medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-1089medvis-1089Research ArticleСЕРДЦЕ И СОСУДЫHEART AND VESSELSОпределение внеклеточного миокардиального матрикса методом двухэнергетической мультиспиральной томографии: систематический обзор с метаанализомDetection of extracellular myocardial matrix with Dual Energy computed tomography: systematic review and meta-analysishttps://orcid.org/0000-0002-8402-7643ЛисицкаяМ. В.LisitskayaM. V.

Лисицкая Мария Валерьевна – канд. мед. наук, врач-рентгенолог отделения рентгенодиагностики с кабинетами КТ и МРТ

119192 Москва, Ломоносовский проспект, 27, к. 10

Тел: +7-196-550-88-11

Scopus ID 57210604921

Maria V. Lisitskaya – Cand. of Sci. (Med.), Radiologist at Radiology department with CT and MR

27-10, Lomonosovsky prospekt, 119192

Scopus ID 57210604921

lissenok@inbox.ruhttps://orcid.org/0000-0001-6034-4698ВершининаО. Ю.VershininaO. Y.

Вершинина Ольга Юрьевна – врач-рентгенолог отделения рентгенодиагностики с кабинетами КТ и МРТ

119192 Москва, Ломоносовский проспект, 27, к. 10

Olga Y. Vershinina – Radiologist at Radiology department with CT and MRI

27-10, Lomonosovsky prospekt, 119192

 

o.y.vershinina@gmail.comhttps://orcid.org/0000-0002-1266-4926МершинаЕ. А.MershinaE. A.

Мершина Елена Александровна – канд. мед. наук, доцент кафедры лучевой диагностики и лучевой терапии; заведующая отделением рентгенодиагностики с кабинетами МРТ и КТ

119192 Москва, Ломоносовский проспект, 27, к. 10

Elena A. Mershina – Cand. of Sci. (Med.), Assistant Professor of Radiology department; Head of Radiology department 

27-10, Lomonosovsky prospekt, 119192

Scopus ID 12787891900

elena_mershina@mail.ruhttps://orcid.org/0000-0001-7533-9867ПлотниковаМ. Л.PlotnikovaM. L.

Плотникова Мария Леонидовна – врач-рентгенолог отделения рентгенодиагностики с кабинетами КТ и МРТ 

119192 Москва, Ломоносовский проспект, 27, к. 10

Maria L. Plotnikova – Radiologist at Radiology department with CT and MRI

27-10, Lomonosovsky prospekt, 119192

mashamotyleva@mail.ruhttps://orcid.org/0000-0002-7757-6273БаженоваД. А.BazhenovaD. A.

Баженова Дарья Анатольевна – врач-рентгенолог отделения рентгенодиагностики с кабинетами КТ и МРТ

119192 Москва, Ломоносовский проспект, 27, к. 10

Darya A. Bazhenova – Radiologist at Radiology department with CT and MRI

27-10, Lomonosovsky prospekt, 119192

bazhenova.darya@gmail.comhttps://orcid.org/0000-0002-1435-4729ШляпкинаО. С.ShlyapkinaO. S.

Шляпкина Ольга Сергеевна – врач рентгенолог отделения рентгенодиагностики с кабинетами КТ и МРТ

119192 Москва, Ломоносовский проспект, 27, к. 10

Olga S. Shlyapkina – Radiologist at Radiology department with CT and MRI

27-10, Lomonosovsky prospekt, 119192

shlyapkinaolga571@gmail.comhttps://orcid.org/0000-0002-5649-2193СиницынВ. Е.SinitsinV. E.

Синицын Валентин Евгеньевич – доктор мед. наук, профессор, заведующий отделом лучевой диагностики; заведующий кафедрой лучевой диагностики и лучевой терапии факультета фундаментальной медицины

119192 Москва, Ломоносовский проспект, 27, к. 10

Valentin E. Sinitsin – Doct. of Sci. (Med.), Professor, Head of Radiology department; Chief of Radiology and Radiotherapy Chair, Faculty of Fundamental Medicine 

27-10, Lomonosovsky prospekt, 119192

vsini@mail.ruМедицинский научно-образовательный центр ФГБОУ ВО “Московский государственный университет имени М.В. Ломоносова”РоссияMedical Research and Education Center of Lomonosov Moscow State UniversityRussian Federation2022110820222637786Copyright © Лисицкая М.В., Вершинина О.Ю., Мершина Е.А., Плотникова М.Л., Баженова Д.А., Шляпкина О.С., Синицын В.Е., 20222022Лисицкая М.В., Вершинина О.Ю., Мершина Е.А., Плотникова М.Л., Баженова Д.А., Шляпкина О.С., Синицын В.Е.Lisitskaya M.V., Vershinina O.Y., Mershina E.A., Plotnikova M.L., Bazhenova D.A., Shlyapkina O.S., Sinitsin V.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/1089Введение

Введение. Неинвазивное измерение внеклеточного миокардиального матрикса (ВММ) является перспек тивным инструментом для количественной оценки фиброзной ткани в миокарде. “Золотым стандартом” неинвазивного определения принято считать магнитно-резонансную томографию (МРТ) с отсроченным контрастированием. Двухэнергетическая мультиспиральная компьютерная томография (ДЭКТ) является новым способом вычисления ВММ и ее прогностическая ценность по сравнению с другими методами при фиброзе различной этиологии остается неясной.

Цель исследования

Цель исследования: обобщение имеющихся данных и изучение прогностической ценности ДЭКТ для диагностики рубцовых изменений миокарда у взрослых пациентов.

Материал и методы

Материал и методы. Проводился систематический поиск опубликованных исследований в базах данных MEDLINE, EMBASE, Библиотеки Cochrane, SCOPUS и Web of Science, оценивающих измерение ВММ по данным двухэнергетической МСКТ и МРТ при фиброзе миокарда любой этиологии. В результате для метаанализа было отобрано 13 статей.

Результаты

Результаты. Представленные исследования продемонстрировали отличие показателя ВММ у пациентов с фиброзом или воспалением миокарда, а также хорошую сопоставимость результатов ДЭКТ и МРТ. Значение ВММ в участках с рубцовыми и воспалительными изменениями было выше, чем в неизмененном миокарде.

Заключение

Заключение. Отличие значения ВММ у пациентов с фиброзом миокарда различной этиологии и здоровых лиц позволяет использовать показатель ВММ по данным ДЭКТ в качестве неинвазивного маркера миокардиального фиброза.

Background

Background. The amount of extracellular myocardial matrix is a non-invasive tool for quantitative assessment of myocardial fibrosis. MRI with late gadolinium-enhancement is considered to be the “Gold standard” of non-invasive practice.  Dual Energy computed tomography is a new non-invasive approach for detection of myocardial fibrosis and its prognostic value remains unclear. The purpose of this study was to summarize all available data and to study prognostic value of DECT for the detection of fibrotic changes in myocardium.

Methods

Methods. We searched MEDLINE, EMBASE, Cochrane, SCOPUS and Web of Science for cohort studies up to October 2021 that reported myocardial extracellular volume fraction quantification using contrast enhanced dual energy CT or/and MRI with delayed enhancement.

Results

Results. Eleven studies met eligibility criteria. A systematic analysis demonstrated the difference in extracellular volume fraction in patients with fibrotic and inflammation changes of the myocardium, as well as good comparability between DECT and MRI. The value of extracellular volume fraction in myocardium with fibrotic or inflammatory changes was higher than in healthy tissue, which makes it possible to use the ECV as a non-invasive marker of myocardial fibrosis.

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The authors declare that there are no conflicts of interest present.