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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medvis</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская визуализация</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Visualization</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-0763</issn><issn pub-type="epub">2408-9516</issn><publisher><publisher-name>RDS-Media Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24835/1607-0763-932</article-id><article-id custom-type="elpub" pub-id-type="custom">medvis-1011</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БРЮШНАЯ ПОЛОСТЬ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ABDOMEN</subject></subj-group></article-categories><title-group><article-title>Основные критерии ASL-перфузии печени при вирусных гепатитах</article-title><trans-title-group xml:lang="en"><trans-title>The main criteria for ASL-perfusion of the liver in viral hepatitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4983-5300</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, заведующая кафедрой лучевой диагностики и лучевой терапии,</p><p>214019 Смоленск, ул. Крупской, 28</p></bio><bio xml:lang="en"><p>Doct. of Sci. (Med.), Head of the Department of Radiation Diagnostics and Radiation Therapy,</p><p>28, Krupskaya str, Smolensk, 214019</p></bio><email xlink:type="simple">t.g.morozova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5709-8913</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симакина</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Simakina</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры инфекционных болезней с курсом эпидемиологии,</p><p>214019 Смоленск, ул. Крупской, 28</p></bio><bio xml:lang="en"><p>assistant of the department of infectious diseases with a course of epidemiology,</p><p>28, Krupskaya str, Smolensk, 214019</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3661-3370</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гельт</surname><given-names>Т. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Gelt</surname><given-names>T. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, ассистент кафедры лучевой диагностики и лучевой терапии,</p><p>214019 Смоленск, ул. Крупской, 28</p></bio><bio xml:lang="en"><p>Cand. of Sci. (Med.), assistant of the Department of Radiation Diagnostics and Radiation Therapy,</p><p>28, Krupskaya str, Smolensk, 214019</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО “Смоленский государственный медицинский университет” Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Smolensk State Medical University of the Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>24</day><month>03</month><year>2021</year></pub-date><volume>25</volume><issue>1</issue><fpage>73</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Морозова Т.Г., Симакина Е.Н., Гельт Т.Д., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Морозова Т.Г., Симакина Е.Н., Гельт Т.Д.</copyright-holder><copyright-holder xml:lang="en">Morozova T.G., Simakina E.N., Gelt T.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medvis.rdsmedia.ru/jour/article/view/1011">https://medvis.rdsmedia.ru/jour/article/view/1011</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: оценить основные критерии ASL-перфузии печени при вирусных гепатитах.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. На базе ОГБУЗ “Клиническая больница №1” Смоленска обследовано 111 пациентов с вирусными гепатитами, среди них 69 (62,2%) мужчин и 42 (37,8) женщины, средний возраст пациентов составил 48 ± 5,4 года. Всем обследуемым (n = 111) были проведены УЗИ органов брюшной полости с допплеровским исследованием сосудов, клиническая эластография, ASL-перфузия печени при магнитно-резонансной томографии (МРТ). Референтным методом являлась трепанбиопсия печени у 69 (62,1%) человек.</p></sec><sec><title>Результаты</title><p>Результаты. Пациенты наблюдались в течение 9 мес. Составлена пропорция прогноза течения вирусных гепатитов с последующим получением коэффициента PHBF/PABF, где PHBF – коэффициент кровотока в паренхиме печени, PABF – кровоток в печеночной артерии или брюшном отделе аорты. По результатам наблюдения за пациентами было установлено, что при поступлении у 54 (48,6%) пациентов коэффициент прогноза составил больше 1, у 57 (51,3%) – меньше 1. Отмечена высокая корреляционная связь при положительной клинико-лабораторной динамике и увеличением показателей ASL-перфузии печени (r = 0,889), а также при отрицательной клинико-лабораторной динамике и снижением показателей ASL-перфузии печени (r = 0,887). Было установлено, что у пациентов с минимальной степенью активности вирусного гепатита объемный печеночный кровоток (HBF) по данным ASL-перфузии печени при МРТ составил от 140 до 159 мл/100 г/мин, с умеренной – 118–139 мл/100 г/мин, с высокой – 40–117 мл/100 г/мин.</p></sec><sec><title>Заключение</title><p>Заключение. Таким образом, при параметре коэффициента прогноза более 1 прогнозируют благоприятное течение (AUC = 0,897 (95% ДИ 0,884 – 0,951)), при коэффициенте менее 1 – неблагоприятное (AUC = 0,895 (95% ДИ 0,881 – 0,953)). </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. Evaluate the main criteria for ASL-liver perfusion in viral hepatitis.</p></sec><sec><title>Material and methods</title><p>Material and methods. 111 patients with viral hepatitis, including 69 (62.2%) men and 42 (37.8) women, were examined on the basis of “Clinical hospital N 1”, Smolensk. The average age of patients was 48 ± 5.4 years. All subjects (n = 111) underwent abdominal ultrasound with Doppler vascular examination, clinical elastography, and ASL-liver perfusion with magnetic resonance imaging (MRI). The reference method was trepan liver biopsy in 69 (62.1%) people.</p></sec><sec><title>Results</title><p>Results. Patients were observed for 9 months. A proportion of the prognosis of the course of the viral hepatitis was compiled, followed by a coefficient-PHBF/PABF, where PHBF is the coefficient of blood flow in the liver parenchyma, PABF is the blood flow in the hepatic artery or abdominal aorta. According to the results of observation of patients, it was found that 54 (48.6%) received more than 1, and 57 (51.3%) had a prognosis coefficient of less than 1. There was a high correlation between positive clinical and laboratory dynamics and an increase in ASL-perfusion of the liver (r = 0.889), as well as negative clinical and laboratory dynamics and a decrease in ASL-perfusion of the liver (r = 0.887). it was found that in patients with a minimum degree of VH activity, the volume of hepatic blood flow (HBF) according to ASL-perfusion of the liver during MRI was from 140 – 159 ml/100 g/min, with a moderate – 118–139 ml/100 g/min, with high – 40–117 ml/100 g/min.</p></sec><sec><title>Conclusion</title><p>Conclusion. Thus, if the ratio of forecast of more than 1 predict a favorable course (AUC = 0,897 (95% CI 0,884– 0,951)), with a coefficient less than 1 is unfavorable (AUC = 0,895 (95% CI 0,881–0,953)). </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ASL-перфузия</kwd><kwd>магнитно-резонансная томография</kwd><kwd>вирусные гепатиты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ASL-perfusion</kwd><kwd>magnetic resonance imaging</kwd><kwd>viral hepatitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Нealth organization: resolution of the 63rd World Health Assembly on Viral Hepatitis (WHA63.18);2010. [accessed 5Aug 2018]. Available at: http://apps.who.int/gb/ebwha/pdf_files/WHA63/A63_R18-ru.pdf</mixed-citation><mixed-citation xml:lang="en">World Нealth organization: resolution of the 63rd World Health Assembly on Viral Hepatitis (WHA63.18);2010. 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