцией и ИБС.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В группу обследования включено 32 пациента с ВИЧ-инфекцией, группу сравнения составили 25 сопоставимых по возрасту пациентов без ВИЧ-инфекции с ИБС. Всем пациентам проведена перфузионная сцинтиграфия миокарда (с помощью ОФЭКТ), ПЭТ/КТ сердца с ФДГ проводилась при необходимости оценки жизнеспособности миокарда в комплексе с диагностической коронароангиографией и стандартным набором лабораторно-инструментальных методов диагностики.</p></sec><sec><title>Результаты</title><p>Результаты. Полученные результаты подтверждают высокую эффективностью методов радионуклидной диагностики для выявления нарушений перфузии, сократимости и жизнеспособности миокарда у пациентов с ВИЧ-инфекцией даже на ранней стадии и могут быть рекомендованы к использованию в комплексном обследовании пациентов с ВИЧ-инфекцией.</p></sec></abstract><trans-abstract xml:lang="en"><p>Cardiovascular disease is one of the most frequent cause of death globally. The greatest part is occupied by ischemic heart disease. HIV patients are composed to a higher risk of coronary heart disease.</p><p>The purpose of this work is to evaluate the possibility of using molecular imaging methods in a comprehensive examination of patients with HIV infection and ischemic heart disease.</p><sec><title>Materials and methods</title><p>Materials and methods. The survey group includes 32 patients with HIV infection. The comparison group consists of 25 age-matched patients with coronary heart disease and without HIV Infection. All patients were underwent myocardial perfusion scintigraphy using single photon emission computed tomography. Positron emission tomography with FDG were performed if necessary to assess the viability of the myocardium. The patients of the main group undergo diagnostic coronary angiography and standard set of laboratory and institutional diagnostic methods.</p></sec><sec><title>Results</title><p>Results. The results of which confirm the high efficiency of radionuclide diagnostic methods for detecting perfusion disorders, contractility and myocardial viability in patients with HIV infection even at an early stage. They can be recommended for using in a comprehensive examination of patients with HIV infection.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>молекулярная визуализация</kwd><kwd>ИБС</kwd><kwd>ВИЧ</kwd><kwd>ОФЭКТ/КТ</kwd><kwd>ПЭТ/КТ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>radiology</kwd><kwd>coronary heart disease</kwd><kwd>HIV</kwd><kwd>SPECT/CT</kwd><kwd>PET/CT</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Khan M.A., Hashim M.J., Mustafa H., et al. Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. Cureus. 2020; 12 (7): e9349. https://doi.org/10.7759/cureus.9349</mixed-citation><mixed-citation xml:lang="en">Khan M.A., Hashim M.J., Mustafa H., et al. Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. 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