medvisМедицинская визуализацияMedical Visualization1607-07632408-9516RDS-Media Ltd.10.24835/1607-0763-991medvis-1008Research ArticleCOVID-19COVID-19Возможности низкодозной лучевой терапии в лечении внутрилегочных поражений, вызванных инфекцией COVID-19. Обзор литературыPossibilities of low-dose radiation therapy in the treatment of intrapulmonary injuries caused by COVID-19 infectionhttps://orcid.org/0000-0001-9508-2202ХомутоваЕ. Ю.KhomutovaE. Y.

доктор мед. наук, заведующая кафедрой лучевой диагностики, 644099 Омск, ул. Ленина, 12;

644111 Омск, ул. Березовая, 3

Doct. of Sci. (Med.), Head of the department radiodiagnostics, 12, Lenina str., 644099, Omsk;

3, Berezovaya str., Omsk, 644099

elenahomutova68@gmail.comhttps://orcid.org/0000-0001-9264-8071НовиковП. В.NovikovP. V.

канд. мед. наук, ассистент кафедры лучевой диагностики, 644099 Омск, ул. Ленина, 12;

644111 Омск, ул. Березовая, 3

Cand. of Sci. (Med.), assistant of the department radiodiagnostics, 12, Lenina str., 644099, Omsk;

3, Berezovaya str., Omsk, 644099

https://orcid.org/0000-0001-8958-2454ШаталовА. С.ShatalovA. S.

врач ординатор кафедры лучевой диагностики,

644099 Омск, ул. Ленина, 12

resident of the department radiodiagnostics,

12, Lenina str., 644099, Omsk

ФГБОУ ВО “Омский государственный медицинский университет” Минздрава России; БУЗОО “Областная клиническая больница”РоссияOmsk State Medical University; Omsk regional clinical hospitalRussian FederationФГБОУ ВО “Омский государственный медицинский университет” Минздрава РоссииРоссияOmsk State Medical UniversityRussian Federation2021240320212512734Copyright © Хомутова Е.Ю., Новиков П.В., Шаталов А.С., 20212021Хомутова Е.Ю., Новиков П.В., Шаталов А.С.Khomutova E.Y., Novikov P.V., Shatalov A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medvis.rdsmedia.ru/jour/article/view/1008

В данной работе рассматривается актуальность применения однократного облучения легких в лечении пневмонии, вызванной новой коронавирусной инфекцией. Представлены опубликованные результаты о клинических наблюдениях, демонстрирующих перспективу в лечении данного заболевания. Пациенты с тяжелой пневмонией, которым была назначена LD-RT (низкодозная лучевая терапия) в дозе 0,5–1,5 Гр, показали более короткие сроки выздоровления и отсутствие осложнений. Данный метод лечения продемонстрировал свою эффективность в ряде исследований из разных стран, предрекая успех и экономическую выгоду при его дальнейшем использовании и изучении. Поиск литературы, содержащей информацию о соответствующих исследованиях, проводился в системах PubMed, EMBASE, Web of Science и Google Scholar. Внимание было сосредоточено на полнотекстовых статьях, учитывая их общую доступность в условиях пандемии. 

This paper examines the relevance of the use of a single irradiation of lungs in treatment of pneumonia caused by a new coronavirus infection. Clinical observations are presented that demonstrate perspectives in the treatment of this disease. Patients with severe pneumonia who were prescribed LD-RT (low-dose radiation therapy) at a dose of 0.5–1.5 Gy showed shorter recovery times and no complications. This method of treatment has shown its effectiveness in a number of studies from different countries, predicting success and economic benefits in its further use and study. A literature search containing information on relevant studies was carried out in PubMed, EMBASE, Web of Science and Google Scholar systems. Attention was focused on full-text articles given their general availability in a pandemic.

SARS-CoV-2COVID-19коронавирусная пневмониянизкодозная лучевая терапияцитокиновый штормтяжелый острый респираторный синдромSARS-CoV-2COVID-19coronavirus pneumonialow-dose radiation therapycytokine stormsevere acute respiratory syndromeReferencesГоренков Д.В., Хантимирова Л.М., Шевцов В.А., Рукавишников А.В., Меркулов В.А., Олефир Ю.В. Вспышка нового инфекционного заболевания COVID-19: β-корона вирусы как угроза глобальному здравоохранению. БИОпрепараты. Профилактика, диагностика, лечение. 2020; 20 (1): 6–20. https://doi.org/10.30895/2221-996X-2020-20-1-6-20Gorenkov D.V., Khantimirova L.M., Shevtsov V.A., Rukavishnikov A.V., Merkulov V.A., Olefir Yu.V. An Outbreak of a New Infectious Disease COVID-19: β-coronaviruses as a Threat to Global Healthcare. BIOpreparations. Prevention, Diagnosis, Treatment. 2020; 20 (1): 6–20. https://doi.org/10.30895/2221-996X-2020-20-1-6-20 (In Russian)Pneumonia of unknown cause – China. Disease outbreak news. 5 January 2020. WHO [Electronic resource]. – 2020. – Available at: www.who.int/csr/don/05-january2020-pneumonia-of-unkown-cause-china/en/. – [Date of treatment: 14.10.2020].Pneumonia of unknown cause – China. Disease outbreak news. 5 January 2020. WHO [Electronic resource]. – 2020. – Available at: www.who.int/csr/don/05-january2020-pneumonia-of-unkown-cause-china/en/. – [Date of treatment: 14.10.2020].Novel coronavirus – China. WHO [Electronic resource]. – 2020. – Available at: www.who.int/csr/don/12-january2020-novel-coronavirus-china/en/. – [Date of treatment: 14.10.2020].Novel coronavirus – China. WHO [Electronic resource]. – 2020. – Available at: www.who.int/csr/don/12-january2020-novel-coronavirus-china/en/. – [Date of treatment: 14.10.2020].Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека. Эпидемиологическая обстановка и распространение COVID-19 в мире по состоянию на 08.00 (мск) от 28.02.2020 г. [Электронный ресурс] – 2020. – Режим доступа: rospotrebnadzor.ru/region/korono_virus/epid.php. – [Дата обращения: 13.10.2020].Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. The epidemiological situation and the spread of COVID-19 in the world as of 08.00 (Moscow time) from 02.28.2020. [Electronic resource] – 2020. – Available at: rospotrebnadzor.ru/region/korono_virus/epid.php. – [Date of treatment: 05.01.2021] (In Russian)Романов Б.К. Коронавирусная инфекция COVID-2019. Безопасность и риск фармакотерапии. 2020; 8 (1): 3–8. https://doi.org/10.30895/2312-7821-2020-8-1-3-8Romanov B.K. Coronavirus Disease COVID-2019. Safety and Risk of Pharmacotherapy. 2020. 8 (1): 3–8. https://doi.org/10.30895/2312-7821-2020-8-1-3-8 (In Russian)Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome. GenBank: MN908947.3 [Electronic resource]. – 2020. – Available at: www.ncbi.nlm.nih.gov/nuccore/MN908947.3. – [Date of treatment: 05.01.2021].Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome. GenBank: MN908947.3 [Electronic resource]. – 2020. – Available at: www.ncbi.nlm.nih.gov/nuccore/MN908947.3. – [Date of treatment: 05.01.2021].Костинов М.П., Шмитько А.Д., Полищук В.Б., Хромова Е.А. Современные представления о новом коронавирусе и заболевании, вызванном SARSCOV-2. Инфекционные болезни: Новости. Мнения. Обучение. 2020; 9 (2): 33–42.Kostinov M.P., Shmitko A.D., Polishchuk V.B., Khromova E.A. Modern representations of the new coronavirus and the disease caused by SARS-COV-2. Infectious Diseases: News, Opinions, Training. 2020; 9 (2): 33–42. (In Russian)Zhou P., Yang X.-L., Wang X.-G., Hu B., Zhang L., Zhang W., Si H.-R., Zhu Y., Li B., Huang C.-L., Chen H.-D., Chen J., Luo Y., Guo H., Jiang R.-D., Liu M.-Q., Chen Y., Shen X.-R., Wang X., Zheng X.-S., Zhao K., Chen Q.-J., Deng F., Liu L.-L., Yan B., Zhan F.-X., Wang Y.-Y., Xiao G.-F., Shi Z.-L. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579 (7798): 270–273. https://doi.org/10.1038/s41586-020-2012-7Zhou P., Yang X.-L., Wang X.-G., Hu B., Zhang L., Zhang W., Si H.-R., Zhu Y., Li B., Huang C.-L., Chen H.-D., Chen J., Luo Y., Guo H., Jiang R.-D., Liu M.-Q., Chen Y., Shen X.-R., Wang X., Zheng X.-S., Zhao K., Chen Q.-J., Deng F., Liu L.-L., Yan B., Zhan F.-X., Wang Y.-Y., Xiao G.-F., Shi Z.-L. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579 (7798): 270–273. https://doi.org/10.1038/s41586-020-2012-7Kuba K., Imai Y., Rao S., Gao H., Guo F., Guan B., Huan Y., Yang P., Zhang Y., Deng W., Bao L., Zhang B., Liu G., Wang Z., Chappell M., Liu Y., Zheng D., Leibbrandt A., Wada T., Slutsky A.S., Liu D., Qin C., Jiang C., Penninger J.M. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus – induced lung injury. Nature medicine. 2005; 11 (8): 875–879. https://doi.org/10.1038/nm1267Kuba K., Imai Y., Rao S., Gao H., Guo F., Guan B., Huan Y., Yang P., Zhang Y., Deng W., Bao L., Zhang B., Liu G., Wang Z., Chappell M., Liu Y., Zheng D., Leibbrandt A., Wada T., Slutsky A.S., Liu D., Qin C., Jiang C., Penninger J.M. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus – induced lung injury. Nature medicine. 2005; 11 (8): 875–879. https://doi.org/10.1038/nm1267Li W., Moore M.J., Vasilieva N., Sui J., Wong S.K., Berne M.A., Somasundaran M., Sullivan J.L., Luzuriaga K., Greenough T.C., Choe H., Farzan M. Angiotensinconverting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003; 426 (6965): 450–454.Li W., Moore M.J., Vasilieva N., Sui J., Wong S.K., Berne M.A., Somasundaran M., Sullivan J.L., Luzuriaga K., Greenough T.C., Choe H., Farzan M. Angiotensinconverting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003; 426 (6965): 450–454.Callaway E. The coronavirus is mutating-does it matter? Nature. 2020; 585 (7824): 174–177.Callaway E. The coronavirus is mutating-does it matter? Nature. 2020; 585 (7824): 174–177.Исаков В. Профилактика и терапия коронавирусной инфекции. Врач. 2020; 31 (2): 72–74. https://doi.org/10.29296/25877305-2020-02-15Isakov V. Prevention and therapy of coronavirus infection. Doctor. 2020; 31 (2): 72–74. (In Russian) https://doi.org/10.29296/25877305-2020-02-15Камкин Е.Г. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19): временные методические рекомендации. Министерство здравоохранения Российской Федерации. М., 2020. 226 с.Kamkin E.G. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19): temporary methodical recommendations. Ministry of Health of Russian Federation. Moscow, 2020. 226 p. (In Russian)Всемирная организация здравоохранения. Европейское региональное бюро [Электронный ресурс]. – 2020. – Режим доступа: www.euro.who.int/ru/healthtopics/health-emergencies/coronavirus-covid-19/news/news/2020/3/who-announces-covid-19-outbreak-apandemic. – [Дата обращения: 05.01.2021].World Health Organization. Regional office for Europe. [Electronic resource]. – 2020. – Available at: www.euro.who.int/ru/health-topics/health-emergencies/coronavirus-covid-19/news/news/2020/3/whoannounces-covid-19-outbreak-a-pandemic. – [Date of treatment: 05.01.2021].Беляков Н.А., Рассохин В.В., Ястребова Е.Б. Коронавирусная инфекция COVID-19. Природа вируса, патогенез, клинические проявления. Сообщение 1. ВИЧинфекция и иммуносупрессии. 2020; 12 (1): 7–21. https://doi.org/10.22328/2077-9828-2020-12-1-7-21N.A. Belyakov, V.V. Rassokhin, E.B.Yastrebova. Coronavirus infectious disease covid-19. Nature of virus, pathogenesis, clinical manifestations, report 1. HIV infection and immunosuppression. 2020; 12 (1): 7–21. https://doi.org/10.22328/2077-9828-2020-12-1-7-21 (In Russian)Никифоров В.В., Суранова Т.Г., Чернобровкина Т.Я., Янковская Я.Д., Бурова С.В. Новая коронавирусная инфекция (COVID-19): клинико-эпидемиологические аспекты. Архивъ внутренней медицины. 2020; 10 (2 (52)): 87–93.Nikiforov V.V., Suranova T.G., Chernobrovkina T.Yu., Yankovskaya Y.D., Burova S.V. New Coronavirus Infection (Covid-19): Clinical and Epidemiological Aspects. The Russian Archives of Internal Medicine. 2020; 10 (2 (52)): 87–93. https://doi.org/10.20514/2226-6704-2020-10-2-87-93 (In Russian)Никифоров В.В., Суранова Т.Г., Миронов А.Ю., Забозлаев Ф.Г. Новая коронавирусная инфекция (COVID-19): этиология, эпидемиология, клиника, диагностика, лечение и профилактика. М.: ФГБУ ФНКЦ ФМБА, 2020. 48 с.Nikiforov V.V., Suranova T.G., Mironov A.Yu., Zabozlaev F.G. New coronavirus infection (COVID-19): etiology, epidemiology, clinic, diagnosis, treatment and prevention. Moscow: FMBA Academy of Graduate Education, 2020. 48 с. (In Russian)Wu Y. C., Chen C. S., Chan Y. J.The outbreak of COVID-19: An overview. J. Chinese Med. Assoc. 2020; 83 (3): 217.Wu Y. C., Chen C. S., Chan Y. J.The outbreak of COVID-19: An overview. J. Chinese Med. Assoc. 2020; 83 (3): 217.Braciale T.J., Sun J., Kim T.S. Regulating the adaptive immune response to respiratory virus infection. Nat. Rev. Immunol. 2012; 12 (4): 295–305. https://doi.org/10.1038/nri3166Braciale T.J., Sun J., Kim T.S. Regulating the adaptive immune response to respiratory virus infection. Nat. Rev. Immunol. 2012; 12 (4): 295–305. https://doi.org/10.1038/nri3166Hamada H., Bassity E., Flies A., Strutt T.M., GarciaHernandez M.de L., McKinstry K.K., Zou T., Swain S.L., Dutton R.W. Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection. J. Immunol. 2013; 190 (1): 296–306. https://doi.org/10.4049/jimmunol.1200571Hamada H., Bassity E., Flies A., Strutt T.M., GarciaHernandez M.de L., McKinstry K.K., Zou T., Swain S.L., Dutton R.W. Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection. J. Immunol. 2013; 190 (1): 296–306. https://doi.org/10.4049/jimmunol.1200571Zhou Y., Fu B., Zheng X., Wang D., Zhao C., Qi Y., Sun R., Tian Z., Xu X., Wei H. Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients. Nat. Sci. Rev. 2020; 7: 998–1002. https://doi.org/10.1093/nsr/nwaa041Zhou Y., Fu B., Zheng X., Wang D., Zhao C., Qi Y., Sun R., Tian Z., Xu X., Wei H. Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients. Nat. Sci. Rev. 2020; 7: 998–1002. https://doi.org/10.1093/nsr/nwaa041Тюляндина Е.В., Писков Д.А. Цитокиновый шторм: Особенности патогенеза, роль в развитии вирусной инфекции. Литературный обзор. Устойчивое развитие науки и образования. 2019; 1: 256–260.Tiuliandina E.V., Piskov D.A. Cytokine-release syndrome: pathogenesis features, the role in the development of viral infection. A literature review. Sustainable development of science and education. 2019; 1: 256–260. (In Russian)Шипилов М.В. “Цитокиновый шторм” при гриппе: перспективы диагностики. Уральский медицинский журнал. 2011; 7: 67–71.Shipilov M.V. “Cytokine storm” of the influenza: prospects for diagnosis. Ural Medical Journal. 2011; 7: 67–71. (In Russian)Ye Q., Wang B., Mao J. Cytokine storm in COVID-19 and treatment. J. Infection. 2020; 80: 607–613. https://doi.org/10.1016/j.jinf.2020.03.037Ye Q., Wang B., Mao J. Cytokine storm in COVID-19 and treatment. J. Infection. 2020; 80: 607–613. https://doi.org/10.1016/j.jinf.2020.03.037Sequeira J.H. et al. A discussion on radiography, “X”-Ray treatment, the high-frequency method, and light treatment. Br. Med. J. 1902; 2 (2182): 1316–1319.Sequeira J.H. et al. A discussion on radiography, “X”-Ray treatment, the high-frequency method, and light treatment. Br. Med. J. 1902; 2 (2182): 1316–1319.Russell E.J. The effect of radium on the growth of plants. Nature. 1915; 96 (2397): 147–148.Russell E.J. The effect of radium on the growth of plants. Nature. 1915; 96 (2397): 147–148.Кузин А.М. Ведущие механизмы радиационного гормезиса. Известия РАН. Серия биология. 1993; 6 (34): 824–832.Kuzin A.M. Leading mechanisms of radiation hormesis. Bulletin of the Russian Academy of Sciences. Biology series. 1993; 6 (34): 824–832. (In Russian)Кузин А.М. Идеи радиационного гормезиса в атомном веке. М.: Наука, 1995. 156 с.Kuzin A.M. The ideas of radiation hormesis in the atomic age. Moscow: The science, 1995. 156 с. (In Russian)Ивановский Ю.А. Радиационный гормезис. Благоприятны ли малые дозы ионизирующей радиации? Вестник Дальневосточного отделения Российской академии наук. 2006; 6: 86–90.Ivanovsky Yu.A. Radiation hormesis. Is low-dose ionizing irradiation favorable? Far Eastern National University, Vladivostok. 2006; 6: 86–90. (In Russian)Calabrese E.J., Dhawan G. How radiotherapy was historically used to treat pneumonia: could it be useful today? Yale J. Biol. Med. 2013; 86 (4): 555–570.Calabrese E.J., Dhawan G. How radiotherapy was historically used to treat pneumonia: could it be useful today? Yale J. Biol. Med. 2013; 86 (4): 555–570.Kirkby C., Mackenzie M. Is low dose radiation therapy a potential treatment for COVID-19 pneumonia? Radiother. Oncol. 2020; 147: 221. https://doi.org/10.1016/j.radonc.2020.04.004Kirkby C., Mackenzie M. Is low dose radiation therapy a potential treatment for COVID-19 pneumonia? Radiother. Oncol. 2020; 147: 221. https://doi.org/10.1016/j.radonc.2020.04.004Wilson G.D., Mehta M.P., Welsh J.S., Chakravarti A., Rogers C.L., Fontanesi J. Investigating low-dose thoracic radiation as a treatment for COVID-19 patients to prevent respiratory failure. Radiat. Res. 2020; 194 (1): 1–8. https://doi.org/10.1667/RADE-20-00108.1Wilson G.D., Mehta M.P., Welsh J.S., Chakravarti A., Rogers C.L., Fontanesi J. Investigating low-dose thoracic radiation as a treatment for COVID-19 patients to prevent respiratory failure. Radiat. Res. 2020; 194 (1): 1–8. https://doi.org/10.1667/RADE-20-00108.1Dhawan G., Kapoor R., Dhawan R., Singh R., Monga B., Giordano J., Calabrese E.J. Low dose radiation therapy as a potential life saving treatment for COVID-19-induced acute respiratory distress syndrome (ARDS). Radiother. Oncol. 2020; 147: 212–216. https://doi.org/10.1016/j.radonc.2020.05.002.Dhawan G., Kapoor R., Dhawan R., Singh R., Monga B., Giordano J., Calabrese E.J. Low dose radiation therapy as a potential life saving treatment for COVID-19-induced acute respiratory distress syndrome (ARDS). Radiother. Oncol. 2020; 147: 212–216. https://doi.org/10.1016/j.radonc.2020.05.002.Dubin I.N., Baylin G.J., Gobble J.W.G. The effect of roentgen therapy on experimental virus pneumonia; on pneumonia produced in white mice by swine influenza. Am. J. Roentgenol. Radium Ther. 1946; 55: 478–481.Dubin I.N., Baylin G.J., Gobble J.W.G. The effect of roentgen therapy on experimental virus pneumonia; on pneumonia produced in white mice by swine influenza. Am. J. Roentgenol. Radium Ther. 1946; 55: 478–481.Hess C.B., Buchwald Z.S., Stokes W., Nasti T.H., Switchenko J.M., Weinberg B.D., Rouphael N., Steinberg J.P., Godette K.D., Murphy D., Ahmed R., Curran W.J. Jr, Khan M.K. Low-dose whole-lung radiation for COVID-19 pneumonia. medRxiv. 2020. Available at: https://doi.org/10.1101/2020.07.11.20147793. [Date of treatment: 05.01.2021].Hess C.B., Buchwald Z.S., Stokes W., Nasti T.H., Switchenko J.M., Weinberg B.D., Rouphael N., Steinberg J.P., Godette K.D., Murphy D., Ahmed R., Curran W.J. Jr, Khan M.K. Low-dose whole-lung radiation for COVID-19 pneumonia. medRxiv. 2020. Available at: https://doi.org/10.1101/2020.07.11.20147793. [Date of treatment: 05.01.2021].Hess C.B. et al. Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19 (RESCUE 1-19): A Randomized Phase III Trial of Best Supportive Care versus Whole Lung Low-Dose Radiation Therapy in Hospitalized Patients with COVID-19 [Electronic resource]. Emory Winship Cancer Institute. – 2020. – Available at: www.clinicaltrials.gov/ProvidedDocs/91/NCT04366791/Prot_SAP_000.pdf. – [Date of treatment: 05.01.2021].Hess C.B. et al. Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19 (RESCUE 1-19): A Randomized Phase III Trial of Best Supportive Care versus Whole Lung Low-Dose Radiation Therapy in Hospitalized Patients with COVID-19 [Electronic resource]. Emory Winship Cancer Institute. – 2020. – Available at: www.clinicaltrials.gov/ProvidedDocs/91/NCT04366791/Prot_SAP_000.pdf. – [Date of treatment: 05.01.2021].Ameri А. et al. Low-dose whole-lung irradiation for COVID-19 pneumonia: short course results [Electronic resource]. International Journal of Radiation Oncology, Biology, Physics. – 2020. – Available at: doi.org/10.1016/j.ijrobp.2020.07.026. – [Date of treatment: 05.01.2021].Ameri А. et al. Low-dose whole-lung irradiation for COVID-19 pneumonia: short course results [Electronic resource]. International Journal of Radiation Oncology, Biology, Physics. – 2020. – Available at: doi.org/10.1016/j.ijrobp.2020.07.026. – [Date of treatment: 05.01.2021].Castillo R. et al. Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review [Electronic resource]. Strahlentherapie und Onkologie. – 2020. – Available at: doi.org/10.1007/s00066-020-01675-z. – [Date of treatment: 05.01.2021].Castillo R. et al. Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review [Electronic resource]. Strahlentherapie und Onkologie. – 2020. – Available at: doi.org/10.1007/s00066-020-01675-z. – [Date of treatment: 05.01.2021].Kirsch D.G., Diehn M., Cucinotta F.A., Weichselbaum R. Lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable. Radiother. Oncol. 2020; 147: 217–220.Kirsch D.G., Diehn M., Cucinotta F.A., Weichselbaum R. Lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable. Radiother. Oncol. 2020; 147: 217–220.

The authors declare that there are no conflicts of interest present.